Higher prevalence of wheezing and lower FEV1 and FVC percent predicted in adults with sickle cell anaemia: A cross-sectional study

Respirology ◽  
2016 ◽  
Vol 22 (2) ◽  
pp. 284-288 ◽  
Author(s):  
Baba M. Musa ◽  
Najibah A. Galadanci ◽  
Mark Rodeghier ◽  
Michael R. Debaun
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Arterial Blood Pressure in Children with Sickle Cell Anaemia and Controls: A Cross Sectional Study

2020 ◽  
Vol 17 (2) ◽  
pp. 1-9
Author(s):  
Abubakar Garba Farouk ◽  
Halima Umar Ibrahim ◽  
Bello Abdullahi Ibrahim ◽  
Hassan Abdullahi Elechi ◽  
Jamila Audu Idrisa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Arterial Blood

scholarly journals Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0158182 ◽  
Author(s):  
Céline Renoux ◽  
Marc Romana ◽  
Philippe Joly ◽  
Séverine Ferdinand ◽  
Camille Faes ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Blood Rheology ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Effect Of Age ◽  
Haemoglobin C

scholarly journals Ovarian reserve in nigerian women with sickle cell anaemia: a cross- sectional study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Sunusi Rimi Garba ◽  
Christian Chigozie Makwe ◽  
Vincent Oluseye Osunkalu ◽  
Olufunto Olufela Kalejaiye ◽  
Adaiah Priscillia Soibi-Harry ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Teaching Hospital ◽  
Ovarian Reserve ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
University Teaching ◽  
Health Clinic ◽  
Sectional Study ◽  
Cross Sectional ◽  
Nigerian Women

Abstract Introduction Sickle cell disease is the most common monogenetic disorder worldwide. There have been reports of endocrine dysfunction and gonadal failure among affected individuals, especially in males. The findings on ovarian reserve and failure in women with sickle anaemia have been inconsistent. Aim and objective The aim of this study was to determine and compare the ovarian reserve of Nigerian women with and without sickle cell anaemia attending a University Teaching Hospital. Study Design This cross-sectional study was carried out at the Adult Sickle Cell Clinic and the Community Health Clinic of the Lagos University Teaching Hospital. Methodology A total of 166 participants who met the selection criteria, were recruited for the study. The study population consisted of two groups of women matched for age: 83 women with HbSS and 83 women with HbAA. The haemoglobin phenotype of each participant was determined on alkaline electrophoresis (pH 8.4) before analysis. Serum Anti-Mullerian Hormone (AMH) was determined using Enzyme-linked immunosorbent assay (ELISA) method (Calbiotech Inc. USA, Catalog no AM448T). Results The mean ± SD of serum AMH level in women with HbSS was 3.64 ± 0.65 ng/mL and was lower than that of women with HbAA 7.35 ±1.19 ng/mL (p < 0.001). Serum AMH negatively correlated with age in both study groups (HbAA and HbSS). Also, a significant negative correlation was found between serum AMH and BMI in women with HbAA. Conclusion The study showed diminished ovarian reserve in women with HbSS when compared to age-matched women with HbAA.

scholarly journals Ovarian Reserve in Nigerian Women with Sickle Cell Anaemia: A Cross-Sectional Study.

2021 ◽  
Author(s):  
Sunusi-Rimi Rimi Garba ◽  
Christian Chigozie Makwe ◽  
Vincent Oluseye Osunkalu ◽  
Olufunto Olufela Kalejaiye ◽  
Adaiah Priscillia Soibi-Harry ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Teaching Hospital ◽  
Ovarian Reserve ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
University Teaching ◽  
Health Clinic ◽  
Sectional Study ◽  
Cross Sectional ◽  
Nigerian Women

Abstract Introduction: Sickle cell disease is the most common monogenetic disorder worldwide. There have been reports of endocrine dysfunction and gonadal failure among affected individuals, especially in males. The findings on ovarian reserve and failure in women with sickle anaemia has been inconsistent.Aim and objective: The aim of this study was to determine and compare the ovarian reserve of Nigerian women with and without sickle cell anaemia attending a University Teaching Hospital.Study Design: This cross-sectional study was carried out at the Adult Sickle Cell Clinic and the Community Health Clinic of the Lagos University Teaching Hospital.Methodology: A total of 166 participants who met the selection criteria, were recruited for the study. The study population consisted of two groups of women matched for age; 83 women with HbSS and 83 women with HbAA. The haemoglobin phenotypes of each participant were determined on alkaline electrophoresis (pH 8.4) before analysis. serum Anti-Mullerian Hormone (AMH) were determined using Enzyme-linked immunosorbent assay (ELISA) method (Calbiotech Inc. USA, Catalog no AM448T).Results: The mean ± SD serum Anti-Mullerian Hormone (AMH) level in women with HbSS 3.64 ± 0.65 ng/mL was lower than that of women with HbAA 7.35 ±1.19 ng/mL (p < 0.001). Serum AMH negatively correlated with age in both study groups (HbAA and HbSS). Also, a significant negative correlation was found between serum AMH and BMI in women with HbAA.Conclusion: The study showed diminished ovarian reserve in women with HbSS when compared to age-matched women with HbAA.

