scholarly journals Effect of Multimodal Pore Channels on Cargo Release from Mesoporous Silica Nanoparticles

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Sushilkumar A. Jadhav ◽  
Valentina Brunella ◽  
Gloria Berlier ◽  
Elena Ugazio ◽  
Dominique Scalarone
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Nitrogen Adsorption ◽  
Average Diameter ◽  
Pore Channel ◽  
Prolonged Release ◽  
Model Drug ◽  
Adsorption Desorption

Mesoporous silica nanoparticles (MSNs) with multimodal pore channels were fully characterized by TEM, nitrogen adsorption-desorption, and DLS analyses. MSNs with average diameter of 200 nm with dual pore channel zones with pore diameters of 1.3–2.6 and 4 nm were tested for their use in drug delivery application. Important role of the multimodal pore systems present on MSNs on the quantitative release of model drug ibuprofen was investigated. The results obtained revealed that the release profile for ibuprofen clearly shows distinct zones which can be attributed to the respective porous channel zones present on the particles. The fluctuations in the concentration of ibuprofen during the prolonged release from MSNs were caused by the multimodal pore channel systems.

scholarly journals Synthesis and Testing of Functional Mesoporous Silica Nanoparticles for Removal of Cr(VI) Ions From Water

2020 ◽  
Vol 11 (2) ◽  
pp. 8599-8607
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Porous Silica ◽  
Nitrogen Adsorption ◽  
Attenuated Total Reflection ◽  
Functionalized Mesoporous Silica ◽  
Adsorption Removal ◽  
Transmission Electron ◽  
Adsorption Desorption

This work reports a reliable and reproducible synthesis and in situ functionalization protocol for the synthesis of amino-functionalized mesoporous silica nanoparticles (MSNs). The porous amino-functional (pSiO2-NH2) nanoparticles were fully characterized by high-resolution transmission electron microscopy (TEM), X-ray diffraction (XRD), Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and nitrogen adsorption-desorption (BET) analyses. The size of the particles was in the range of 80-200 nm with a specific surface area (SSA) of 721 m2 g-1, and the pore diameter was 31Å. The pSiO2-NH2 nanoparticles were tested for their efficiency in removing Cr(VI) ions from water. Almost quantitative removal of the ions was achieved by using the particles just within two hours. The adsorption efficiency of the particles was about 50 mg g-1. The synthesized porous silica particles can be repeatedly used as nano adsorbent for the adsorption removal of Cr(VI) ions from water. The nanoparticles can be potentially used for the selective capture, removal, and recovery of various other metal ions that can be complexed by amino groups.

scholarly journals Pore Characteristics and Hydrothermal Stability of Mesoporous Silica: Role of Oleic Acid

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Junhyun Choi ◽  
Yosep Han ◽  
Soyeon Park ◽  
Jayhyun Park ◽  
Hyunjung Kim
Keyword(s):  
Oleic Acid ◽  
Mesoporous Silica ◽  
Nitrogen Adsorption ◽  
Hydrothermal Stability ◽  
Pore Characteristics ◽  
Silica Surfaces ◽  
Mesopore Structure ◽  
Infrared Spectrometer ◽  
Adsorption Desorption

Silicate mesoporous materials were synthesized with nonionic surfactant and their surfaces were modified by oleic acid adsorption. Infrared spectrometer, nitrogen adsorption-desorption isotherm, scanning electron microscopy, and thermogravimetric analyses were used to investigate the structure of oleic acid modified mesoporous material. The effects of heat treatment at various temperatures on oleic acid modified materials were also studied. Oleic acids on silica surfaces were found to be bonded chemically and/or physically and be capable of enduring up to180°C. The adsorbed oleic acid improved the hydrothermal stability of mesoporous silica and assisted mesopore structure to grow more in hydrothermal treatment process by preventing the approach of water.

scholarly journals Cytostatic and Cytotoxic Effects of Hollow-Shell Mesoporous Silica Nanoparticles Containing Magnetic Iron Oxide

Nanomaterials ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2455
Author(s):  
Manuel Pérez-Garnes ◽  
Victoria Morales ◽  
Raul Sanz ◽  
Rafael A. García-Muñoz
Keyword(s):  
Iron Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Target Cells ◽  
One Pot ◽  
Hollow Shell ◽  
Magnetic Iron Oxide ◽  
Model Drug

