Late stent thrombosis: Considerations and practical advice for the use of drug-eluting stents: A report from the Society for Cardiovascular Angiography and Interventions drug-eluting stent task force

2007 ◽  
Vol 69 (3) ◽  
pp. 327-333 ◽  
Author(s):  
John McB. Hodgson ◽  
Gregg W. Stone ◽  
A. Michael Lincoff ◽  
Lloyd Klein ◽  
Howard Walpole ◽  
...  
2017 ◽  
Vol 0 (Ahead of Print) ◽  
Author(s):  
Sam Lovibond ◽  
Michael Leung

We present two rare cases of very late stent thrombosis (VLST) occurring beyond ten years post initial drug eluting stent (DES) deployment


2015 ◽  
Vol 42 (5) ◽  
pp. 487-490 ◽  
Author(s):  
Kevin Liou ◽  
Nigel Jepson

Very late stent thrombosis is an infrequent yet potentially fatal complication associated with drug-eluting stents. We report the case of an 88-year-old man who sustained an ST-segment-elevation myocardial infarction 11 years after initial sirolimus-eluting stent implantation. Optical coherence tomograms of the lesion showed that the focal incomplete endothelialization of the stent struts was the likely cause; neointimal formation, neoatherosclerosis, and late stent malapposition might also have contributed. To our knowledge, this is the longest reported intervening period between stent insertion and the development of an acute coronary event secondary to very late stent thrombosis. The associated prognostic and therapeutic implications are considerable, because they illuminate the uncertainties surrounding the optimal duration of antiplatelet therapy in patients who have drug-eluting stents. Clinicians face challenges in treating these patients, particularly when competing medical demands necessitate the discontinuation of antiplatelet therapy. In addition to the patient's case, we discuss factors that can contribute to very late stent thrombosis.


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