scholarly journals Antioxidative Effects of Natural Products on Diabetic Cardiomyopathy

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Bingdi Yan ◽  
Jin Ren ◽  
Qinghua Zhang ◽  
Rong Gao ◽  
Fenglian Zhao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trials ◽  
Natural Products ◽  
Diabetic Cardiomyopathy ◽  
Mechanism Of Action ◽  
High Mortality ◽  
Therapeutic Strategy ◽  
Present Review ◽  
Beneficial Effects ◽  
Antioxidative Effects

Diabetic cardiomyopathy (DCM) is a common and severe complication of diabetes and results in high mortality. It is therefore imperative to develop novel therapeutics for the prevention or inhibition of the progression of DCM. Oxidative stress is a key mechanism by which diabetes induces DCM. Hence, targeting of oxidative stress-related processes in DCM could be a promising therapeutic strategy. To date, a number of studies have shown beneficial effects of several natural products on the attenuation of DCM via an antioxidative mechanism of action. The aim of the present review is to provide a comprehensive and concise overview of the previously reported antioxidant natural products in the inhibition of DCM progression. Clinical trials of the antioxidative natural products in the management of DCM are included. In addition, discussion and perspectives are further provided in the present review.

scholarly journals Antioxidants of Natural Products

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 612
Author(s):  
Mee Ree Kim
Keyword(s):  
Oxidative Stress ◽  
Health Promotion ◽  
Natural Products ◽  
Disease Prevention ◽  
Biological Systems ◽  
Reactive Oxygen ◽  
Nitrogen Species ◽  
Beneficial Effects

Antioxidant ingredients are known to contribute to the beneficial effects of natural products in health promotion as well as disease prevention by reducing oxidative stress, caused by reactive oxygen or nitrogen species, in biological systems [...]

scholarly journals Trehalose for Ocular Surface Health

Biomolecules ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 809
Author(s):  
Jarmo Laihia ◽  
Kai Kaarniranta
Keyword(s):  
Oxidative Stress ◽  
Clinical Trials ◽  
Animal Models ◽  
Dry Eye ◽  
Ocular Surface ◽  
Stress Protein ◽  
Life Forms ◽  
Beneficial Effects ◽  
Protein Clearance ◽  
Ocular Surface Health

Trehalose is a natural disaccharide synthesized in various life forms, but not found in vertebrates. An increasing body of evidence demonstrates exceptional bioprotective characteristics of trehalose. This review discusses the scientific findings on potential functions of trehalose in oxidative stress, protein clearance, and inflammation, with an emphasis on animal models and clinical trials in ophthalmology. The main objective is to help understand the beneficial effects of trehalose in clinical trials and practice, especially in patients suffering from ocular surface disease. The discussion is supplemented with an overview of patents for the use of trehalose in dry eye and with prospects for the 2020s.

scholarly journals Isosteviol ameliorates diabetic cardiomyopathy in rats by inhibiting ERK and NF-κB signaling pathways

2018 ◽  
Vol 238 (1) ◽  
pp. 47-60 ◽  
Author(s):  
Sheng-Gao Tang ◽  
Xiao-Yu Liu ◽  
Ji-Ming Ye ◽  
Ting-Ting Hu ◽  
Ying-Ying Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Diabetic Cardiomyopathy ◽  
Nuclear Factor Κb ◽  
Diabetic Rats ◽  
Signal Pathways ◽  
Mortality And Morbidity ◽  
Beneficial Effects ◽  
Male Wistar Rats ◽  
Glucose Plasma

