scholarly journals Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis

Diabetes ◽  
2010 ◽  
Vol 59 (9) ◽  
pp. 2288-2296 ◽  
Author(s):  
R. Kursawe ◽  
M. Eszlinger ◽  
D. Narayan ◽  
T. Liu ◽  
M. Bazuine ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
Subcutaneous Adipose Tissue ◽  
Obese Adolescents ◽  
Subcutaneous Adipose

scholarly journals Downregulation of ADIPOQ and PPARγ2 Gene Expression in Subcutaneous Adipose Tissue of Obese Adolescents With Hepatic Steatosis

Obesity ◽  
2010 ◽  
Vol 18 (10) ◽  
pp. 1911-1917 ◽  
Author(s):  
Romy Kursawe ◽  
Deepak Narayan ◽  
Anna M.G. Cali ◽  
Melissa Shaw ◽  
Bridget Pierpont ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Hepatic Steatosis ◽  
Subcutaneous Adipose Tissue ◽  
Obese Adolescents ◽  
Subcutaneous Adipose

Insulin resistance, systemic and regional inflammation in subcutaneous adipose tissue during weight loss in a population with obesity

2019 ◽  
Author(s):  
Frederique Van de Velde ◽  
Margriet Ouwens ◽  
Arsene-Helene Batens ◽  
Samyah Shadid ◽  
Bruno Lapauw ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Subcutaneous Adipose

Inflammation and impaired adipogenesis in hypertrophic obesity in man

2009 ◽  
Vol 297 (5) ◽  
pp. E999-E1003 ◽  
Author(s):  
Birgit Gustafson ◽  
Silvia Gogg ◽  
Shahram Hedjazifar ◽  
Lachmi Jenndahl ◽  
Ann Hammarstedt ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Molecular Mechanisms ◽  
Whole Body ◽  
Preadipocyte Differentiation ◽  
Metabolic Complications ◽  
Adipose Cell ◽  
Subcutaneous Adipose ◽  
Adipose Cell Size

Obesity is associated mainly with adipose cell enlargement in adult man (hypertrophic obesity), whereas the formation of new fat cells (hyperplastic obesity) predominates in the prepubertal age. Adipose cell size, independent of body mass index, is negatively correlated with whole body insulin sensitivity. Here, we review recent findings linking hypertrophic obesity with inflammation and a dysregulated adipose tissue, including local cellular insulin resistance with reduced IRS-1 and GLUT4 protein content. In addition, the number of preadipocytes in the abdominal subcutaneous adipose tissue capable of undergoing differentiation to adipose cells is reduced in hypertrophic obesity. This is likely to promote ectopic lipid accumulation, a well-known finding in these individuals and one that promotes insulin resistance and cardiometabolic risk. We also review recent results showing that TNFα, but not MCP-1, resistin, or IL-6, completely prevents normal adipogenesis in preadipocytes, activates Wnt signaling, and induces a macrophage-like phenotype in the preadipocytes. In fact, activated preadipocytes, rather than macrophages, may completely account for the increased release of chemokines and cytokines by the adipose tissue in obesity. Understanding the molecular mechanisms for the impaired preadipocyte differentiation in the subcutaneous adipose tissue in hypertrophic obesity is a priority since it may lead to new ways of treating obesity and its associated metabolic complications.

scholarly journals Subcutaneous adipose tissue insulin resistance is associated with visceral adiposity in postmenopausal women

Obesity ◽  
2014 ◽  
Vol 22 (6) ◽  
pp. 1458-1463 ◽  
Author(s):  
Beret A. Casey ◽  
Wendy M. Kohrt ◽  
Robert S. Schwartz ◽  
Rachael E. Van Pelt
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Postmenopausal Women ◽  
Subcutaneous Adipose Tissue ◽  
Visceral Adiposity ◽  
Subcutaneous Adipose

scholarly journals Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women

Diabetologia ◽  
2008 ◽  
Vol 51 (12) ◽  
pp. 2303-2308 ◽  
Author(s):  
T. McLaughlin ◽  
A. Deng ◽  
O. Gonzales ◽  
M. Aillaud ◽  
G. Yee ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Obese Women ◽  
Modest Increase ◽  
Subcutaneous Adipose

scholarly journals Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans: a cross-sectional study

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e038071 ◽  
Author(s):  
Pernille Falberg Rønn ◽  
Gregers Stig Andersen ◽  
Torsten Lauritzen ◽  
Dirk Lund Christensen ◽  
Mette Aadahl ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Cardiometabolic Risk ◽  
Abdominal Fat ◽  
Cardiometabolic Risk Factors ◽  
Hepatic Insulin Resistance ◽  
Cross Sectional ◽  
Subcutaneous Adipose

ObjectivesAbdominal fat has been identified as a risk marker of cardiometabolic disease independent of overall adiposity. However, it is not clear whether there are ethnic disparities in this risk. We investigated the associations of visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) with cardiometabolic risk factors in three ethnic diverse populations of Inuit, Africans and Europeans.DesignCross-sectional pooled study.SettingGreenland, Kenya and Denmark.MethodsA total of 5113 participants (2933 Inuit, 1397 Africans and 783 Europeans) from three studies in Greenland, Kenya and Denmark were included. Measurements included abdominal fat distribution assessed by ultrasound, oral glucose tolerance test, hepatic insulin resistance, blood pressure and lipids. The associations were analysed using multiple linear regressions.ResultsAcross ethnic group and gender, an increase in VAT of 1 SD was associated with higher levels of hepatic insulin resistance (ranging from 14% to 28%), triglycerides (8% to 16%) and lower high-density lipoprotein cholesterol (HDL-C, −1.0 to −0.05 mmol/L) independent of body mass index. VAT showed positive associations with most of the other cardiometabolic risk factors in Inuit and Europeans, but not in Africans. In contrast, SAT was mainly associated with the outcomes in Inuit and Africans. Of notice was that higher SAT was associated with higher HDL-C in African men (0.11 mmol/L, 95% CI: 0.03 to 0.18) and with lower HDL-C in Inuit (−0.07 mmol/L, 95% CI: -0.12 to –0.02), but not in European men (−0.02 mmol/L, 95% CI: −0.09 to 0.05). Generally weaker associations were observed for women. Furthermore, the absolute levels of several of the cardiometabolic outcomes differed between the ethnic groups.ConclusionsVAT and SAT were associated with several of the cardiometabolic risk factors beyond overall adiposity. Some of these associations were specific to ethnicity, suggesting that ethnicity plays a role in the pathway from abdominal fat to selected cardiometabolic risk factors.

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