scholarly journals Diffusion tensor imaging of the optic radiations after optic neuritis

2011 ◽  
Vol 33 (9) ◽  
pp. 2047-2061 ◽  
Author(s):  
Scott Kolbe ◽  
Clare Bajraszewski ◽  
Caron Chapman ◽  
Tan Nguyen ◽  
Peter Mitchell ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Optic Neuritis ◽  
Diffusion Tensor ◽  
Optic Radiations

scholarly journals Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Scott C. Kolbe ◽  
Anneke van der Walt ◽  
Helmut Butzkueven ◽  
Alexander Klistorner ◽  
Gary F. Egan ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Diffusion Tensor ◽  
Average Rate ◽  
Mean Diffusivity ◽  
Retinal Nerve Fibre Layer ◽  
Optic Radiation ◽  
Acute Optic Neuritis ◽  
Optic Radiations

Previous studies have reported diffusion tensor imaging (DTI) changes within the optic radiations of patients after optic neuritis (ON). We aimed to study optic radiation DTI changes over 12 months following acute ON and to study correlations between DTI parameters and damage to the optic nerve and primary visual cortex (V1). We measured DTI parameters [fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD)] from the optic radiations of 38 acute ON patients at presentation and 6 and 12 months after acute ON. In addition, we measured retinal nerve fibre layer thickness, visual evoked potential amplitude, optic radiation lesion load, and V1 thickness. At baseline, FA was reduced and RD and MD were increased compared to control. Over 12 months, FA reduced in patients at an average rate of −2.6% per annum (control = −0.51%;p=0.006). Change in FA, RD, and MD correlated with V1 thinning over 12 months (FA:R=0.450,p=0.006; RD:R=-0.428,p=0.009; MD:R=-0.365,p=0.029). In patients with no optic radiation lesions, AD significantly correlated with RNFL thinning at 12 months (R=0.489,p=0.039). In conclusion, DTI can detect optic radiation changes over 12 months following acute ON that correlate with optic nerve and V1 damage.

Magnetic resonance diffusion tensor imaging (MRDTI) of the optic nerve and optic radiations at 3T in children with neurofibromatosis type I (NF-1)

2011 ◽  
Vol 42 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Christopher G. Filippi ◽  
Aaron Bos ◽  
Joshua P. Nickerson ◽  
Michael B. Salmela ◽  
Chris J. Koski ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Optic Nerve ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Neurofibromatosis Type ◽  
Type I ◽  
Neurofibromatosis Type I ◽  
Optic Radiations

Bidirectional degeneration in the visual pathway in neuromyelitis optica spectrum disorder (NMOSD)

2017 ◽  
Vol 24 (12) ◽  
pp. 1585-1593 ◽  
Author(s):  
De-Cai Tian ◽  
Lei Su ◽  
Moli Fan ◽  
Jian Yang ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Diffusion Tensor ◽  
Retinal Thickness ◽  
Three Dimensional ◽  
Visual Pathway ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Fiber Layer ◽  
Optic Radiations

Objective: This study aims to investigate whether bidirectional degeneration occurs within the visual pathway and, if so, the extent of such changes in neuromyelitis optica spectrum disorder (NMOSD). Methods: In total, 36 NMOSD and 24 healthy controls (HCs) were enrolled. Three-dimensional T1-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging were used to analyze damage to the posterior visual pathway. Damage to the anterior visual pathway was measured by optical coherence tomography. Results: In total, 24 NMOSD with prior optic neuritis (NMOON) patients showed significant reduction of peripapillary retinal nerve fiber layer, inner and outer retinal thickness, lateral geniculate nucleus volume, primary visual cortex volume, and decreased integrity of optic radiations, compared with 12 NMOSD without prior optic neuritis (NMONON) patients and 24 HCs. In NMONON, only the inner retinal thickness and the integrity of optic radiations were significantly reduced in comparison with HCs. Moreover, patients with optic neuritis showed severe bidirectional degeneration, the loss of the RNFL was greater than the atrophy of V1. Conclusion: Our study indicated the presence of trans-synaptic degeneration in NMOSD. Damage to the inner retina and optic radiations can be observed even in NMONON. After an episode of optic neuritis, the anterior visual pathway damage is greater than the posterior visual pathway damage.

scholarly journals Diffusion tensor imaging of occult injury of optic radiation following optic neuritis in multiple sclerosis

2016 ◽  
Vol 12 (4) ◽  
pp. 2505-2510 ◽  
Author(s):  
Jiafeng Chen ◽  
Lijun Zhu ◽  
He Li ◽  
Ziwen Lu ◽  
Xin Chen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Diffusion Tensor Imaging ◽  
Optic Neuritis ◽  
Diffusion Tensor ◽  
Optic Radiation

Optic nerve diffusion tensor imaging in optic neuritis

NeuroImage ◽  
2006 ◽  
Vol 30 (2) ◽  
pp. 498-505 ◽  
Author(s):  
S. Anand Trip ◽  
Claudia Wheeler-Kingshott ◽  
Stephen J. Jones ◽  
Wai-Yung Li ◽  
Gareth J. Barker ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Diffusion Tensor

38. The Reproducibility of Diffusion Tensor Imaging measures in Acute Optic Neuritis in a longitudinal pilot study

2009 ◽  
Vol 16 (11) ◽  
pp. 1538
Author(s):  
Walt A Van der ◽  
SC Kolbe ◽  
M Marriott ◽  
M Paine ◽  
M Kean ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Pilot Study ◽  
Optic Neuritis ◽  
Diffusion Tensor ◽  
Acute Optic Neuritis

Diffusion Tensor Imaging Correlates of Visual Impairment in Multiple Sclerosis and Chronic Optic Neuritis

2012 ◽  
Vol 53 (2) ◽  
pp. 825 ◽  
Author(s):  
Scott C. Kolbe ◽  
Mark Marriott ◽  
Anneke van der Walt ◽  
Joanne Fielding ◽  
Alexander Klistorner ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Diffusion Tensor Imaging ◽  
Optic Neuritis ◽  
Visual Impairment ◽  
Diffusion Tensor
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