Micro-albuminuria in Ugandan children with sickle cell anaemia: a cross-sectional study

2011 ◽  
Vol 31 (2) ◽  
pp. 115-121 ◽  
Author(s):  
M Mawanda ◽  
J M Ssenkusu ◽  
A Odiit ◽  
S Kiguli ◽  
A Muyingo* ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Sexual Maturity in Adolescents Suffering from Sickle Cell Disease: A Cross-sectional Study

2021 ◽  
Author(s):  
Vijay Shah ◽  
Akash Patel ◽  
Praful Bambharoliya ◽  
Jigisha Patadia
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sexual Maturity ◽  
Tanner Stage ◽  
Cross Sectional Study ◽  
Reproductive Capacity ◽  
Sectional Study ◽  
Cell Disease ◽  
Cross Sectional ◽  
The Mean

Introduction: Sickle Cell Disease (SCD) is an inherited chronic haemolytic anaemia. The diseased person suffers from various complications such as anaemia, frequent infection, fever, hand-foot syndrome, stroke, etc. Puberty changes includes the appearance of the secondary sexual characteristics, increase in height, change in body composition and development of reproductive capacity. Aim: To study the sexual maturity and effect of multiple blood transfusions in adolescents suffering from SCD. Materials and Methods: It was a cross-sectional study conducted on 35 adolescents of age group 11 to 15 years, suffering from SCD. Study was conducted over a period of six months from March 2018 to September 2018 at Department of Paediatrics. SCD was diagnosed by Haemoglobin (Hb) electrophoresis. Weight and height were measured of all the participants. For assessing the sexual maturity, Tanners staging was used. Unpaired t-test was done for data analysis. Results: The mean age of the patients was 13.03±1.7 years. There were 25 males and 10 females. The mean age of male patients between Tanner stage 2(14.63±0.52 years) and Tanner stage 3 (14.75±0.5 years) was significantly higher than the Indian data for males (11.3 and 12.8 years, respectively). The mean age of female patients between Tanner stages 2 (13.5±2.12 years) and Tanner stage 3 (14.33±1.16 years) was higher than the Indian reference data for girls (10.2 and 11.6 years respectively). Conclusion: This study concluded that adolescents with SCD were significantly shorter in height and weight than the standard reference population. Sexual maturity is delayed in adolescents with sickle cell anaemia.

scholarly journals Asymmetric Dimethyl Arginine Level in Children with Sickle Cell Disease: A Cross Sectional Study

2021 ◽  
pp. 93-98
Author(s):  
Seham Fathy Khedr ◽  
Mohamed Hosny El Bradaey ◽  
Hala Mohamed Nagy ◽  
Mohamed Ramadan El-Shanshory ◽  
Eslam Elhawary
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cell Disease ◽  
Adma Level ◽  
Cross Sectional ◽  
Asymmetric Dimethyl Arginine ◽  
Dimethyl Arginine

Background: Sickle cell disease (SCD) consists of a group of hemoglobinopathies in which individuals inherit hemoglobin variants derived from single point mutations. Asymmetric dimethylarginine (ADMA) contributes to limiting Nitric Oxide (NO)  bioavailability in SCD. The aim of the present study was to assess the level of the Asymmetric Dimethyl Arginine in children with sickle cell. Methods: This cohort cross-sectional study was carried out on 60 children which were divided in to 3 equal groups. Group I: SCD children with sickle retinopathy. Group II: SCD children without retinopathy. Group III: healthy control children who were selected from the outpatient clinic. Results: There was a significant increase in ADMA level among participants withSCD. There was a positive significant correlation between ADMA  level and family history as well as the  incidence of hepatomegaly. There was no significant correlation between ADMA level and demographic and laboratory parameters except LDH. Conclusions: The level of ADMA is elevated in children with sickle cell anemia. High plasma ADMA level is a risk for hepatomegaly in children with sickle cell anemia.

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