scholarly journals Corrigendum to “Influence of the Thermal Treatment to Address a Better Osseointegration of Ti6Al4V Dental Implants: Histological and Histomorphometrical Study in a Rabbit Model”

2018 ◽  
Vol 2018 ◽  
pp. 1-1
Author(s):  
Antonio Scarano ◽  
Ezio Crocetta ◽  
Alessandro Quaranta ◽  
Felice Lorusso
Keyword(s):  
Thermal Treatment ◽  
Dental Implants ◽  
Rabbit Model

scholarly journals Influence of the Thermal Treatment to Address a Better Osseointegration of Ti6Al4V Dental Implants: Histological and Histomorphometrical Study in a Rabbit Model

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Antonio Scarano ◽  
Ezio Crocetta ◽  
Alessandro Quaranta ◽  
Felice Lorusso
Keyword(s):  
Thermal Treatment ◽  
Dental Implants ◽  
Bone Healing ◽  
Rabbit Model ◽  
Titanium Implants ◽  
Control Group ◽  
Left Femur ◽  
Bone Response ◽  
First Choice ◽  
Significant Difference

Background. Pure titanium continues to be the first choice for dental implants and represents the gold standard for their biocompatibility and physical and mechanical characteristics, while the titanium alloy (Ti6Al4V) has good mechanical properties. The surface structure of the titanium oxide layer formation on the surface influences and improves the bone response around dental implants. Purpose. The purpose of this study is to evaluate the influence of a thermal treatment of Ti6Al4V implant surfaces and the bone healing response in a rabbit model. Methods. Altogether sixteen implants with same design were inserted into the distal femoral metaphysis. A screw (13 mm long, 4 mm in diameter) was inserted in an implant bed. Each rabbit received two implants, one in the left femur and one in the right femur. The samples were histologically and histomorphometrically evaluated at 8 weeks. Results. A statistically significant difference (p = 0.000034) was present histologically in the percentages of bone-implant contact (BIC) between the test group (BIC = 69.25±4.49%.) and control group (BIC = 56.25 ± 4.8%) by one-way analysis of variance (ANOVA). Significance was set at p ≤ 0.05. Conclusions. The outcome of the present study indicates a novel approach to improving bone healing around titanium implants.

scholarly journals Intermittent administration of parathyroid hormone enhances primary stability of dental implants in a bone-reduced rabbit model

2016 ◽  
Vol 58 (2) ◽  
pp. 241-246 ◽  
Author(s):  
Yoshifumi Oki ◽  
Kazuya Doi ◽  
Yusuke Makihara ◽  
Takayasu Kubo ◽  
Hiroshi Oue ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Dental Implants ◽  
Rabbit Model ◽  
Primary Stability ◽  
Intermittent Administration

scholarly journals Effects of Bisphosphonates on Osseointegration of Dental Implants in Rabbit Model

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Ru Qing Yu ◽  
Jing Yi Wang ◽  
Nian Jing Rao ◽  
Lei Huo ◽  
Li Wu Zheng
Keyword(s):  
Zoledronic Acid ◽  
Dental Implants ◽  
Dental Implant ◽  
Growth Rates ◽  
Acid Treatment ◽  
Bone Growth ◽  
Rabbit Model ◽  
Short Term ◽  
Calvarial Bone

This study is to investigate the effect of bisphosphonates on the osseointegration of dental implants in a rabbit model. Twenty female New Zealand White rabbits were equally assigned into control and experiment groups which received saline or zoledronic acid treatment 4 weeks prior to surgery. Titanium dental implant was placed on the calvarial bone. Zoledronic acid or saline treatment continued after surgery for 4 weeks (short-term subgroup) or 8 weeks (long-term subgroup) until sacrifice. Three different fluorochrome labeling solutions were administrated for assessing bone growth rates. Samples of the calvarial bone and mandible were subjected to microcomputed tomography (micro-CT), confocal microscope, and histology analysis. Zoledronic acid treatment significantly reduced bone growth rates in the calvarial bone, but had no significant influence in bone mineral density and trabecular microarchitecture. Significantly lower bone-to-implant contact ratios were found in zoledronic acid-treated animals compared to controls at week 4 but not at week 8. Oncologic dose zoledronic acid suppresses the bone growth rates of the calvarial bone; ZA may have an adverse effect on osseointegration of dental implant in short term, but this effect tends to diminish in long term.

scholarly journals The Impact of Nandrolone Decanoate in the Osseointegration of Dental Implants in a Rabbit Model: Histological and Micro-Radiographic Results

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2258
Author(s):  
Saturnino Marco Lupi ◽  
Alessandra Nicole Sassi ◽  
Alessandro Addis ◽  
Ruggero Rodriguez y Baena
Keyword(s):  
Dental Implants ◽  
Bone Fractures ◽  
Rabbit Model ◽  
Test Group ◽  
Control Group ◽  
Clinical Effects ◽  
Nandrolone Decanoate ◽  
Implant Placement ◽  
Increased Risk ◽  
The Impact

