scholarly journals Porous Cellulose Beads Fabricated from Regenerated Cellulose as Potential Drug Delivery Carriers

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Lee Ken Voon ◽  
Suh Cem Pang ◽  
Suk Fun Chin
Keyword(s):  
Drug Delivery ◽  
Release Kinetics ◽  
Morphological Characteristics ◽  
Cost Effective ◽  
Solution Concentration ◽  
Regenerated Cellulose ◽  
Release Kinetic ◽  
Loading Capacity ◽  
The Mean ◽  
Model Drug

Highly porous cellulose beads (CBs) of various mean sizes were successfully prepared from regenerated cellulose of paper wastes. The drug delivery characteristics of CBs with different mean sizes were investigated using curcumin as the model drug under controlled conditions. The loading capacity and efficiency of curcumin onto CBs were substantially influenced by factors such as their morphological characteristics, curcumin concentration, and duration of loading. The release kinetic profiles of curcumin from CBs of different mean sizes were investigated in media of pH values resembling digestive juices and intestinal fluids. Release kinetic models were used to simulate and elucidate release kinetics and mechanisms of curcumin from CBs under specific conditions. The loading capacity and efficiency of curcumin onto CBs could be enhanced via the optimization of curcumin solution concentration and the morphological characteristics of CBs, whereas the release kinetic profiles of curcumin from CBs could be modulated by varying the mean diameter of CBs. Optimized CBs derived from regenerated cellulose of paper wastes are potentially useful as cost-effective drug delivery carriers.

scholarly journals Optimizing Delivery Characteristics of Curcumin as a Model Drug via Tailoring Mean Diameter Ranges of Cellulose Beads

2017 ◽  
Vol 2017 ◽  
pp. 1-10
Author(s):  
Lee Ken Voon ◽  
Suh Cem Pang ◽  
Suk Fun Chin
Keyword(s):  
Reaction Temperature ◽  
Surfactant Concentration ◽  
Regenerated Cellulose ◽  
Release Kinetic ◽  
Mean Diameter ◽  
The Mean ◽  
Model Drug ◽  
Fabrication Parameters ◽  
Cellulose Concentration

Spherical cellulose beads with tailored mean diameter between micrometer (20–80 μm) and nanometer (40–200 nm) ranges were fabricated from regenerated cellulose of paper wastes via water-in-oil (W/O) microemulsion and nanoprecipitation processes, respectively. The mean diameter ranges of cellulose beads were precisely controlled via modulating fabrication parameters such as stirring speed, surfactant concentration, cellulose concentration, and reaction temperature. By tailoring their mean diameter ranges and using curcumin as a model drug, cellulose beads with enhanced loading capacities and optimized release kinetic profiles of curcumin were fabricated.

scholarly journals Synthesis and Characterization of Stearic Acid-Beclomethasone Dipropionate Conjugates with the Potential for Improving Loading Capacity in Lipid-based Nanoparticles

2021 ◽  
Author(s):  
Shishuai Dang ◽  
Zhengwei Huang ◽  
Ying Huang ◽  
Xin Pan ◽  
Chuanbin Wu
Keyword(s):  
Drug Delivery ◽  
Stearic Acid ◽  
Beclomethasone Dipropionate ◽  
Drug Loading ◽  
Pulmonary Delivery ◽  
Dynamics Simulation ◽  
Loading Capacity ◽  
Technology Platform ◽  
New Type ◽  
Model Drug

<p>Lipid-based nanoparticles (LBNs) are a new type of nanoparticulate drug delivery system, which have been gradually shown broad prospects in pulmonary drug delivery systems. However, the main disadvantage of these LBNs for inhalable drugs with limited lipophilicity is the low encapsulation capacity. Herein, this study anticipates establishing a technology platform to improve the loading capacity of low lipophilicity drugs in LBNs, for the therapy of lung diseases. A proof-of-concept was carried out using Beclomethasone dipropionate (BDP) as a model drug. BDP was conjugated with stearic acid (SA), a kind of the lipid matrix for LBN. The conjugate was characterized and the interactions between the conjugate and SA were investigated by molecular dynamics simulation. It is expected that the drug loading capacity of weak-lipophilic drugs in LBN can be increased by establishing the technology platform, and the application of LBNs in pulmonary delivery can be broadened.</p>

