scholarly journals Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Scott C. Kolbe ◽  
Anneke van der Walt ◽  
Helmut Butzkueven ◽  
Alexander Klistorner ◽  
Gary F. Egan ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Diffusion Tensor ◽  
Average Rate ◽  
Mean Diffusivity ◽  
Retinal Nerve Fibre Layer ◽  
Optic Radiation ◽  
Acute Optic Neuritis ◽  
Optic Radiations

Previous studies have reported diffusion tensor imaging (DTI) changes within the optic radiations of patients after optic neuritis (ON). We aimed to study optic radiation DTI changes over 12 months following acute ON and to study correlations between DTI parameters and damage to the optic nerve and primary visual cortex (V1). We measured DTI parameters [fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD)] from the optic radiations of 38 acute ON patients at presentation and 6 and 12 months after acute ON. In addition, we measured retinal nerve fibre layer thickness, visual evoked potential amplitude, optic radiation lesion load, and V1 thickness. At baseline, FA was reduced and RD and MD were increased compared to control. Over 12 months, FA reduced in patients at an average rate of −2.6% per annum (control = −0.51%;p=0.006). Change in FA, RD, and MD correlated with V1 thinning over 12 months (FA:R=0.450,p=0.006; RD:R=-0.428,p=0.009; MD:R=-0.365,p=0.029). In patients with no optic radiation lesions, AD significantly correlated with RNFL thinning at 12 months (R=0.489,p=0.039). In conclusion, DTI can detect optic radiation changes over 12 months following acute ON that correlate with optic nerve and V1 damage.

scholarly journals Optic Nerve Diffusion Tensor Imaging after Acute Optic Neuritis Predicts Axonal and Visual Outcomes

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e83825 ◽  
Author(s):  
Anneke van der Walt ◽  
Scott C. Kolbe ◽  
Yejun E. Wang ◽  
Alexander Klistorner ◽  
Neil Shuey ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Diffusion Tensor ◽  
Visual Outcomes ◽  
Acute Optic Neuritis

Magnetic resonance diffusion tensor imaging (MRDTI) of the optic nerve and optic radiations at 3T in children with neurofibromatosis type I (NF-1)

2011 ◽  
Vol 42 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Christopher G. Filippi ◽  
Aaron Bos ◽  
Joshua P. Nickerson ◽  
Michael B. Salmela ◽  
Chris J. Koski ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Optic Nerve ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Neurofibromatosis Type ◽  
Type I ◽  
Neurofibromatosis Type I ◽  
Optic Radiations

scholarly journals Diffusion tensor imaging of the optic radiations after optic neuritis

2011 ◽  
Vol 33 (9) ◽  
pp. 2047-2061 ◽  
Author(s):  
Scott Kolbe ◽  
Clare Bajraszewski ◽  
Caron Chapman ◽  
Tan Nguyen ◽  
Peter Mitchell ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Optic Neuritis ◽  
Diffusion Tensor ◽  
Optic Radiations

scholarly journals Retinal nerve fibre layer thickness correlates with brain white matter damage in multiple sclerosis: A combined optical coherence tomography and diffusion tensor imaging study

2014 ◽  
Vol 20 (14) ◽  
pp. 1904-1907 ◽  
Author(s):  
Michael Scheel ◽  
Carsten Finke ◽  
Timm Oberwahrenbrock ◽  
Alina Freing ◽  
Luisa-Maria Pech ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Corpus Callosum ◽  
Layer Thickness ◽  
Diffusion Tensor ◽  
Retinal Nerve Fibre Layer ◽  
Optic Radiation ◽  
White Matter Damage ◽  
Nerve Fibre Layer

We investigated the association of retinal nerve fibre layer thickness (RNFL) with white matter damage assessed by diffusion tensor imaging (DTI). Forty-four MS patients and 30 healthy subjects underwent optical coherence tomography. DTI was analysed with a voxel-based whole brain and region-based analysis of optic radiation, corpus callosum and further white matter. Correlations between RNFL, fractional anisotropy (FA) and other DTI-based parameters were assessed in patients and controls. RNFL correlated with optic radiation FA, but also with corpus callosum and remaining white matter FA. Our findings demonstrate that RNFL changes indicate white matter damage exceeding the visual pathway.

scholarly journals Diffusion tensor imaging of occult injury of optic radiation following optic neuritis in multiple sclerosis

2016 ◽  
Vol 12 (4) ◽  
pp. 2505-2510 ◽  
Author(s):  
Jiafeng Chen ◽  
Lijun Zhu ◽  
He Li ◽  
Ziwen Lu ◽  
Xin Chen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Diffusion Tensor Imaging ◽  
Optic Neuritis ◽  
Diffusion Tensor ◽  
Optic Radiation

Optic nerve diffusion tensor imaging in optic neuritis

NeuroImage ◽  
2006 ◽  
Vol 30 (2) ◽  
pp. 498-505 ◽  
Author(s):  
S. Anand Trip ◽  
Claudia Wheeler-Kingshott ◽  
Stephen J. Jones ◽  
Wai-Yung Li ◽  
Gareth J. Barker ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Diffusion Tensor

