scholarly journals Effectiveness and Safety of Contrast Cryolipolysis for Subcutaneous-Fat Reduction

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Marília Bueno Savacini ◽  
Débora Tazinaffo Bueno ◽  
Ana Carolina Souza Molina ◽  
Ana Caroline Almeida Lopes ◽  
Caroline Nogueira Silva ◽  
...  
Keyword(s):  
Laboratory Testing ◽  
Subcutaneous Fat ◽  
Body Contouring ◽  
Noninvasive Treatment ◽  
Fat Reduction ◽  
Laboratory Results ◽  
Safety Assessments ◽  
Level Of Significance ◽  
Skinfold Caliper

Cryolipolysis is the noninvasive treatment of localized fat through cold-induced panniculitis. The purpose of the present study was to evaluate the safety and efficacy of contrast cryolipolysis for subcutaneous-fat reduction. Contrast cryolipolysis mixes the principles of conventional cryolipolysis and periods of heating in accordance with the contrast lipocryolysis process. Twenty-one subjects aged 34 ± 9 years were treated with contrast cryolipolysis in the regions of abdomen and flanks through the Polarys® device. Anthropometry, standardized photographs, measurements with a skinfold caliper, and diagnostic ultrasounds were performed at the baseline and during follow-ups at 30, 60, and 90 days after the treatment. The safety assessments included laboratory testing and monitoring of the adverse events. The level of significance for all tests was set at P < 0.05. No significant differences in weight and body mass index were found. The waist measurements at the baseline and 30-day follow-up had significant differences, as did the measurements at the 30-day and 60-day follow-ups. The skinfold and ultrasound measurements were significantly reduced in the treated areas in all the time points compared to the baseline. The laboratory results showed no significant changes from baseline. Temporary adverse effects were resolved spontaneously. This study confirmed that contrast cryolipolysis is safe and effective in reducing the fat layer and improving body contouring.

scholarly journals Clinical application of cryolipolysis in Asian patients for subcutaneous fat reduction and body contouring

2020 ◽  
Vol 47 (2) ◽  
pp. 200-200
Author(s):  
Chang Hyun Oh ◽  
Jeong Su Shim ◽  
Kwang Il Bae ◽  
Jae Hoon Chang
Keyword(s):  
Clinical Application ◽  
Subcutaneous Fat ◽  
Body Contouring ◽  
Asian Patients ◽  
Fat Reduction

scholarly journals The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Bill Zhou ◽  
Benny Yuk Kin Leung ◽  
Lei Sun
Keyword(s):  
Body Fat ◽  
Lipid Level ◽  
Subcutaneous Fat ◽  
Body Contouring ◽  
Plasma Lipid ◽  
High Intensity Focused Ultrasound ◽  
Plasma Lipid Level ◽  
Low Intensity ◽  
Fat Reduction ◽  
Low Intensity Ultrasound

Nonfocused low-intensity ultrasound is generally believed to be less efficacious than High-Intensity Focused Ultrasound (HIFU) at body fat reduction; nevertheless, this technology has already been widely used clinically for body contouring purposes. This study aimed to evaluate the efficacy and safety of this new technology by applying 1 MHz nonfocused ultrasound at 3 W/cm2to the outer-thigh region of rat models. Ultrasonography measurement demonstrated an average reduction of 0.5 mm of subcutaneous fat thickness that persisted for at least three days after treatment. Biochemical analysis quantified a significant increase in lipid levels, specifically triglyceride, high-density lipoprotein, and total cholesterol. These two findings of subcutaneous fat reduction and plasma lipid increase showed a positive correlation. No evidence of adverse events or complications was observed after the treatment. This study validated nonfocused low-intensity ultrasound as an effective and safe method for body fat reduction, especially with repetitive treatment. However, the concurrent increase in plasma lipid level will require further investigation to determine this technology’s long-term impact, if any, on health.

scholarly journals Clinical application of cryolipolysis in Asian patients for subcutaneous fat reduction and body contouring