Synthesis, characterization and formulation of sodium calcium silicate bioceramic for drug delivery applications

2016 ◽  
Vol 23 (4) ◽  
pp. 375-380
Author(s):  
P. Manohar Reddy ◽  
Ravy Lakshmi ◽  
Febin Prabhu Dass ◽  
Swamiappan Sasikumar
Keyword(s):  
Drug Delivery ◽  
Calcium Silicate ◽  
Release Kinetics ◽  
Release Profile ◽  
Apatite Formation ◽  
X Ray Diffraction ◽  
Drug Release Profile ◽  
Sodium Calcium ◽  
Calcium Magnesium ◽  
Model Drug

AbstractSodium calcium silicate (Na2CaSiO4) is a bioactive silicate with Na2O, CaO and SiO2 as its basic components, which is similar to that of the composition of bioactive glasses. In the present study, pure sodium calcium silicate was synthesized by rapid combustion technique, and the synthesized sample was characterized by powder X-ray diffraction to check the phase purity. The scaffolds were prepared by varying the ratio of sodium calcium silicate and polyvinyl alcohol, and the apatite-formation ability of the scaffolds was examined by soaking them in a simulated body fluid. The results revealed the formation of hydroxyapatite on the surface of the scaffold after 5 days, which is found to be rapid when compared with the bioactivity of the calcium silicates and calcium magnesium silicates. The scaffolds were also loaded with ciprofloxacin as a model drug and analyzed for its drug release profile using UV spectrophotometer. The release profile did not vary with the change in bioceramic-to-biopolymer ratio, and 60% of the drug was released in 10 days, which is within the appreciable range for a targeted drug delivery system. Moreover, the experimental and simulated values of the release kinetics were compared by applying the existing mathematical model.

scholarly journals Synthesis and Characterization of Stearic Acid-Beclomethasone Dipropionate Conjugates with the Potential for Improving Loading Capacity in Lipid-based Nanoparticles

2021 ◽  
Author(s):  
Shishuai Dang ◽  
Zhengwei Huang ◽  
Ying Huang ◽  
Xin Pan ◽  
Chuanbin Wu
Keyword(s):  
Drug Delivery ◽  
Stearic Acid ◽  
Beclomethasone Dipropionate ◽  
Drug Loading ◽  
Pulmonary Delivery ◽  
Dynamics Simulation ◽  
Loading Capacity ◽  
Technology Platform ◽  
New Type ◽  
Model Drug

<p>Lipid-based nanoparticles (LBNs) are a new type of nanoparticulate drug delivery system, which have been gradually shown broad prospects in pulmonary drug delivery systems. However, the main disadvantage of these LBNs for inhalable drugs with limited lipophilicity is the low encapsulation capacity. Herein, this study anticipates establishing a technology platform to improve the loading capacity of low lipophilicity drugs in LBNs, for the therapy of lung diseases. A proof-of-concept was carried out using Beclomethasone dipropionate (BDP) as a model drug. BDP was conjugated with stearic acid (SA), a kind of the lipid matrix for LBN. The conjugate was characterized and the interactions between the conjugate and SA were investigated by molecular dynamics simulation. It is expected that the drug loading capacity of weak-lipophilic drugs in LBN can be increased by establishing the technology platform, and the application of LBNs in pulmonary delivery can be broadened.</p>

scholarly journals Microfluidic Fabrication of Monodisperse Microcapsules for Thermo-Triggered Release of Liposoluble Drugs

