pH-Disintegrable Polyelectrolyte Multilayer-Coated Mesoporous Silica Nanoparticles Exhibiting Triggered Co-Release of Cisplatin and Model Drug Molecules

2011 ◽  
Vol 32 (14) ◽  
pp. 1082-1089 ◽  
Author(s):  
Xuejuan Wan ◽  
Guoying Zhang ◽  
Shiyong Liu
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Polyelectrolyte Multilayer ◽  
Drug Molecules ◽  
Model Drug

Glutathione-triggered release of model drug molecules from mesoporous silica nanoparticles via a non-redox process

RSC Advances ◽  
2015 ◽  
Vol 5 (36) ◽  
pp. 28836-28839 ◽  
Author(s):  
Xiaoxi Huang ◽  
Tao Zhang ◽  
Anandarup Goswami ◽  
Feixiang Luo ◽  
Tewodros Asefa
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Redox Process ◽  
Triggered Release ◽  
Drug Molecules ◽  
Model Drug

Model drug-loaded mesoporous silica nanoparticles (MSNs) that are responsive to the pH rather than the redox changes related to glutathione (GSH) are prepared using surfactant-free MSNs as a precursor.

Ultra-small mesoporous silica nanoparticles as efficient carriers for pH responsive releases of anti-cancer drugs

2015 ◽  
Vol 44 (46) ◽  
pp. 20186-20192 ◽  
Author(s):  
Haoquan Zheng ◽  
Cheuk-Wai Tai ◽  
Jie Su ◽  
Xiaodong Zou ◽  
Feifei Gao
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Electrostatic Interactions ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Responsive ◽  
Drug Molecule ◽  
Drug Molecules ◽  
Anti Cancer

A pH-responsive drug delivery system via mesoporous silica nanoparticles as carriers can be achieved based on electrostatic interactions between drug molecules and carriers, when the isoelectric point of the drug molecule is high.

scholarly journals Cytostatic and Cytotoxic Effects of Hollow-Shell Mesoporous Silica Nanoparticles Containing Magnetic Iron Oxide

Nanomaterials ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2455
Author(s):  
Manuel Pérez-Garnes ◽  
Victoria Morales ◽  
Raul Sanz ◽  
Rafael A. García-Muñoz
Keyword(s):  
Iron Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Target Cells ◽  
One Pot ◽  
Hollow Shell ◽  
Magnetic Iron Oxide ◽  
Model Drug

Among the different types of nanoparticles used in biomedical applications, Fe nanoparticles and mesoporous siliceous materials have been extensively investigated because of their possible theranostic applications. Here, we present hollow-shell mesoporous silica nanoparticles that encapsulate iron oxide and that are prepared using a drug-structure-directing agent concept (DSDA), composed of the model drug tryptophan modified by carbon aliphatic hydrocarbon chains. The modified tryptophan can behave as an organic template that allows directing the hollow-shell mesoporous silica framework, as a result of its micellisation and subsequent assembly of the silica around it. The one-pot synthesis procedure facilitates the incorporation of hydrophobically stabilised iron oxide nanoparticles into the hollow internal silica cavities, with the model drug tryptophan in the shell pores, thus enabling the incorporation of different functionalities into the all-in-one nanoparticles named mesoporous silica nanoparticles containing magnetic iron oxide (Fe3O4@MSNs). Additionally, the drug loading capability and the release of tryptophan from the silica nanoparticles were examined, as well as the cytostaticity and cytotoxicity of the Fe3O4@MSNs in different colon cancer cell lines. The results indicate that Fe3O4@MSNs have great potential for drug loading and drug delivery into specific target cells, thereby overcoming the limitations associated with conventional drug formulations, which are unable to selectively reach the sites of interest.

scholarly journals Effect of Multimodal Pore Channels on Cargo Release from Mesoporous Silica Nanoparticles

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Sushilkumar A. Jadhav ◽  
Valentina Brunella ◽  
Gloria Berlier ◽  
Elena Ugazio ◽  
Dominique Scalarone
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Nitrogen Adsorption ◽  
Average Diameter ◽  
Pore Channel ◽  
Prolonged Release ◽  
Model Drug ◽  
Adsorption Desorption

Mesoporous silica nanoparticles (MSNs) with multimodal pore channels were fully characterized by TEM, nitrogen adsorption-desorption, and DLS analyses. MSNs with average diameter of 200 nm with dual pore channel zones with pore diameters of 1.3–2.6 and 4 nm were tested for their use in drug delivery application. Important role of the multimodal pore systems present on MSNs on the quantitative release of model drug ibuprofen was investigated. The results obtained revealed that the release profile for ibuprofen clearly shows distinct zones which can be attributed to the respective porous channel zones present on the particles. The fluctuations in the concentration of ibuprofen during the prolonged release from MSNs were caused by the multimodal pore channel systems.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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