scholarly journals Natural products in Cyperus rotundus L. (Cyperaceae): an update of the chemistry and pharmacological activities

RSC Advances ◽  
2021 ◽  
Vol 11 (25) ◽  
pp. 15060-15077
Author(s):  
Smith B. Babiaka ◽  
Aurélien F. A. Moumbock ◽  
Stefan Günther ◽  
Fidele Ntie-Kang
Keyword(s):  
Natural Products ◽  
Cyperus Rotundus ◽  
Pharmacological Activities ◽  
The World

Cyperus rotundus L. (Nutgrass, family Cyperaceae) is a notorious weed which is widespread in temperate tropical and subtropical regions of the world.

scholarly journals GenusSpondias: A Phytochemical and Pharmacological Review

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Salma Sameh ◽  
Eman Al-Sayed ◽  
Rola M. Labib ◽  
Abdel Nasser Singab
Keyword(s):  
Oxidative Stress ◽  
Natural Products ◽  
Therapeutic Strategy ◽  
Flowering Plants ◽  
Degenerative Diseases ◽  
Pharmacological Activities ◽  
Tropical Regions ◽  
The World ◽  
Phytochemical Constituents ◽  
Therapeutic Alternatives

It is believed that many degenerative diseases are due to oxidative stress. In view of the limited drugs available for treating degenerative diseases, natural products represent a promising therapeutic strategy in the search for new and effective candidates for treating degenerative diseases. This review focuses on the genusSpondiaswhich is widely used in traditional medicine for the treatment of many diseases.Spondiasis a genus of flowering plants belonging to the cashew family (Anacardiaceae). This genus comprises 18 species distributed across tropical regions in the world. A variety of bioactive phytochemical constituents were isolated from different plants belonging to the genusSpondias. Diverse pharmacological activities were reported for the genusSpondiasincluding cytotoxic, antioxidant, ulcer protective, hepatoprotective, anti-inflammatory, antiarthritic, and antidementia effects. These attributes indicate their potential to treat various degenerative diseases. The aim of this review is to draw attention to the unexplored potential of phytochemicals obtained fromSpondiasspecies, thereby contributing to the development of new therapeutic alternatives that may improve the health of people suffering from degenerative diseases and other health problems.

Novel Phytochemical Constituents and their Potential to Manage Diabetes

2020 ◽  
Vol 26 ◽  
Author(s):  
Shaik Ibrahim Khalivulla ◽  
Arifullah Mohammed ◽  
Kokkanti Mallikarjuna
Keyword(s):  
Natural Products ◽  
Large Population ◽  
World Health ◽  
In Vivo Studies ◽  
Antidiabetic Activity ◽  
Therapeutic Drug ◽  
Pharmacological Activities ◽  
Chemical Structures

Background: Diabetes is a chronic disease affecting a large population worldwide and stands as one of the major global health challenges to be tackled. According to World Health Organization, about 400 million are having diabetes worldwide and it is the seventh leading cause of deaths in 2016. Plant based natural products had been in use from ancient time as ethnomedicine for the treatment of several diseases including diabetes. As a result of that, there are several reports on plant based natural products displaying antidiabetic activity. In the current review, such antidiabetic potential compounds reported from all plant sources along with their chemical structures are collected, presented and discussed. This kind of reports are essential to pool the available information to one source followed by statistical analysis and screening to check the efficacy of all known compounds in a comparative sense. This kind of analysis can give rise to few numbers of potential compounds from hundreds, whom can further be screened through in vitro and in vivo studies, and human trails leading to the drug development. Methods: Phytochemicals along with their potential antidiabetic property were classified according to their basic chemical skeleton. The chemical structures of all the compounds with antidiabetic activities were elucidated in the present review. In addition to this, the distribution and their other remarkable pharmacological activities of each species is also included. Results: The scrutiny of literature led to identification of 44 plants with antidiabetic compounds (70) and other pharmacological activities. For the sake of information, the distribution of each species in the world is given. Many plant derivatives may exert antidiabetic properties by improving or mimicking the insulin production or action. Different classes of compounds including sulfur compounds (1-4), alkaloids (5-11), phenolic compounds (12-17), tannins (18-23), phenylpropanoids (24-27), xanthanoids (28-31), amino acid (32), stilbenoid (33), benzofuran (34), coumarin (35), flavonoids (36-49) and terpenoids (50-70) were found to be active potential compounds for antidiabetic activity. Of the 70 listed compounds, majorly 17 compounds are from triterpenoids, 13 flavonoids and 7 are from alkaloids. Among all the 44 plant species, maximum number (7) of compounds are reported from Lagerstroemia speciosa followed by Momordica charantia (6) and S. oblonga with 5 compounds. Conclusion: This is the first paper to summarize the established chemical structures of phytochemicals that have been successfully screened for antidiabetic potential and their mechanisms of inhibition. The reported compounds could be considered as potential lead molecules for the treatment of type-2 diabetes. Further, molecular and clinical trials are required to select and establish the therapeutic drug candidates.