2020 ◽  
Vol 47 (1) ◽  
pp. 62-69 ◽  
Author(s):  
Chang Hyun Oh ◽  
Jeong Su Shim ◽  
Kwang Il Bae ◽  
Jae Hoon Chang
Keyword(s):  
Clinical Application ◽  
Subcutaneous Fat ◽  
Body Contouring ◽  
Asian Patients ◽  
Fat Reduction

scholarly journals Utilisation of Cryolipolysis among Asians: A Review on Efficacy and Safety

2019 ◽  
Vol 7 (9) ◽  
pp. 1548-1554 ◽  
Author(s):  
Imam Budi Putra ◽  
Nelva Karmila Jusuf ◽  
Nani Kumala Dewi
Keyword(s):  
Reduction Method ◽  
Subcutaneous Fat ◽  
Body Contouring ◽  
Asian Population ◽  
Caucasian Population ◽  
Efficacy And Safety ◽  
Limited Data ◽  
Non Invasive ◽  
Asian Patients ◽  
Fat Reduction

Cryolipolysis is a non-invasive fat reduction method that is capable of reducing subcutaneous fat significantly without damaging surrounding tissues, by applying cold temperature to induce adipocyte apoptosis. Most of the clinical studies in cryolipolysis were conducted in the Caucasian population, and only a few numbers in Asian, who has darker skin with Fitzpatrick skin type III to V. Higher rate of pigmentary changes were reported with the use of cryotherapy in darker skin. Therefore, this report is aimed to provide a comprehensive review regarding utilisation, efficacy and safety profiles of cryolipolysis among Asians. Currently, there are only four clinical trials conducted exclusively in an Asian population. Two studies were conducted in Korea, whereas others in China and Thailand. Cryolipolysis was performed in the abdomen, arm, inner thighs, and submental regions. The reported side effects were mild and transient, including erythema, hematoma, numbness, and pain. There were no pigmentary changes reported. Although only limited data available, those studies have proved that cryolipolysis utilisation among Asians or darker skin types provides the same efficacy and safety profiles as in Caucasians. Therefore, cryolipolysis might be proposed as the first treatment choice for Asian patients who opted to do body contouring.

Abstract 9: Consistency of Laboratory Monitoring during Initiation of Mineralocorticoid Receptor Antagonists in Heart Failure

2015 ◽  
Vol 8 (suppl_2) ◽  
Author(s):  
Lauren B Cooper ◽  
Bradley G Hammill ◽  
Eric D Peterson ◽  
Bertram Pitt ◽  
Matthew L Maciejewski ◽  
...  
Keyword(s):  
Heart Failure ◽  
Adverse Events ◽  
Laboratory Testing ◽  
Mineralocorticoid Receptor ◽  
Laboratory Monitoring ◽  
Medicare Beneficiaries ◽  
Mineralocorticoid Receptor Antagonists ◽  
Receptor Antagonists ◽  
Laboratory Results

Introduction: The ACC/AHA heart failure guidelines recommend routine monitoring of serum potassium and renal function of patients treated with mineralocorticoid receptor antagonists (MRAs). However, compliance with these safety recommendations in routine clinical practice is unknown. Methods: We analyzed a cohort of Medicare beneficiaries in 10 states with prevalent heart failure as of July 1, 2011 and incident MRA use between May 1, 2011 and September 30, 2011. Medicare claims data were linked to laboratory results data from a large vendor. Outcomes included guideline recommended testing of serum creatinine and potassium prior to MRA initiation as well as follow-up testing in the early (day 1-10) and extended (day 11-90) post-initiation periods. Additional outcomes included abnormal laboratory results and adverse events proximate to MRA initiation. Results: We identified 10,443 Medicare beneficiaries with heart failure started on an MRA with 19.7% (2,056 of 10,443) initiated during a hospitalization. The table displays the frequency of laboratory testing before and after inpatient or outpatient MRA initiation. While overall 91.6% (9,564 of 10,443) of patients received appropriate pre-initiation testing, only 13.3% (1,384 of 10,443) received appropriate early post-initiation testing and 29.9% (3,122 of 10,443) received appropriate extended post-initiation testing. Among those patients initiated on an MRA during a hospitalization, 25.2% (518 of 2,056) had appropriate testing across all time periods. Chronic kidney disease was associated with increased likelihood of appropriate laboratory testing (RR 1.83, 95% CI: 1.58, 2.13), as was concomitant diuretic use (RR 1.78, 95% CI: 1.44, 2.21). In the early follow-up period, 1.8% (184 of 10,443) of overall patients started on a MRA had hyperkalemia or acute renal insufficiency requiring hospitalization or emergency department visit, and 8.7% (910 of 10,443) experienced these adverse events within the 90-day follow-up period. Conclusions: Rates of guideline recommended laboratory monitoring of creatinine and potassium after MRA initiation were low, which represents an area for quality improvement to ensure MRAs can safely and effectively be used in care of heart failure patients.

