scholarly journals Cortical Reorganization in Patients Recovered from Bell’s Palsy: An Orofacial and Finger Movements Task-State fMRI Study

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Jaeyoun Lee ◽  
Jun Yang ◽  
Chuanfu Li ◽  
Aihong Yuan ◽  
Hongli Wu ◽  
...  
Keyword(s):  
Bell’S Palsy ◽  
Cortical Reorganization ◽  
Control Group ◽  
Finger Movements ◽  
Bell's Palsy ◽  
Orofacial Movements ◽  
Fmri Study ◽  
The Relationship ◽  
The Brain ◽  
Motor Areas

Objective.To explore cortical reorganization of patients recovered from Bell’s palsy (BP) by task-state functional magnetic resonance imaging (fMRI) during finger and orofacial movements and provide more evidence for acupuncture clinical treatment of BP.Methods.We collected 17 BP patients with complete clinical recovery (BP group) and 20 healthy volunteers (control group) accepted the task-state fMRI scans with lip pursing movements and finger movements, respectively.Results.It was found that there were significant differences of brain functional status between the two groups.Conclusions.The results showed that there was cortical reorganization in the brain of patients recovered from BP after acupuncture treatment, which also suggested the relationship between the hand motor areas and facial motor areas of BP patients.

Evaluation of serum ischaemia-modified albumin levels in patients with Bell's palsy

2019 ◽  
Vol 133 (09) ◽  
pp. 810-813
Author(s):  
A E Göker ◽  
M H Alagöz ◽  
G Güntaş ◽  
A Baskadem Yilmazer ◽  
G Berkiten ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bell’S Palsy ◽  
Control Group ◽  
Study Group ◽  
Healthy Individuals ◽  
Bell's Palsy ◽  
Control Groups ◽  
Blood Samples ◽  
And Control ◽  
The Relationship

AbstractObjectiveThis prospective study aimed to evaluate the relationship between serum ischaemia-modified albumin levels and Bell's palsy severity.MethodsThe study included 30 patients diagnosed with Bell's palsy and 30 healthy individuals. The patients were separated into three disease severity groups (grades 2, 3 and 4) according to House–Brackmann classification. Blood samples were collected from all participants and the results compared between groups.ResultsSignificant differences in serum ischaemia-modified albumin were found between the study and control groups (p < 0.001); values were significantly higher in the study group than in the control group.ConclusionThe significantly higher levels of serum ischaemia-modified albumin in the study group suggest that Bell's palsy pathogenesis is associated with oxidative stress.

scholarly journals Intratympanic steroid therapy for Bell’s palsy with poor prognostic results

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Akira Inagaki ◽  
Sachiyo Katsumi ◽  
Shinji Sekiya ◽  
Shingo Murakami
Keyword(s):  
Facial Nerve ◽  
Steroid Therapy ◽  
Standard Dose ◽  
Neuroprotective Effect ◽  
Bell’S Palsy ◽  
Control Group ◽  
Average Dose ◽  
Test Results ◽  
Bell's Palsy ◽  
Intratympanic Dexamethasone

AbstractIn Bell’s palsy, electrodiagnosis by electroneurography (ENoG) is widely used to predict a patient’s prognosis. The therapeutic options for patients with poor prognostic results remain controversial. Here, we investigated whether early intervention with intratympanic steroid therapy (ITST) is an effective treatment for Bell’s palsy patients with poor electrodiagnostic test results (≤ 10% electroneurography value). Patients in the concurrent ITST group (n = 8) received the standard systemic dose of prednisolone (410 mg total) and intratympanic dexamethasone (16.5 mg total) and those in the control group (n = 21) received systemic prednisolone at the standard dose or higher (average dose, 605 ± 27 mg). A year after onset, the recovery rate was higher in the ITST group than in the control group (88% vs 43%, P = 0.044). The average House-Brackmann grade was better in the concurrent ITST group (1.13 ± 0.13 vs 1.71 ± 0.16, P = 0.035). Concurrent ITST improves the facial nerve outcome in patients with poor electroneurography test results, regardless of whether equivalent or lower glucocorticoid doses were administered. This may be ascribed to a neuroprotective effect of ITST due to a higher dose of steroid reaching the lesion due to dexamethasone transfer in the facial nerve.

scholarly journals Brain Responses to Acupuncture Are Probably Dependent on the Brain Functional Status

