scholarly journals Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Juan Du ◽  
Maofeng Zhong ◽  
Dong Liu ◽  
Shufang Liang ◽  
Xiaolin Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Chinese Medicine ◽  
Roc Analysis ◽  
Primary Liver Cancer ◽  
The Body ◽  
Metabolic Characteristics ◽  
Yin Deficiency ◽  
Body Constitution ◽  
Deficiency Group ◽  
The Relationship

Traditional Chinese medicine formulates treatment according to body constitution (BC) differentiation. Different constitutions have specific metabolic characteristics and different susceptibility to certain diseases. This study aimed to assess the characteristic genes of gan-shen Yin deficiency constitution in different diseases. Fifty primary liver cancer (PLC) patients, 94 hypertension (HBP) patients, and 100 diabetes mellitus (DM) patients were enrolled and classified into gan-shen Yin deficiency group and non-gan-shen Yin deficiency group according to the body constitution questionnaire to assess the clinical manifestation of patients. The mRNA expressions of 17 genes in PLC patients with gan-shen Yin deficiency were different from those without gan-shen Yin deficiency. However, considering all patients with PLC, HBP, and DM, only MLH3 was significantly lower in gan-shen Yin deficiency group than that in non-gen-shen Yin deficiency. By ROC analysis, the relationship between MLH3 and gan-shen Yin deficiency constitution was confirmed. Treatment of MLH3 (−/− and −/+) mice with Liuweidihuang wan, classical prescriptions for Yin deficiency, partly ameliorates the body constitution of Yin deficiency in MLH3 (−/+) mice, but not in MLH3 (−/−) mice. MLH3 might be one of material bases of gan-shen Yin deficiency constitution.

scholarly journals The Relationships between Leptin, Genotype, and Chinese Medicine Body Constitution for Obesity

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Hsiang-I. Hou ◽  
Hsing-Yu Chen ◽  
Jang-Jih Lu ◽  
Shih-Cheng Chang ◽  
Hsueh-Yu Li ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Personal Information ◽  
Uncoupling Protein ◽  
The Body ◽  
High Expression ◽  
Nucleotide Polymorphisms ◽  
Severe Problem ◽  
Yin Deficiency ◽  
Body Constitution

Background and Purpose. Obesity is a widespread and increasingly severe problem worldwide. Several single nucleotide polymorphisms (SNPs) associated with obesity have been identified, reflecting metabolic disorders between the environment, diet, and body constitution. Traditional Chinese medicine body constitution (TCMBC) plays a central role in the classification of human body constitution from the viewpoint of traditional Chinese medicine (TCM). This study aims at exploring the relations between TCMBC and obesity-related biochemistry profiles and SNPs. Methods. The adults with body mass index (BMI) more than 27 kg/m2 were enrolled in the study. General personal information, physical condition, TCMBC, biochemical, and SNPs were collected for eligible subjects. The body constitution questionnaire (BCQ) was used to evaluate the relationships between TCMBC tendency, biochemical values, and obesity-related SNPs. Results. Obesity patients tended to have a yin deficiency constitution (YinDC) (n = 33, 66.0%); however, TCMBC in combination is not uncommon (30 subjects with more than two TCMBC in combination). For biochemical profiles, leptin was higher among patients with yang deficiency constitution (YangDC) (YangDC versus non-YangDC: 29.7 ± 24.8 versus 15.9 ± 9.9, P = 0.020 ) and YinDC (YinDC versus non-YinDC: 28.8 ± 23.5 versus 14.4 ± 9.6, P = 0.020 ). The leptin level was highest among YangDC subjects. Higher leptin was found among subjects with three-combined TCMBC than balanced TCMBC subjects who were not inclined to any of three TCMBC. For obesity-related SNPs, the adrenergic receptor beta-3 (ADRB3) gene tended to be high expression among YangDC (YangDC versus non-YangDC: 89.7% versus 71.4%, P = 0.091 ) and uncoupling protein 1 (UCP1) tended to be high expression among phlegm-stasis constitution (PSC) (PSC versus non-PSC: 37.9% versus 9.5%, P = 0.052 ). Conclusions. The relationships between TCMBC, leptin, and SNPs present alternative viewpoints about TCMBC and could be used as a guide to treat obese patients.

scholarly journals Study onYang-XuUsing Body Constitution Questionnaire and Blood Variables in Healthy Volunteers

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Hong-Jhang Chen ◽  
Yii-Jeng Lin ◽  
Pei-Chen Wu ◽  
Wei-Hsiang Hsu ◽  
Wan-Chung Hu ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Logistic Regression Model ◽  
Cross Validation ◽  
Blood Biomarkers ◽  
Metabolic Characteristics ◽  
Body Constitution ◽  
Leave One Out ◽  
The Relationship ◽  
Fold Cross Validation ◽  
Blood Variables

