scholarly journals GenusSpondias: A Phytochemical and Pharmacological Review

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Salma Sameh ◽  
Eman Al-Sayed ◽  
Rola M. Labib ◽  
Abdel Nasser Singab
Keyword(s):  
Oxidative Stress ◽  
Natural Products ◽  
Therapeutic Strategy ◽  
Flowering Plants ◽  
Degenerative Diseases ◽  
Pharmacological Activities ◽  
Tropical Regions ◽  
The World ◽  
Phytochemical Constituents ◽  
Therapeutic Alternatives

It is believed that many degenerative diseases are due to oxidative stress. In view of the limited drugs available for treating degenerative diseases, natural products represent a promising therapeutic strategy in the search for new and effective candidates for treating degenerative diseases. This review focuses on the genusSpondiaswhich is widely used in traditional medicine for the treatment of many diseases.Spondiasis a genus of flowering plants belonging to the cashew family (Anacardiaceae). This genus comprises 18 species distributed across tropical regions in the world. A variety of bioactive phytochemical constituents were isolated from different plants belonging to the genusSpondias. Diverse pharmacological activities were reported for the genusSpondiasincluding cytotoxic, antioxidant, ulcer protective, hepatoprotective, anti-inflammatory, antiarthritic, and antidementia effects. These attributes indicate their potential to treat various degenerative diseases. The aim of this review is to draw attention to the unexplored potential of phytochemicals obtained fromSpondiasspecies, thereby contributing to the development of new therapeutic alternatives that may improve the health of people suffering from degenerative diseases and other health problems.

Medicinal Inula Species: Phytochemistry, Biosynthesis, and Bioactivities

2021 ◽  
pp. 1-44
Author(s):  
Cheng-Peng Sun ◽  
Zi-Li Jia ◽  
Xiao-Kui Huo ◽  
Xiang-Ge Tian ◽  
Lei Feng ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Drug Development ◽  
Scientific Basis ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Traditional Medicines ◽  
The World ◽  
Phytochemical Constituents ◽  
New Drug Development ◽  
First Time

As a genus of the Asteraceae, Inula is widely distributed all over the world, and several of them are being used in traditional medicines. A number of metabolites were isolated from Inula species, and some of these have shown to possess ranges of pharmacological activities. The genus Inula contains abundant sesquiterpenoids, such as eudesmanes, xanthanes, and sesquiterpenoid dimers and trimers. In addition, other types of terpenoids, flavonoids, and lignins also exist in the genus Inula. Since 2010, more than 300 new secondary metabolites, including several known natural products that were isolated for the first time from the genus Inula. Most of them exhibited potential bioactivities in various diseases. The review aimed to summarize the advance of recent researches (2010–2020) on phytochemical constituents, biosynthesis, and pharmacological properties of the genus Inula for providing a scientific basis and supporting its application and exploitation for new drug development.

scholarly journals Recent Advances in the Discovery of Novel Antiprotozoal Agents

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3886 ◽  
Author(s):  
Lee ◽  
Kim ◽  
Hayat ◽  
Shin
Keyword(s):  
Drug Resistance ◽  
New Drugs ◽  
Parasitic Diseases ◽  
Protozoan Parasites ◽  
Pharmacological Activities ◽  
Mortality And Morbidity ◽  
Tropical Regions ◽  
Recent Advances ◽  
The World ◽  
Effective Medication

Parasitic diseases have serious health, social, and economic impacts, especially in the tropical regions of the world. Diseases caused by protozoan parasites are responsible for considerable mortality and morbidity, affecting more than 500 million people worldwide. Globally, the burden of protozoan diseases is increasing and is been exacerbated because of a lack of effective medication due to the drug resistance and toxicity of current antiprotozoal agents. These limitations have prompted many researchers to search for new drugs against protozoan parasites. In this review, we have compiled the latest information (2012–2017) on the structures and pharmacological activities of newly developed organic compounds against five major protozoan diseases, giardiasis, leishmaniasis, malaria, trichomoniasis, and trypanosomiasis, with the aim of showing recent advances in the discovery of new antiprotozoal drugs.

scholarly journals Pistacia integerrima (Shringi)- A Plant with Significant Pharmacological Activities

2021 ◽  
Vol 10 (5) ◽  
pp. 323-330
Author(s):  
Manish Grover ◽  
Keyword(s):  
Skin Diseases ◽  
Pharmacological Activities ◽  
North West ◽  
Alpha Pinene ◽  
Anti Cancer ◽  
The Family ◽  
The World ◽  
Anti Oxidant ◽  
Phytochemical Constituents ◽  
Important Medicinal Plant