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Chuanfu Li ◽  
Jun Yang ◽  
Jinbo Sun ◽  
Chunsheng Xu ◽  
Yuanqiang Zhu ◽  
...  
Keyword(s):  
Functional Status ◽  
Bell’S Palsy ◽  
Healthy Adults ◽  
Bell's Palsy ◽  
Brain Response ◽  
Brain Responses ◽  
Underlying Mechanisms ◽  
Pathological Stages ◽  
The Brain ◽  
Normal Controls

In recent years, neuroimaging studies of acupuncture have explored extensive aspects of brain responses to acupuncture in finding its underlying mechanisms. Most of these studies have been performed on healthy adults. Only a few studies have been performed on patients with diseases. Brain responses to acupuncture in patients with the same disease at different pathological stages have not been explored, although it may be more important and helpful in uncovering its underlying mechanisms. In the present study, we used fMRI to compare brain responses to acupuncture in patients with Bell’s palsy at different pathological stages with normal controls and found that the brain response to acupuncture varied at different pathological stages of Bell’s palsy. The brain response to acupuncture decreased in the early stages, increased in the later stages, and nearly returned to normal in the recovered group. All of the changes in the brain response to acupuncture could be explained as resulting from the changes in the brain functional status. Therefore, we proposed that the brain response to acupuncture is dependent on the brain functional status, while further investigation is needed to provide more evidence in support of this proposition.

Prevalence of ADHD in children born by mothers consuming Frankincense during pregnancy

2021 ◽  
Author(s):  
Alimohammad Ranjbar ◽  
Elahe Kamali Ardakani ◽  
Rahele Zareshahi
Keyword(s):  
Data Gathering ◽  
Control Group ◽  
Case Group ◽  
Dsm V ◽  
History Of ◽  
The Difference ◽  
The Impact ◽  
The Relationship ◽  
The Brain ◽  
Positive Effect

Aims: In Iranian culture, due to some narratives from the prophet Mohammad about the use of frankincense during pregnancy for increasing IQ in children, some women consume frankincense during expectancy. This study's goal is to evaluate the relationship between frankincense used during pregnancy and the incidence of ADHD. Methods: In this study, the case group comprised children 4-17 years old referring to Shahid Chamran Pharmacy in Yazd from summer to winter 2018 for receiving Methylphenidate, those with whom a psychologist had identified ADHD based on DSM-V factors.  The control group included children of the same age group but without ADHD. For data gathering, a checklist was used with some questions on smoking, family history of ADHD, presence/absence of a specific disease during pregnancy, frankincense used during pregnancy, and a chemical medication consumed during pregnancy. Results: The main result demonstrated that the children whose mothers used frankincense during pregnancy were 0.67 times less likely to be affected by ADHD than those whose mothers did not use this substance. However, the difference failed to be statistically significant (P>0.05). Conclusion: Some studies report that frankincense can bear a positive effect on the development of the brain and possibly adequate formation of dendrites trees, axons and induce proper communication between them, so the impact of frankincense on the brain may be justified by its protective effect against the hyperactive child.

Auditory Brain Stem Response Abnormalities in Patients with Bell's Palsy

1983 ◽  
Vol 91 (4) ◽  
pp. 412-416 ◽  
Author(s):  
Ulf Rosenhall ◽  
Staffan Edström ◽  
Per Hanner ◽  
Gaby Badr ◽  
Anders Vahlne
Keyword(s):  
Brain Stem ◽  
Herpes Simplex Virus Infection ◽  
Bell’S Palsy ◽  
Bell's Palsy ◽  
Cns Involvement ◽  
Auditory Brain Stem Response ◽  
Auditory Brain Stem ◽  
Simplex Virus ◽  
The Brain ◽  
Brain Stem Response

To evaluate the hypothesis of CNS involvement in Bell's palsy, the auditory brain stem responses (ABR) of 31 patients were studied. In nine of these patients ABR abnormalities were found. None of these patients showed evidence of dysfunction of the cochlear nerve. Six of the patients who had abnormal ABR were retested after they recovered from the facial paresis. Five of these patients showed persistent ABR abnormality, and one showed a normalization of the ABR. These results may be consistent with an injury at the brain stem level in some patients with Bell's palsy. The possible causative agent of a reactivation of a herpes simplex virus infection is discussed.

