scholarly journals Awareness, Knowledge, and Acceptance of Haematopoietic Stem Cell Transplantation for Sickle Cell Anaemia in Nigeria

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Adewumi Adediran ◽  
Modu Baba Kagu ◽  
Tamunomieibi Wakama ◽  
Aliyu Ahmadu Babadoko ◽  
Dapus Obadiah Damulak ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Allogeneic Bone Marrow Transplantation ◽  
Clinical Manifestations ◽  
Developed Countries ◽  
Cross Sectional Study ◽  
Haematopoietic Stem Cell ◽  
Allogeneic Bone ◽  
Cross Sectional ◽  
Knowledge And Acceptance

Background. Sickle cell anaemia (SCA) is an inherited condition whose clinical manifestations arise from the tendency of haemoglobin to polymerize and deform red blood cells into characteristic sickle shape. Allogeneic bone marrow transplantation offers a cure. The aim of this study was to determine the level of awareness, knowledge, and acceptance of this beneficial procedure in Nigeria. Materials and Methods. This multicentre cross-sectional study was conducted in 7 tertiary hospitals in Nigeria in 2015. Approval was obtained from each institution’s research and ethics committee. A pretested structured questionnaire was administered to respondents aged 18 years and above and to the parents or guardians of those below 18 years of age. Results. There were 265 respondents comprising 120 males and 145 females. One hundred and seventy-one (64.5%) respondents were aware of BMT for the treatment of SCA. About 67.8% (116 of 171) of those who were aware believed SCA can be cured with BMT (p=0.001) and 49.7% (85 of 171) of the respondents accepted BMT (p=0.001). Conclusion. Awareness of BMT in Nigeria is low when compared with reports from developed countries. The knowledge is poor and acceptance is low. With adequate information, improved education, and psychological support, more Nigerians will embrace BMT.

scholarly journals ADULT SICKLE CELL ANAEMIA PATIENTS IN BONE PAIN CRISIS HAVE ELEVATED PRO-INFLAMMATORY CYTOKINES

2018 ◽  
Vol 10 (1) ◽  
pp. e2018017 ◽  
Author(s):  
Adekunle Emmanuel Alagbe ◽  
John Ayodele Olaniyi ◽  
Oladapo Wale Aworanti
Keyword(s):  
Steady State ◽  
Sickle Cell ◽  
Plasma Levels ◽  
Bone Pain ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Tnf Α ◽  
Pain Crisis ◽  
State Group

Background and Objective: Inflammatory markers that influence bone pain crisis (BPC) and other complications of sickle cell anaemia (SCA) are numerous and play various roles. This study determined the plasma levels of tumour necrosis factor (TNF) - α, interleukin - 8 (IL-8), and endothelin - 1 (ET-1) in adult SCA patients during BPC and in steady state. In addition, the plasma levels of these cytokines were correlated with the severity of BPC of the patients.Methods and Materials: Sixty adult SCA patients (30 during BPC and 30 during steady state) and 30 haemoglobin A controls were enrolled for this cross-sectional study. The severity of BPC was assessed clinically, and questionnaires were filled. Plasma levels of TNF- α, IL-8 and ET-1 were quantified by ELISA, and haematological parameters were determined using a 5-part auto-analyzer. Plasma levels were correlated with the severity of bone pain crisis. Results were considered statistically significant if p<0.05.Results: Plasma TNF-α, IL-8, and ET-1 were significantly elevated in the BPC group than in the steady state group and the controls. Plasma TNF-α, IL-8 and ET-1 were markedly higher in the severe BPC groups than the steady state and control groups, There was a positive correlation between TNF-α and ET-1 in the bone pain crisis group.Conclusion: Elevated levels of plasma TNF-α, IL-8, and ET-1 further establish the chronic inflammatory state in SCA and equally affirm their significant contribution, not only to pathogenesis but also to the severity of pain in SCA. Keywords: Sickle cell anaemia, Cytokines, Bone pain crisis, Severity, Steady state.

scholarly journals Arterial Blood Pressure in Children with Sickle Cell Anaemia and Controls: A Cross Sectional Study