Among the different types of nanoparticles used in biomedical applications, Fe nanoparticles and mesoporous siliceous materials have been extensively investigated because of their possible theranostic applications. Here, we present hollow-shell mesoporous silica nanoparticles that encapsulate iron oxide and that are prepared using a drug-structure-directing agent concept (DSDA), composed of the model drug tryptophan modified by carbon aliphatic hydrocarbon chains. The modified tryptophan can behave as an organic template that allows directing the hollow-shell mesoporous silica framework, as a result of its micellisation and subsequent assembly of the silica around it. The one-pot synthesis procedure facilitates the incorporation of hydrophobically stabilised iron oxide nanoparticles into the hollow internal silica cavities, with the model drug tryptophan in the shell pores, thus enabling the incorporation of different functionalities into the all-in-one nanoparticles named mesoporous silica nanoparticles containing magnetic iron oxide (Fe3O4@MSNs). Additionally, the drug loading capability and the release of tryptophan from the silica nanoparticles were examined, as well as the cytostaticity and cytotoxicity of the Fe3O4@MSNs in different colon cancer cell lines. The results indicate that Fe3O4@MSNs have great potential for drug loading and drug delivery into specific target cells, thereby overcoming the limitations associated with conventional drug formulations, which are unable to selectively reach the sites of interest.

scholarly journals Synthesis, Characterization and Textural Analysis of Functionalized Mesoporous Silica Using Sodium Silicate as Precursor and Silicone Surfactant as Template

2014 ◽  
Vol 11 (2) ◽  
pp. 419-428
Author(s):  
Baghdad Science Journal
Keyword(s):  
Mesoporous Silica ◽  
Sodium Silicate ◽  
Nitrogen Adsorption ◽  
Average Diameter ◽  
Functionalized Silica ◽  
Average Pore ◽  
Force Microscopy ◽  
Functionalized Mesoporous Silica ◽  
One Step ◽  
Adsorption Desorption

Three mesoporous silica with different functional group were prepared by one-step synthesis based on the simultaneous hydrolysis and condensation of sodium silicate with organo - silane in the presence of template surfactant polydimethylsiloxane - polyethyleneoxide (PDMS - PEO). The prepared materials were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), atomic force microscopy (AFM) and nitrogen adsorption/desorption experiments. The results indicate that the preparation of methyl and phenyl functionalized silica were successful and the mass of methyl and phenyl groups bonded to the silica structure are 15, 38 mmol per gram silica. The average diameter of the silica particles are 103.51, 167.25 , and 86.41 nm while the average pore diameter are 6.7, 16.4, and 2.7 nm for unfunctionalized, methyl, and phenyl functionalized silica respectively.

scholarly journals Role of mesoporous silica nanoparticles for the drug delivery applications

2020 ◽  
Vol 7 (10) ◽  
pp. 102002
Author(s):  
Baranya Murugan ◽  
Suresh Sagadevan ◽  
Anita Lett J ◽  
Is Fatimah ◽  
Kamrun Nahar Fatema ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Delivery Applications

On the role of the colloidal stability of mesoporous silica nanoparticles as gene delivery vectors

2011 ◽  
Vol 13 (9) ◽  
pp. 4097-4108 ◽  
Author(s):  
Virginia Cebrián ◽  
Clara Yagüe ◽  
Manuel Arruebo ◽  
Francisco M. Martín-Saavedra ◽  
Jesus Santamaría ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Colloidal Stability ◽  
Mesoporous Silica Nanoparticles ◽  
Gene Delivery Vectors

Efficient photoacoustic imaging using indocyanine green (ICG) loaded functionalized mesoporous silica nanoparticles

2019 ◽  
Vol 7 (12) ◽  
pp. 5002-5015 ◽  
Author(s):  
Zanib Chaudhary ◽  
Gul Majid Khan ◽  
Muhammad Mustafa Abeer ◽  
Naisarg Pujara ◽  
Brian Wan-Chi Tse ◽  
...  
Keyword(s):  
Surface Modification ◽  
Mesoporous Silica ◽  
Indocyanine Green ◽  
Silica Nanoparticles ◽  
Photoacoustic Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica

Herein, we demonstrate the role of surface modification of nanocarriers on their ability to load and protect sensitive payloads.

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