Assessing Sexual Dysfunction, Part 1: Male Sexual Dysfunction

2016 ◽  
Vol 21 (2) ◽  
pp. 3-8
Author(s):  
Seth D. Cohen ◽  
Steven Mandel ◽  
David B. Samadi
Keyword(s):  
Sexual Dysfunction ◽  
Health Care Professionals ◽  
Laboratory Testing ◽  
Aging Male ◽  
Testosterone Deficiency ◽  
Subjective Complaint ◽  
Validated Questionnaire ◽  
Male Sexual Dysfunction ◽  
Multiple Health

Abstract To properly assess men and women with sexual dysfunction, evaluators should take a biopsychosocial approach that may require consultation with multiple health care professionals from various fields in order to get to the root of the sexual dysfunction; this multidisciplinary methodology offers the best chance of successful treatment. For males, this article focuses on erectile dysfunction (ED) and hypogonadism. The initial evaluation of ED involves a thorough case history, preferably taken from the patient and partner, physical examination, and proper laboratory and diagnostic tests, including an acknowledgment of the subjective complaint. The diagnosis is established on the basis of an individual's report of the consistent inability to attain and maintain an erection sufficient to permit satisfactory sexual intercourse. Initial workups for ED should entail a detailed history that can be obtained from a validated questionnaire such as the International Index of Erectile Function and the Sexual Health Inventory for Men. Hypogonadism is evaluated using the validated Androgen Deficiency in the Aging Male questionnaire and laboratory testing for testosterone deficiency. Treatments logically can begin with the least invasive and then progress to more invasive strategies after appropriate counseling. The last and most important treatment component when caring for men with sexual dysfunction—and, arguably, the least practiced—is close follow-up.

scholarly journals Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort Study

2021 ◽  
Vol 10 (5) ◽  
pp. 896
Author(s):  
Anthia Papazoglou ◽  
Anna Conen ◽  
Sebastian Haubitz ◽  
Markus Tschopp ◽  
Viviane J. Guignard ◽  
...  
Keyword(s):  
Animal Studies ◽  
Clinical Course ◽  
Intraocular Inflammation ◽  
Ocular Motility ◽  
Corrected Visual Acuity ◽  
Published Evidence ◽  
Laboratory Results ◽  
Minimum Angle ◽  
Observation Period

Postmortem pathological examinations, animal studies, and anecdotal reports suggest that coronavirus disease 2019 (COVID-19) could potentially affect intraocular tissue. However, published evidence is scarce and conflicting. In our study, we screened 100 eyes of 50 patients hospitalized for COVID-19. Relevant medical and ophthalmological history was assessed as well as symptoms, laboratory results, specific treatments, clinical course, and outcome. Ophthalmic exams including assessment of best corrected visual acuity (BCVA), intraocular pressure (IOP), color perception, ocular motility, ophthalmoscopy as well as optical coherence tomography (OCT) of the macula and the optic disc was performed at hospital admission and 29 to 192 days later. Of the 50 patients included, 14 (28%) were female. Median age was 64.5 (range 29–90) years. COVID-19 severity was mild in 15 (30%), severe in 30 (60%), and critical in five cases (10%). At baseline, median BCVA was 0.1 (0–1.8) Logarithm of the Minimum Angle of Resolution (LogMAR) and median IOP was 16 (8–22) mmHg. At follow-up, no relevant changes in BCVA and IOP were documented. No signs of active intraocular inflammation or optic nerve affection were found and OCT findings were widely stable during the observation period. Our findings suggest that COVID-19 does not regularly affect intraocular tissue.

