scholarly journals Effect of Acupuncture on Functional Connectivity of Anterior Cingulate Cortex for Bell’s Palsy Patients with Different Clinical Duration

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Hongli Wu ◽  
Hongxing Kan ◽  
Chuanfu Li ◽  
Kyungmo Park ◽  
Yifang Zhu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Physiological Mechanism ◽  
Bell’S Palsy ◽  
Anterior Cingulate ◽  
Control Group ◽  
Bell's Palsy ◽  
Brain Response ◽  
Before And After ◽  
The Status ◽  
Healthy Control

Acupuncture is widely used in the treatment of Bell’s palsy (BP) in many countries, but its underlying physiological mechanism remained controversial. In order to explore the potential mechanism, changes of functional connectivity (FC) of anterior cingulate gyrus (ACC) were investigated. We collected 20 healthy (control group) participants and 28 BP patients with different clinical duration accepted resting state functional MRI (rfMRI) scans before and after acupuncture, respectively. The FC of ACC before and after acupuncture was compared with pairedt-test and the detailed results are presented in the paper. Our results showed that effects of the acupuncture on FC were closely related to clinical duration in patients with BP, which suggested that brain response to acupuncture was closely connected with the status of brain functional connectivity and implied that acupuncture plays a homeostatic role in the BP treatment.

scholarly journals Functional Connectivity Modulation by Acupuncture in Patients with Bell’s Palsy

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Yunpeng Bian ◽  
Xiaoxuan He ◽  
Sheng Hu ◽  
Chuanfu Li ◽  
Chunsheng Xu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Resting State ◽  
Bell’S Palsy ◽  
Potential Mechanism ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Bell's Palsy ◽  
Before And After

Bell’s palsy (BP), an acute unilateral facial paralysis, is frequently treated with acupuncture in many countries. However, the mechanism of treatment is not clear so far. In order to explore the potential mechanism, 22 healthy volunteers and 17 BP patients with different clinical duration were recruited. The resting-state functional magnetic resonance imaging scans were conducted before and after acupuncture at LI4 (Hegu), respectively. By comparing BP-induced functional connectivity (FC) changes with acupuncture-induced FC changes in the patients, the abnormal increased FC that could be reduced by acupuncture was selected. The FC strength of the selected FC at various stages was analyzed subsequently. Our results show that FC modulation of acupuncture is specific and consistent with the tendency of recovery. Therefore, we propose that FC modulation by acupuncture may be beneficial to recovery from the disease.

Increasing functional connectivity of the anterior cingulate cortex during the course of recovery from Bell’s palsy

Neuroreport ◽  
2015 ◽  
Vol 26 (1) ◽  
pp. 6-12 ◽  
Author(s):  
Sheng Hu ◽  
Yuanyuan Wu ◽  
Chuanfu Li ◽  
Kyungmo Park ◽  
Guangming Lu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Bell’S Palsy ◽  
Anterior Cingulate ◽  
Bell's Palsy

scholarly journals Intratympanic steroid therapy for Bell’s palsy with poor prognostic results

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Akira Inagaki ◽  
Sachiyo Katsumi ◽  
Shinji Sekiya ◽  
Shingo Murakami
Keyword(s):  
Facial Nerve ◽  
Steroid Therapy ◽  
Standard Dose ◽  
Neuroprotective Effect ◽  
Bell’S Palsy ◽  
Control Group ◽  
Average Dose ◽  
Test Results ◽  
Bell's Palsy ◽  
Intratympanic Dexamethasone

AbstractIn Bell’s palsy, electrodiagnosis by electroneurography (ENoG) is widely used to predict a patient’s prognosis. The therapeutic options for patients with poor prognostic results remain controversial. Here, we investigated whether early intervention with intratympanic steroid therapy (ITST) is an effective treatment for Bell’s palsy patients with poor electrodiagnostic test results (≤ 10% electroneurography value). Patients in the concurrent ITST group (n = 8) received the standard systemic dose of prednisolone (410 mg total) and intratympanic dexamethasone (16.5 mg total) and those in the control group (n = 21) received systemic prednisolone at the standard dose or higher (average dose, 605 ± 27 mg). A year after onset, the recovery rate was higher in the ITST group than in the control group (88% vs 43%, P = 0.044). The average House-Brackmann grade was better in the concurrent ITST group (1.13 ± 0.13 vs 1.71 ± 0.16, P = 0.035). Concurrent ITST improves the facial nerve outcome in patients with poor electroneurography test results, regardless of whether equivalent or lower glucocorticoid doses were administered. This may be ascribed to a neuroprotective effect of ITST due to a higher dose of steroid reaching the lesion due to dexamethasone transfer in the facial nerve.

