scholarly journals Polysaccharide-Coated Magnetic Nanoparticles for Imaging and Gene Therapy

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Saji Uthaman ◽  
Sang Joon Lee ◽  
Kondareddy Cherukula ◽  
Chong-Su Cho ◽  
In-Kyu Park
Keyword(s):  
Magnetic Nanoparticles ◽  
Biomedical Applications ◽  
Magnetic Particles ◽  
Metal Oxide Nanoparticles ◽  
Vital Role ◽  
Imaging Characteristics ◽  
Magnetic Metal ◽  
Therapeutic Properties ◽  
The Many ◽  
Imaging Properties

Today, nanotechnology plays a vital role in biomedical applications, especially for the diagnosis and treatment of various diseases. Among the many different types of fabricated nanoparticles, magnetic metal oxide nanoparticles stand out as unique and useful tools for biomedical applications, because of their imaging characteristics and therapeutic properties such as drug and gene carriers. Polymer-coated magnetic particles are currently of particular interest to investigators in the fields of nanobiomedicine and fundamental biomaterials. Theranostic magnetic nanoparticles that are encapsulated or coated with polymers not only exhibit imaging properties in response to stimuli, but also can efficiently deliver various drugs and therapeutic genes. Even though a large number of polymer-coated magnetic nanoparticles have been fabricated over the last decade, most of these have only been used for imaging purposes. The focus of this review is on polysaccharide-coated magnetic nanoparticles used for imaging and gene delivery.

scholarly journals Investigation of Magnetic Nanoparticle Motion under a Gradient Magnetic Field by an Electromagnet

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Weizhong Wei ◽  
Zhen Wang
Keyword(s):  
Magnetic Field ◽  
Finite Element ◽  
Electromagnetic Field ◽  
Magnetic Nanoparticles ◽  
Particle Motion ◽  
Biomedical Applications ◽  
Magnetic Nanoparticle ◽  
Magnetic Particles ◽  
Magnetic Force ◽  
Gradient Magnetic Field

Finite element numerical simulations were carried out in 2D geometry to calculate the magnetic force on magnetic nanoparticles under a specially fabricated electromagnet. The particle motion was modeled by a system of ordinary differential equations. The snapshots of trajectories of 4000 MNPs with and without magnetic field were analyzed and qualitatively found to be in agreement with camera visualizations of MNP movement in a container. The results of the analysis could be helpful for the design of electromagnetic field and motion analysis of magnetic particles for the delivery of magnetic materials in biomedical applications.

Functionalized magnetic nanoparticles for biomedical applications

2015 ◽  
Vol 21 (42) ◽  
pp. 6038-6054 ◽  
Author(s):  
Dragoș Gudovan ◽  
Paul Balaure ◽  
Dan Mihăiescu ◽  
Adrian Fudulu ◽  
Bogdan Purcăreanu ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Biomedical Applications ◽  
Functionalized Magnetic Nanoparticles

scholarly journals How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1510
Author(s):  
Sylwia Grabska-Zielińska ◽  
Alina Sionkowska
Keyword(s):  
Silk Fibroin ◽  
Biomedical Applications ◽  
Magnetic Particles ◽  
Chemical Properties ◽  
Ternary Mixtures ◽  
Cross Linking ◽  
Advantages And Disadvantages ◽  
Physico Chemical ◽  
Binary And Ternary Mixtures ◽  
To Receive

This review supplies a report on fresh advances in the field of silk fibroin (SF) biopolymer and its blends with biopolymers as new biomaterials. The review also includes a subsection about silk fibroin mixtures with synthetic polymers. Silk fibroin is commonly used to receive biomaterials. However, the materials based on pure polymer present low mechanical parameters, and high enzymatic degradation rate. These properties can be problematic for tissue engineering applications. An increased interest in two- and three-component mixtures and chemically cross-linked materials has been observed due to their improved physico-chemical properties. These materials can be attractive and desirable for both academic, and, industrial attention because they expose improvements in properties required in the biomedical field. The structure, forms, methods of preparation, and some physico-chemical properties of silk fibroin are discussed in this review. Detailed examples are also given from scientific reports and practical experiments. The most common biopolymers: collagen (Coll), chitosan (CTS), alginate (AL), and hyaluronic acid (HA) are discussed as components of silk fibroin-based mixtures. Examples of binary and ternary mixtures, composites with the addition of magnetic particles, hydroxyapatite or titanium dioxide are also included and given. Additionally, the advantages and disadvantages of chemical, physical, and enzymatic cross-linking were demonstrated.

