Magnetic nanoparticles: biomedical applications and challenges

2010 ◽  
Vol 20 (40) ◽  
pp. 8760 ◽  
Author(s):  
Nhiem Tran ◽  
Thomas J. Webster
Keyword(s):  
Magnetic Nanoparticles ◽  
Biomedical Applications

Functionalized magnetic nanoparticles for biomedical applications

2015 ◽  
Vol 21 (42) ◽  
pp. 6038-6054 ◽  
Author(s):  
Dragoș Gudovan ◽  
Paul Balaure ◽  
Dan Mihăiescu ◽  
Adrian Fudulu ◽  
Bogdan Purcăreanu ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Biomedical Applications ◽  
Functionalized Magnetic Nanoparticles

Simulated Clustering Dynamics of Colloidal Magnetic Nanoparticles

Nanoscale ◽  
2021 ◽  
Author(s):  
Frederik Laust Durhuus ◽  
Lau Halkier Wandall ◽  
Mathias Hoeg Boisen ◽  
Mathias Kure ◽  
Marco Beleggia ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Magnetic Nanoparticle ◽  
Bottom Up ◽  
Novel Materials ◽  
Nanoparticle Clusters ◽  
Clustering Dynamics

Magnetically guided self-assembly of nanoparticles is a promising bottom-up method to fabricate novel materials and superstructures, such as, for example, magnetic nanoparticle clusters for biomedical applications. The existence of assembled...

scholarly journals Modulation of Crystallinity through Radiofrequency Electromagnetic Fields in PLLA/Magnetic Nanoparticles Composites: A Proof of Concept

Materials ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4300
Author(s):  
Marta Multigner ◽  
Irene Morales ◽  
Marta Muñoz ◽  
Victoria Bonache ◽  
Fernando Giacomone ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Magnetic Nanoparticles ◽  
Electromagnetic Fields ◽  
Biomedical Applications ◽  
Infrared Camera ◽  
Proof Of Concept ◽  
Scanning Calorimetry ◽  
Radiofrequency Electromagnetic Fields ◽  
Degradation Properties ◽  
Heat Released

To modulate the properties of degradable implants from outside of the human body represents a major challenge in the field of biomaterials. Polylactic acid is one of the most used polymers in biomedical applications, but it tends to lose its mechanical properties too quickly during degradation. In the present study, a way to reinforce poly-L lactic acid (PLLA) with magnetic nanoparticles (MNPs) that have the capacity to heat under radiofrequency electromagnetic fields (EMF) is proposed. As mechanical and degradation properties are related to the crystallinity of PLLA, the aim of the work was to explore the possibility of modifying the structure of the polymer through the heating of the reinforcing MNPs by EMF within the biological limit range f·H < 5·× 109 Am−1·s−1. Composites were prepared by dispersing MNPs under sonication in a solution of PLLA. The heat released by the MNPs was monitored by an infrared camera and changes in the polymer were analyzed with differential scanning calorimetry and nanoindentation techniques. The crystallinity, hardness, and elastic modulus of nanocomposites increase with EMF treatment.

Gd-Based Magnetic Nanoparticles for Biomedical Applications

2018 ◽  
pp. 137-155 ◽  
Author(s):  
Shane Harstad ◽  
Shivakumar Hunagund ◽  
Zoe Boekelheide ◽  
Zainab A. Hussein ◽  
Ahmed A. El-Gendy ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Biomedical Applications

Next Generation Magnetic Nanoparticles for Biomedical Applications

2012 ◽  
pp. 99-126 ◽  
Author(s):  
Trinh Thuy ◽  
Shinya Maenosono ◽  
Nguyê Thanh
Keyword(s):  
Magnetic Nanoparticles ◽  
Biomedical Applications ◽  
Next Generation

scholarly journals Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death

2018 ◽  
Author(s):  
Mahendran Subramanian ◽  
Arkadiusz Miaskowski ◽  
Stuart Iain Jenkins ◽  
Jenson Lim ◽  
Jon Dobson
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Field Gradient ◽  
Biomedical Applications ◽  
Magnetic Field Gradient ◽  
Field Source ◽  
Remote Manipulation ◽  
Cancer Cell Death ◽  
The Magnetic Field

AbstractThe manipulation of magnetic nanoparticles (MNPs) using an external magnetic field, has been demonstrated to be useful in various biomedical applications. Some techniques have evolved utilizing this non-invasive external stimulus but the scientific community widely adopts few, and there is an excellent potential for more novel methods. The primary focus of this study is on understanding the manipulation of MNPs by a time-varying static magnetic field and how this can be used, at different frequencies and displacement, to manipulate cellular function. Here we explore, using numerical modeling, the physical mechanism which underlies this kind of manipulation, and we discuss potential improvements which would enhance such manipulation with its use in biomedical applications, i.e., increasing the MNP response by improving the field parameters. From our observations and other related studies, we infer that such manipulation depends mostly on the magnetic field gradient, the magnetic susceptibility and size of the MNPs, the magnet array oscillating frequency, the viscosity of the medium surrounding MNPs, and the distance between the magnetic field source and the MNPs. Additionally, we demonstrate cytotoxicity in neuroblastoma (SH-SY5Y) and hepatocellular carcinoma (HepG2) cells in vitro. This was induced by incubation with MNPs, followed by exposure to a magnetic field gradient, physically oscillating at various frequencies and displacement amplitudes. Even though this technique reliably produces MNP endocytosis and/or cytotoxicity, a better biophysical understanding is required to develop the mechanism used for this precision manipulation of MNPs, in vitro.

Recent Advances in the Development of Magnetic Nanoparticles for Biomedical Applications

2021 ◽  
Vol 21 (5) ◽  
pp. 2705-2741
Author(s):  
Maria Monteserín ◽  
Silvia Larumbe ◽  
Alejandro V. Martínez ◽  
Saioa Burgui ◽  
L. Francisco Martín
Keyword(s):  
Magnetic Nanoparticles ◽  
Physicochemical Properties ◽  
Biomedical Applications ◽  
High Surface ◽  
High Surface Area ◽  
Synthetic Methods ◽  
Magnetic Drug Targeting ◽  
Surface Area Ratio ◽  
Biomedical Field

The unique properties of magnetic nanoparticles have led them to be considered materials with significant potential in the biomedical field. Nanometric size, high surface-area ratio, ability to function at molecular level, exceptional magnetic and physicochemical properties, and more importantly, the relatively easy tailoring of all these properties to the specific requirements of the different biomedical applications, are some of the key factors of their success. In this paper, we will provide an overview of the state of the art of different aspects of magnetic nanoparticles, specially focusing on their use in biomedicine. We will explore their magnetic properties, synthetic methods and surface modifications, as well as their most significative physicochemical properties and their impact on the in vivo behaviour of these particles. Furthermore, we will provide a background on different applications of magnetic nanoparticles in biomedicine, such as magnetic drug targeting, magnetic hyperthermia, imaging contrast agents or theranostics. Besides, current limitations and challenges of these materials, as well as their future prospects in the biomedical field will be discussed.

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