scholarly journals Galectin-3 as a Novel Multifaceted and Not Only Cardiovascular Biomarker in Patients with Psoriasis with Regard to Systemic Treatment—Preliminary Data

Biology ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 88
Author(s):  
Anna Baran ◽  
Paulina Kiluk ◽  
Julia Nowowiejska ◽  
Tomasz W. Kaminski ◽  
Magdalena Maciaszek ◽  
...  
Keyword(s):  
Protective Role ◽  
Control Group ◽  
Plaque Type ◽  
Before And After ◽  
Diagnostic Role ◽  
Galectin 3 ◽  
Healthy Control ◽  
History Of ◽  
Cardiovascular Biomarker ◽  
Positive Correlations

Galectin-3 (gal-3) is a multifunctional regulator of various biological processes and diseases, which are common comorbidities in psoriasis. Data regarding potential diagnostic role of gal-3 in psoriasis are insufficient. Serum gal-3 levels were evaluated before and after twelve weeks of treatment with acitretin or methotrexate in 31 patients with plaque-type psoriasis and compared to 11 healthy control group. The mean serum galectin-3 level in patients with psoriasis was significantly higher compared to the control group (p < 0.01). In patients with obesity and long-lasting psoriasis (>20 years) positive relations of gal-3 and PASI were noted. In psoriatics with low gal-3 levels, positive correlations between the gal-3 and BMI, glucose level, and with the latter in short-lasting psoriasis (<20 years) were noted. In the long history of psoriasis, gal-3 was negatively correlated with lipids levels. The Gal-3 level might be a multifaceted modulator of the course of psoriasis and predictive factor of cardiometabolic comorbidities’ development, especially in patients with a long history of the disease or obesity. Patients with low serum gal-3 and short history of psoriasis are presumably at greater risk of diabetes. In patients with long-lasting psoriasis and concomitant obesity, gal-3 may exert a protective role against dyslipidemia or perhaps further CMD development.

scholarly journals Brain Responses to Acupuncture Are Probably Dependent on the Brain Functional Status

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Chuanfu Li ◽  
Jun Yang ◽  
Jinbo Sun ◽  
Chunsheng Xu ◽  
Yuanqiang Zhu ◽  
...  
Keyword(s):  
Functional Status ◽  
Bell’S Palsy ◽  
Healthy Adults ◽  
Bell's Palsy ◽  
Brain Response ◽  
Brain Responses ◽  
Underlying Mechanisms ◽  
Pathological Stages ◽  
The Brain ◽  
Normal Controls

In recent years, neuroimaging studies of acupuncture have explored extensive aspects of brain responses to acupuncture in finding its underlying mechanisms. Most of these studies have been performed on healthy adults. Only a few studies have been performed on patients with diseases. Brain responses to acupuncture in patients with the same disease at different pathological stages have not been explored, although it may be more important and helpful in uncovering its underlying mechanisms. In the present study, we used fMRI to compare brain responses to acupuncture in patients with Bell’s palsy at different pathological stages with normal controls and found that the brain response to acupuncture varied at different pathological stages of Bell’s palsy. The brain response to acupuncture decreased in the early stages, increased in the later stages, and nearly returned to normal in the recovered group. All of the changes in the brain response to acupuncture could be explained as resulting from the changes in the brain functional status. Therefore, we proposed that the brain response to acupuncture is dependent on the brain functional status, while further investigation is needed to provide more evidence in support of this proposition.

scholarly journals Longitudinal Changes in Functional Connectivity of the Caudate Is Associated With Recovery From Bell’s Palsy

2019 ◽  
Vol 11 ◽  
Author(s):  
Sheng Hu ◽  
Hongxing Kan ◽  
Junling Kan ◽  
Chuanfu Li ◽  
Aihong Yuan ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Bell’S Palsy ◽  
Bell's Palsy ◽  
Longitudinal Changes

scholarly journals Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients

2017 ◽  
Vol 14 ◽  
pp. 122-129 ◽  
Author(s):  
Wenwen Song ◽  
Zhijian Cao ◽  
Courtney Lang ◽  
Minhui Dai ◽  
Lihua Xuan ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Bell’S Palsy ◽  
Bell's Palsy

Outcome of Treatment with Valacyclovir and Prednisone in Patients with Bell's Palsy

2003 ◽  
Vol 112 (3) ◽  
pp. 197-201 ◽  
Author(s):  
Sara Axelsson ◽  
Sven Lindberg ◽  
Anna Stjernquist-Desatnik
Keyword(s):  
Treatment Group ◽  
Medical Treatment ◽  
Antiviral Drug ◽  
Complete Recovery ◽  
Bell’S Palsy ◽  
Adult Patients ◽  
University Hospital ◽  
Control Group ◽  
Type I ◽  
Bell's Palsy

