scholarly journals Computed Tomography Measurement of Hepatic Steatosis: Prevalence of Hepatic Steatosis in a Canadian Population

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Malcolm M. Wells ◽  
Zhe Li ◽  
Bryan Addeman ◽  
Charles A. McKenzie ◽  
Amol Mujoomdar ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Adipose Tissue ◽  
Liver Disease ◽  
Hepatic Steatosis ◽  
Subcutaneous Adipose Tissue ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Canadian Population ◽  
Adipose Tissue Volume ◽  
Subcutaneous Adipose

Background/Aims. Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease that can progress to cirrhosis and hepatocellular carcinoma. This retrospective chart review investigated the incidence of hepatic steatosis in London, Ontario, Canada.Methods. A retrospective chart review was performed on emergency room (ER) patients undergoing nonscheduled computed tomography (CT) imaging over a six-month period in London, Ontario. CT images and reports were examined to determine presence of steatosis. Analyses of the electronic chart for a period of six months following the CT and communication with the patients’ family doctors were used to determine if there was follow-up. Waist circumference, subcutaneous fat depth, and abdominal fat volumes were calculated.Results. 48/450 patients meeting inclusion criteria were identified by radiology as having steatosis, with 34/40 (85%) family physicians unaware of the finding. 24.7% (100/405) of patients met standard CT criteria for steatosis, 40 of which were reported by the radiologist. Waist circumference, subcutaneous adipose tissue depth, subcutaneous adipose tissue volume, and visceral adipose tissue volume were significantly associated with steatosis.Conclusions. The hepatic steatosis prevalence we report is the first reported in a Canadian population. Early identification of steatosis will become more important as new pharmacologic therapies arise.

scholarly journals Are Adipose-Derived Stem Cells from Liver Falciform Ligaments Another Possible Source of Mesenchymal Stem Cells?

2017 ◽  
Vol 26 (5) ◽  
pp. 855-866 ◽  
Author(s):  
Sang Woo Lee ◽  
Jae Uk Chong ◽  
Seon Ok Min ◽  
Seon Young Bak ◽  
Kyung Sik Kim
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Liver Disease ◽  
Subcutaneous Adipose Tissue ◽  
Falciform Ligament ◽  
Pcr Analysis ◽  
Marker Genes ◽  
Adipose Derived Stem Cells ◽  
Subcutaneous Adipose

Falciform ligaments in the liver are surrounded by adipose tissue. We investigated the capability of adipose-derived stem cells from human liver falciform ligaments (hLF-ADSCs) to differentiate into hepatic-type cells and confirmed the functional capacity of the cells. Mesenchymal stem cells (MSCs) were isolated from the liver falciform ligament and abdominal subcutaneous adipose tissue in patients undergoing partial hepatectomy for liver disease. Cells were cultivated in MSC culture medium. Properties of MSCs were confirmed by flow cytometry, RT-PCR analysis, immunocytochemistry assays, and multilineage differentiation. Hepatic induction was performed using a three-step differentiation protocol with various growth factors. Morphology, capacity for expansion, and characteristics were similar between hLF-ADSCs and adipose-derived stem cells from human abdominal subcutaneous adipose tissue (hAS-ADSCs). However, hematopoietic– and mesenchymal–epithelial transition (MET)-related surface markers (CD133, CD34, CD45, and E-cadherin) had a higher expression in hLF-ADSCs. The hepatic induction marker genes had a higher expression in hLF-ADSCs on days 7 and 10 after the hepatic induction. Albumin secretion was similar between hLF-ADSCs and hAS-ADSCs at 20 days after the hepatic induction. The hLF-ADSCs had a different pattern of surface marker expression relative to hAS-ADSCs. However, proliferation, multilineage capacity, and hepatic induction were similar between the cell types. Accordingly, it may be a useful source of MSCs for patients with liver disease.

Evaluation of Hepatic Steatosis with CT and Correlation with Anthropometric Measurements

2020 ◽  
Vol 16 (4) ◽  
pp. 452-458 ◽  
Author(s):  
Onur Taydas ◽  
Ural Koc
Keyword(s):  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
Subcutaneous Adipose Tissue ◽  
Anthropometric Measurements ◽  
Liver Fat ◽  
Abdominal Circumference ◽  
Transverse Diameter ◽  
Liver Lobe ◽  
Subcutaneous Adipose ◽  
Anterior Posterior

Objective: The aim of the study was to evaluate hepatic steatosis in an asymptomatic group of patients with unenhanced abdominal computed tomography (CT) and to compare the results with anthropometric measurements. Methods: The study included 617 patients aged 18-93 years, who underwent unenhanced abdominopelvic CT between January 2016 and December 2017. Three imaging criteria were used in the assessment of hepatic steatosis on CT: mean region of interest (ROI) value of measured liver lobe (40 HU ≥), mean ROI value of measured liver lobe / measured spleen mean ROI value (1 ≥), mean ROI value of measured liver lobe - mean ROI value of spleen (10 HU≥). The liver fat was quantitatively assessed both visually and using multidetector CT grading. The anthropometric measurements used were the size of the liver and spleen, abdominal anterior-posterior diameter, abdominal transverse diameter, abdominal circumference, subcutaneous adipose tissue area, and anterior, posterior, and posterolateral subcutaneous adipose tissue thickness. Results: The prevalence of hepatic steatosis was 29.3% according to the visual evaluation, 29.8% according to the quantitative evaluation, 67.1% according to at least one criterion and 23.3% according to at least two criteria. A positive correlation was determined between hepatic steatosis and anthropometric measurements. Differences between the genders were observed in both hepatic steatosis and anthropometric measurements. Conclusion: By setting more objective criteria for evaluation, with the possibility of quantitative analysis in particular, non-contrast CT will have a more important role in assessing liver fat in the future.

