scholarly journals Neoatherosclerosis after Drug-Eluting Stent Implantation: Roles and Mechanisms

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Yuanyuan Cui ◽  
Yue Liu ◽  
Fuhai Zhao ◽  
Dazhuo Shi ◽  
Keji Chen
Keyword(s):  
First Generation ◽  
Critical Role ◽  
Late Complications ◽  
Drug Eluting Stent ◽  
Late Stent Thrombosis ◽  
Fibrous Cap ◽  
Close Relationship ◽  
Drug Eluting ◽  
Improve Clinical Outcome

In-stent neoatherosclerosis (NA), characterized by a relatively thin fibrous cap and large volume of yellow-lipid accumulation after drug-eluting stents (DES) implantation, has attracted much attention owing to its close relationship with late complications, such as revascularization and late stent thrombosis (ST). Accumulating evidence has demonstrated that more than one-third of patients with first-generation DES present with NA. Even in the advent of second-generation DES, NA still occurs. It is indicated that endothelial dysfunction induced by DES plays a critical role in neoatherosclerotic development. Upregulation of reactive oxygen species (ROS) induced by DES implantation significantly affects endothelial cells healing and functioning, therefore rendering NA formation. In light of the role of ROS in suppression of endothelial healing, combining antioxidant therapies with stenting technology may facilitate reestablishing a functioning endothelium to improve clinical outcome for patients with stenting.

scholarly journals Histopathologically confirmed very late stent thrombosis associated with stent fracture after implantation of first-generation drug eluting stent

2020 ◽  
Vol 27 (2) ◽  
pp. 204-205
Author(s):  
Takao Konishi ◽  
Naohiro Funayama ◽  
Tadashi Yamamoto ◽  
Daisuke Hotta ◽  
Yuta Kobayashi ◽  
...  
Keyword(s):  
Stent Thrombosis ◽  
First Generation ◽  
Drug Eluting Stent ◽  
Stent Fracture ◽  
Late Stent Thrombosis ◽  
Very Late Stent Thrombosis ◽  
Drug Eluting

scholarly journals Extremely Late Stent Thrombosis in a First Generation Drug- Eluting Stent 10 Years After Stent Deployment: A Case Report

2021 ◽  
Vol 36 (2) ◽  
pp. 164-168
Author(s):  
Fazila Tun Nesa Malik ◽  
- Md Kalimuddin ◽  
Nazir Ahmed ◽  
Mohammad Badiuzzaman
Keyword(s):  
Case Report ◽  
Stent Thrombosis ◽  
First Generation ◽  
Case Reports ◽  
Drug Eluting Stent ◽  
Late Stent Thrombosis ◽  
Stent Deployment ◽  
St Segment Elevation ◽  
First Case ◽  
Drug Eluting

Stent thrombosis is one of the gravest complications of percutaneous coronary intervention which usually manifest as ST-segment elevation myocardial infarction or sudden death. There are a very few case reports in the literature regarding extremely late stent thrombosis in a drug-eluting stent. Here we report a case of extremely late stent thrombosis in a first generation drug-eluting stent in a 54 year old gentleman. To the best of our knowledge, this is the first case report with the longest duration (10 years) after sirolimus eluting first-generation DES in Bangladesh. Bangladesh Heart Journal 2021; 36(2): 164-168

scholarly journals P01.01 The role of exosome miRNA between tumor cells and microglias during the progression of medulloblastoma

2019 ◽  
Vol 21 (Supplement_3) ◽  
pp. iii24-iii24
Author(s):  
Q Chang ◽  
L Zhu ◽  
N Li
Keyword(s):  
Tumor Cells ◽  
Critical Role ◽  
Expression Level ◽  
Migration And Invasion ◽  
Specific Marker ◽  
Migration Ability ◽  
Daoy Cell ◽  
Bv2 Cells ◽  
Close Relationship

Abstract BACKGROUND Medulloblastoma (MB) is the most common malignant paediatric brain tumor. Recent studies show that M2 cells were relative more abundant in Shh subtype of MBs compared with other three subtypes. It’s known that M2 cells have close relationship with many tumors’ progression. But if they play any role in the progression of Shh subtype of MB is not yet clear. Many studies demonstrate that exosomes carring miRNAs have close relationship with tumor invasion. The aim of present study is to clarify the role of exosome miRNA between tumor cells and microglias during the progression of Shh subtype of medulloblastoma. MATERIAL AND METHODS Immunofluerescence staining using iNOS and Arg1, which is M1 and M2 specific marker, respectively, was performed in four subtypes of MBs. After coculture of exosomes extracted from Shh subtype of MB cell (DAOY) with microglia cell (BV2), Q-PCR and ELISA assay were done to evaluate the polarization status of the microglia. Transwell and scratch assay were then performed to detect the migration ability of DAOY cell after treatment of exosomes from polirized M2 cells. MiRNA sequencing by Ion Proton technology was then done to analyze the miRNAs expression level between Shh subtype and other subtype of MBs. Transformation assay was used to overexpress and inhibit the expression of these miRNAs respectively to further clarify the role of exosome miRNA in the polarization of BV2 cells. RESULTS M2 cells were observed more abundant than other three subtypes of tumors, supporting that M2 cells play some role in this subtype of MBs. Exosomes of DAOY cells can induce the polarization of M2 cells. The polarized M2 cells can improved the migration and invasion ability of DAOY cell. Dozens of miRNAs were identified with different expression level between Shh subtype of MBs and other subtype of MB cells. Among them, 4 miRNAs were reported to be related with polariztion of M2 in many other lesions. Three of the 4 miRNAs can induce the polarization of M2 in present study. CONCLUSION Our study demonstrated exosome miRNA play a critical role between tumor cells and microglias during the progression of Shh subtype of medulloblastoma.

Nanofinishing of Microslots on Surgical Stainless Steel by Abrasive Flow Finishing Process: Experimentation and Modeling

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
Sachin Singh ◽  
Deepu Kumar ◽  
Mamilla Ravi Sankar ◽  
Kamlakar Rajurkar
Keyword(s):  
Surface Roughness ◽  
Stainless Steel ◽  
Critical Role ◽  
Viscoelastic Model ◽  
Three Dimensional ◽  
Drug Eluting Stent ◽  
Initial Surface ◽  
Technological Advancement ◽  
Drug Eluting ◽  
Abrasive Flow Finishing

Miniaturization of components is one of the major demands of the today's technological advancement. Microslots are one of the widely used microfeature found in various industries such as automobile, aerospace, fuel cells and medical. Surface roughness of the microslots plays critical role in high precision applications such as medical field (e.g., drug eluting stent and microfilters). In this paper, abrasive flow finishing (AFF) process is used for finishing of the microslots (width 450 μm) on surgical stainless steel workpiece that are fabricated by electrical discharge micromachining (EDμM). AFF medium is developed in-house and used for performing microslots finishing experiments. Developed medium not only helps in the removal of hard recast layer from the workpiece surfaces but also provides nano surface roughness. Parametric study of microslots finishing by AFF process is carried out with the help of central composite rotatable design (CCRD) method. The initial surface roughness on the microslots wall is in the range of 3.50 ± 0.10 μm. After AFF, the surface roughness is reduced to 192 nm with a 94.56% improvement in the surface roughness. To understand physics of the AFF process, three-dimensional (3D) finite element (FE) viscoelastic model of the AFF process is developed. Later, a surface roughness simulation model is also proposed to predict the final surface roughness after the AFF process. Simulated results are in good agreement with the experimental results.

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