Medicinal importance, pharmacological activities and analytical aspects of canadine in the medicine: An important phytochemical of Hydrastis canadensis

2021 ◽  
Vol 01 ◽  
Author(s):  
Dinesh Kumar Patel
Keyword(s):  
Natural Products ◽  
Data Analysis ◽  
Human Health ◽  
Scientific Information ◽  
Modern Medicine ◽  
Scientific Data ◽  
Pharmacological Activities ◽  
Hydrastis Canadensis ◽  
Biological Importance ◽  
Human Disorders

Background: Natural products and their derived phytochemicals have been used in the medicine and gaining importance in the modern medicine due to their therapeutic potential and health beneficial effect on human disorders. Plenty of herbal drug based products are available in the market and playing an important role in the human health care system due to their health beneficial properties in human being. In the modern age we can find many herbal based products in the market mainly prepared from the natural products and used for the prevention and treatment of various human disorders. Benzylisoquinoline alkaloids are the important class of alkaloidal compounds and the better example are morphine, codeine, sanguinarine, berberine and canadine which are mainly known for their medicinal value in the medicine. Methods: Hydrastis canadensis is the important medicinal plant found to contain a significant amount of canadine, hydrastine and berberine. In the present investigation, numerous scientific databases such as Google, Pubmed, Science direct etc. have been searched to collect the important scientific information of canadine and analyzed to know the health beneficial aspect of canadine in the medicine. All the collected scientific information data’s were analyzed and have been categorized into mainly pharmacological and analytical aspects. Results: From the analysis of the collected scientific information, it was found that Hydrastis canadensis contain significant amount of canadine with many more phytochemical including canadaline, hydrastidine, isohydrastidine etc. Pharmacological activity data analysis revealed the biological importance of Hydrastis canadensis in the medicine for their traditional uses against gastritis, colitis, duodenal ulcers, loss of appetite, liver disease, bile secretion disorder, snake bites and vaginitis in the medicine. However, scientific data analysis of canadine revealed their effectiveness for their acetylcholinesterase inhibitory activity, anti-cancer, anti-microbial, anti-allergic activity and anti-oxidant activity. Different modern analytical tools have been used in the modern medicine for the isolation and quantification of canadine in the Hydrastis canadensis. Conclusion: Present investigation revealed the medicinal importance and pharmacological activities of a canadine in the medicine for the treatment of numerous human health complications. These scientific data will be helpful to the scientist to know the biological importance of canadine in the medicine against various forms of human complications.

scholarly journals Neuroprotective Effects, Biological Activities and Therapeutic Potential of Phytochemicals: A Comprehensive Review

