scholarly journals The Potential Role of Polymethyl Methacrylate as a New Packaging Material for the Implantable Medical Device in the Bladder

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Su Jin Kim ◽  
Bumkyoo Choi ◽  
Kang Sup Kim ◽  
Woong Jin Bae ◽  
Sung Hoo Hong ◽  
...  
Keyword(s):  
Foreign Body ◽  
Polymethyl Methacrylate ◽  
Inflammatory Cytokines ◽  
Medical Devices ◽  
Foreign Body Reaction ◽  
Early Period ◽  
Implantable Medical Device ◽  
Implantable Medical Devices ◽  
Macrophage Activity ◽  
Implanted Medical Devices

Polydimethylsiloxane (PDMS) is used in implantable medical devices; however, PDMS is not a completely biocompatible material for electronic medical devices in the bladder. To identify novel biocompatible materials for intravesical implanted medical devices, we evaluated the biocompatibility of polymethyl methacrylate (PMMA) by analyzing changes in the levels of macrophages, macrophage migratory inhibitory factor (MIF), and inflammatory cytokines in the bladder. A ball-shaped metal coated with PMMA or PDMS was implanted into the bladders of rats, and after intravesical implantation, the inflammatory changes induced by the foreign body reaction were evaluated. In the early period after implantation, increased macrophage activity and MIF in the urothelium of the bladder were observed. However, significantly decreased macrophage activity and MIF in the bladder were observed after implantation with PMMA- or PDMS-coated metal in the later period. In addition, significantly decreased inflammatory cytokines such as IL-1β, IL-6, and TNF-αwere observed with time. Based on these results, we suggest that MIF plays a role in the foreign body reaction and in the biocompatible packaging with PMMA for the implanted medical devices in the bladder.

scholarly journals Biodegradable nanofiber-based piezoelectric transducer

2019 ◽  
Vol 117 (1) ◽  
pp. 214-220 ◽  
Author(s):  
Eli J. Curry ◽  
Thinh T. Le ◽  
Ritopa Das ◽  
Kai Ke ◽  
Elise M. Santorella ◽  
...  
Keyword(s):  
Medical Devices ◽  
Piezoelectric Materials ◽  
Ultrasonic Transducer ◽  
Implantable Medical Devices ◽  
Safety Issues ◽  
Highly Sensitive ◽  
Implanted Medical Devices ◽  
Device Applications ◽  
Processing Device ◽  
Implanted Devices

Piezoelectric materials, a type of “smart” material that generates electricity while deforming and vice versa, have been used extensively for many important implantable medical devices such as sensors, transducers, and actuators. However, commonly utilized piezoelectric materials are either toxic or nondegradable. Thus, implanted devices employing these materials raise a significant concern in terms of safety issues and often require an invasive removal surgery, which can damage directly interfaced tissues/organs. Here, we present a strategy for materials processing, device assembly, and electronic integration to 1) create biodegradable and biocompatible piezoelectric PLLA [poly(l-lactic acid)] nanofibers with a highly controllable, efficient, and stable piezoelectric performance, and 2) demonstrate device applications of this nanomaterial, including a highly sensitive biodegradable pressure sensor for monitoring vital physiological pressures and a biodegradable ultrasonic transducer for blood–brain barrier opening that can be used to facilitate the delivery of drugs into the brain. These significant applications, which have not been achieved so far by conventional piezoelectric materials and bulk piezoelectric PLLA, demonstrate the PLLA nanofibers as a powerful material platform that offers a profound impact on various medical fields including drug delivery, tissue engineering, and implanted medical devices.

scholarly journals An Ultra-Low Power Implantable Medical Devices: An Engineering Perspective

2021 ◽  
Vol 23 (12) ◽  
pp. 46-59
Author(s):  
B. Sathyabhama ◽  
◽  
B. Siva Shankari ◽  
Keyword(s):  
Low Power ◽  
Medical Devices ◽  
Neurological Disorders ◽  
Heart Diseases ◽  
Implantable Devices ◽  
Implantable Medical Device ◽  
Implantable Medical Devices ◽  
Ultra Low Power ◽  
Device Integration ◽  
History Of

Implantable Medical Devices (IMDs) reside within human bodies either temporarily or permanently, for diagnostic, monitoring, or therapeutic purposes. IMDs have a history of outstanding success in the treatment of many diseases, including heart diseases, neurological disorders, and deafness etc.,With the ever-increasing clinical need for implantable devices comes along with the continuous flow of technical challenges. Comparing with the commercial portable products, implantable devices share the same need to reduce size, weight and power. Thus, the need for device integration becomes very much imperative. There are many challenges faced when creating an implantable medical device. While this paper focuses on various techniques adapted to design a reliable device and also focus on the key electronic features of designing an ultra-low power implantable medical circuits for devices and systems.

