scholarly journals Implications of Green Tea and Its Constituents in the Prevention of Cancer via the Modulation of Cell Signalling Pathway

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Arshad H. Rahmani ◽  
Fahad M. Al shabrmi ◽  
Khaled S. Allemailem ◽  
Salah M. Aly ◽  
Masood A. Khan
Keyword(s):  
Green Tea ◽  
Biological Activities ◽  
Cell Signalling ◽  
Epigallocatechin Gallate ◽  
Chemopreventive Agents ◽  
Beneficial Effects ◽  
Prevention And Treatment ◽  
Prevention Of Cancer ◽  
Cell Signalling Pathway ◽  
Cell Signaling Pathways

Green tea is commonly used as a beverage worldwide, especially in China, Japan, Morocco, and Saudi Arabia. Green tea and its constituents have been considered very effective in the prevention and treatment of various diseases. It contains a variety of catechins, which show a pivotal role in the modulation of biological activities and also act as chemopreventive agents. Earlier studies have confirmed that green tea and its chief constituent epigallocatechin gallate (EGCG) have a potential role in the management of cancer through the modulation of cell signaling pathways. In this review, we focused on the beneficial effects of green tea and its constituents in the cancer prevention and treatment and its impact on modulation of molecular pathways.

scholarly journals Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3146 ◽  
Author(s):  
Saleh A. Almatroodi ◽  
Ahmad Almatroudi ◽  
Amjad Ali Khan ◽  
Fahad A. Alhumaydhi ◽  
Mohammed A. Alsahli ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Mechanisms Of Action ◽  
Chemopreventive Agents ◽  
Cancer Management ◽  
Anti Cancer ◽  
Chemopreventive Effect ◽  
Cell Signaling Pathways

Epigallocatechin-3-gallate (EGCG), an active compound of green tea and its role in diseases cure and prevention has been proven. Its role in diseases management can be attributed to its antioxidant and anti-inflammatory properties. The anti-cancer role of this green tea compound has been confirmed in various types of cancer and is still being under explored. EGCG has been proven to possess a chemopreventive effect through inhibition of carcinogenesis process such as initiation, promotion, and progression. In addition, this catechin has proven its role in cancer management through modulating various cell signaling pathways such as regulating proliferation, apoptosis, angiogenesis and killing of various types of cancer cells. The additive or synergistic effect of epigallocatechin with chemopreventive agents has been verified as it reduces the toxicities and enhances the anti-cancerous effects. Despite its effectiveness and safety, the implications of EGCG in cancer prevention is certainly still discussed due to a poor bioavailability. Several studies have shown the ability to overcome poor bioavailability through nanotechnology-based strategies such as encapsulation, liposome, micelles, nanoparticles and various other formulation. In this review, we encapsulate therapeutic implication of EGCG in cancer management and the mechanisms of action are discussed with an emphasis on human clinical trials.

scholarly journals Tea Polyphenols in Promotion of Human Health

Nutrients ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 39 ◽  
Author(s):  
Naghma Khan ◽  
Hasan Mukhtar
Keyword(s):  
Green Tea ◽  
Animal Studies ◽  
Neurological Diseases ◽  
Black Tea ◽  
Polyphenolic Compounds ◽  
Tea Polyphenols ◽  
Beneficial Effects ◽  
Gallocatechin Gallate ◽  
Prevention Of Cancer ◽  
Pharmacologically Active

Tea is the most widely used beverage worldwide. Japanese and Chinese people have been drinking tea for centuries and in Asia, it is the most consumed beverage besides water. It is a rich source of pharmacologically active molecules which have been implicated to provide diverse health benefits. The three major forms of tea are green, black and oolong tea based on the degree of fermentation. The composition of tea differs with the species, season, leaves, climate, and horticultural practices. Polyphenols are the major active compounds present in teas. The catechins are the major polyphenolic compounds in green tea, which include epigallocatechin-3-gallate (EGCG), epigallocatechin, epicatechin-3-gallate and epicatechin, gallocatechins and gallocatechin gallate. EGCG is the predominant and most studied catechin in green tea. There are numerous evidences from cell culture and animal studies that tea polyphenols have beneficial effects against several pathological diseases including cancer, diabetes and cardiovascular diseases. The polyphenolic compounds present in black tea include theaflavins and thearubigins. In this review article, we will summarize recent studies documenting the role of tea polyphenols in the prevention of cancer, diabetes, cardiovascular and neurological diseases.

scholarly journals Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6123
Author(s):  
Fa-Wei Xu ◽  
Ying-Li Lv ◽  
Yu-Fan Zhong ◽  
Ya-Nan Xue ◽  
Yong Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Green Tea ◽  
Clinical Application ◽  
Epigallocatechin Gallate ◽  
Skin Wound ◽  
Wound Dressings ◽  
Skin Wound Healing ◽  
Comprehensive Review ◽  
Beneficial Effects ◽  
Underlying Mechanisms

