scholarly journals Histopathologically confirmed very late stent thrombosis associated with stent fracture after implantation of first-generation drug eluting stent

2020 ◽  
Vol 27 (2) ◽  
pp. 204-205
Author(s):  
Takao Konishi ◽  
Naohiro Funayama ◽  
Tadashi Yamamoto ◽  
Daisuke Hotta ◽  
Yuta Kobayashi ◽  
...  
Keyword(s):  
Stent Thrombosis ◽  
First Generation ◽  
Drug Eluting Stent ◽  
Stent Fracture ◽  
Late Stent Thrombosis ◽  
Very Late Stent Thrombosis ◽  
Drug Eluting

Predictors for very late stent thrombosis after drug-eluting stent implantation in diabetic patients

2009 ◽  
Vol 4 (4) ◽  
pp. 485-491 ◽  
Author(s):  
Vassilis Voudris ◽  
Panagiotis Kariofillis ◽  
Sophia Thomopoulou ◽  
Sotiris Patsilinakos ◽  
Athanasios Manginas ◽  
...  
Keyword(s):  
Stent Thrombosis ◽  
Stent Implantation ◽  
Drug Eluting Stent ◽  
Diabetic Patients ◽  
Late Stent Thrombosis ◽  
Very Late Stent Thrombosis ◽  
Drug Eluting

scholarly journals Pathologic Etiologies of Late and Very Late Stent Thrombosis following First-Generation Drug-Eluting Stent Placement

Thrombosis ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Fumiyuki Otsuka ◽  
Masataka Nakano ◽  
Elena Ladich ◽  
Frank D. Kolodgie ◽  
Renu Virmani
Keyword(s):  
First Generation ◽  
Bare Metal Stents ◽  
Drug Eluting Stent ◽  
Metal Stents ◽  
Steady Increase ◽  
Stent Fracture ◽  
Fibrin Deposition ◽  
Very Late Stent Thrombosis ◽  
Bifurcation Stenting ◽  
Drug Eluting

Several randomized and observational studies have reported steady increase in cumulative incidence of late and very late ST (LST/VLST) following first-generation drug-eluting stents (DES: sirolimus-(SES) and paclitaxel-(PES)) up to 5 years. Pathologic studies have identified uncovered struts as the primary substrate responsible for LST/VLST following DES, where delayed arterial healing is associated with stent struts penetrating into the necrotic core, long/overlapping stents, and bifurcation stenting especially in flow divider region. Grade V stent fracture also induces LST/VLST and restenosis. Hypersensitivity reaction is exclusive to SES as an etiology of LST/VLST, whereas malapposition secondary to excessive fibrin deposition is associated with PES. Uncovered struts can be identified in SES and PES with duration of implant beyond 12 months, particularly in stents placed for “off-label” indications. Neoatherosclerosis is another important contributing factor for VLST in DES and bare metal stents (BMS); however, DES shows rapid and more frequent development of neoatherosclerosis than BMS. Future pathologic studies should address the long-term safety of newer generation DES including zotarolimus- and everolimus-eluting stents in terms of the improvement in reendothelialization, decreased inflammation and fibrin deposition as well as a lower incidence of stent fracture-related adverse events, and reduced neoatherosclerosis, which likely contribute to the decreased risk of LST/VLST and better patient outcomes.

scholarly journals Extremely Late Stent Thrombosis in a First Generation Drug- Eluting Stent 10 Years After Stent Deployment: A Case Report

2021 ◽  
Vol 36 (2) ◽  
pp. 164-168
Author(s):  
Fazila Tun Nesa Malik ◽  
- Md Kalimuddin ◽  
Nazir Ahmed ◽  
Mohammad Badiuzzaman
Keyword(s):  
Case Report ◽  
Stent Thrombosis ◽  
First Generation ◽  
Case Reports ◽  
Drug Eluting Stent ◽  
Late Stent Thrombosis ◽  
Stent Deployment ◽  
St Segment Elevation ◽  
First Case ◽  
Drug Eluting

Stent thrombosis is one of the gravest complications of percutaneous coronary intervention which usually manifest as ST-segment elevation myocardial infarction or sudden death. There are a very few case reports in the literature regarding extremely late stent thrombosis in a drug-eluting stent. Here we report a case of extremely late stent thrombosis in a first generation drug-eluting stent in a 54 year old gentleman. To the best of our knowledge, this is the first case report with the longest duration (10 years) after sirolimus eluting first-generation DES in Bangladesh. Bangladesh Heart Journal 2021; 36(2): 164-168

Sign in / Sign up

Export Citation Format

Share Document