Traditional Chinese medicine (TCM) formulates treatment according to body constitution (BC) differentiation. Different constitutions have specific metabolic characteristics and different susceptibility to certain diseases. This study aimed to assess theYang-Xuconstitution using a body constitution questionnaire (BCQ) and clinical blood variables. A BCQ was employed to assess the clinical manifestation ofYang-Xu. The logistic regression model was conducted to explore the relationship between BC scores and biomarkers. Leave-one-out cross-validation (LOOCV) and K-fold cross-validation were performed to evaluate the accuracy of a predictive model in practice. Decision trees (DTs) were conducted to determine the possible relationships between blood biomarkers and BC scores. According to the BCQ analysis, 49% participants without any BC were classified as healthy subjects. Among them, 130 samples were selected for further analysis and divided into two groups. One group comprised healthy subjects without any BC (68%), while subjects of the other group, named as the sub-healthy group, had three BCs (32%). Six biomarkers, CRE, TSH, HB, MONO, RBC, and LH, were found to have the greatest impact on BCQ outcomes inYang-Xusubjects. This study indicated significant biochemical differences inYang-Xusubjects, which may provide a connection between blood variables and theYang-XuBC.

scholarly journals MicroRNA, Diabetes Mellitus and Colorectal Cancer

Biomedicines ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 530
Author(s):  
Hsiuying Wang
Keyword(s):  
Diabetes Mellitus ◽  
Colorectal Cancer ◽  
The Body ◽  
Incidence And Mortality ◽  
The Common ◽  
Regulation Of Cell Cycle ◽  
The Relationship ◽  
Development Regulation ◽  
Inhibit Cell Proliferation ◽  
Improve Glucose Tolerance

Diabetes mellitus (DM) is an endocrinological disorder that is due to either the pancreas not producing enough insulin, or the body does not respond appropriately to insulin. There are many complications of DM such as retinopathy, nephropathy, and peripheral neuropathy. In addition to these complications, DM was reported to be associated with different cancers. In this review, we discuss the association between DM and colorectal cancer (CRC). CRC is the third most commonly diagnosed cancer worldwide that mostly affects older people, however, its incidence and mortality are rising among young people. We discuss the relationship between DM and CRC based on their common microRNA (miRNA) biomarkers. miRNAs are non-coding RNAs playing important functions in cell differentiation, development, regulation of cell cycle, and apoptosis. miRNAs can inhibit cell proliferation and induce apoptosis in CRC cells. miRNAs also can improve glucose tolerance and insulin sensitivity. Therefore, investigating the common miRNA biomarkers of both DM and CRC can shed a light on how these two diseases are correlated and more understanding of the link between these two diseases can help the prevention of both DM and CRC.

scholarly journals THE RELATIONSHIP BETWEEN CALPROTECTIN AND PARAMETERS OF LIPID AND CARBOHYDRATE METABOLISM, ANTHROPOMETRIC AND INFLAMMATORY PARAMETERS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND DIABETES MELLITUS TYPE 2

2019 ◽  
Vol 19 (2) ◽  
pp. 16-18
Author(s):  
M. I. Zhuravlova
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Insulin Resistance ◽  
Acute Myocardial Infarction ◽  
Carbohydrate Metabolism ◽  
Diabetes Mellitus Type 2 ◽  
The Body ◽  
Diabetes Mellitus Type ◽  
The Relationship

Nowadays, an acute myocardial infarction is one of the leading causes of mortality among the population. The EHS-DH registry data clearly illustrate the association between the comorbidities and high mortality following acute myocardial infarction during a year period of follow up. The pronounced influence of carbohydrate metabolism disturbances on the survival of such patients has already been reported. The aim of the study was to analyze the immune inflammation relationships based on assessing calprotectin and the parameters of lipid and carbohydrate metabolism, to evaluate the presence and nature of the relationship between these parameters and carbohydrate metabolism parameters based on the study of blood glucose, insulin and insulin resistance (by the indices HOMA, QUICKI, Caro), anthropometric indicators and inflammatory indicators (monocyte and neutrophile levels). Materials and methods. The study included 64 patients (mean age 65, 31 ± 1.62 years) with acute myocardial infarction and concomitant diabetes mellitus type 2. The design of the study included the primary laboratory investigation of patients during the first day since the onset of acute myocardial infarction with the elevation of the ST segment before the initiation of thrombolytic therapy or percutaneous intervention. The direct correlation between the calprotectin concentration and the HOMA insulin resistance index (R = 0.52; p <0.05), insulinemia (R = 0.57; p <0.05), fasting glycaemia (R = 0, 59; p <0.05), as well as inverse correlation relationships between the Caro index (R = 0.68; p <0.05) and the QUICKI index (R = 0.59; p <0.05) were found out. Moreover, a direct correlation between calprotectin and triglyceride levels (R = 0.31; p <0.05), and negative correlation with high density lipoprotein (R = 0.35; p <0.05) was established as well. The level of total cholesterol and low density lipoproteins showed no significant association with the proinflammatory factor (R = 0.12; p> 0.05 and R = 0.18; p> 0.05, respectively). Conclusions. The increase in the body mass index and the activity of serum monocytes and neutrophils is associated with high concentrations of calprotectin that is accompanied by disturbances of carbohydrate homeostasis towards the growth of insulin resistance and changes of lipidograms of proatherrogenic nature.