38. The Reproducibility of Diffusion Tensor Imaging measures in Acute Optic Neuritis in a longitudinal pilot study

2009 ◽  
Vol 16 (11) ◽  
pp. 1538
Author(s):  
Walt A Van der ◽  
SC Kolbe ◽  
M Marriott ◽  
M Paine ◽  
M Kean ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Pilot Study ◽  
Optic Neuritis ◽  
Diffusion Tensor ◽  
Acute Optic Neuritis

Wallerian and trans-synaptic degeneration contribute to optic radiation damage in multiple sclerosis: a diffusion tensor MRI study

2013 ◽  
Vol 19 (12) ◽  
pp. 1610-1617 ◽  
Author(s):  
Maria A Rocca ◽  
Sarlota Mesaros ◽  
Paolo Preziosa ◽  
Elisabetta Pagani ◽  
Tatjana Stosic-Opincal ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Diffusion Tensor ◽  
Lesion Volume ◽  
Optic Radiation ◽  
Focal Lesions ◽  
Normal Appearing White Matter ◽  
Topographical Distribution ◽  
Synaptic Degeneration

Background: Optic radiation (OR) damage occurs in multiple sclerosis (MS). Objectives: The purpose of this study was to explore the contribution of local and distant mechanisms associated with OR damage in MS. Methods: Diffusion tensor (DT) magnetic resonance imaging (MRI) tractography probability maps of the ORs were derived from 102 MS patients and 11 controls. Between-group differences of OR normal-appearing white matter (NAWM) damage and topographical distribution of OR damage were assessed using quantitative and voxel-wise analyses, considering the influence of previous optic neuritis (ON+) and T2 OR lesions (T2 OR+). Results: OR NAWM diffusivity abnormalities were more severe in ON+ patients vs patients without previous optic neuritis (ON–) and T2 OR+ vs T2 OR– patients. Damage to the anterior portions of the ORs was more severe in ON+ vs ON– patients. Compared to controls and T2 OR– patients, T2 OR+ patients experienced a more distributed pattern of DT MRI abnormalities along the ORs, with an increased axial diffusivity limited to the anterior portions of the ORs. In T2 OR+ group, ON+ vs ON– patients showed DT MRI abnormalities in the middle portion of the ORs, in correspondence with focal lesions. OR damage correlated with OR T2 lesion volume, visual dysfunction and optic nerve atrophy. Conclusions: Both trans-synaptic degeneration secondary to optic nerve damage and Wallerian degeneration due to local T2 lesions contribute to OR damage in MS.

Glaucoma severity affects diffusion tensor imaging (DTI) parameters of the optic nerve and optic radiation

2014 ◽  
Vol 83 (8) ◽  
pp. 1437-1441 ◽  
Author(s):  
S. Sidek ◽  
N. Ramli ◽  
K. Rahmat ◽  
N.M. Ramli ◽  
F. Abdulrahman ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Optic Nerve ◽  
Diffusion Tensor ◽  
Optic Radiation ◽  
Diffusion Tensor Imaging Dti

scholarly journals Changes of Radial Diffusivity and Fractional Anisotopy in the Optic Nerve and Optic Radiation of Glaucoma Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Tobias Engelhorn ◽  
Georg Michelson ◽  
Simone Waerntges ◽  
Marlen Otto ◽  
Ahmed El-Rafei ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Optic Nerve ◽  
Diffusion Tensor ◽  
Regions Of Interest ◽  
Optic Radiation ◽  
Radial Diffusivity ◽  
Optic Nerve Atrophy ◽  
Temporal Contrast ◽  
Mean Values ◽  
Diffusion Tensor Imaging Dti

Purpose of this study was to evaluate with diffusion-tensor imaging (DTI) changes of radial diffusivity (RD) and fractional anisotropy (FA) in the optic nerve (ON) and optic radiation (OR) in glaucoma and to determine whether changes in RD and FA correlate with disease severity. Therefore, glaucoma patients and controls were examined using 3T. Regions of interest were positioned on RD and FA maps, and mean values were calculated for ON and OR and correlated with optic nerve atrophy and reduced spatial-temporal contrast sensitivity (STCS) of the retina. We found, that RD in glaucoma patients was significantly higher in the ON (0.74 ± 0.21 versus 0.58 ± 0.17⋅10−3 mm2 s−1;P<0.05) and OR (0.79 ± 0.23 versus 0.62 ± 0.14⋅10−3 mm2 s−1;P<0.05) compared to controls. Aside, FA was significantly decreased (0.48 ± 0.15 versus 0.66 ± 0.12 and 0.50 ± 0.20 versus 0.66 ± 0.11;P<0.05). Hereby, correlation between changes in RD/FA and optic nerve atrophy/STCS was observed (r>0.77). In conclusion, DTI at 3 Tesla allows robust RD and FA measurements in the ON and OR. Hereby, the extent of RD increase and FA decrease in glaucoma correlate with established ophthalmological examinations.

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