2020 ◽  
Vol 17 (2) ◽  
pp. 1-9
Author(s):  
Abubakar Garba Farouk ◽  
Halima Umar Ibrahim ◽  
Bello Abdullahi Ibrahim ◽  
Hassan Abdullahi Elechi ◽  
Jamila Audu Idrisa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Arterial Blood

Higher prevalence of wheezing and lower FEV1 and FVC percent predicted in adults with sickle cell anaemia: A cross-sectional study

Respirology ◽  
2016 ◽  
Vol 22 (2) ◽  
pp. 284-288 ◽  
Author(s):  
Baba M. Musa ◽  
Najibah A. Galadanci ◽  
Mark Rodeghier ◽  
Michael R. Debaun
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0158182 ◽  
Author(s):  
Céline Renoux ◽  
Marc Romana ◽  
Philippe Joly ◽  
Séverine Ferdinand ◽  
Camille Faes ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Blood Rheology ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Effect Of Age ◽  
Haemoglobin C

Clonal structure ofStaphylococcus aureuscolonizing children with sickle cell anaemia and healthy controls

2012 ◽  
Vol 141 (8) ◽  
pp. 1717-1720 ◽  
Author(s):  
F. SCHAUMBURG ◽  
B. BIALLAS ◽  
A. S. ALABI ◽  
M. P. GROBUSCH ◽  
E. N. FEUGAP ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Population Based ◽  
Cross Sectional Study ◽  
Healthy Children ◽  
Clonal Structure ◽  
Cross Sectional ◽  
Hospital Stays ◽  
Resistance Rates ◽  
Healthy Participants

SUMMARYChildren with sickle cell anaemia (SCA) might carry hospital-associated bacterial lineages due to frequent hospital stays and antibiotic treatments. In this study we comparedStaphylococcus aureusfrom SCA patients (n = 73) and healthy children (n = 143) in a cross-sectional study in Gabon.S. aureuscarriage did not differ between children with SCA (n = 34, 46·6%) and controls matched for age, residence and sex (n = 67, 46·9%). Both groups shared similarS. aureusgenotypes. This finding points towards a transmission ofS. aureusbetween both groups in the community. We conclude that resistance rates from population-based studies with healthy participants could therefore also be used to guide treatment and prophylaxis of endogenous infections in children with SCA despite a different selection pressure.

scholarly journals Association between clinical manifestations of sickle cell anaemia in children and the occurrence of dental caries: A cross-sectional study

2020 ◽  
Vol 23 (2) ◽  
Author(s):  
Anderson Santos Carvalho ◽  
Danilo Antônio Da Silva Duarte ◽  
José Leopoldo Ferreira Antunes ◽  
Maria Cristina Teixeira Cangussu ◽  
Maria Cristina Teixeira Cangussu
Keyword(s):  
Dental Caries ◽  
Sickle Cell ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
World Health ◽  
Crude Odds Ratio ◽  
Cross Sectional ◽  
Caries Epidemiology ◽  
Pain Crisis ◽  
Health Organization

Objective: The aim of this study was to determine the association between clinical manifestations of sickle cell anemia (including hospitalization and pain crisis) and dental caries in children in Bahia. Material and Methods: The study design was crosssectional, and the population included children aged from 6 to 96 months from August 2007 to July 2008 (N = 686). Interviews were performed to identify the sociodemographic profiles of the participants, and oral examinations were conducted by three examiners who were previously trained and calibrated to identify the presence of dental caries according to World Health Organization (WHO) criteria. Logistic regression analysis was performed for confirmatory analysis and estimation of confidence intervals (CIs). Results: The results showed that pain crises and hospitalizations were positively associated with caries (crude odds ratio (OR) = 2.11 and adjusted OR = 1.24; crude OR = 2.50 and adjusted OR = 1.46, respectively), but these associations were not statistically significant. Conclusion: The severity of the sickle cell condition alone was not sufficient to aggravate the prevalence of caries; thus, there are no major differences in caries prevalence between children with and without sickle cell disease.KEYWORDSSickle cell anemia; Dental caries; Epidemiology; Paediatrics.

