scholarly journals Biological Activities of Gedunin—A Limonoid from the Meliaceae Family

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 493 ◽  
Author(s):  
Teresa M. Braga ◽  
Lídia Rocha ◽  
Tsz Yan Chung ◽  
Rita F. Oliveira ◽  
Cláudia Pinho ◽  
...  
Keyword(s):  
Heat Shock ◽  
Literature Review ◽  
Heat Shock Protein ◽  
Natural Compound ◽  
Therapeutic Agent ◽  
Biological Activities ◽  
Neuroprotective Effects ◽  
Future Directions ◽  
Important Landmark ◽  
Critical Literature

Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Several biological activities have been attributed to gedunin, including antibacterial, insecticidal, antimalarial, antiallergic, anti-inflammatory, anticancer, and neuroprotective effects. The discovery of gedunin as a heat shock protein (Hsp) inhibitor represented a very important landmark for its application as a biological therapeutic agent. The current study is a critical literature review based on the several biological activities so far described for gedunin, its therapeutic effect on some human diseases, and future directions of research for this natural compound.

Pharmacological induction of heat shock protein exerts neuroprotective effects in experimental intracerebral hemorrhage

2007 ◽  
Vol 1135 ◽  
pp. 167-176 ◽  
Author(s):  
Dong-In Sinn ◽  
Kon Chu ◽  
Soon-Tae Lee ◽  
Eun-Cheol Song ◽  
Keun-Hwa Jung ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Intracerebral Hemorrhage ◽  
Neuroprotective Effects

Effects of ferulic acid on oxidative stress, heat shock protein 70, connexin 43, and monoamines in the hippocampus of pentylenetetrazole-kindled rats

2017 ◽  
Vol 95 (6) ◽  
pp. 732-742 ◽  
Author(s):  
Abdelaziz M. Hussein ◽  
Khaled M. Abbas ◽  
Osama A. Abulseoud ◽  
El-Hussainy M.A. El-Hussainy
Keyword(s):  
Oxidative Stress ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Ferulic Acid ◽  
Group Treatment ◽  
Heat Shock Protein 70 ◽  
Connexin 43 ◽  
Hsp70 Expression ◽  
Neuroprotective Effects ◽  
Cx43 Expression

The present study investigated the effects of ferulic acid (FA) on pentylenetetrazole (PTZ)-induced seizures, oxidative stress markers (malondialdehyde (MDA), catalase, and reduced glutathione (GSH)), connexin (Cx) 43, heat shock protein 70 (Hsp 70), and monoamines (serotonin (5-HT) and norepinephrine (NE)) levels in a rat model of PTZ-induced kindling. Sixty Sprague Dawley rats were divided into 5 equal groups: (a) normal group; (b) FA group: normal rats received FA at a dose of 40 mg/kg daily; (c) PTZ group: normal rats received PTZ at a dose of 50 mg/kg i.p. on alternate days for 15 days; (d) FA-before group: treatment was the same as for the PTZ group, except rats received FA; and (e) FA-after group: rats received FA from sixth dose of PTZ. PTZ caused a significant increase in MDA, Cx43, and Hsp70 along with a significant decrease in GSH, 5-HT, and NE levels and CAT activity in the hippocampus (p < 0.05). Pre- and post-treatment with FA caused significant improvement in behavioral parameters, MDA, CAT, GSH, 5-HT, NE, Cx43 expression, and Hsp70 expression in the hippocampal region (p < 0.05). We conclude that FA has neuroprotective effects in PTZ-induced epilepsy, which might be due to attenuation of oxidative stress and Cx43 expression and upregulation of neuroprotective Hsp70 and neurotransmitters (5-HT and NE).

scholarly journals A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus

Molecules ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 1888 ◽  
Author(s):  
Wenhua Chen ◽  
Huiying Tan ◽  
Qian Liu ◽  
Xiaohua Zheng ◽  
Hua Zhang ◽  
...  
Keyword(s):  
Recent Progress ◽  
Therapeutic Agent ◽  
Biological Activities ◽  
Review Article ◽  
Phellinus Linteus ◽  
Medicinal Mushroom ◽  
Asian Countries ◽  
Bioactive Components ◽  
Neuroprotective Effects ◽  
Made In

Phellinus linteus is a popular medicinal mushroom that is widely used in China, Korea, Japan, and other Asian countries. P. linteus comprises various bioactive components, such as polysaccharides, triterpenoids, phenylpropanoids, and furans, and has proven to be an effective therapeutic agent in traditional Chinese medicine for the treatment and the prevention of various diseases. A number of studies have reported that P. linteus possesses many biological activities useful for pharmacological applications, including anticancer, anti-inflammatory, immunomodulatory, antioxidative, and antifungal activities, as well as antidiabetic, hepatoprotective, and neuroprotective effects. This review article briefly presents the recent progress made in understanding the bioactive components, biological activities, pharmacological applications, safety, and prospects of P. linteus, and provides helpful references and promising directions for further studies of P. linteus.

scholarly journals Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions

2014 ◽  
Vol 23 (5) ◽  
pp. 611-628 ◽  
Author(s):  
Komal Jhaveri ◽  
Stefan O Ochiana ◽  
Mark PS Dunphy ◽  
John F Gerecitano ◽  
Adriana D Corben ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 90 ◽  
Current Status ◽  
Future Directions

The cardioprotective role of small heat-shock protein 20

2014 ◽  
Vol 42 (2) ◽  
pp. 270-273 ◽  
Author(s):  
Tamara P. Martin ◽  
Susan Currie ◽  
George S. Baillie
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Therapeutic Agent ◽  
Contractile Function ◽  
Small Heat Shock Protein ◽  
Dependent Protein Kinase ◽  
Heat Shock Protein 20 ◽  
Dependent Protein ◽  
Stress Damage

The small HSP (heat-shock protein) HSP20 is a molecular chaperone that is transiently up-regulated in response to cellular stress/damage. Although ubiquitously expressed in various tissues, it is most highly expressed in skeletal, cardiac and smooth muscle. Phosphorylation at Ser16 by PKA (cAMP-dependent protein kinase) is essential for HSP20 to confer its protective qualities. HSP20 and its phosphorylation have been implicated in a variety of pathophysiological processes, but most prominently cardiovascular disease. A wealth of knowledge of the importance of HSP20 in contractile function and cardioprotection has been gained over the last decade. The present mini-review highlights more recent findings illustrating the cardioprotective properties of HSP20 and its potential as a therapeutic agent.

scholarly journals The Neuroprotective Effects of Heat Shock Protein 27 Overexpression in Transgenic Animals against Kainate-induced Seizures and Hippocampal Cell Death

2003 ◽  
Vol 278 (22) ◽  
pp. 19956-19965 ◽  
Author(s):  
Mohammed T. Akbar ◽  
Anna M. C. Lundberg ◽  
Ke Liu ◽  
Sharmili Vidyadaran ◽  
Kim E. Wells ◽  
...  
Keyword(s):  
Cell Death ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Transgenic Animals ◽  
Heat Shock Protein 27 ◽  
Neuroprotective Effects ◽  
Hippocampal Cell
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