scholarly journals Skeletal Muscle Cell Induction from Pluripotent Stem Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Yusaku Kodaka ◽  
Gemachu Rabu ◽  
Atsushi Asakura
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Muscle Cell ◽  
Pluripotent Stem Cells ◽  
Myogenic Differentiation ◽  
Embryonic Stem ◽  
Muscle Cells ◽  
Skeletal Muscle Cell ◽  
Skeletal Muscle Cells ◽  
Cell Induction

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the potential to differentiate into various types of cells including skeletal muscle cells. The approach of converting ESCs/iPSCs into skeletal muscle cells offers hope for patients afflicted with the skeletal muscle diseases such as the Duchenne muscular dystrophy (DMD). Patient-derived iPSCs are an especially ideal cell source to obtain an unlimited number of myogenic cells that escape immune rejection after engraftment. Currently, there are several approaches to induce differentiation of ESCs and iPSCs to skeletal muscle. A key to the generation of skeletal muscle cells from ESCs/iPSCs is the mimicking of embryonic mesodermal induction followed by myogenic induction. Thus, current approaches of skeletal muscle cell induction of ESCs/iPSCs utilize techniques including overexpression of myogenic transcription factors such as MyoD or Pax3, using small molecules to induce mesodermal cells followed by myogenic progenitor cells, and utilizing epigenetic myogenic memory existing in muscle cell-derived iPSCs. This review summarizes the current methods used in myogenic differentiation and highlights areas of recent improvement.

scholarly journals Induction of Skeletal Muscle Progenitors and Stem Cells from human induced Pluripotent Stem Cells

2020 ◽  
Vol 7 (4) ◽  
pp. 395-405
Author(s):  
Takahiko Sato
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Myogenic Differentiation ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Induced Pluripotent ◽  
Myogenic Induction

Induced pluripotent stem cells (iPSCs) have the potential to differentiate into various types of cells and tissues including skeletal muscle. The approach to convert these stem cells into skeletal muscle cells offers hope for patients afflicted with skeletal muscle diseases such as Duchenne muscular dystrophy (DMD). Several methods have been reported to induce myogenic differentiation with iPSCs derived from myogenic patients. An important point for generating skeletal muscle cells from iPSCs is to understand in vivo myogenic induction in development and regeneration. Current protocols of myogenic induction utilize techniques with overexpression of myogenic transcription factors such as Myod1(MyoD), Pax3, Pax7, and others, using recombinant proteins or small molecules to induce mesodermal cells followed by myogenic progenitors, and adult muscle stem cells. This review summarizes the current approaches used for myogenic induction and highlights recent improvements.

Superparamagnetic Nanoparticles Direct Differentiation of Embryonic Stem Cells Into Skeletal Muscle Cells

2014 ◽  
Vol 4 (7) ◽  
pp. 579-585 ◽  
Author(s):  
Tannaz Norizadeh-Abbariki ◽  
Omid Mashinchian ◽  
Mohammad Ali Shokrgozar ◽  
Nooshin Haghighipour ◽  
Tapas Sen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Muscle Cells ◽  
Superparamagnetic Nanoparticles ◽  
Skeletal Muscle Cells ◽  
Direct Differentiation

scholarly journals Epigenetic Reprogramming of Human Embryonic Stem Cells into Skeletal Muscle Cells and Generation of Contractile Myospheres

Cell Reports ◽  
2013 ◽  
Vol 3 (3) ◽  
pp. 661-670 ◽  
Author(s):  
Sonia Albini ◽  
Paula Coutinho ◽  
Barbora Malecova ◽  
Lorenzo Giordani ◽  
Alex Savchenko ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Muscle Cells ◽  
Epigenetic Reprogramming ◽  
Skeletal Muscle Cells

Syncitium in Motion: Exploring Movement in the Skeletal Muscle Cell Shared by Scientific and Artistic Nuclei

Leonardo ◽  
2015 ◽  
Vol 48 (3) ◽  
pp. 272-273
Author(s):  
Stuart Hodgetts
Keyword(s):  
Skeletal Muscle ◽  
Muscle Cell ◽  
Muscle Cells ◽  
Skeletal Muscle Cell ◽  
Skeletal Muscle Cells ◽  
Complex Mechanism ◽  
Art And Science ◽  
Common Framework

The marriage of art and science often requires the sharing of unique characteristics. Skeletal muscle cells have provided a format in which the biology mimics the interaction of the artist and scientist within a common framework. This interaction, like the complex mechanism of fused muscle cells themselves, reveals and reminds those in both disciplines of the remarkable dynamic of movement between the two fields. This movement stimulates and rewards the artist and the scientist alike. For a scientist who works closely with artists, it is important to re-visit the fundamental concepts that drive the curiosity and stimulate the passion.

scholarly journals Skeletal Muscle Cells Generated from Pluripotent Stem Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-2 ◽  
Author(s):  
Yuko Miyagoe-Suzuki ◽  
Atsushi Asakura ◽  
Masatoshi Suzuki
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Muscle Cells ◽  
Skeletal Muscle Cells

Hydrogels containing metallic glass sub-micron wires for regulating skeletal muscle cell behaviour

2015 ◽  
Vol 3 (11) ◽  
pp. 1449-1458 ◽  
Author(s):  
Samad Ahadian ◽  
Ramin Banan Sadeghian ◽  
Shin Yaginuma ◽  
Javier Ramón-Azcón ◽  
Yuji Nashimoto ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Metallic Glass ◽  
Muscle Cell ◽  
Muscle Cells ◽  
Skeletal Muscle Cell ◽  
Skeletal Muscle Cells ◽  
Cell Behaviour ◽  
Hydrogel Scaffolds

Hybrid Pd-based metallic glass sub-micron wires-hydrogel scaffolds are efficient in regulating behaviours of skeletal muscle cells.

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