Diabetes-induced injury of myocardium, defined as diabetic cardiomyopathy (DCM), accounts for significant mortality and morbidity in diabetic population. Alleviation of DCM by a potent drug remains considerable interests in experimental and clinical researches because hypoglycemic drugs cannot effectively control this condition. Here, we explored the beneficial effects of isosteviol sodium (STVNa) on type 1 diabetes-induced DCM and the potential mechanisms involved. Male Wistar rats were induced to diabetes by injection of streptozotocin (STZ). One week later, diabetic rats were randomly grouped to receive STVNa (STZ/STVNa) or its vehicle (STZ). After 11 weeks of treatment or 11 weeks treatment following 4 weeks of removal of the treatment, the cardiac function and structure were evaluated and related mechanisms were investigated. In diabetic rats, oxidative stress, inflammation, blood glucose and plasma advanced glycation end products (AGEs) were significantly increased, whereas superoxide dismutase 2 (SOD-2) expression and activity were decreased. STVNa treatment inhibited cardiac hypertrophy, fibrosis and inflammation, showed similar ratio of heart to body weight and antioxidant capacities almost similar to the normal controls, which can be sustained at least 4 weeks. Moreover, STVNa inhibited diabetes-inducted stimulation of both extracellular signal-regulated kinase (ERK) and nuclear factor κB (NF-κB) signal pathways. However, blood glucose, plasma AGE and insulin levels were not altered by STVNa treatment. These results indicate that STVNa may be developed into a potent therapy for DCM. The mechanism underlying this therapeutic effect involves the suppression of oxidative stress and inflammation by inhibiting ERK and NF-κB without changing blood glucose or AGEs.

Astragaloside IV ameliorates preeclampsia-induced oxidative stress through the Nrf2/HO-1 pathway in a rat model

2020 ◽  
Vol 319 (5) ◽  
pp. E904-E911 ◽  
Author(s):  
Shuangyan Yang ◽  
Ruixue Zhang ◽  
Baoheng Xing ◽  
Ling Zhou ◽  
Peipei Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Target Genes ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Astragaloside Iv ◽  
Pregnant Rats ◽  
Beneficial Effects ◽  
Antioxidative Effects ◽  
Protein Serum

Preeclampsia (PE) can cause serious health problems for pregnant women and their infants. Astragaloside IV has been shown to exert cardioprotective, anti-inflammatory, and antioxidative effects on various disorders. We aimed to study the effects of Astragaloside IV on PE symptoms using an NG-nitro-l-arginine methyl ester (l-NAME)-induced rat model of PE. The pregnant rats’ physiological features, including blood pressure, urine protein, serum soluble fms-like tyrosine kinase- 1 ( sFlt - 1)/placental growth factor (PlGF) ratio, and weight of placenta, as well as the weight, length, and survival of pups, were documented. The expression levels of target genes were analyzed by Western blot and qRT-PCR assays. The levels of target secreted proteins were determined by ELISA. We demonstrated that the administration of Astragaloside IV might exert a multitude of beneficial effects on attenuated PE symptoms in a rat model of PE. We further revealed that the effects of Astragaloside IV on PE rats were achieved, at least partially, through elimination of oxidative stress and stimulation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. Our study indicated that Astragaloside IV may serve as a promising candidate for the development of new therapeutic methods for patients with PE.

scholarly journals Melatonin Ameliorates The Toxicity Induced By Deoxynivalenol In Murine Ovary Granulosa Cells By Antioxidative And Anti-Inflammatory

2021 ◽  
Author(s):  
Hairui Fan ◽  
Shiqin Wang ◽  
Haifei Wang ◽  
Mingan Sun ◽  
Shenglong Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Granulosa Cells ◽  
Therapeutic Strategy ◽  
Intracellular Reactive Oxygen Species ◽  
Reproductive Hormone ◽  
Oxygen Species ◽  
Fusarium Mycotoxin ◽  
Animal Development ◽  
Beneficial Effects ◽  
Anti Inflammatory

Abstract Background: Deoxynivalenol (DON) is a common fusarium mycotoxin contaminant of food and feedstuff, posing a serious threat to human and animal reproductive system by inducing oxidative stress and inflammation. The antioxidant melatonin participates in immunoregulation, playing a crucial role in animal development. So, our present study aimed to explore DON-induced toxicity in murine ovary granulosa cells (GCs), and assess the potential protective effect of melatonin. Results: Melatonin inhibits DON-induced oxidative stress in murine ovary GCs by decreased the generation of intracellular reactive oxygen species, ameliorates DON-induced mitochondrial dysfunction. And inhibits the inflammatory response through inhibits reduce the activation of NF-κB and phosphorylation of ERK, JNK, and p38 MAPKs induced by DON. Moreover, melatonin significantly improved the down-regulation of reproductive hormone gene expression induced by DON contaminant. These results once again demonstrate the properties of melatonin: antioxidant and anti-inflammatory.Conclusions: Melatonin have beneficial effects on mitigating the toxicity induced by deoxynivalenol in ovary Granulosa Cells. Offer a novel therapeutic strategy against mycotoxin contamination-induce diseases