Epigallocatechin gallate (EGCG) is associated with various health benefits. In this review, we searched current work about the effects of EGCG and its wound dressings on skin for wound healing. Hydrogels, nanoparticles, micro/nanofiber networks and microneedles are the major types of EGCG-containing wound dressings. The beneficial effects of EGCG and its wound dressings at different stages of skin wound healing (hemostasis, inflammation, proliferation and tissue remodeling) were summarized based on the underlying mechanisms of antioxidant, anti-inflammatory, antimicrobial, angiogenesis and antifibrotic properties. This review expatiates on the rationale of using EGCG to promote skin wound healing and prevent scar formation, which provides a future clinical application direction of EGCG.

scholarly journals Guava (Psidium guajava L.) Leaves: Nutritional Composition, Phytochemical Profile and Health-Promoting Bioactivities

Foods ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 752
Author(s):  
Manoj Kumar ◽  
Maharishi Tomar ◽  
Ryszard Amarowicz ◽  
Vivek Saurabh ◽  
M. Sneha Nair ◽  
...  
Keyword(s):  
Biological Activities ◽  
Epigallocatechin Gallate ◽  
Psidium Guajava ◽  
Nutritional Composition ◽  
Lipid Lowering ◽  
Beneficial Effects ◽  
Health Promoting ◽  
Tropical Areas ◽  
Phytochemical Profile ◽  
Guava Leaves

Psidium guajava (L.) belongs to the Myrtaceae family and it is an important fruit in tropical areas like India, Indonesia, Pakistan, Bangladesh, and South America. The leaves of the guava plant have been studied for their health benefits which are attributed to their plethora of phytochemicals, such as quercetin, avicularin, apigenin, guaijaverin, kaempferol, hyperin, myricetin, gallic acid, catechin, epicatechin, chlorogenic acid, epigallocatechin gallate, and caffeic acid. Extracts from guava leaves (GLs) have been studied for their biological activities, including anticancer, antidiabetic, antioxidant, antidiarrheal, antimicrobial, lipid-lowering, and hepatoprotection activities. In the present review, we comprehensively present the nutritional profile and phytochemical profile of GLs. Further, various bioactivities of the GL extracts are also discussed critically. Considering the phytochemical profile and beneficial effects of GLs, they can potentially be used as an ingredient in the development of functional foods and pharmaceuticals. More detailed clinical trials need to be conducted to establish the efficacy of the GL extracts.

Epigallocatechin-3-Gallate-Rich Green Tea Extract Ameliorates Fatty Liver and Weight Gain in Mice Fed a High Fat Diet by Activating the Sirtuin 1 and AMP Activating Protein Kinase Pathway

2018 ◽  
Vol 46 (03) ◽  
pp. 617-632 ◽  
Author(s):  
Ui-Jin Bae ◽  
John Park ◽  
Il Woon Park ◽  
Byung Min Chae ◽  
Mi-Ra Oh ◽  
...  
Keyword(s):  
Weight Gain ◽  
Protein Kinase ◽  
Green Tea ◽  
High Fat Diet ◽  
Epigallocatechin Gallate ◽  
Green Tea Extract ◽  
Sirtuin 1 ◽  
High Fat ◽  
Beneficial Effects ◽  
Tea Extract

The prevalence of metabolic diseases has risen globally in parallel with the obesity epidemic over the past few decades. Green tea has been reported to have metabolically beneficial effects on obesity; however, the mechanism by which green tea regulates lipid metabolism is not clearly understood. Male c57BL/6 mice were fed a normal chow diet, a high-fat diet (HFD), or an HFD supplemented with various doses of epigallocatechin gallate-rich green tea extract (GTE) for 12 weeks. GTE supplementation reduced body weight gain, prevented hepatic fat accumulation, decreased hypertriglyceridemia, and improved hyperglycemia and insulin resistance in HFD-fed mice. The underlying mechanisms of these beneficial effects of GTE might involve the upregulation of sirtuin 1 and AMP activated protein kinase (AMPK) and the downregulation of enzymes related to de novo lipogenesis. Consistent with the in vivo findings, GTE increased the expression and activity of sirtuin 1, enhanced the binding of sirtuin 1 to liver kinase B1 (LKB1) and subsequent deacetylation of LKB1, and reduced triglyceride accumulation in HepG2 cells. These results suggest the possible therapeutic potential of dietary epigallocatechin gallate-rich GTE supplementation for preventing the development and progression of hepatic steatosis and obesity.

