scholarly journals Changes of Radial Diffusivity and Fractional Anisotopy in the Optic Nerve and Optic Radiation of Glaucoma Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Tobias Engelhorn ◽  
Georg Michelson ◽  
Simone Waerntges ◽  
Marlen Otto ◽  
Ahmed El-Rafei ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Optic Nerve ◽  
Diffusion Tensor ◽  
Regions Of Interest ◽  
Optic Radiation ◽  
Radial Diffusivity ◽  
Optic Nerve Atrophy ◽  
Temporal Contrast ◽  
Mean Values ◽  
Diffusion Tensor Imaging Dti

Purpose of this study was to evaluate with diffusion-tensor imaging (DTI) changes of radial diffusivity (RD) and fractional anisotropy (FA) in the optic nerve (ON) and optic radiation (OR) in glaucoma and to determine whether changes in RD and FA correlate with disease severity. Therefore, glaucoma patients and controls were examined using 3T. Regions of interest were positioned on RD and FA maps, and mean values were calculated for ON and OR and correlated with optic nerve atrophy and reduced spatial-temporal contrast sensitivity (STCS) of the retina. We found, that RD in glaucoma patients was significantly higher in the ON (0.74 ± 0.21 versus 0.58 ± 0.17⋅10−3 mm2 s−1;P<0.05) and OR (0.79 ± 0.23 versus 0.62 ± 0.14⋅10−3 mm2 s−1;P<0.05) compared to controls. Aside, FA was significantly decreased (0.48 ± 0.15 versus 0.66 ± 0.12 and 0.50 ± 0.20 versus 0.66 ± 0.11;P<0.05). Hereby, correlation between changes in RD/FA and optic nerve atrophy/STCS was observed (r>0.77). In conclusion, DTI at 3 Tesla allows robust RD and FA measurements in the ON and OR. Hereby, the extent of RD increase and FA decrease in glaucoma correlate with established ophthalmological examinations.

Glaucoma severity affects diffusion tensor imaging (DTI) parameters of the optic nerve and optic radiation

2014 ◽  
Vol 83 (8) ◽  
pp. 1437-1441 ◽  
Author(s):  
S. Sidek ◽  
N. Ramli ◽  
K. Rahmat ◽  
N.M. Ramli ◽  
F. Abdulrahman ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Optic Nerve ◽  
Diffusion Tensor ◽  
Optic Radiation ◽  
Diffusion Tensor Imaging Dti

scholarly journals Diagnostic value of diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) in differentiation between normal and abnormally thickened endometrium: prospective study

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Mahmoud Abdel Latif ◽  
M. Salah Tantawy ◽  
Hebatullah Safwat Mosaad
Keyword(s):  
Diffusion Tensor Imaging ◽  
Statistical Difference ◽  
Diffusion Tensor ◽  
Diagnostic Value ◽  
Early Management ◽  
Mean Values ◽  
Significant Statistical Difference ◽  
Sensitivity Specificity ◽  
Histopathological Results ◽  
Diffusion Tensor Imaging Dti

Abstract Background Diffusion tensor imaging (DTI) can be beneficial to differentiate between endometrium and other uterine layers. It is believed that it can be used to differentiate between normal and abnormally thickened endometrium. The purpose of this study was to find out the diagnostic value of DTI as an extension of DWI in characterization of abnormally thickened endometrium and differentiate it from normal. Results This study included 68 females, results of 3 of them were excluded (unable to complete the study), so the final number was 65 females subdivided into 2 groups; (A) control: 24 (13 premenopausal and 11 asymptomatic postmenopausal), (B) pathological thickened endometrium: 41 (11 premenopausal and 30 postmenopausal): benign (21 patients) and malignant (20 patients). The collected data was correlated to the histopathological results (as the gold standard) in cases of endometrial pathologies. The mean DW-ADC values for normal, benign, and malignant patients were 1.43 ± 0.13, 1.56 ± 0.17, and 0.86 ± 0.16 respectively and with significant statistical difference between normal and benign endometrial lesions (P value = 0.006), and between normal and malignant endometrial lesions, and between benign and malignant endometrial lesions (P value ˂ 0.001). The DTI-FA mean values for normal, benign, and malignant patients were 0.349 ± 0.08, 0.29 ± 0.09, and 0.299 ± 0.08 respectively and with significant statistical difference between normal and benign endometrial lesions (P value = 0.02), but there is no significant statistical difference regarding DTI-FA values between normal and malignant endometrial lesions or between benign and malignant endometrial lesions (P value ˃ 0.05). Also, there is a significant statistical difference regarding DTI-MD mean values between normal (1.59 ± 0.06) and benign (1.37 ± 0.09), normal and malignant (0.71 ± 0.25), and between benign and malignant endometrial lesions (P value ˂ 0.001). The DT-MD had a higher sensitivity, specificity, and accuracy than both DW-ADC and DT-FA in differentiating normal, benign, and malignant endometrial pathologies. Conclusion DTI (added to DWI) is a valuable non-invasive tool that can increase the accuracy in differentiating normal, benign, and malignant endometrial conditions, helping early management, and decrease the possibility of misdiagnosis.