scholarly journals Relationship Of Abdominal Circumference, BMI and Sweet Food Consumption with Diabetes Mellitus in Adults 26-45 Years Old in DKI Jakarta (Riskesdas 2018 Analysis)

2021 ◽  
Vol 1 (2) ◽  
pp. 41-49
Author(s):  
Anisa Putri Etika Ramadena ◽  
Sintha Fransiske Simanungkalit ◽  
A’immatul Fauziyah
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Body Mass ◽  
The Body ◽  
Abdominal Circumference ◽  
Chi Square ◽  
Sweet Foods ◽  
Relationship Of ◽  
The Relationship ◽  
Prevalence Of Diabetes Mellitus

Diabetes mellitus occurs, one of which is characterized by hyperglycemia that occurs due to insulin abnormalities or insulin action (Perkeni, 2015). The 2018 Riskesdas survey showed an increase in the prevalence of diabetes mellitus in people over 15 years of age. High carbohydrate intake can affect the incidence of diabetes mellitus. This is caused carbohydrates that have been broken down by the body into glucose will be circulated throughout the body and the glucose balance will be controlled by the pancreas by releasing the hormone insulin. If a insulin produced is few, the glucose level in the blood will be excess and increase the occurrence of hyperglycemia. This study aims to analyze the relationship between consumption of sweet foods, body mass index and abdominal circumference with the incidence of diabetes mellitus in adults aged 26-45 years in DKI Jakarta based on the Riskesdas 2018 analysis. The results of the bivariate test with chi square showed a relationship between consumption of sweet foods (p = 0,000), body mass index (p = 0,000) and abdominal circumference (p = 0,000) with the incidence of diabetes mellitus. It can be concluded that there is a relationship between consumption of sweet foods, body mass index and abdominal circumference with the incidence of diabetes mellitus in adults aged 26-45 years in DKI Jakarta.

scholarly journals Association study of diabetes mellitus and body constitution of traditional Chinese medicine

2019 ◽  
Vol 02 (01) ◽  
pp. 1-6
Author(s):  
Nabijan Mohammadturusn ◽  
Yizhe Xu ◽  
Fei Xu ◽  
Yuanhao Zhang ◽  
Zihui Tang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Total Sample ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Epidemiological Evidence ◽  
Related Information ◽  
Body Constitution ◽  
Baseline Characteristics

Objective: We report on the association between traditional Chinese medicine (TCM) constitution and diabetes mellitus (DM) and provide epidemiological evidence for the theory of correlation between constitution and disease. Methods: A total of 3748 participants were used for data analysis, and all study subjects underwent a complete clinical baseline characteristics evaluation to collect related information. DM was determined by an oral glucose tolerance test. Multiple logistic regression (MLR) models were employed to detect the associations. Results: In total, 16.84% of the participants had DM in the total sample. Significant differences were found in age, height, weight, and heart rate, between the DM and non-DM groups. Univariate linear regression analyses indicated that the variables Qi_Deficient and Yang_Deficient were significantly associated with the outcome, and a negative correlation between TCM constitution and DM was found. After adjustment for relevant potential confounding factors, the MLR detected significant associations between both the Qi_Deficient and Yang_Deficient variables and DM ([Formula: see text]-value [Formula: see text] 0.015 for Qi_Deficient and [Formula: see text]-value [Formula: see text] for Yang_Deficient). In Qi_Deficient and Yin_Deficient participants, the odds ratios (ORs) for DM were 0.778 and 0.646, respectively. Conclusion: Qi_Deficient and Yang_Deficient were significantly associated with DM. These findings may provide insights for clinical practice for the prevention and diagnosis of DM.