scholarly journals CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

Polymers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 924
Author(s):  
Alexander B. Shcherbakov ◽  
Vladimir V. Reukov ◽  
Alexander V. Yakimansky ◽  
Elena L. Krasnopeeva ◽  
Olga S. Ivanova ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Metal Oxide Nanoparticles ◽  
Polymeric Materials ◽  
Negative Effects ◽  
New Horizons ◽  
Beneficial Effects ◽  
Advanced Composite ◽  
Unique Material ◽  
Biomedical Polymers ◽  
Biomedical Potential

The development of advanced composite biomaterials combining the versatility and biodegradability of polymers and the unique characteristics of metal oxide nanoparticles unveils new horizons in emerging biomedical applications, including tissue regeneration, drug delivery and gene therapy, theranostics and medical imaging. Nanocrystalline cerium(IV) oxide, or nanoceria, stands out from a crowd of other metal oxides as being a truly unique material, showing great potential in biomedicine due to its low systemic toxicity and numerous beneficial effects on living systems. The combination of nanoceria with new generations of biomedical polymers, such as PolyHEMA (poly(2-hydroxyethyl methacrylate)-based hydrogels, electrospun nanofibrous polycaprolactone or natural-based chitosan or cellulose, helps to expand the prospective area of applications by facilitating their bioavailability and averting potential negative effects. This review describes recent advances in biomedical polymeric material practices, highlights up-to-the-minute cerium oxide nanoparticle applications, as well as polymer-nanoceria composites, and aims to address the question: how can nanoceria enhance the biomedical potential of modern polymeric materials?

scholarly journals Biomedical Uses of Sulfobetaine-Based Zwitterionic Materials

2020 ◽  
Vol 02 (04) ◽  
pp. 342-357
Author(s):  
Francesco Zaccarian ◽  
Matthew B. Baker ◽  
Matthew J. Webber
Keyword(s):  
Biomedical Applications ◽  
Foreign Body Reaction ◽  
Inflammatory Responses ◽  
Cellular Adhesion ◽  
Review Of The Literature ◽  
Future Prospects ◽  
Protein Fouling ◽  
Biomedical Device ◽  
The Many ◽  
Hydrophilic Coatings

Protein fouling can render a biomedical device dysfunctional, and also serves to nucleate the foreign body reaction to an implanted material. Hydrophilic coatings have emerged as a commonly applied route to combat interface-mediated complications and promote device longevity and limited inflammatory response. While polyethylene glycol has received a majority of the attention in this regard, coatings based on zwitterionic moieties have been more recently explored. Sulfobetaines in particular constitute one such class of zwitterions explored for use in mitigating surface fouling, and have been shown to reduce protein adsorption, limit cellular adhesion, and promote increased functional lifetimes and limited inflammatory responses when applied to implanted materials and devices. Here, we present a focused review of the literature surrounding sulfobetaine, beginning with an understanding of its chemistry and the methods by which it is applied to the surface of a biomedical device in molecular and polymeric forms, and then advancing to the many early demonstrations of function in a variety of biomedical applications. Finally, we provide some insights into the benefits and challenges presented by its use, as well as some outlook on the future prospects for using this material to improve biomedical device practice by addressing interface-mediated complications.