scholarly journals Free-water diffusion tensor imaging detects occult periependymal abnormality in the AQP4-IgG-seropositive neuromyelitis optica spectrum disorder

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Minchul Kim ◽  
Kyu Sung Choi ◽  
Ryoo Chang Hyun ◽  
Inpyeong Hwang ◽  
Tae Jin Yun ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Free Water ◽  
White Matter Injury ◽  
Radial Diffusivity ◽  
Post Hoc Analysis ◽  
Significant Difference ◽  
Dependent Variables ◽  
Post Hoc ◽  
Diffusion Tensor Imaging Dti

AbstractTo compare free-water corrected diffusion tensor imaging (DTI) measures in the normal-appearing periependymal area between AQP4-IgG-seropositive NMOSD and multiple sclerosis (MS) to investigate occult pathophysiology. This prospective study included 44 patients (mean age, 39.52 ± 11.90 years; 14 men) with AQP4-IgG-seropositive NMOSD (n = 20) and MS (n = 24) who underwent DTI between April 2014 and April 2020. Based on free-water corrected DTI measures obtained from normal-appearing periependymal voxels of (1) lateral ventricles and (2) the 3rd and 4th ventricles as dependent variables, MANCOVA was conducted to compare the two groups, using clinical variables as covariates. A significant difference was found between AQP4-IgG-seropositive NMOSD and MS in the 3rd and 4th periependymal voxels (λ = 0.462, P = 0.001). Fractional anisotropy, axial diffusivity was significantly decreased and radial diffusivity was increased in AQP4-IgG-seropositive NMOSD in post-hoc analysis, compared with MS (F = 27.616, P < 0.001, F = 7.336, P = 0.011, and F = 5.800, P = 0.022, respectively). Free-water corrected DTI measures differ in the periependymal area surrounding the diencephalon and brain stem/cerebellum between MS and NMOSD, which may suggest occult white matter injury in areas with distribution of AQP-4 in NMOSD.

scholarly journals Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Scott C. Kolbe ◽  
Anneke van der Walt ◽  
Helmut Butzkueven ◽  
Alexander Klistorner ◽  
Gary F. Egan ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Diffusion Tensor ◽  
Average Rate ◽  
Mean Diffusivity ◽  
Retinal Nerve Fibre Layer ◽  
Optic Radiation ◽  
Acute Optic Neuritis ◽  
Optic Radiations

Previous studies have reported diffusion tensor imaging (DTI) changes within the optic radiations of patients after optic neuritis (ON). We aimed to study optic radiation DTI changes over 12 months following acute ON and to study correlations between DTI parameters and damage to the optic nerve and primary visual cortex (V1). We measured DTI parameters [fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD)] from the optic radiations of 38 acute ON patients at presentation and 6 and 12 months after acute ON. In addition, we measured retinal nerve fibre layer thickness, visual evoked potential amplitude, optic radiation lesion load, and V1 thickness. At baseline, FA was reduced and RD and MD were increased compared to control. Over 12 months, FA reduced in patients at an average rate of −2.6% per annum (control = −0.51%;p=0.006). Change in FA, RD, and MD correlated with V1 thinning over 12 months (FA:R=0.450,p=0.006; RD:R=-0.428,p=0.009; MD:R=-0.365,p=0.029). In patients with no optic radiation lesions, AD significantly correlated with RNFL thinning at 12 months (R=0.489,p=0.039). In conclusion, DTI can detect optic radiation changes over 12 months following acute ON that correlate with optic nerve and V1 damage.

scholarly journals Diffusion Tensor Imaging for In Vivo Detection of Degenerated Optic Radiation

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Georg Michelson ◽  
Tobias Engelhorn ◽  
Simone Waerntges ◽  
Arnd Doerfler
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Open Angle Glaucoma ◽  
Optic Radiation ◽  
New Approach ◽  
Transneuronal Degeneration ◽  
In Vivo Detection ◽  
Magnetic Resonance Imaging Mri ◽  
Diffusion Tensor Imaging Dti

Glaucomatous optic nerve atrophy may continue to the linked optic radiation by transneuronal degeneration, as described in animal models of glaucoma. In vivo visualization of the visual pathway represents a new challenge in the field of ophthalmology. We present a new approach for illustration of the optic radiation by diffusion tensor imaging (DTI) based on magnetic resonance imaging (MRI). The DTI was established by use of a 3T high-field scanner. The case of a patient with primary open-angle glaucoma is opposed to this one of a healthy subject to demonstrate the visible rarefication of the optic radiation. The goal was to introduce the technique of the DTI also in ophthalmology and to demonstrate that it may be useful to judge glaucoma-related differences.