scholarly journals The Relationship between Body Weight Change and Body Constitutions of Traditional Chinese Medicine in Patients with Schizophrenia

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Jui-Fen Cheng ◽  
Xuan-Yi Huang ◽  
Te-Le Liu ◽  
Ruey-Yun Wang ◽  
Han-Yi Ching
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Waist Circumference ◽  
Health Care Providers ◽  
Weight Change ◽  
The Body ◽  
Care Providers ◽  
Body Constitution ◽  
Significant Difference ◽  
The Relationship

Objective. To explore the relationship between body constitution (BC) types and weight change in patients with schizophrenia and who underwent second-generation antipsychotics (SGAs) treatment.Method. Body weight and waist circumference of eighty-five participants were measured for 6 consecutive weeks. Constitutions of Yin-Xu, Yang-Xu, and Stasis were assessed using the Body Constitution Questionnaire (BCQ).Results. Participants with body constitutions Yin-Xu (50.6%), Yang-Xu (49.4%), or Stasis (38.8%) exhibited worse physical condition and unhealthy daily habits, particularly in Stasis constitution. Moreover, Stasis constitution was significantly associated with several factors, including BMI, body weight, waist circumference, perception of stress, perception of health, staying up late, and less physical exercise. However, perception of stress showed significant difference in Yin-Xu, Yang-Xu, and Stasis. Generalized estimating equation (GEE) analysis revealed that significant time effects in body weight increase in the imbalanced BC types and gentleness BC type. SGAs induced weight gain in imbalanced BC type as well as gentleness BC type, especially treated with olanzapine.Conclusions. This is the first study to explore the longitudinal relationship between BC and weight gain in schizophrenia patients undergoing SGAs treatment. Health care providers should focus on weight gain problems in schizophrenia patients who underwent SGAs treatment.

scholarly journals Mare's milk as a prospective functional product

2018 ◽  
Vol 8 (11) ◽  
pp. 548 ◽  
Author(s):  
Almagul Kushugulova ◽  
Samat Kozhakhmetov ◽  
Rashida Sattybayeva ◽  
Ayaulym Nurgozhina ◽  
Arailym Ziyat ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pulmonary Tuberculosis ◽  
Inflammatory Diseases ◽  
The Body ◽  
Functional Product ◽  
Ancient Times ◽  
The Relationship

Background: Food has a significant effect on the health of the body, the relationship between diet and health actualizes the importance of expanding the research of functional products. Kazakhstan has a huge potential for functional products, such as saumal, or mare's milk. Since ancient times saumal has been used as an antidote, since it has the ability to excrete toxins. Today it is used for pulmonary tuberculosis, anemia, rickets, diabetes mellitus, obesity, nerve diseases, inflammatory diseases of the stomach and intestines. Saumal is called a longevity drink.

scholarly journals Analysis of Family Duty with Diet Compliance in Mellitus Diabetes Patients in the Working Area of Dinas Kesehatan, Jayawijaya District

2021 ◽  
Vol 5 (1) ◽  
pp. 120-126
Author(s):  
Winarko Winarko ◽  
Indasah Indasah
Keyword(s):  
Diabetes Mellitus ◽  
Family Support ◽  
Sampling Technique ◽  
The Body ◽  
Spearman Correlation ◽  
District Health Office ◽  
District Health ◽  
Dietary Compliance ◽  
Diet Compliance ◽  
The Relationship

Non-Communicable Diseases (PTM) has become a serious health problem in the community. One PTM that has received a lot of attention is Diabetes Mellitus (DM) which occurs when the body cannot produce enough of the hormone insulin or cannot use insulin effectively. The aim of this study was to analyze the relationship between family support tasks and dietary adherence in Diabetes Mellitus patients in Jayawijaya District Health Office. The type of research used is survey research with explanatory research methods. The population in this study were 145 diabetes mellitus patients treated at the Jayawijaya District Health Office. The sample of this study were patients with militus diabetes who underwent treatment at the Jayawijaya District Health Office who met the sample criteria of 58 people. The sampling technique used in this research is purposive sampling technique. Based on the results of the study there is a relationship between family duties and dietary compliance in diabetus mellitus patients using spearman correlation calculations of 0.000 < 0.05 in addition to data obtained as many as 38 (65.5% ) respondents from 43 respondents of family duties are good and obedient to the diet diabetus mellitus, while from 13 respondents with family duties are quite obtained data as many as 7 respondents (12.1%) disobedient. And from 2 respondents with family duties, less data was obtained by 2 respondents (3.4%) disobedient. Based on the results of the research, it is hoped that further communication, information, and education (IEC) will improve regarding the dietary needs of diabetes mellitus.

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