scholarly journals Age-related skin changes

2012 ◽  
Vol 65 (5-6) ◽  
pp. 191-195 ◽  
Author(s):  
Aleksandra Levakov ◽  
Nada Vuckovic ◽  
Matilda Djolai ◽  
Mihaela Mocko-Kacanski ◽  
Snezana Bozanic
Keyword(s):  
Inflammatory Infiltrate ◽  
Subcutaneous Fat ◽  
The Sun ◽  
Intercellular Substance ◽  
Dermoepidermal Junction ◽  
Skin Changes ◽  
Age Related ◽  
Fat Reduction ◽  
Males And Females ◽  
Skin Samples

Age-related skin changes can be induced by chronological ageing, manifested in subcutaneous fat reduction, and photo-ageing eliciting increased elastotic substance in the upper dermis, destruction of its fibrilar structure, augmented intercellular substance and moderate inflammatory infiltrate. Forty-five biopsy skin samples of the sun-exposed and sun-protected skin were analyzed. The patients were both males and females, aged from 17 to 81 years. The thickness of the epidermal layers and the number of cellular living layers is greater in younger skin. The amount of keratohyaline granules is enlarged in older skin. Dermoepidermal junction is flattened and the presence of elastotic material in the dermis is pronounced with age. The amount of inflammatory infiltrate is increased, the fibrous trabeculae are thickened in older skin and the atrophy of the hypodermis is observed. Chronological ageing alters the fibroblasts metabolism by reducing their life span, capacity to divide and produce collagen. During ageing, the enlargement of collagen fibrils diminishes the skin elasticity.

Blood Pressure

PEDIATRICS ◽  
1987 ◽  
Vol 80 (3) ◽  
pp. 459-460
Author(s):  
MYUNG K. PARK
Keyword(s):  
Blood Pressure ◽  
Laboratory Testing ◽  
Normative Data ◽  
Task Force ◽  
Pressure Control ◽  
Proper Treatment ◽  
Blood Institute ◽  
National Heart Lung ◽  
Standards And Guidelines

To the Editor.— Recently the National Heart, Lung, and Blood Institute Task Force on Blood Pressure Control in Children published revised normal BP standards and guidelines for children.1 I welcome this effort, as reliable normative data have been unavailable but are prerequisite for the early detection of hypertension and its proper treatment. The guidelines published by the Task Force for the detection of hypertension, the diagnostic evaluation, follow-up laboratory testing, and treatment are, in my opinion, excellent.

Rhabdomyolysis in a Female Caucasian Adolescent Distance Runner: A Case Report

2016 ◽  
Vol 21 (6) ◽  
pp. 26-32 ◽  
Author(s):  
R. Mitchell Todd ◽  
Michelle Cleary ◽  
J. Susan Griffith
Keyword(s):  
Case Report ◽  
Laboratory Testing ◽  
Heat Stroke ◽  
Distance Runner ◽  
Heat Illness ◽  
Adolescent Female ◽  
Systemic Symptoms ◽  
Return To Competition

We present the case of an adolescent female collegiate distance runner competing in her first 6K race. She presented with multiple systemic symptoms of dizziness, nausea, confusion, muscle cramping, and syncope. The patient was immediately treated for heat stroke and, on follow-up, reported to the AT with a headache, lack of appetite, muscle aches, and dark-colored urine. Rhabdomyolysis should be considered following a heat illness event with necessary treatments performed immediately. Symptomatic patients must be referred to a physician for evaluation and laboratory testing. We present recommendations for a supervised return-to-participation protocol and acclimatization to safely return to competition readiness.

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