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2200
Author(s):  
Yuanyuan Wang ◽  
Yongyue Li ◽  
Jinghua Gong ◽  
Jinghong Ma
Keyword(s):  
Drug Delivery ◽  
Methacrylic Acid ◽  
Environmental Temperature ◽  
In Vitro Release ◽  
Loading Capacity ◽  
Triggered Release ◽  
Model Drug ◽  
Monodisperse Microcapsules ◽  
Vitro Release

Here, we report a novel thermo-triggered-releasing microcapsule for liposoluble drug delivery. Monodisperse microcapsules with a poly(N-isopropylacrylamide-co-methacrylic acid) hydrogel shell and an oil core were successfully fabricated by a double coaxial microfluidic device. Fluorescent dye Lumogen Red F300 as a model liposoluble drug was dissolved in the oil core with controllable loading capacity. The volume phase transition temperature (VPTT) of the microcapsule was adjusted by copolymerizing with the hydrophilic methacrylic acid. The in vitro release study demonstrates that the shells shrink, leading to the thermo-triggered release of the model drug from the microcapsules at the environmental temperature above the VPTT, while the swollen hydrogel shells can protect the encapsulated drug from leakage and contamination below the VPTT. The proposed microcapsule is a promising liposoluble drug delivery system with controllable loading and smart thermo-triggered release.

scholarly journals Design, Development, and Optimization of Sterculia Gum-Based Tablet Coated with Chitosan/Eudragit RLPO Mixed Blend Polymers for Possible Colonic Drug Delivery

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Bipul Nath ◽  
Lila Kanta Nath
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Release Kinetics ◽  
Release Kinetic ◽  
Design Development ◽  
Colonic Delivery ◽  
Colonic Drug Delivery ◽  
Sterculia Urens ◽  
Eudragit Rlpo

The purpose of this study is to explore the possible applicability of Sterculia urens gum as a novel carrier for colonic delivery system of a sparingly soluble drug, azathioprine. The study involves designing a microflora triggered colon-targeted drug delivery system (MCDDS) which consists of a central polysaccharide core and is coated to different film thicknesses with blends of chitosan/Eudragit RLPO, and is overcoated with Eudragit L00 to provide acid and intestinal resistance. The microflora degradation property of gum was investigated in rat caecal medium. Drug release study in simulated colonic fluid revealed that swelling force of the gum could concurrently drive the drug out of the polysaccharide core due to the rupture of the chitosan/Eudargit coating in microflora-activated environment. Chitosan in the mixed film coat was found to be degraded by enzymatic action of the microflora in the colon. Release kinetic data revealed that the optimized MCDDS was fitted well into first-order model, and apparent lag time was found to be 6 hours, followed by Higuchi release kinetics. In vivo study in rabbits shows delayed , prolonged absorption time, decreased , and absorption rate constant (Ka), indicating a reduced systemic toxicity of the drug as compared to other dosage forms.

SYNTHESIS OF ELECTROSPRAYED CHITOSAN NANOPARTICLES FOR DRUG SUSTAINED RELEASE

Nano LIFE ◽  
2012 ◽  
Vol 02 (01) ◽  
pp. 1250003 ◽  
Author(s):  
DOAN VAN HONG THIEN ◽  
SHENG WEN HSIAO ◽  
MING HUA HO
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Encapsulation Efficiency ◽  
Drug Carrier ◽  
Chitosan Nanoparticles ◽  
Average Diameter ◽  
Loading Capacity ◽  
Model Drug ◽  
Size And Morphology ◽  
Two Stages

