scholarly journals A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 734
Author(s):  
Zhuo Chen ◽  
Zhinan Fu ◽  
Li Li ◽  
Enguang Ma ◽  
Xuhong Guo
Keyword(s):  
Drug Loading ◽  
Scale Up ◽  
Cost Effective ◽  
Vinyl Pyrrolidone ◽  
Loading Capacity ◽  
Flash Nanoprecipitation ◽  
High Drug ◽  
Model Drug ◽  
Poly Vinyl Pyrrolidone ◽  
High Drug Loading

Flash nanoprecipitation (FNP) is an efficient technique for encapsulating drugs in particulate carriers assembled by amphiphilic polymers. In this study, a novel nanoparticular system of a model drug curcumin (CUR) based on FNP technique was developed by using cheap and commercially available amphiphilic poly(vinyl pyrrolidone) (PVP) as stabilizer and natural polymer chitosan (CS) as trapping agent. Using this strategy, high encapsulation efficiency (EE > 95%) and drug loading capacity (DLC > 40%) of CUR were achieved. The resulting CUR-loaded nanoparticles (NPs) showed a long-term stability (at least 2 months) and pH-responsive release behavior. This work offers a new strategy to prepare cost-effective drug-loaded NPs with high drug loading capacity and opens a unique opportunity for industrial scale-up.

Design of dual-responsive nanocarries with high drug loading capacity based on hollow mesoporous organosilica nanoparticles

2019 ◽  
Vol 233 ◽  
pp. 230-235 ◽  
Author(s):  
Li-li Lu ◽  
Wen-ya Xiong ◽  
Jun-bin Ma ◽  
Tian-fang Gao ◽  
Si-yuan Peng ◽  
...  
Keyword(s):  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Dual Responsive ◽  
Mesoporous Organosilica ◽  
High Drug Loading

scholarly journals Cancer Nanomedicines Stabilized by π-π Stacking between Heterodimeric Prodrugs Enable Exceptionally High Drug Loading Capacity and Safer Delivery of Drug Combinations

Theranostics ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 3638-3652 ◽  
Author(s):  
Hangxiang Wang ◽  
Jianmei Chen ◽  
Chang Xu ◽  
Linlin Shi ◽  
Munire Tayier ◽  
...  
Keyword(s):  
Drug Loading ◽  
Drug Combinations ◽  
Loading Capacity ◽  
High Drug ◽  
Π Stacking ◽  
High Drug Loading

scholarly journals Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview

RSC Advances ◽  
2019 ◽  
Vol 9 (61) ◽  
pp. 35566-35578 ◽  
Author(s):  
Subhankar Mukhopadhyay ◽  
Hanitrarimalala Veroniaina ◽  
Tadious Chimombe ◽  
Lidong Han ◽  
Wu Zhenghong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
High Drug Loading

Protean mesoporous silica nanoparticles are propitious candidates over decades for nanoscale drug delivery systems due to their unique characteristics, including changeable pore size, mesoporosity, high drug loading capacity and biodegradability.

Magnetic carbon nanotubes with particle-free surfaces and high drug loading capacity

2011 ◽  
Vol 22 (35) ◽  
pp. 355602 ◽  
Author(s):  
Eleni C Vermisoglou ◽  
George Pilatos ◽  
George E Romanos ◽  
Eamon Devlin ◽  
Nick K Kanellopoulos ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Loading ◽  
Loading Capacity ◽  
Free Surfaces ◽  
High Drug ◽  
Magnetic Carbon ◽  
High Drug Loading ◽  
Magnetic Carbon Nanotubes

Water soluble multiarm-polyethylene glycol–betulinic acid prodrugs: design, synthesis, and in vivo effectiveness

2014 ◽  
Vol 5 (19) ◽  
pp. 5775-5783 ◽  
Author(s):  
Lin Dai ◽  
Dan Li ◽  
Jing Cheng ◽  
Jing Liu ◽  
Li-Hong Deng ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Betulinic Acid ◽  
Water Solubility ◽  
Drug Loading ◽  
Water Soluble ◽  
Loading Capacity ◽  
Design Synthesis ◽  
High Drug ◽  
High Drug Loading

Multiarm-polyethylene glycol–betulinic acid prodrugs were prepared by using multiarm-polyethylene glycol linkers and betulinic acid, which exhibited high drug loading capacity, good water solubility, and excellent anticancer activity.

A ROS-scavenging multifunctional nanoparticle for combinational therapy of diabetic nephropathy

Nanoscale ◽  
2020 ◽  
Vol 12 (46) ◽  
pp. 23607-23619
Author(s):  
Yuna Tong ◽  
Lijuan Zhang ◽  
Rong Gong ◽  
Jianyou Shi ◽  
Lei Zhong ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Mesoporous Silica ◽  
Drug Loading ◽  
Loading Capacity ◽  
Ros Scavenging ◽  
High Drug ◽  
Combinational Therapy ◽  
Multifunctional Nanoparticle ◽  
Hollow Mesoporous Silica ◽  
High Drug Loading

A renoprotective activity hollow mesoporous silica nanocomposite (HMSN) particle doped with trace cerium oxide has been constructed, which not only has the ability to prevent ROS-associated DN pathogenesis but also has high drug loading capacity.

Doxorubicin-loaded micelles with high drug-loading capacity and stability based on zwitterionic oligopeptides

2020 ◽  
Vol 44 (29) ◽  
pp. 12633-12638
Author(s):  
Weili Xue ◽  
Ashish Trital ◽  
Sihang Liu ◽  
Liangbo Xu
Keyword(s):  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
High Drug Loading

Scheme of preparing doxorubicin-loaded micelles based on zwitterionic oligopeptides EKCEK.

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