Intraspinal Tumors: The Value of Diffusion Tensor Imaging (DTI) and Tractography: A Preliminary Study

2018 ◽  
Author(s):  
F. Cartes-Zumelzu ◽  
S. Ingorokva ◽  
H. Kostron ◽  
G. Feuchtner ◽  
C. Kremser ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Preliminary Study ◽  
Diffusion Tensor Imaging Dti

Diffusion tensor imaging reveals microstructural differences between subtypes of trigeminal neuralgia

2020 ◽  
Vol 133 (2) ◽  
pp. 573-579 ◽  
Author(s):  
Matthew S. Willsey ◽  
Kelly L. Collins ◽  
Erin C. Conrad ◽  
Heather A. Chubb ◽  
Parag G. Patil
Keyword(s):  
Diffusion Coefficient ◽  
Diffusion Tensor Imaging ◽  
Trigeminal Neuralgia ◽  
Apparent Diffusion Coefficient ◽  
Diffusion Tensor ◽  
Statistical Significance ◽  
Region Of Interest ◽  
Pain Syndrome ◽  
Radial Diffusivity ◽  
Apparent Diffusion

OBJECTIVETrigeminal neuralgia (TN) is an uncommon idiopathic facial pain syndrome. To assist in diagnosis, treatment, and research, TN is often classified as type 1 (TN1) when pain is primarily paroxysmal and episodic or type 2 (TN2) when pain is primarily constant in character. Recently, diffusion tensor imaging (DTI) has revealed microstructural changes in the symptomatic trigeminal root and root entry zone of patients with unilateral TN. In this study, the authors explored the differences in DTI parameters between subcategories of TN, specifically TN1 and TN2, in the pontine segment of the trigeminal tract.METHODSThe authors enrolled 8 patients with unilateral TN1, 7 patients with unilateral TN2, and 23 asymptomatic controls. Patients underwent DTI with parameter measurements in a region of interest within the pontine segment of the trigeminal tract. DTI parameters were compared between groups.RESULTSIn the pontine segment, the radial diffusivity (p = 0.0049) and apparent diffusion coefficient (p = 0.023) values in TN1 patients were increased compared to the values in TN2 patients and controls. The DTI measures in TN2 were not statistically significant from those in controls. When comparing the symptomatic to asymptomatic sides in TN1 patients, radial diffusivity was increased (p = 0.025) and fractional anisotropy was decreased (p = 0.044) in the symptomatic sides. The apparent diffusion coefficient was increased, with a trend toward statistical significance (p = 0.066).CONCLUSIONSNoninvasive DTI analysis of patients with TN may lead to improved diagnosis of TN subtypes (e.g., TN1 and TN2) and improve patient selection for surgical intervention. DTI measurements may also provide insights into prognosis after intervention, as TN1 patients are known to have better surgical outcomes than TN2 patients.

scholarly journals Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines

2017 ◽  
Vol 30 (5) ◽  
pp. 454-460
Author(s):  
Dana M Middleton ◽  
Jonathan Y Li ◽  
Steven D Chen ◽  
Leonard E White ◽  
Patricia I Dickson ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Fractional Anisotropy ◽  
Imaging System ◽  
Diffusion Tensor ◽  
Brain Regions ◽  
Magnetic Resonance Imaging System ◽  
Radial Diffusivity ◽  
Mucopolysaccharidosis I ◽  
Diffusivity Measurements

Purpose We compared fractional anisotropy and radial diffusivity measurements between pediatric canines affected with mucopolysaccharidosis I and pediatric control canines. We hypothesized that lower fractional anisotropy and higher radial diffusivity values, consistent with dysmyelination, would be present in the mucopolysaccharidosis I cohort. Methods Six canine brains, three affected with mucopolysaccharidosis I and three unaffected, were euthanized at 7 weeks and imaged using a 7T small-animal magnetic resonance imaging system. Average fractional anisotropy and radial diffusivity values were calculated for four white-matter regions based on 100 regions of interest per region per specimen. A 95% confidence interval was calculated for each mean value. Results No difference was seen in fractional anisotropy or radial diffusivity values between mucopolysaccharidosis affected and unaffected brains in any region. In particular, the 95% confidence intervals for mucopolysaccharidosis affected and unaffected canines frequently overlapped for both fractional anisotropy and radial diffusivity measurements. In addition, in some brain regions a large range of fractional anisotropy and radial diffusivity values were seen within the same cohort. Conclusion The fractional anisotropy and radial diffusivity values of white matter did not differ between pediatric mucopolysaccharidosis affected canines and pediatric control canines. Possible explanations include: (a) a lack of white matter tissue differences between mucopolysaccharidosis affected and unaffected brains at early disease stages; (b) diffusion tensor imaging does not detect any existing differences; (c) inflammatory processes such as astrogliosis produce changes that offset the decreased fractional anisotropy values and increased radial diffusivity values that are expected in dysmyelination; and (d) our sample size was insufficient to detect differences. Further studies correlating diffusion tensor imaging findings to histology are warranted.

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