Pistacia integerrima is an important medicinal plant belongs to the family Anacardiacea. It is commonly called as Crab’s claw in English and Shani/Shringi in Hindi. It is a single-stemmed, dioecious tree widely distributed in countries like Nepal, China, Afghanistan, Pakistan, Armenia, North-west and West Himalayas. The plant has significant applications in the traditional systems of medications such as Ayurveda, Unani and Siddha. In addition, the plant is also used in many folkloric cultures around the world to treat a vast array of human ailments such as diarrhoea, dysentery, fever, vomiting, skin diseases, respiratory ailments and psoriasis appetizer, hepatitis and liver related disorders. The characteristic feature of the plant is its essential oil content comprised of many important phytochemical constituents such as alpha-pinene, camphene, di-limonene, 1:8-cineol, caprylic acid, alpha-terpineol and aromadendrene. However, the plant contains many other important secondary metabolites such as steroids, flavonoids, tannins, saponins and phenols which are associated with important pharmacological activities such as anti-bacterial, anti-oxidant, anti-inflammatory, cardio-protective, anti-cancer, antidiarrhoeal, anticonvulsant and muscle relaxant. The aim of the present study is to summarize the recent pharmacological activities of Pistacia integerrima along with its utilization in traditional medication systems

scholarly journals Isolation of 2,4-Di-tert-butylphenol and Butyrospermol 3-?-O-palmitate from Syzygium aqueum stem bark

2020 ◽  
Vol 5 (4) ◽  
Author(s):  
Alfinda Novi Kristanti ◽  
Ei Ei Aung ◽  
Nanik Siti Aminah ◽  
Yoshiaki Takaya ◽  
Rico Ramadhan
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Traditional Medicine ◽  
Stem Bark ◽  
Tropical Regions ◽  
Chemical Substances ◽  
The World ◽  
Pure Compounds ◽  
Phytochemical Constituents ◽  
Column Chromatographic

Syzygium genus in Myrtaceae family is a rich source of phytochemical constituents that possess various bioactivities. One of well-known species of this genus, Syzygium aqueum, has been already utilized as traditional medicine. This plant is cultivated in countries of tropical regions of the world such as Malaysia and Indonesia. The aim of this study was intended to isolate phytochemical constituents from the stem bark of S. aqueum. To date, there have been no reports of chemical substances isolated from the stem bark of this plant. The powder of the stem bark was extracted followed by partitioned in order to obtain n-hexane extract which then was separated using silica gel column chromatographic several times until the pure compounds were resulted. The isolated compounds were identified by spectroscopie method including Fouirer Transform Infrared (FTIR) and nuclear magnetic resonance (NMR) and were known as 2,4-Di-tert-butylphenol & butyrospermol 3-β-O-palmitate, respectively. The spectoscopie data of those compounds were compared with references.

scholarly journals Natural products in Cyperus rotundus L. (Cyperaceae): an update of the chemistry and pharmacological activities

RSC Advances ◽  
2021 ◽  
Vol 11 (25) ◽  
pp. 15060-15077
Author(s):  
Smith B. Babiaka ◽  
Aurélien F. A. Moumbock ◽  
Stefan Günther ◽  
Fidele Ntie-Kang
Keyword(s):  
Natural Products ◽  
Cyperus Rotundus ◽  
Pharmacological Activities ◽  
The World

Cyperus rotundus L. (Nutgrass, family Cyperaceae) is a notorious weed which is widespread in temperate tropical and subtropical regions of the world.

Review on pharmacological activities and phytochemical constituents of Phyllanthus niruri (Amarus)

2018 ◽  
Vol 7 (3) ◽  
pp. 341-348
Author(s):  
S Danladi ◽  
◽  
MA Idris ◽  
II Umar ◽  
◽  
...  
Keyword(s):  
Unwanted Pregnancy ◽  
Folk Medicine ◽  
Scientific Investigation ◽  
Tropical Region ◽  
Phyllanthus Amarus ◽  
Phyllanthus Niruri ◽  
Pharmacological Activities ◽  
The World ◽  
Microbial Infections ◽  
Phytochemical Constituents

Phyllanthus amarus Schum and Thonn (Euphobiaceae); is found in tropical and sub-tropical region of the world. It grows as a weed in moist abandoned land. It has various applications in tradition and folk medicine for treatment of various diseases such as hepatitis, cough, diuretic, menstruation problem and dysentery. It is commonly used by many countries across the world. Scientific investigation revealed that Phyllanthus amarus has potent activity against various diseases such as hepatitis B, HIV, microbial infections, plasmodiasis, nematode infestation, lithiasis, hyperlipidemia, diabetes, hyperuricemia, nephrotoxicity, platelet aggregation, radiation exposure, algesia, unwanted pregnancy, vasoconstriction, hepatotoxity and biological oxidation

scholarly journals FivePistaciaspecies (P. vera,P. atlantica,P. terebinthus,P. khinjuk, andP. lentiscus): A Review of Their Traditional Uses, Phytochemistry, and Pharmacology