Outcome of Treatment with Valacyclovir and Prednisone in Patients with Bell's Palsy

2003 ◽  
Vol 112 (3) ◽  
pp. 197-201 ◽  
Author(s):  
Sara Axelsson ◽  
Sven Lindberg ◽  
Anna Stjernquist-Desatnik
Keyword(s):  
Treatment Group ◽  
Medical Treatment ◽  
Antiviral Drug ◽  
Complete Recovery ◽  
Bell’S Palsy ◽  
Adult Patients ◽  
University Hospital ◽  
Control Group ◽  
Type I ◽  
Bell's Palsy

Idiopathic facial paralysis, or Bell's palsy, shows a nonepidemic pattern that might indicate reactivation of a latent microorganism such as herpes simplex type I as a causative agent. Thirty percent of patients with Bell's palsy given no treatment will not recover completely, and 5% will have severe sequelae. The aim of this study was to find out whether treatment with an antiviral drug in combination with corticosteroids is more effective than no medical treatment at all in patients with Bell's palsy. Fifty-six consecutive adult patients attending the otorhinolaryngology department of the University Hospital of Lund from 1997 to 1999 were treated with 1 g of valacyclovir hydrochloride 3 times per day for 7 days and 50 mg of prednisone daily for 5 days, with the dose being reduced by 10 mg daily for the next 5 days. Fifty-six adult patients with Bell's palsy attending the same department between 1995 and 1996 who were given no medical treatment were studied retrospectively and used as the control group. Forty-nine patients (87.5%) in the treatment group recovered completely, as compared with 38 patients (68%) in the control group (p <.05). One patient (1.8%) in the treatment group displayed severe sequelae, defined as a House-Brackmann score of IV or worse, as compared with 10 of 56 patients (18%) in the control group (p <.01). Among patients over 60 years old, 10 of 10 in the treatment group had complete recovery, as compared with 5 of 12 patients in the control group (p <.01). The present study showed a significantly better outcome in patients with Bell's palsy treated with valacyclovir and prednisone as compared with patients given no medical treatment. This difference in outcome was especially pronounced among elderly patients.

scholarly journals Predictive Values of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Other Prognostic Factors in Pediatric Patients With Bell’s Palsy

2020 ◽  
pp. 014556132092209 ◽  
Author(s):  
Dong Hyun Kim ◽  
Jae Hwan Oh ◽  
Junsuk Kim ◽  
Chang Hyun Cho ◽  
Ju Hyoung Lee
Keyword(s):  
Prognostic Factors ◽  
Pediatric Patients ◽  
Bell’S Palsy ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
Low Grade ◽  
High Grade ◽  
Bell's Palsy ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio

Background and Objectives: Bell’s palsy (BP) is the most frequent cause of unilateral facial paralysis, and inflammation is believed to play an important role in pathogenesis. Due to its rarity, however, no consensus has been reached regarding optimum treatment or factors affecting prognosis. In the present study, treatment outcomes and prognostic factors of BP were investigated in pediatric patients who underwent steroid therapy. The goal was to investigate the relationship between BP and inflammation using multiple inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), and red cell distribution width (RDW). Materials and Methods: In all, 54 patients diagnosed with BP and 39 healthy randomly selected controls were enrolled in this retrospective study. Demographic characteristics and complete blood cell count test results were compared. In addition, prognostic factors were sought by dividing the 54 patients with BP into 2 groups according to the House-Brackmann grading system: low grade BP (grades II and III) and high grade BP (grades IV and V). Serum samples were analyzed retrospectively on initial presentation and 6 months after the symptom begins. Meaningful hematological parameters include NLR, PLR, MPV, and RDW. Results: The NLR values in the BP group were significantly higher than in the control group. The NLR value in the 2 groups of patients with BP differed significantly. The mean PLR value in the BP group was higher than in the control group; however, there were no significant differences between the low-grade and high-grade BP groups nor were there any statically significant differences in the other characteristics. Conclusion: The NLR and PLR values are readily accessible parameters that may be useful prognostic markers in pediatric patients with BP. Further studies are required to confirm these results and their utility in predicting prognosis and treating pediatric patients with BP.

scholarly journals Steroids with and Without Antivirals in the Treatment of Bell’s Palsy: Does It Make any Difference in Recovery? A Study at a Tertiary Care Center, Karachi, Pakistan

