scholarly journals ADULT SICKLE CELL ANAEMIA PATIENTS IN BONE PAIN CRISIS HAVE ELEVATED PRO-INFLAMMATORY CYTOKINES

2018 ◽  
Vol 10 (1) ◽  
pp. e2018017 ◽  
Author(s):  
Adekunle Emmanuel Alagbe ◽  
John Ayodele Olaniyi ◽  
Oladapo Wale Aworanti
Keyword(s):  
Steady State ◽  
Sickle Cell ◽  
Plasma Levels ◽  
Bone Pain ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Tnf Α ◽  
Pain Crisis ◽  
State Group

Background and Objective: Inflammatory markers that influence bone pain crisis (BPC) and other complications of sickle cell anaemia (SCA) are numerous and play various roles. This study determined the plasma levels of tumour necrosis factor (TNF) - α, interleukin - 8 (IL-8), and endothelin - 1 (ET-1) in adult SCA patients during BPC and in steady state. In addition, the plasma levels of these cytokines were correlated with the severity of BPC of the patients.Methods and Materials: Sixty adult SCA patients (30 during BPC and 30 during steady state) and 30 haemoglobin A controls were enrolled for this cross-sectional study. The severity of BPC was assessed clinically, and questionnaires were filled. Plasma levels of TNF- α, IL-8 and ET-1 were quantified by ELISA, and haematological parameters were determined using a 5-part auto-analyzer. Plasma levels were correlated with the severity of bone pain crisis. Results were considered statistically significant if p<0.05.Results: Plasma TNF-α, IL-8, and ET-1 were significantly elevated in the BPC group than in the steady state group and the controls. Plasma TNF-α, IL-8 and ET-1 were markedly higher in the severe BPC groups than the steady state and control groups, There was a positive correlation between TNF-α and ET-1 in the bone pain crisis group.Conclusion: Elevated levels of plasma TNF-α, IL-8, and ET-1 further establish the chronic inflammatory state in SCA and equally affirm their significant contribution, not only to pathogenesis but also to the severity of pain in SCA. Keywords: Sickle cell anaemia, Cytokines, Bone pain crisis, Severity, Steady state.

scholarly journals Lung Function Abnormalities in Sickle Cell Anaemia

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Yvonne A. Dei-Adomakoh ◽  
Jane S. Afriyie-Mensah ◽  
Audrey Forson ◽  
Martin Adadey ◽  
Thomas A. Ndanu ◽  
...  
Keyword(s):  
Steady State ◽  
Lung Function ◽  
Sickle Cell ◽  
Clinical History ◽  
Cross Sectional Study ◽  
Cell Disease ◽  
Cross Sectional ◽  
Plasma Haemoglobin ◽  
Free Plasma Haemoglobin ◽  
Free Plasma

Background. Abnormalities in lung function tests have been shown to commonly occur in a majority of patients with sickle cell disease (SCD) even at steady state. The prevalence and pattern of these lung function abnormalities have been described in other populations but this is unknown among our sickle cell cohort. There is generally little information available on risk factors associated with the lung function abnormalities and its relevance in patient care. Method. This was an analytical cross-sectional study involving 76 clinically stable, hydroxyurea-naive adult Hb-SS participants and 76 nonsickle cell disease (non-SCD) controls. A structured questionnaire was used to obtain sociodemographic data and clinical history of the participants. Investigations performed included spirometry, pulse oximetry, tricuspid regurgitant jet velocity (TRV) measurements via echocardiogram, complete blood counts, free plasma haemoglobin, serum urea, and creatinine. Results. Weight, BMI, mean FVC, and FEV1% predicted values were comparatively lower among the Hb-SS patients (p < 0.001). Abnormal spirometry outcome occurred in 70.4% of Hb-SS patients, predominantly restrictive defects (p < 0.001), and showed no significant association with steady-state Hb, WBC count, free plasma haemoglobin, frequency of sickling crisis, chronic leg ulcers, and TRV measurements (p > 0.05). The mean oxygen saturation was comparatively lower among Hb-SS patients (p < 0.001). Conclusion. Measured lung volumes were significantly lower in Hb-SS patients when compared to non-SCD controls and this difference was not influenced by anthropometric variance. Lung function abnormalities, particularly restrictive defects, are prevalent in Hb-SS patients but showed no significant association with recognized markers of disease severity.

scholarly journals Arterial Blood Pressure in Children with Sickle Cell Anaemia and Controls: A Cross Sectional Study

2020 ◽  
Vol 17 (2) ◽  
pp. 1-9
Author(s):  
Abubakar Garba Farouk ◽  
Halima Umar Ibrahim ◽  
Bello Abdullahi Ibrahim ◽  
Hassan Abdullahi Elechi ◽  
Jamila Audu Idrisa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Arterial Blood

Higher prevalence of wheezing and lower FEV1 and FVC percent predicted in adults with sickle cell anaemia: A cross-sectional study

Respirology ◽  
2016 ◽  
Vol 22 (2) ◽  
pp. 284-288 ◽  
Author(s):  
Baba M. Musa ◽  
Najibah A. Galadanci ◽  
Mark Rodeghier ◽  
Michael R. Debaun
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0158182 ◽  
Author(s):  
Céline Renoux ◽  
Marc Romana ◽  
Philippe Joly ◽  
Séverine Ferdinand ◽  
Camille Faes ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Blood Rheology ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Effect Of Age ◽  
Haemoglobin C

scholarly journals A Multiyear Cross-sectional Study of Guideline Adherence for the Timeliness of Opioid Administration in Children With Sickle Cell Pain Crisis