Idiopathic facial paralysis, or Bell's palsy, shows a nonepidemic pattern that might indicate reactivation of a latent microorganism such as herpes simplex type I as a causative agent. Thirty percent of patients with Bell's palsy given no treatment will not recover completely, and 5% will have severe sequelae. The aim of this study was to find out whether treatment with an antiviral drug in combination with corticosteroids is more effective than no medical treatment at all in patients with Bell's palsy. Fifty-six consecutive adult patients attending the otorhinolaryngology department of the University Hospital of Lund from 1997 to 1999 were treated with 1 g of valacyclovir hydrochloride 3 times per day for 7 days and 50 mg of prednisone daily for 5 days, with the dose being reduced by 10 mg daily for the next 5 days. Fifty-six adult patients with Bell's palsy attending the same department between 1995 and 1996 who were given no medical treatment were studied retrospectively and used as the control group. Forty-nine patients (87.5%) in the treatment group recovered completely, as compared with 38 patients (68%) in the control group (p <.05). One patient (1.8%) in the treatment group displayed severe sequelae, defined as a House-Brackmann score of IV or worse, as compared with 10 of 56 patients (18%) in the control group (p <.01). Among patients over 60 years old, 10 of 10 in the treatment group had complete recovery, as compared with 5 of 12 patients in the control group (p <.01). The present study showed a significantly better outcome in patients with Bell's palsy treated with valacyclovir and prednisone as compared with patients given no medical treatment. This difference in outcome was especially pronounced among elderly patients.

scholarly journals Intestinal Permeability before and after Ibuprofen in Families of Children with Crohn’s Disease

1999 ◽  
Vol 13 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Samuel A Zamora ◽  
Robert J Hilsden ◽  
Jon B Meddings ◽  
J Decker Butzner ◽  
R Brent Scott ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Acetylsalicylic Acid ◽  
Intestinal Permeability ◽  
Control Group ◽  
Reference Limit ◽  
First Degree Relatives ◽  
Before And After ◽  
Healthy Control ◽  
Upper Reference Limit

BACKGROUND: Members of a subset of first-degree relatives of adults with Crohn’s disease have been shown to have an increased baseline intestinal permeability and/or an exaggerated increase in intestinal permeability after the administration of acetylsalicylic acid.PURPOSE: To determine intestinal permeability in unaffected first-degree relatives of children with Crohn’s disease before and after the administration of an ibuprofen challenge.METHODS: Lactulose-mannitol ratios, a measure of intestinal permeability, were determined in 14 healthy control families (41 subjects) and 14 families with a child with Crohn’s disease (36 relatives, 14 probands) before and after ingestion of ibuprofen. An upper reference limit was defined using the control group as mean ± 2 SD.RESULTS: The proportion of healthy, first-degree relatives with an exaggerated response to ibuprofen (20%, 95% CI 7% to 33%) was significantly higher than controls (P=0.003). The exaggerated response was more common among siblings than among parents of pediatric probands.CONCLUSIONS: Members of a subset of first-degree relatives of children with Crohn’s disease have an exaggerated increase in intestinal permeability after ibuprofen ingestion. These findings are compatible with there being a genetic link between abnormalities of intestinal permeability and Crohn’s disease.

scholarly journals The intervention of maternal nutrition literacy has the potential to prevent childhood stunting: Randomized control trials

2021 ◽  
Vol 10 (2) ◽  
Author(s):  
Sirajuddin Sirajuddin ◽  
Saifuddin Sirajuddin ◽  
Amran Razak ◽  
Ansariadi Ansariadi ◽  
Ridwan M Thaha ◽  
...  
Keyword(s):  
Maternal Nutrition ◽  
Stress Test ◽  
Intervention Group ◽  
Control Group ◽  
Normal Children ◽  
Before And After ◽  
The Status ◽  
Randomized Control ◽  
Families With Children ◽  
The Impact

Background: Stunting is the impaired growth and development of children due to poor nutrition, repeated infection, and inadequate psychological stimulation. This research aims to examine the impact of maternal nutrition literacy (MNL) in increasing the height or score of a stunted child.Design and Methods: This study is a randomized control trial, which uses a sample size of 85 participants, 43 interventions and 42 controls, an 80% stress test and a 95% confidence level. The intervention group of the MNL consists of families with children under the age of five, focused on the mother's ability to perform breastfeeding, hygiene activities, care, and intervention for 3 months.Result: The status of stunting was determined by the different distribution of stunting before and after the intervention in both the intervention and control groups. There was a decrease of about 9.3% of MNL in the intervention group, while in the control group it decreased by just 2.4% (p<0.05).Conclusions: It can be concluded that MNL has an effect in preventing stunting, and it is recommended that preventive measures should focus more on normal children, while stunted children should be provided with breastfeeding as the core of MNL.

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