scholarly journals Liver cancer cells: targeting and prolonged-release drug carriers consisting of mesoporous silica nanoparticles and alginate microspheres

2014 ◽  
pp. 2767 ◽  
Author(s):  
Kevin Wu ◽  
Yu-Te Liao ◽  
Chia-Hung Liu ◽  
Jiashing Yu
Keyword(s):  
Liver Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carriers ◽  
Prolonged Release ◽  
Liver Cancer Cells ◽  
Release Drug

Controlled Tyrosine Kinase Inhibitor Delivery to Liver Cancer Cells by Gate-Capped Mesoporous Silica Nanoparticles

2019 ◽  
Vol 3 (1) ◽  
pp. 239-251
Author(s):  
Mahsa Sedighi ◽  
Fereshteh Rahimi ◽  
Mohammad-Ali Shahbazi ◽  
Ali Hossein Rezayan ◽  
Helene Kettiger ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Mesoporous Silica ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Kinase Inhibitor ◽  
Mesoporous Silica Nanoparticles ◽  
Liver Cancer Cells

Anti-CD155 and anti-CD112 monoclonal antibodies conjugated to a fluorescent mesoporous silica nanosensor encapsulating rhodamine 6G and fluorescein for sensitive detection of liver cancer cells

The Analyst ◽  
2016 ◽  
Vol 141 (16) ◽  
pp. 4933-4940 ◽  
Author(s):  
Liang Tao ◽  
Chaojun Song ◽  
Chenyang Huo ◽  
Yuanjie Sun ◽  
Chunmei Zhang ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Liver Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Rhodamine 6G ◽  
Mesoporous Silica Nanoparticles ◽  
Sensitive Detection ◽  
Liver Cancer Cells

Sensitive detection of liver cancer cells using anti-CD155 and anti-CD112 monoclonal antibodies conjugated to ultrabright fluorescent mesoporous silica nanoparticles (FMSNs) encapsulating Rhodamine 6G and fluorescein was developed.

scholarly journals Targeting laryngeal cancer cells with 5-fluorouracil and curcumin using mesoporous silica nanoparticles

2020 ◽  
Vol 19 ◽  
pp. 153303382096211
Author(s):  
Ding Wang ◽  
Dan Yu ◽  
Xueshibojie Liu ◽  
Qian Wang ◽  
Xuyang Chen ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Mesoporous Silica ◽  
Cell Cycle Arrest ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Laryngeal Cancer ◽  
Synergistic Effects ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carriers ◽  
Cycle Arrest

Objective: To explore the inhibitory and synergistic effects of 5-fluorouracil and curcumin on Hep-2 laryngeal cancer cells and clarify the effect of mesoporous silica nanoparticles as drug carriers. Methods: The inhibitory effects of 5-fluorouracil and curcumin on Hep-2 cells were detected using the CCK-8 assay. CompuSyn was used to calculate the synergistic effect of the 2 drugs. Flow cytometry was used to detect apoptosis and cell cycle arrest induced by 5-fluorouracil and curcumin. The drugs were loaded into mesoporous nanoparticles. Western blotting was used to detect the expression of related proteins after treatment. The growth of subcutaneous tumors in BALB/c nude after the intraperitoneal injection with drug-loaded mesoporous silica nanoparticles was recorded. Results: 5-Fluorouracil and curcumin synergistically induced apoptosis and cell cycle arrest in Hep-2 cells. Mesoporous silica nanoparticles as drug carriers enhanced the therapeutic effects of 5-fluorouracil and curcumin. Conclusions: Mesoporous silica nanoparticles are expected to be effective drug carriers that enhance the synergistic effects of 5-fluorouracil and curcumin on laryngeal cancer.

Exploiting mesoporous silica nanoparticles as versatile drug carriers for several routes of administration

2021 ◽  
Vol 312 ◽  
pp. 110774
Author(s):  
Rafael Miguel Sábio ◽  
Andréia Bagliotti Meneguin ◽  
Aline Martins dos Santos ◽  
Andreia Sofia Monteiro ◽  
Marlus Chorilli
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carriers ◽  
Routes Of Administration

scholarly journals Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles

2020 ◽  
Vol 21 (24) ◽  
pp. 9696
Author(s):  
Miguel Gisbert-Garzarán ◽  
Daniel Lozano ◽  
María Vallet-Regí
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
State Of The Art ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Distribution ◽  
Chemical Properties ◽  
Drug Carriers ◽  
Subcellular Organelles ◽  
Physico Chemical ◽  
Tumoral Cells

Current chemotherapy treatments lack great selectivity towards tumoral cells, which leads to nonspecific drug distribution and subsequent side effects. In this regard, the use of nanoparticles able to encapsulate and release therapeutic agents has attracted growing attention. In this sense, mesoporous silica nanoparticles (MSNs) have been widely employed as drug carriers owing to their exquisite physico-chemical properties. Because MSNs present a surface full of silanol groups, they can be easily functionalized to endow the nanoparticles with many different functionalities, including the introduction of moieties with affinity for the cell membrane or relevant compartments within the cell, thus increasing the efficacy of the treatments. This review manuscript will provide the state-of-the-art on MSNs functionalized for targeting subcellular compartments, focusing on the cytoplasm, the mitochondria, and the nucleus.

Tunable multi-responsive nano-gated mesoporous silica nanoparticles as drug carriers

2021 ◽  
pp. 112119
Author(s):  
Riyasudheen Nechikkattu ◽  
Jungwon Kong ◽  
Young-Shin Lee ◽  
Hyun-Jung Moon ◽  
Jae-Ho Bae ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carriers

scholarly journals Targeted delivery of mesoporous silica nanoparticles loaded monastrol into cancer cells: an in vitro study

2017 ◽  
Vol 7 (8) ◽  
pp. 549-555 ◽  
Author(s):  
Huzaifa Hanif ◽  
Samina Nazir ◽  
Kehkashan Mazhar ◽  
Muhammad Waseem ◽  
Shazia Bano ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
In Vitro Study ◽  
Vitro Study

Gated Mesoporous Silica Nanoparticles for the Controlled Delivery of Drugs in Cancer Cells

Langmuir ◽  
2015 ◽  
Vol 31 (12) ◽  
pp. 3753-3762 ◽  
Author(s):  
Cristina Giménez ◽  
Cristina de la Torre ◽  
Mónica Gorbe ◽  
Elena Aznar ◽  
Félix Sancenón ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Delivery
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