2020 ◽  
Vol 76 (3) ◽  
pp. S6-S11
Author(s):  
David C. Brousseau ◽  
Elizabeth R. Alpern ◽  
James M. Chamberlain ◽  
Angela M. Ellison ◽  
Lalit Bajaj ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Guideline Adherence ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Opioid Administration ◽  
Pain Crisis

scholarly journals Magnitude of elevated iron stores and risk associated in steady state sickle cell anemia Congolese children: a cross sectional study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jean-Robert Makulo ◽  
Karen Efombola Itokua ◽  
Rosette Kevani Lepira ◽  
Gloire Mavinga Bundutidi ◽  
Michel Ntetani Aloni ◽  
...  
Keyword(s):  
Steady State ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Iron Stores

Clonal structure ofStaphylococcus aureuscolonizing children with sickle cell anaemia and healthy controls

2012 ◽  
Vol 141 (8) ◽  
pp. 1717-1720 ◽  
Author(s):  
F. SCHAUMBURG ◽  
B. BIALLAS ◽  
A. S. ALABI ◽  
M. P. GROBUSCH ◽  
E. N. FEUGAP ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Population Based ◽  
Cross Sectional Study ◽  
Healthy Children ◽  
Clonal Structure ◽  
Cross Sectional ◽  
Hospital Stays ◽  
Resistance Rates ◽  
Healthy Participants

SUMMARYChildren with sickle cell anaemia (SCA) might carry hospital-associated bacterial lineages due to frequent hospital stays and antibiotic treatments. In this study we comparedStaphylococcus aureusfrom SCA patients (n = 73) and healthy children (n = 143) in a cross-sectional study in Gabon.S. aureuscarriage did not differ between children with SCA (n = 34, 46·6%) and controls matched for age, residence and sex (n = 67, 46·9%). Both groups shared similarS. aureusgenotypes. This finding points towards a transmission ofS. aureusbetween both groups in the community. We conclude that resistance rates from population-based studies with healthy participants could therefore also be used to guide treatment and prophylaxis of endogenous infections in children with SCA despite a different selection pressure.

scholarly journals Association between clinical manifestations of sickle cell anaemia in children and the occurrence of dental caries: A cross-sectional study

2020 ◽  
Vol 23 (2) ◽  
Author(s):  
Anderson Santos Carvalho ◽  
Danilo Antônio Da Silva Duarte ◽  
José Leopoldo Ferreira Antunes ◽  
Maria Cristina Teixeira Cangussu ◽  
Maria Cristina Teixeira Cangussu
Keyword(s):  
Dental Caries ◽  
Sickle Cell ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
World Health ◽  
Crude Odds Ratio ◽  
Cross Sectional ◽  
Caries Epidemiology ◽  
Pain Crisis ◽  
Health Organization

Objective: The aim of this study was to determine the association between clinical manifestations of sickle cell anemia (including hospitalization and pain crisis) and dental caries in children in Bahia. Material and Methods: The study design was crosssectional, and the population included children aged from 6 to 96 months from August 2007 to July 2008 (N = 686). Interviews were performed to identify the sociodemographic profiles of the participants, and oral examinations were conducted by three examiners who were previously trained and calibrated to identify the presence of dental caries according to World Health Organization (WHO) criteria. Logistic regression analysis was performed for confirmatory analysis and estimation of confidence intervals (CIs). Results: The results showed that pain crises and hospitalizations were positively associated with caries (crude odds ratio (OR) = 2.11 and adjusted OR = 1.24; crude OR = 2.50 and adjusted OR = 1.46, respectively), but these associations were not statistically significant. Conclusion: The severity of the sickle cell condition alone was not sufficient to aggravate the prevalence of caries; thus, there are no major differences in caries prevalence between children with and without sickle cell disease.KEYWORDSSickle cell anemia; Dental caries; Epidemiology; Paediatrics.

scholarly journals Electrocardiographic Study in Adult Homozygous Sickle Cell Disease Patients in Lagos, Nigeria

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Adedoyin Dosunmu ◽  
Akinsegun Akinbami ◽  
Ebele Uche ◽  
Adewumi Adediran ◽  
Sarah John-Olabode
Keyword(s):  
Steady State ◽  
Sickle Cell ◽  
Ventricular Hypertrophy ◽  
Sickle Cell Anaemia ◽  
Left Ventricular ◽  
The Body ◽  
University Teaching ◽  
Cross Sectional ◽  
Noninvasive Test ◽  
Significant Difference

Background. This study sought to identify the pattern of electrocardiographic changes in steady state adult sickle cell anaemia.Methods.A case-control, cross-sectional study was conducted amongst sickle cell patients attending the sickle cell clinic of Lagos State University Teaching Hospital, Ikeja, and HbAA controls. All consenting participants had haemoglobin electrophoresis done and were subjected to electrocardiography (ECG). The descriptive data were given as means ± standard deviation (SD). The differences were considered to be statistically significant when thepvalue obtained was <0.05.Results.A total of ninety-three sickle cell anaemia (SCA) patients and ninety haemoglobin AA (controls) were enrolled. There was no significant difference in the age of the participants with SCA and that of the controls but the body mass index was significantly higher in controls (p=0.0001). Overall, 73.1% (68 of 93) had abnormal ECG while only 2 of 90 (2.2%) of controls had abnormal ECG. The common abnormalities observed were left ventricular hypertrophy, biventricular hypertrophy, and right ventricular hypertrophy.Conclusion.Patients with SCA in steady state tend to have normal heart rate but about 50% of them would have had ECG changes before the age of 20 years. ECG being a noninvasive test may be used to identify patients at risk for early intervention.

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