scholarly journals ORIGINAL ARTICLE: CLINICAL PROFILE AND EPIDEMIOLOGICAL ASPECTS OF DIPHTHERIA CASES IN RUANG ISOLASI KHUSUS RSUD DR SOETOMO FROM JANUARY UNTIL DECEMBER 2015

2019 ◽  
Vol 19 (1) ◽  
pp. 29-34
Author(s):  
Andi Airina Binti A Agus ◽  
Dominicus Husada ◽  
Pudji Lestari
Keyword(s):  
Clinical Manifestations ◽  
Immunization Coverage ◽  
Developed Countries ◽  
Cross Sectional Study ◽  
Clinical Profile ◽  
Age Group ◽  
Childhood Immunization ◽  
Cross Sectional ◽  
Complications And Mortality ◽  
Age Shift

Abstract. Background Diphtheria is a vaccine-preventable disease and is eradicated mostly in developed countries. But the prevalence of diphtheria cases still remains endemic in developing countries such as Indonesia, mainly in East Java. Purpose: To study the clinical profile and epidemiological aspects of diphtheria cases admitted in Ruang Isolasi Khusus RSUD Dr. Soetomo in 2015. Method: This research is a hospital-based, cross-sectional study. The samples are all patients admitted in Ruang Isolasi Khusus RSUD Dr Soetomo with the diagnosis of diphtheria in 2015. Results: There were 23 diphtheria cases reported in Ruang Isolasi Khusus RSUD Dr. Soetomo in 2015. The most prevalent age group was 6 until 10 years old (56.52%) and the most common gender was male (57%). Most of the patients came from a non-endemic area (82.61%) and most of them are not fully vaccinated (73.91%). There are more unknowledgeable mothers (91%) about DPT immunization. The most prevalent clinical manifestations are fever, dysphagia and pseudomembrane (100%). Tonsillar diphtheria (86.96%) was the most prevalent type of diphtheria presented. There were no complications and mortality reported and the main managements used were isolation (100%), antibiotics (100%) and anti diphteria serum (82.61%). Conclusion: There is an age shift in the occurrence of diphtheria to 6 until 10 years of age. The immunization coverage especially the booster dose is still low among the patients. Less knowledge about DPT immunization contributes to low childhood immunization coverage. No complications and mortality reported.

scholarly journals Ovarian reserve in nigerian women with sickle cell anaemia: a cross- sectional study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Sunusi Rimi Garba ◽  
Christian Chigozie Makwe ◽  
Vincent Oluseye Osunkalu ◽  
Olufunto Olufela Kalejaiye ◽  
Adaiah Priscillia Soibi-Harry ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Teaching Hospital ◽  
Ovarian Reserve ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
University Teaching ◽  
Health Clinic ◽  
Sectional Study ◽  
Cross Sectional ◽  
Nigerian Women

Abstract Introduction Sickle cell disease is the most common monogenetic disorder worldwide. There have been reports of endocrine dysfunction and gonadal failure among affected individuals, especially in males. The findings on ovarian reserve and failure in women with sickle anaemia have been inconsistent. Aim and objective The aim of this study was to determine and compare the ovarian reserve of Nigerian women with and without sickle cell anaemia attending a University Teaching Hospital. Study Design This cross-sectional study was carried out at the Adult Sickle Cell Clinic and the Community Health Clinic of the Lagos University Teaching Hospital. Methodology A total of 166 participants who met the selection criteria, were recruited for the study. The study population consisted of two groups of women matched for age: 83 women with HbSS and 83 women with HbAA. The haemoglobin phenotype of each participant was determined on alkaline electrophoresis (pH 8.4) before analysis. Serum Anti-Mullerian Hormone (AMH) was determined using Enzyme-linked immunosorbent assay (ELISA) method (Calbiotech Inc. USA, Catalog no AM448T). Results The mean ± SD of serum AMH level in women with HbSS was 3.64 ± 0.65 ng/mL and was lower than that of women with HbAA 7.35 ±1.19 ng/mL (p < 0.001). Serum AMH negatively correlated with age in both study groups (HbAA and HbSS). Also, a significant negative correlation was found between serum AMH and BMI in women with HbAA. Conclusion The study showed diminished ovarian reserve in women with HbSS when compared to age-matched women with HbAA.