scholarly journals Prognostic value of subcutaneous adipose tissue volume in hepatocellular carcinoma treated with transcatheter intra-arterial therapy

2018 ◽  
Vol Volume 10 ◽  
pp. 2231-2239 ◽  
Author(s):  
Takamasa Kobayashi ◽  
Hirokazu Kawai ◽  
Oki Nakano ◽  
Satoshi Abe ◽  
Hiroteru Kamimura ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Prognostic Value ◽  
Tissue Volume ◽  
Adipose Tissue Volume ◽  
Subcutaneous Adipose

Abstract 19405: Association of Deep and Superficial Abdominal Subcutaneous Tissue With Hepatic Fat Content

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Inge v Munckhof ◽  
Tessa Brand ◽  
Marinette v Graaf ◽  
Jacqueline d Graaf ◽  
Joost Rutten
Keyword(s):  
Adipose Tissue ◽  
Alcohol Use ◽  
Hepatic Steatosis ◽  
Subcutaneous Adipose Tissue ◽  
Large Population ◽  
Univariate Analysis ◽  
Liver Fat ◽  
Alcoholic Fatty Liver ◽  
Increased Risk ◽  
Subcutaneous Adipose

Introduction: The prevalence of non-alcoholic fatty liver disease (NAFLD) has increased dramatically during the past decades, affecting 50-75 % of the obese subjects. Visceral adipose tissue (VAT) is regarded to be an important factor in the pathogenesis of NAFLD. Subcutaneous adipose tissue (SAT) is separated by the fascia superficialis into the deep SAT (dSAT) and superficial SAT (sSAT). It has been suggested that dSAT is related to an increased risk for obesity related complications, whereas sSAT has a more favorable profile. The aim of this study was to investigate the association of superficial and deep subcutaneous adipose tissue with hepatic steatosis. Methods: We recruited a subcohort of the Nijmegen Biomedical Study, a large population based cohort, including 133 subjects, BMI > 27 kg/m 2 , aged 55-81 years. Abdominal magnetic resonance imaging was performed at level L4-L5 to measure VAT, dSAT and sSAT volumes. The amount of liver fat was quantified by MR spectroscopy. Results: Men had significantly higher volumes of VAT and lower volumes of sSAT compared with women. No differences in volumes of dSAT were observed. In univariate analysis, the VAT volume was found to be correlated with hepatic steasosis (r = 0.339; p <0.001), while no significant correlation was found between total SAT, sSAT or dSAT with hepatic steatosis. After adjustment for age, alcohol use and sex, VAT was still positively correlated with hepatic steatosis with a standardized β of 0,276 (p=0.007), and sSAT, but not total SAT or dSAT, was negatively correlated with hepatic steatosis with a standardized β of -0,363 (p=0.033). Conclusions: VAT as measured by MRI is positively correlated with hepatic steatosis, in contrast to sSAT which is negatively correlated after adjustment for age, alcohol use and sex. We found no significant correlation between total SAT or dSAT and hepatic steatosis.

scholarly journals Superficial versus Deep Subcutaneous Adipose Tissue: Sex-Specific Associations with Hepatic Steatosis and Metabolic Traits

2021 ◽  
Author(s):  
Tessa Brand ◽  
Inge Christina Lamberta van den Munckhof ◽  
Marinette van der Graaf ◽  
Kiki Schraa ◽  
Helena Maria Dekker ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Alcohol Use ◽  
Hepatic Steatosis ◽  
Subcutaneous Adipose Tissue ◽  
Abdominal Fat ◽  
Fat Content ◽  
Multivariate Model ◽  
Metabolic Traits ◽  
Hepatic Fat ◽  
Subcutaneous Adipose

Abstract Objective Subcutaneous adipose tissue (SAT) is not homogeneous, as the fascia scarpa separates the deep SAT (dSAT) from the superficial SAT (sSAT). The aim of this study was to evaluate the sex-specific associations of sSAT and dSAT with hepatic steatosis and the metabolic syndrome in overweight individuals. Methods We recruited 285 individuals with a BMI≥27 kg/m 2, aged 55-81 years. Abdominal magnetic resonance imaging was performed around level L4-L5 to measure VAT, dSAT and sSAT volumes. The amount of hepatic fat was quantified by MR spectroscopy. Results Men had significantly higher volumes of VAT (122.6 cm 3 versus 98.7 cm 3, p&lt;0.001) and had only half of the volume of sSAT compared to women adjusted for BMI (50.3 cm 3 in men versus 97.0 cm 3 in women, p&lt;0.001). dSAT correlated significantly with hepatic fat content in univariate analysis (stand. β=0.190, p&lt;0.05), while VAT correlated significantly with hepatic steatosis in a multivariate model, adjusted for age, alcohol use and other abdominal fat compartments (stand. β=0.184, p=0.037). Moreover, dSAT in men correlated negatively with HDL-c (stand. β=-0.165, p=0.038) in multivariate analyses. In women with a BMI between 30-40 kg/m 2, in a multivariate model adjusted for age, alcohol use and other abdominal fat compartments, VAT correlated positively (stand. β=-0.404, p=0.003), and sSAT negatively (stand. β=-0.300, p=0.04) with hepatic fat content. Conclusions In men, dSAT is associated with hepatic steatosis and adverse metabolic traits, such as lower HDL-cholesterol levels; while in women with obesity sSAT shows a beneficial relation with respect to hepatic fat content.

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