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Abu Talib ◽  
Gohar Baloch ◽  
Iftikhar Haider Naqvi ◽  
Muhammad Ubaid
Keyword(s):  
Quality Of Life ◽  
Utility Score ◽  
Health Utility ◽  
Complete Recovery ◽  
Bell’S Palsy ◽  
Control Group ◽  
Study Group ◽  
Facial Appearance ◽  
Bell's Palsy

Objectives: To compare the pharmacological effects of steroids in comparison to steroids with antiviral drugs for the treatment of Bell’s Palsy. Methods: A total 60 patients were enrolled and segregated equally into two groups, where patients on prednisolone were labeled as group A (Control group), whereas patients on prednisolone + acyclovir were labeled as group B (study group). All patients had House Brackmann score. The control group started oral prednisolone 1 mg/kg for 10 days, whereas the study group started acyclovir 400 mg 4 times a day for 10 days along with prednisolone tablets. Patients were regularly observed till the study was completed. Primary outcome measure was facial nerve recovery. Health-related quality of life and facial appearance were considered secondary outcomes. Results: The primary outcomes assessed as complete recovery from Bell’s Palsy by Brackmann score at week 4 were found in 17/30 (57%) patients and 23/30 (77%) patients at week 8 in the control group. Complete recovery from Bell’s Palsy was also shown in the experimental group (Prednisolone + acyclovir) where 25/30 (83%) patients completed recovery at week 4, while 27/30 (90%) patients at week 8. Comparison of the two groups showed a significant improvement in the study group (prednisolone + acyclovir) (P = 0.047) at week 4 and (P = 0.02) at week 8. The secondary outcomes were assessed as improvement in the quality of life and facial appearance from Bell’s Palsy. Health utility score was 0.84 ± 0.01 in the control group (On prednisolone) with facial appearance score of (Derriford appearance scale 59) 61 ± 28. At week 4, the study group (on prednisolone+ acyclovir) showed 0.88 ± 0.12 score on Health utility index scale-3 and 46 ± 26 score on Derriford appearance scale. Comparison of the quality of life (Health quality index scale-3) and facial appearance among both control and study groups showed a significant improvement in the study group (P = 0.001 and P = 0.005, respectively). Moreover, when health utility score and Derriford appearance were compared among both groups, it showed a significant improvement in the study group (P = 0.001 and 0.016, respectively). Conclusions: The combination of prednisolone with acyclovir is found superior to prednisolone alone, and this combination treatment results in improvement in both recovery and quality of life.

scholarly journals Effect of Acupuncture on Functional Connectivity of Anterior Cingulate Cortex for Bell’s Palsy Patients with Different Clinical Duration

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Hongli Wu ◽  
Hongxing Kan ◽  
Chuanfu Li ◽  
Kyungmo Park ◽  
Yifang Zhu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Physiological Mechanism ◽  
Bell’S Palsy ◽  
Anterior Cingulate ◽  
Control Group ◽  
Bell's Palsy ◽  
Brain Response ◽  
Before And After ◽  
The Status ◽  
Healthy Control

Acupuncture is widely used in the treatment of Bell’s palsy (BP) in many countries, but its underlying physiological mechanism remained controversial. In order to explore the potential mechanism, changes of functional connectivity (FC) of anterior cingulate gyrus (ACC) were investigated. We collected 20 healthy (control group) participants and 28 BP patients with different clinical duration accepted resting state functional MRI (rfMRI) scans before and after acupuncture, respectively. The FC of ACC before and after acupuncture was compared with pairedt-test and the detailed results are presented in the paper. Our results showed that effects of the acupuncture on FC were closely related to clinical duration in patients with BP, which suggested that brain response to acupuncture was closely connected with the status of brain functional connectivity and implied that acupuncture plays a homeostatic role in the BP treatment.

The relationship between Bell’s palsy and morphometric aspects of the facial nerve

2011 ◽  
Vol 269 (6) ◽  
pp. 1691-1695 ◽  
Author(s):  
Yoichiro Kondo ◽  
Hiroshi Moriyama ◽  
Shuichi Hirai ◽  
Ning Qu ◽  
Masahiro Itoh
Keyword(s):  
Facial Nerve ◽  
Bell’S Palsy ◽  
Bell's Palsy ◽  
The Relationship
Sign in / Sign up

Export Citation Format

Share Document