Kefir: A synbiotic with approved anticarcinogenic properties

2020 ◽  
Vol 16 ◽  
Author(s):  
Wissam Zam ◽  
Sally Shahoud ◽  
Mansour Hayek ◽  
Alaa Saad
Keyword(s):  
Cancer Prevention ◽  
Biological Activities ◽  
Research Literature ◽  
Bibliographic Databases ◽  
Middle Income ◽  
Prevention And Treatment ◽  
Prevention Of Cancer

Background:: As by WHO report, cancer is the second leading cause of death globally, and approximately 70% of deaths from cancer occur in low- and middle-income countries. From this point more attention has been given to the role of nutrition in the prevention of cancer development. Methods:: We undertook a structured search of bibliographic databases for peer-reviewed research literature dealing with the role of kefir in cancer prevention and treatment. Results:: Probiotics are one of the most important food fortifications which are proved to have anti-carcinogenic properties. Probiotics can directly bind to carcinogens and alter the production of enzymes by modifying intestinal environment. Kefir, originating from the Balkan–Caucasian region, is a synbiotic composed of a wide number microflora and exopolysaccharides with approved in vitro and in vivo biological activities. Kefir plays a great potential role in cancer prevention and treatment interfering with apoptosis, proliferation and transformation. Conclusion:: This review highlights the important role of probiotics, exopolysaccharides and common kefir in preventing different types of cancer including colon cancer, sarcoma, breast cancer, lung cancer, leukemia, gastric cancer and melanoma.

scholarly journals Quantitative evaluation of the beneficial effects in the mdx mouse of epigallocatechin gallate, an antioxidant polyphenol from green tea

2012 ◽  
Vol 137 (6) ◽  
pp. 811-827 ◽  
Author(s):  
Yoshiko Nakae ◽  
Olivier M. Dorchies ◽  
Peter J. Stoward ◽  
Benno F. Zimmermann ◽  
Christina Ritter ◽  
...  
Keyword(s):  
Green Tea ◽  
Quantitative Evaluation ◽  
Epigallocatechin Gallate ◽  
Mdx Mouse ◽  
Beneficial Effects

scholarly journals ANALYSIS OF IFN- CONCENTRATION IN WISTAR RAT BLOOD AFTER ORAL ADMINISTRATION OF STANDARDIZED GREEN TEA WATER EXTRACT

2010 ◽  
Vol 10 (3) ◽  
pp. 390-395
Author(s):  
Djoko Agus Purwanto ◽  
Retno Pudji Rahayu ◽  
A. Toto Purnomo
Keyword(s):  
Oral Administration ◽  
Green Tea ◽  
Blood Concentration ◽  
Inhibitory Action ◽  
Epigallocatechin Gallate ◽  
Water Extract ◽  
Wistar Rat ◽  
Mechanisms Of Action ◽  
Chemopreventive Agents ◽  
Male And Female

Green tea and its polyphenols have been studied extensively as cancer chemopreventive agents in recent years. However, the mechanisms of action are still not clearly understood. Some researchers suggest that immune system plays important role to destroy cancer cells. Because of that reason, the present study was designed to analyse the effects of oral administration standardized green tea water extract on increasing of IFN-g blood concentration and to elucidate possible mechanisms involved in the inhibitory action of the cancer development. Two groups (male and female) of 5 rats have given p.o. administration 1.25% of standardized green tea water extract and got 300 mg of (-)-epigallocatechin gallate (EGCG)/kg body weight, while two groups others (male and female) were used as control. We found that IFN-g blood concentration on male and female Wistar rat are significantly increase with 13.11% and 17.59%, respectively (p

scholarly journals The Beneficial Effects of Principal Polyphenols from Green Tea, Coffee, Wine, and Curry on Obesity

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 453
Author(s):  
Tomokazu Ohishi ◽  
Ryuuta Fukutomi ◽  
Yutaka Shoji ◽  
Shingo Goto ◽  
Mamoru Isemura
Keyword(s):  
Green Tea ◽  
Animal Studies ◽  
Epigallocatechin Gallate ◽  
Nuclear Factor Κb ◽  
Epidemiological Studies ◽  
Ros Generation ◽  
Beneficial Effects ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Amp Activated Protein Kinase

Several epidemiological studies and clinical trials have reported the beneficial effects of green tea, coffee, wine, and curry on human health, with its anti-obesity, anti-cancer, anti-diabetic, and neuroprotective properties. These effects, which have been supported using cell-based and animal studies, are mainly attributed to epigallocatechin gallate found in green tea, chlorogenic acid in coffee, resveratrol in wine, and curcumin in curry. Polyphenols are proposed to function via various mechanisms, the most important of which is related to reactive oxygen species (ROS). These polyphenols exert conflicting dual actions as anti- and pro-oxidants. Their anti-oxidative actions help scavenge ROS and downregulate nuclear factor-κB to produce favorable anti-inflammatory effects. Meanwhile, pro-oxidant actions appear to promote ROS generation leading to the activation of 5′-AMP-activated protein kinase, which modulates different enzymes and factors with health beneficial roles. Currently, it remains unclear how these polyphenols exert either pro- or anti-oxidant effects. Similarly, several human studies showed no beneficial effects of these foods, and, by extension polyphenols, on obesity. These inconsistencies may be attributed to different confounding study factors. Thus, this review provides a state-of-the-art update on these foods and their principal polyphenol components, with an assumption that it prevents obesity.

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