scholarly journals Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases

2020 ◽  
Vol 21 (21) ◽  
pp. 7870 ◽  
Author(s):  
Francisco Miguel Gutierrez-Mariscal ◽  
Antonio Pablo Arenas-de Larriva ◽  
Laura Limia-Perez ◽  
Juan Luis Romero-Cabrera ◽  
Elena Maria Yubero-Serrano ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trials ◽  
Chronic Diseases ◽  
Coenzyme Q10 ◽  
Chronic Obstructive ◽  
Clinical Implications ◽  
Main Function ◽  
Alcoholic Fatty Liver ◽  
Beneficial Effects ◽  
Coq10 Supplementation

Apart from its main function in the mitochondria as a key element in electron transport, Coenzyme Q10 (CoQ10) has been described as having multiple functions, such as oxidant action in the generation of signals and the control of membrane structure and phospholipid and cellular redox status. Among these, the most relevant and most frequently studied function is the potent antioxidant capability of its coexistent redox forms. Different clinical trials have investigated the effect of CoQ10 supplementation and its ability to reduce oxidative stress. In this review, we focused on recent advances in CoQ10 supplementation, its role as an antioxidant, and the clinical implications that this entails in the treatment of chronic diseases, in particular cardiovascular diseases, kidney disease, chronic obstructive pulmonary disease, non-alcoholic fatty liver disease, and neurodegenerative diseases. As an antioxidant, CoQ10 has proved to be of potential use as a treatment in diseases in which oxidative stress is a hallmark, and beneficial effects of CoQ10 have been reported in the treatment of chronic diseases. However, it is crucial to reach a consensus on the optimal dose and the use of different formulations, which vary from ubiquinol or ubiquinone Ubisol-Q10 or Qter®, to new analogues such as MitoQ, before we can draw a clear conclusion about its clinical use. In addition, a major effort must be made to demonstrate its beneficial effects in clinical trials, with a view to making the implementation of CoQ10 possible in clinical practice.

scholarly journals Oxidative Stress and Diabetic Retinopathy

2007 ◽  
Vol 2007 ◽  
pp. 1-12 ◽  
Author(s):  
Renu A. Kowluru ◽  
Pooi-See Chan
Keyword(s):  
Oxidative Stress ◽  
Clinical Trials ◽  
Animal Studies ◽  
Antioxidant Defense System ◽  
Oxygen Metabolism ◽  
Developed Countries ◽  
Causal Link ◽  
Diabetic Patients ◽  
Metabolic Abnormalities ◽  
Beneficial Effects

Oxygen metabolism is essential for sustaining aerobic life, and normal cellular homeostasis works on a fine balance between the formation and elimination of reactive oxygen species (ROS). Oxidative stress, a cytopathic consequence of excessive production of ROS and the suppression of ROS removal by antioxidant defense system, is implicated in the development of many diseases, including Alzheimer's disease, and diabetes and its complications. Retinopathy, a debilitating microvascular complication of diabetes, is the leading cause of acquired blindness in developed countries. Many diabetes-induced metabolic abnormalities are implicated in its development, and appear to be influenced by elevated oxidative stress; however the exact mechanism of its development remains elusive. Increased superoxide concentration is considered as a causal link between elevated glucose and the other metabolic abnormalities important in the pathogenesis of diabetic complications. Animal studies have shown that antioxidants have beneficial effects on the development of retinopathy, but the results from very limited clinical trials are somewhat ambiguous. Although antioxidants are being used for other chronic diseases, controlled clinical trials are warranted to investigate potential beneficial effects of antioxidants in the development of retinopathy in diabetic patients.

scholarly journals Parkinson’s Disease: Potential Actions of Lithium by Targeting the WNT/β-Catenin Pathway, Oxidative Stress, Inflammation and Glutamatergic Pathway