2020 ◽  
pp. 1-11
Author(s):  
Xi-jun Wang ◽  
Shi Qiu ◽  
Aihua Zhang ◽  
Jian-hua Miao ◽  
Hui Sun ◽  
...  
Keyword(s):  
Natural Products ◽  
Neurological Disorders ◽  
Chemical Biology ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Therapeutic Agents ◽  
Neuroprotective Effects ◽  
Alternative Medicines ◽  
Pharmacological Targets ◽  
The World

The incidence of neurological disorders is growing in the world together with an increased lifespan. Nowadays, there are still no effective treatments for neurodegenerative pathology, which make necessary to search for new therapeutic agents. Natural products, most of them used in phytochemicals from herbal medicine, are considered promising alternatives for the treatment of neurodegenerative diseases. Numerous herbs have been applied to neurodegenerative disease treatments as complementary and alternative medicines. In the 21st century, omics-coupled functional pharmacology was developed for neurodegenerative drug discovery from natural products. In this article, we firstly provide the latest understanding of neurological disorders on risk factors, category, diagnosis and treatment, and then specially present an overview of natural products in neuroprotective effects research from chemical biology to pharmacological targets, and also discuss the natural products application and future challenge.

Cyperus rotundus L.: Traditional uses, phytochemistry, and pharmacological activities

2015 ◽  
Vol 174 ◽  
pp. 540-560 ◽  
Author(s):  
Arslan Masood Peerzada ◽  
Hafiz Haider Ali ◽  
Muhammad Naeem ◽  
Muhammad Latif ◽  
Asad Hussain Bukhari ◽  
...  
Keyword(s):  
Cyperus Rotundus ◽  
Pharmacological Activities ◽  
Traditional Uses

Description of Purple and Yellow Nutsedge (Cyperus rotundusandC. esculentus)

1987 ◽  
Vol 1 (1) ◽  
pp. 2-9 ◽  
Author(s):  
Gene D. Wills
Keyword(s):  
United States ◽  
North Carolina ◽  
Southern California ◽  
The United States ◽  
Southern Region ◽  
Cyperus Rotundus ◽  
Purple Nutsedge ◽  
Yellow Nutsedge ◽  
The World

Both purple nutsedge (Cyperus rotundusL. # CYPRO) and yellow nutsedge (C. esculentusL. # CYPES) are problem weeds in crops in many parts of the world. Yellow nutsedge is found in all U.S. states. Purple nutsedge is confined to the southern region of the United States, ranging from North Carolina across southern Arkansas and into southern California.

Fluvoxamine and amantadine: central nervous system acting drugs repositioned for COVID-19 as early intervention

2021 ◽  
Vol 19 ◽  
Author(s):  
Konrad Rejdak ◽  
Paweł Grieb
Keyword(s):  
Clinical Evidence ◽  
Drug Repositioning ◽  
Neurological Diseases ◽  
Scientific Evidence ◽  
Late Phase ◽  
Protective Effects ◽  
Pharmacological Activities ◽  
The World ◽  
Published Research ◽  
Early Phases

Background: Whereas the World faces an unprecedented pandemic caused by the SARS-CoV-2 virus, repositioning existing drugs to treat COVID-19 disease is urgently awaited, provided that high-quality scientific evidence supporting safety and efficacy in this new indication is gathered. Efforts concerning drug repositioning to COVID-19 were mostly focused on antiviral drugs or drugs targeting the late phase of the disease. Methods: Based on published research, the pharmacological activities of fluvoxamine and amantadine, two well-known drugs widely used in clinical practice for psychiatric and neurological diseases, respectively, have been reviewed, focusing on their potential therapeutic importance in the treatment of COVID-19. Result: Several preclinical and clinical reports were identified suggesting that these two drugs might exert protective effects in the early phases of COVID-19. Conclusion: Preclinical and early clinical evidence are presented indicating that these drugs hold promise to prevent COVID-19 progression when administered early during infection.