Simulated Clustering Dynamics of Colloidal Magnetic Nanoparticles

Nanoscale ◽  
2021 ◽  
Author(s):  
Frederik Laust Durhuus ◽  
Lau Halkier Wandall ◽  
Mathias Hoeg Boisen ◽  
Mathias Kure ◽  
Marco Beleggia ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Magnetic Nanoparticle ◽  
Bottom Up ◽  
Novel Materials ◽  
Nanoparticle Clusters ◽  
Clustering Dynamics

Magnetically guided self-assembly of nanoparticles is a promising bottom-up method to fabricate novel materials and superstructures, such as, for example, magnetic nanoparticle clusters for biomedical applications. The existence of assembled...

scholarly journals Modulation of Crystallinity through Radiofrequency Electromagnetic Fields in PLLA/Magnetic Nanoparticles Composites: A Proof of Concept

Materials ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4300
Author(s):  
Marta Multigner ◽  
Irene Morales ◽  
Marta Muñoz ◽  
Victoria Bonache ◽  
Fernando Giacomone ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Magnetic Nanoparticles ◽  
Electromagnetic Fields ◽  
Biomedical Applications ◽  
Infrared Camera ◽  
Proof Of Concept ◽  
Scanning Calorimetry ◽  
Radiofrequency Electromagnetic Fields ◽  
Degradation Properties ◽  
Heat Released

To modulate the properties of degradable implants from outside of the human body represents a major challenge in the field of biomaterials. Polylactic acid is one of the most used polymers in biomedical applications, but it tends to lose its mechanical properties too quickly during degradation. In the present study, a way to reinforce poly-L lactic acid (PLLA) with magnetic nanoparticles (MNPs) that have the capacity to heat under radiofrequency electromagnetic fields (EMF) is proposed. As mechanical and degradation properties are related to the crystallinity of PLLA, the aim of the work was to explore the possibility of modifying the structure of the polymer through the heating of the reinforcing MNPs by EMF within the biological limit range f·H < 5·× 109 Am−1·s−1. Composites were prepared by dispersing MNPs under sonication in a solution of PLLA. The heat released by the MNPs was monitored by an infrared camera and changes in the polymer were analyzed with differential scanning calorimetry and nanoindentation techniques. The crystallinity, hardness, and elastic modulus of nanocomposites increase with EMF treatment.

Prognosis-associated methylation subtypes in endometrial carcinoma patients and the role of magnetic nanoparticles in gene extraction

2021 ◽  
Vol 11 (8) ◽  
pp. 1288-1298
Author(s):  
Liang Wang ◽  
Fengxia Xue
Keyword(s):  
Endometrial Cancer ◽  
Magnetic Nanoparticles ◽  
Endometrial Carcinoma ◽  
High Throughput Sequencing ◽  
Risk Groups ◽  
Vital Role ◽  
Low Risk ◽  
The Cancer Genome Atlas ◽  
Consensus Clustering ◽  
Tumor Subtypes

Endometrial cancer is one of the most common gynecological malignancies, and DNA methylation plays a vital role in its occurrence and development. In this study, we collected the relevant data on endometrial cancer from the Cancer Genome Atlas database and UCSC website. By screening and processing the data, we obtained 410 samples and 16,381 methylation sites. Endometrial carcinoma can be divided into seven molecular subtypes using consensus clustering method. Based on the analysis of the differences among subtypes, the methylation degree of different sites was obtained, and the prognosis model of methylation sites was established. Based on the median value of the train group, the train and test groups were divided into high and low-risk groups. The survival between the high and low-risk groups was different. It also showed that this model can predict the survival of patients, with better accuracy. In conclusion, the tumor subtypes based on methylation sites can provide a better guidance for treatment, relapse, and prognosis of endometrial cancer. In this study, magnetic nanoparticles can be used to extract genomic DNA and total RNA due to their paramagnetism and biocompatibility, then transcriptome high-throughput sequencing was performed. It may serve as potential cancer immune biomarker targets for developing future oncological treatments.

Gd-Based Magnetic Nanoparticles for Biomedical Applications

2018 ◽  
pp. 137-155 ◽  
Author(s):  
Shane Harstad ◽  
Shivakumar Hunagund ◽  
Zoe Boekelheide ◽  
Zainab A. Hussein ◽  
Ahmed A. El-Gendy ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Biomedical Applications
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