2013 ◽  
Vol 2013 ◽  
pp. 1-33 ◽  
Author(s):  
Mahbubeh Bozorgi ◽  
Zahra Memariani ◽  
Masumeh Mobli ◽  
Mohammad Hossein Salehi Surmaghi ◽  
Mohammad Reza Shams-Ardekani ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Flowering Plants ◽  
Gastrointestinal Disorders ◽  
Pharmacological Activities ◽  
Beneficial Effects ◽  
Comprehensive Information ◽  
The Family ◽  
Phytochemical Constituents ◽  
Ethnomedicinal Uses ◽  
Different Parts

Pistacia, a genus of flowering plants from the family Anacardiaceae, contains about twenty species, among them five are more popular includingP. vera, P. atlantica, P. terebinthus, P. khinjuk,andP. lentiscus. Different parts of these species have been used in traditional medicine for various purposes like tonic, aphrodisiac, antiseptic, antihypertensive and management of dental, gastrointestinal, liver, urinary tract, and respiratory tract disorders. Scientific findings also revealed the wide pharmacological activities from various parts of these species, such as antioxidant, antimicrobial, antiviral, anticholinesterase, anti-inflammatory, antinociceptive, antidiabetic, antitumor, antihyperlipidemic, antiatherosclerotic, and hepatoprotective activities and also their beneficial effects in gastrointestinal disorders. Various types of phytochemical constituents like terpenoids, phenolic compounds, fatty acids, and sterols have also been isolated and identified from different parts ofPistaciaspecies. The present review summarizes comprehensive information concerning ethnomedicinal uses, phytochemistry, and pharmacological activities of the five mentionedPistaciaspecies.

scholarly journals Antioxidative Effects of Natural Products on Diabetic Cardiomyopathy

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Bingdi Yan ◽  
Jin Ren ◽  
Qinghua Zhang ◽  
Rong Gao ◽  
Fenglian Zhao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trials ◽  
Natural Products ◽  
Diabetic Cardiomyopathy ◽  
Mechanism Of Action ◽  
High Mortality ◽  
Therapeutic Strategy ◽  
Present Review ◽  
Beneficial Effects ◽  
Antioxidative Effects

Diabetic cardiomyopathy (DCM) is a common and severe complication of diabetes and results in high mortality. It is therefore imperative to develop novel therapeutics for the prevention or inhibition of the progression of DCM. Oxidative stress is a key mechanism by which diabetes induces DCM. Hence, targeting of oxidative stress-related processes in DCM could be a promising therapeutic strategy. To date, a number of studies have shown beneficial effects of several natural products on the attenuation of DCM via an antioxidative mechanism of action. The aim of the present review is to provide a comprehensive and concise overview of the previously reported antioxidant natural products in the inhibition of DCM progression. Clinical trials of the antioxidative natural products in the management of DCM are included. In addition, discussion and perspectives are further provided in the present review.

scholarly journals Dietary Phytochemicals: Natural Swords Combating Inflammation and Oxidation-Mediated Degenerative Diseases

2016 ◽  
Vol 2016 ◽  
pp. 1-25 ◽  
Author(s):  
Md. Asiful Islam ◽  
Fahmida Alam ◽  
Md. Solayman ◽  
Md. Ibrahim Khalil ◽  
Mohammad Amjad Kamal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Natural Products ◽  
Poor Quality ◽  
Degenerative Disease ◽  
Degenerative Diseases ◽  
Dietary Phytochemicals ◽  
Alternative Medications

Cumulatively, degenerative disease is one of the most fatal groups of diseases, and it contributes to the mortality and poor quality of life in the world while increasing the economic burden of the sufferers. Oxidative stress and inflammation are the major pathogenic causes of degenerative diseases such as rheumatoid arthritis (RA), diabetes mellitus (DM), and cardiovascular disease (CVD). Although a number of synthetic medications are used to treat these diseases, none of the current regimens are completely safe. Phytochemicals (polyphenols, carotenoids, anthocyanins, alkaloids, glycosides, saponins, and terpenes) from natural products such as dietary fruits, vegetables, and spices are potential sources of alternative medications to attenuate the oxidative stress and inflammation associated with degenerative diseases. Based onin vitro,in vivo, and clinical trials, some of these active compounds have shown good promise for development into novel agents for treating RA, DM, and CVD by targeting oxidative stress and inflammation. In this review, phytochemicals from natural products with the potential of ameliorating degenerative disease involving the bone, metabolism, and the heart are described.

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