Medicinal Inula Species: Phytochemistry, Biosynthesis, and Bioactivities

2021 ◽  
pp. 1-44
Author(s):  
Cheng-Peng Sun ◽  
Zi-Li Jia ◽  
Xiao-Kui Huo ◽  
Xiang-Ge Tian ◽  
Lei Feng ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Drug Development ◽  
Scientific Basis ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Traditional Medicines ◽  
The World ◽  
Phytochemical Constituents ◽  
New Drug Development ◽  
First Time

As a genus of the Asteraceae, Inula is widely distributed all over the world, and several of them are being used in traditional medicines. A number of metabolites were isolated from Inula species, and some of these have shown to possess ranges of pharmacological activities. The genus Inula contains abundant sesquiterpenoids, such as eudesmanes, xanthanes, and sesquiterpenoid dimers and trimers. In addition, other types of terpenoids, flavonoids, and lignins also exist in the genus Inula. Since 2010, more than 300 new secondary metabolites, including several known natural products that were isolated for the first time from the genus Inula. Most of them exhibited potential bioactivities in various diseases. The review aimed to summarize the advance of recent researches (2010–2020) on phytochemical constituents, biosynthesis, and pharmacological properties of the genus Inula for providing a scientific basis and supporting its application and exploitation for new drug development.

Pyrazole Containing Anti-HIV Agents: An Update

2022 ◽  
Vol 18 ◽  
Author(s):  
Sanjay Kumar ◽  
Shiv Gupta ◽  
Varsha Rani ◽  
Priyanka Sharma
Keyword(s):  
Review Article ◽  
Pyrazole Derivatives ◽  
Therapeutic Activity ◽  
Pharmacological Activities ◽  
Drug Discovery And Development ◽  
The World ◽  
Hiv Drugs ◽  
Anti Hiv Agents ◽  
Comprehensive Compilation ◽  
Anti Hiv

Background: Pyrazole scaffolds have gained importance in drug discovery and development for various pharmacological activities like antiviral, antifungal, anticancer, antidepressant, anti-inflammatory, antibacterial, etc. Additionally, the pyrazole moiety has shown potent anti-HIV activity as a core heterocycle or substituted heterocycles derivatives (mono, di, tri, tetra, and fused pyrazole derivatives). To assist the development of further potential anti-HIV agents containing pyrazole nucleus, here we have summarized pyrazole containing anti-HIV compounds that have been reported by researchers all over the world for the last two decades. Objective: The present review concentrates on an assortment of pyrazole containing compounds, particularly for potential therapeutic activity against HIV. Methods: Google Scholar, Pubmed, and SciFinder were searched databases with ‘‘pyrazol’’ keywords. Further, the year of publication and keywords ‘‘Anti-HIV’’ filter was applied to obtain relevant reported literature for anti-HIV agents containing pyrazole as a core or substituted derivatives. Results: This review article has shown the comprehensive compilation of 220 compounds containing pyrazole nucleus and possessing anti-HIV activity by sorting approximately 40 research articles from 2001 to date. 1-(4-Benzoylpiperazin-1-yl)-2-(4-fluoro-7-(1H-pyrazol-3-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (13), 3-(3-(2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl)-4-fluoro-1H-pyrrolo[2,3-c]pyridin-7-yl)-1H-pyrazole-5-carboxamide (31), 3-(3-(2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl)-4-fluoro-1H-pyrrolo[2,3-c]pyridin-7-yl)-1H-pyrazole-5-carboxamide (88), 3-cyanophenoxypyrazole derivative (130), and 4-(4-chlorophenyl)-5-(4-methyl-5-((4-nitrophenyl)diazenyl)thiazol-2-yl)-3-phenyl-5,6-dihydro-4H-pyrazolo[4,3-d]isoxazole (178) were the most potent mono-, di-, tri-, tetra-substituted, and fused pyrazole derivatives, respectively, which have shown potent anti-HIV activity among all the described derivatives as compared with standard anti-HIV drugs. Conclusion: This review article provides an overview of the potential therapeutic activity of pyrazole derivatives against HIV that will be helpful for designing pyrazole containing compounds for anti-HIV activity.

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