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 230
Author(s):  
Alexandre Vallée ◽  
Jean-Noël Vallée ◽  
Yves Lecarpentier
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Trials ◽  
Therapeutic Strategy ◽  
Substantia Nigra Pars Compacta ◽  
Progressive Neurodegeneration ◽  
New Treatment ◽  
Multiple Interactions ◽  
Stimulation Of

Parkinson’s disease (PD) is one of the major neurodegenerative diseases (ND) which presents a progressive neurodegeneration characterized by loss of dopamine in the substantia nigra pars compacta. It is well known that oxidative stress, inflammation and glutamatergic pathway play key roles in the development of PD. However, therapies remain uncertain and research for new treatment is mandatory. This review focuses on the potential effects of lithium, as a potential therapeutic strategy, on PD and some of the presumed mechanisms by which lithium provides its benefit properties. Lithium medication downregulates GSK-3beta, the main inhibitor of the WNT/β-catenin pathway. The stimulation of the WNT/β-catenin could be associated with the control of oxidative stress, inflammation, and glutamatergic pathway. Future prospective clinical trials could focus on lithium and its different and multiple interactions in PD.

scholarly journals Serum levels of antioxidants and its supplementation in people living with HIV: integrative review

2021 ◽  
Vol 11 (2) ◽  
pp. 43-50
Author(s):  
Aline Roberta Rodrigues da Silva ◽  
Patricia Dias de Brito
Keyword(s):  
Oxidative Stress ◽  
Clinical Trials ◽  
Antiretroviral Therapy ◽  
Serum Levels ◽  
Integrative Review ◽  
Food Sources ◽  
People Living With Hiv ◽  
Beneficial Effects ◽  
Significant Damage ◽  
Living With Hiv

Objective: To conduct an integrative review of serum levels of antioxidants and the effects of their supplementation on people living with HIV (PLHIV). Methods: A research was performed in the electronic databases LILACS and MEDLINE, using the descriptors "HIV" AND "antioxidants"; 110 publications were identified, 92 of which were available in the MEDLINE database and 3 in the LILACS database. After applying the exclusion criteria, 8 articles were selected for final evaluation.Results: The studies selected for the review were divided into 4 prospective observational studies and 4 clinical trials with supplementation of antioxidants or food sources of antioxidants. We observed that the initiation of antiretroviral therapy and its prolonged use negatively influenced the parameters of oxidative stress, and that deficiency of antioxidants was associated with more significant damage to mitochondrial DNA. Supplementation of foods that are sources of antioxidants, such as dark chocolate and spirulina, has had beneficial effects on serum lipids and antioxidant capacity. Conclusion: Clinical trials with a more robust methodology, supplementation of isolated nutrients, for more extended periods of intervention, and with the assessment of food consumption are necessary to elucidate their effects on oxidative stress in PLHIV faced with factors such as the use of antiretroviral therapy and changes in metabolic rates of this population.

Antioxidant compounds from marine seaweeds and their mechanism of action

2020 ◽  
Vol 78 (2) ◽  
pp. 131-148
Author(s):  
Trishna Debnath ◽  
Eun-Kyung Kim ◽  
Kwang-Geun Lee ◽  
Narayan Chandra Debnath ◽  
Ramkumar Mathur
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Natural Products ◽  
Mechanism Of Action ◽  
Biologically Active ◽  
New Drugs ◽  
Antioxidant Compounds ◽  
Valuable Contribution ◽  
Major Mechanism ◽  
Nutritional Benefits

Investigation of natural products has moved toward marine environments as they are a source of many biologically active agents. The natural antioxidant compounds isolated from seaweeds provide a valuable contribution to the innovation of new drugs for chronic diseases associated with oxidative stress. While the antioxidant activity and nutritional benefits of various seaweed products are well recognized, their proper utilization as antioxidants remains at initial stages that require further investigative studies. This review provides a detailed study of isolated antioxidant compounds from seaweeds and their major mechanism of action by focusing on the reports from 2015 to 2019. The report discusses various active antioxidant compounds, including phenolics (e.g., phlorotannins), polysaccharides, and pigments with proven benefits against oxidative stress-related diseases, especially carotenoids, from the aspect of benefits to human health.

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