Despite high rates of osseointegration in healthy patients, complex cases present an increased risk of osseointegration failure when treated with dental implants. Furthermore, if immediate loading of the implants is used, maximizing the response of the host organism would be desirable. Anabolic steroids, such as Nandrolone Decanoate (ND), are reported to have beneficial clinical effects on various bone issues such as osteoporosis and bone fractures. However, their beneficial effects in promoting osseointegration in dental implant placement have not been documented. The study aimed to examine histological changes induced by ND in experimental dental implants in rabbit models. Two dental implants were placed in the tibias of 24 adult rabbits. Rabbits were allocated to one of two groups: control group or test group. Rabbits in the latter group were given nandrolone decanoate (15 mg/kg, immediately after implant placement and after 1 week). Micro-radiographic and histological analyses were assessed to characterize the morphological changes promoted by the nandrolone decanoate use. Total bone volume and fluorescence were significantly higher in the control group after 2 weeks. Such a difference between the two groups might indicate that, initially, nandrolone lengthens the non-specific healing period characteristic of all bone surgeries. However, after the beginning of the reparative processes, the quantity of newly formed bone appears to be significantly higher, indicating a positive stimulation of the androgen molecule on bone metabolism. Based on micro-radiology and fluorescence microscopy, nandrolone decanoate influenced bone regeneration in the implant site. The anabolic steroid nandrolone decanoate affects the healing processes of the peri-implant bone and therefore has the potential to improve the outcomes of implant treatment in medically complex patients.

scholarly journals Comparison between Sandblasted Acid-Etched and Oxidized Titanium Dental Implants: In Vivo Study

2019 ◽  
Vol 20 (13) ◽  
pp. 3267 ◽  
Author(s):  
Eugenio Velasco-Ortega ◽  
Ivan Ortiz-García ◽  
Alvaro Jiménez-Guerra ◽  
Loreto Monsalve-Guil ◽  
Fernando Muñoz-Guzón ◽  
...  
Keyword(s):  
Residual Stress ◽  
Dental Implants ◽  
Rabbit Model ◽  
Chemical Properties ◽  
In Vivo Study ◽  
Implant Surface ◽  
Bone Response ◽  
Etched Surface ◽  
Titanium Dental Implants

The surface modifications of titanium dental implants play important roles in the enhancement of osseointegration. The objective of the present study was to test two different implant surface treatments on a rabbit model to investigate the osseointegration. The tested surfaces were: a) acid-etched surface with sandblasting treatment (SA) and b) an oxidized implant surface (OS). The roughness was measured by an interferometeric microscope with white light and the residual stress of the surfaces was measured with X-ray residual stress Bragg–Bentano diffraction. Six New Zealand white rabbits were used for the in vivo study. Implants with the two different surfaces (SA and OS) were inserted in the femoral bone. After 12 weeks of implantation, histological and histomorphometric analyses of the blocks containing the implants and the surrounding bone were performed. All the implants were correctly implanted and no signs of infection were observed. SA and OS surfaces were both surrounded by newly formed trabeculae. Histomorphometric analysis revealed that the bone–implant contact % (BIC) was higher around the SA implants (53.49 ± 8.46) than around the OS implants (50.94 ± 16.42), although there were no significant statistical differences among them. Both implant surfaces (SA and OS) demonstrated a good bone response with significant amounts of newly formed bone along the implant surface after 12 weeks of implantation. These results confirmed the importance of the topography and physico–chemical properties of dental implants in the osseointegration.

scholarly journals Influence of Three Dental Implant Surfaces on Cell Viability and Bone Behavior. An In Vitro and a Histometric Study in a Rabbit Model

2020 ◽  
Vol 10 (14) ◽  
pp. 4790
Author(s):  
María Rizo-Gorrita ◽  
Ignacio Fernandez-Asian ◽  
Andreina Garcia-de-Frenza ◽  
Celia Vazquez-Pachon ◽  
Maria-Angeles Serrera-Figallo ◽  
...  
Keyword(s):  
Bone Density ◽  
Cell Viability ◽  
Dental Implants ◽  
Surface Characterization ◽  
Rabbit Model ◽  
Surface Characteristics ◽  
Study Groups ◽  
Bone Response

The chemical composition and the surface characteristics of dental implants are factors that have a decisive effect on the osseointegration process. The surface characterization at the compositional and topographic level of three dental implants available in the market was performed with different surface treatments: (1) sandblasted and acid etched surface (SLA), (2) hydroxyapatite (HA) and tricalcium phosphate (TCP) blasted surface (HA/TCP), and (3) HA-blasted and non-etching acid washed surface (HA + AW). In addition, an in vitro viability study of MG-63 osteoblast cells was performed with a JC-1 test. To complete the study, an in vivo study was conducted in New Zealand rabbits. The study analyzed the histometric characteristics of the bone formed around the implants at the level of area, volume, bone density, accumulated bone density, and bone–implant contact (BIC). The rabbits were sacrificed at 6 weeks after implants were placed in the tibial metaphysis. No statistically significant differences were observed at the level of cell viability or histometric parameters between the different study groups (p > 0.05). SLA and HA/TCP surfaces were the ones that obtained a higher BIC value. Taking into account the limitations of this study, it can be concluded that the different implant surfaces analyzed favor a good bone response.

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