Chitosan (CS) nanoparticles for drug delivery were fabricated by an electrospraying method. The effects of CS molecular weight on electrospraying were investigated. The size and morphology of CS particles were strongly influenced by CS molecular weight. Besides, CS concentration, electrical field, acetic acid concentration, and solution feeding rate in the electrospraying process were also studied. To evaluate the potential of electrosprayed CS nanoparticles in drug delivery, indomethacin (ID) was used as a model drug, where the encapsulation efficiency, the loading capacity, and the releasing profiles were identified. The CS-ID spherical nanoparticles were fabricated by the electrospraying technique, with the average diameter of 340 nm. Zeta potential of the ID-CS particles indicated that the particles were stable in the suspension. The encapsulation efficiency (EE) and loading capacity (LC) of ID were higher for 150-kDa CS than for 310-kDa CS. The EE of ID in electrosprayed CS particles was higher than that in particles prepared by other methods. The release profiles revealed that there were two stages for releasing and the long-term delivery could be obtained in the second stage. In summary, this research optimized the electrospraying process for the fabrication of CS nanoparticles and demonstrated the potential of electrosprayed CS nanoparticles as a drug carrier.

scholarly journals A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 734
Author(s):  
Zhuo Chen ◽  
Zhinan Fu ◽  
Li Li ◽  
Enguang Ma ◽  
Xuhong Guo
Keyword(s):  
Drug Loading ◽  
Scale Up ◽  
Cost Effective ◽  
Vinyl Pyrrolidone ◽  
Loading Capacity ◽  
Flash Nanoprecipitation ◽  
High Drug ◽  
Model Drug ◽  
Poly Vinyl Pyrrolidone ◽  
High Drug Loading

Flash nanoprecipitation (FNP) is an efficient technique for encapsulating drugs in particulate carriers assembled by amphiphilic polymers. In this study, a novel nanoparticular system of a model drug curcumin (CUR) based on FNP technique was developed by using cheap and commercially available amphiphilic poly(vinyl pyrrolidone) (PVP) as stabilizer and natural polymer chitosan (CS) as trapping agent. Using this strategy, high encapsulation efficiency (EE > 95%) and drug loading capacity (DLC > 40%) of CUR were achieved. The resulting CUR-loaded nanoparticles (NPs) showed a long-term stability (at least 2 months) and pH-responsive release behavior. This work offers a new strategy to prepare cost-effective drug-loaded NPs with high drug loading capacity and opens a unique opportunity for industrial scale-up.

scholarly journals Fully amino acid-based hydrogel as potential scaffold for cell culturing and drug delivery

2019 ◽  
Vol 10 ◽  
pp. 2579-2593 ◽  
Author(s):  
Dávid Juriga ◽  
Evelin Sipos ◽  
Orsolya Hegedűs ◽  
Gábor Varga ◽  
Miklós Zrínyi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Amino Acid ◽  
Drug Release ◽  
Disulfide Bonds ◽  
Release Kinetics ◽  
Building Blocks ◽  
Periodontal Ligament Cells ◽  
Polymer Backbone ◽  
Model Drug

Polymer hydrogels are ideal scaffolds for both tissue engineering and drug delivery. A great advantage of poly(amino acid)-based hydrogels is their high similarity to natural proteins. However, their expensive and complicated synthesis often limits their application. The use of poly(aspartic acid) (PASP) seems an appropriate solution for this problem due to the relatively cheap and simple synthesis of PASP. Using amino acids not only as building blocks in the polymer backbone but also as cross-linkers can improve the biocompatibility and the biodegradability of the hydrogel. In this paper, PASP cross-linked with cystamine (CYS) and lysine-methylester (LYS) was introduced as fully amino acid-based polymer hydrogel. Gels were synthesized employing six different ratios of CYS and LYS. The pH dependent swelling degree and the concentration of the elastically active chain were determined. After reduction of the disulfide bonds of CYS, the presence of thiol side groups was also detected. To determine the concentration of the reactive cross-linkers in the hydrogels, a new method based on the examination of the swelling behavior was established. Using metoprolol as a model drug, cell proliferation and drug release kinetics were studied at different LYS contents and in the presence of thiol groups. The optimal ratio of cross-linkers for the proliferation of periodontal ligament cells was found to be 60−80% LYS and 20−40% CYS. The reductive conditions resulted in an increased drug release due to the cleavage of disulfide bridges in the hydrogels. Consequently, these hydrogels provide new possibilities in the fields of both tissue engineering and controlled drug delivery.

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