scholarly journals Nocturnal haemoglobin oxygen desaturation in urban and rural East African paediatric cohorts with and without sickle cell anaemia: a cross-sectional study

2015 ◽  
Vol 101 (4) ◽  
pp. 352-355 ◽  
Author(s):  
VS L'Esperance ◽  
T Ekong ◽  
SE Cox ◽  
J Makani ◽  
CR Newton ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
Sleep Apnoea ◽  
Night Time ◽  
Cross Sectional ◽  
The North ◽  
Obstructive Sleep ◽  
The Difference ◽  
Few Data

Low haemoglobin oxygen saturation (SpO2) predicts complications in children with sickle cell anaemia (SCA) in the North but there are few data from Africa, where the majority of the patients reside. We measured daytime and overnight SpO2 in children with SCA in routine follow-up clinic, and controls without symptoms of SCA, comparing rural (Kilifi, Kenya) and urban (Dar-es-Salaam, Tanzania) cohorts. Daytime SpO2 was lower in 65 Tanzanian children with SCA (TS; median 97 (IQR 94–100)%); p<0.0001) than in 113 Kenyan children with SCA (KS; 99 (98–100)%) and 20 Tanzanian controls (TC; 100 (98–100)%). Compared with 95 Kenyan children with SCA, in 54 Tanzanian children with SCA and 19 TC who returned for overnight oximetry, mean (KS 99.0 (96.7–99.8)%; TS 97.9 (95.4–99.3)%; TC 98.4 (97.5–99.1)%; p=0.01) and minimum nocturnal SpO2 (92 (86–95)%; 87 (78.5–91)%; 90 (83.5–93)% p=0.0001) were lower. The difference between children with SCA persisted after adjustment for haemoglobin (p=0.004). Urban Tanzanian children, with and without SCA, experience greater exposure to low daytime and night-time SpO2 compared with rural Kenyan children with SCA. Possible explanations include differences in the prevalence of obstructive sleep apnoea or asthma, alterations in the oxyhaemoglobin desaturation curve or cardiovascular compromise, for example, to shunting at atrial or pulmonary level secondary to increased pulmonary artery pressure. The fact that non-SCA siblings in the urban area are also affected suggests that environmental exposures, for example, air pollution, nutrition or physical exercise, may play a role. Further studies should determine aetiology and clinical relevance for the SCA phenotype in children resident in Africa.

scholarly journals Clinical and Laboratory Predictors of Elevated TRV In Sickle Cell Anaemia

2018 ◽  
pp. 29-38 ◽  
Author(s):  
Jane S. Afriyie-Mensah ◽  
Yvonne A Dei-Adomakoh ◽  
Audrey Forson ◽  
Martin Adadey ◽  
Thomas A. Ndanu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Systolic Pressure ◽  
Clinical History ◽  
Cross Sectional Study ◽  
Sub Saharan Africa ◽  
Pulmonary Artery Systolic Pressure ◽  
Resource Poor Setting ◽  
Cross Sectional

Pulmonary hypertension (PH) has become an increasingly recognized complication in sickle cell anaemia (SCA) and is a major cause of morbidity and mortality. Though the burden of SCA in sub-Saharan Africa is high, there is paucity of data on SCA-associated PH with little or no attention given to it in routine patient care. The current study therefore sought to determine the prevalence of PH and its associated risk factors among adult patients with SCA. This was a cross-sectional study involving 76 clinically stable, hydroxyurea-naive participants. We obtained socio-demographic and clinical history. Measurement of Tricuspid Regurgitant jet Velocity (TRV) was obtained via transthoracic echocardiography and lung function was assessed using spirometry and pulse oximetry. Other investigations were complete blood counts, free plasma haemoglobin, serum urea and creatinine. Twenty-five (32.9%) of study participants had elevated TRV (≥ 2.5m/s) on Doppler echocardiography, which was suggestive of raised pulmonary artery systolic pressure. There were significant associations between elevated TRV and steady-state haemoglobin (p < 0.001), blood urea level (p = 0.030), presence of chronic leg ulcers (p = 0.043) and oxygen saturation (p < 0.001) and these may be identifiable and modifiable risk factors for selective screening with echocardiography in a resource poor setting.

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