Wireless Power Transfer to Implantable Medical Devices With Multi-Layer Planar Spiral Coils

2021 ◽  
pp. 457-481
Author(s):  
N. Sertac Artan ◽  
Reza K. Amineh
Keyword(s):  
Medical Devices ◽  
Wireless Power Transfer ◽  
Health Condition ◽  
Implantable Cardioverter Defibrillators ◽  
Power Transfer ◽  
Wireless Power ◽  
Implantable Medical Devices ◽  
Implanted Medical Devices ◽  
Spiral Coils ◽  
Cardioverter Defibrillators

Implantable medical devices such as pacemakers, implantable cardioverter defibrillators, deep brain stimulators, retinal and cochlear implants are gaining significant attraction and growth due to their capability to monitor the health condition in real time, diagnose a particular disease, or provide treatment for a particular disease. In order to charge these devices, wireless power transfer technology is considered as a powerful means. This eliminates the need for extra surgery to replace the battery. In this chapter, some of the major implanted medical devices are reviewed. Then, various wireless power transfer configurations are reviewed briefly for charging such devices. The chapter continues with reviewing wireless power transfer configurations based on the multi-layer printed or non-printed planar spiral coils. At the end, some of the recent works related to using multi-layer planar spiral coils for safe and efficient powering of IMDs will be discussed.

Perspectives on In Vivo Testing of Biomaterials, Prostheses, and Artificial Organs

1988 ◽  
Vol 7 (4) ◽  
pp. 469-479 ◽  
Author(s):  
James M. Anderson
Keyword(s):  
Foreign Body ◽  
Medical Device ◽  
Medical Devices ◽  
Host Response ◽  
Foreign Body Reaction ◽  
Artificial Organs ◽  
In Vivo Testing ◽  
Biological Environment

The goal of in vivo testing of a medical device is to determine the safety or biocompatibility of the device in a biological environment. Biocompatibility is the ability of a medical device to perform with an appropriate host response in a specific application. Biocompatibility assessment is considered to be a measure of the magnitude and duration of adverse alterations in homeostatic mechanisms that determine the host response. Perspectives are provided on the role of injury, tissue responses to medical devices, and blood responses to medical devices. The concept of the normal foreign body reaction is presented. The potential importance of the macrophage, an important component of the foreign body reaction, in controlling the biocompatibility in the in vivo environment is discussed.

scholarly journals Challenges for the Implantation of Symbiotic Nanostructured Medical Devices

2020 ◽  
Vol 10 (8) ◽  
pp. 2923 ◽  
Author(s):  
Jean-Pierre Alcaraz ◽  
Gauthier Menassol ◽  
Géraldine Penven ◽  
Jacques Thélu ◽  
Sarra El Ichi ◽  
...  
Keyword(s):  
Medical Device ◽  
Medical Devices ◽  
The Body ◽  
Biofuel Cells ◽  
Implantable Medical Devices ◽  
Enzymatic Biofuel Cells ◽  
Starting Point ◽  
Implanted Medical Devices ◽  
Biomimetic Approach ◽  
Implanted Device

We discuss the perspectives of designing implantable medical devices that have the criterion of being symbiotic. Our starting point was whether the implanted device is intended to have any two-way (“duplex”) communication of energy or materials with the body. Such duplex communication extends the existing concepts of a biomaterial and biocompatibility to include the notion that it is important to consider the intended functional use of the implanted medical device. This demands a biomimetic approach to design functional symbiotic implantable medical devices that can be more efficient in mimicking what is happening at the molecular and cellular levels to create stable interfaces that allow for the unfettered exchanges of molecules between an implanted device and a body. Such a duplex level of communication is considered to be a necessary characteristic of symbiotic implanted medical devices that are designed to function for long periods of time inside the body to restore and assist the function of the body. We illustrate these perspectives with experience gained from implanting functional enzymatic biofuel cells.

scholarly journals The Inflammatory and Foreign Body Reaction of Polymethyl Methacrylate Glaucoma Drainage Device in the Rabbit Eye

2020 ◽  
Vol 9 (3) ◽  
pp. 20
Author(s):  
Virna D. Oktariana Asrory ◽  
Ratna Sitompul ◽  
Widya Artini ◽  
Sri Estuningsih ◽  
Deni Noviana ◽  
...  
Keyword(s):  
Foreign Body ◽  
Polymethyl Methacrylate ◽  
Foreign Body Reaction ◽  
Glaucoma Drainage Device ◽  
Rabbit Eye ◽  
Drainage Device

scholarly journals All-polymeric transient neural probe for prolonged in-vivo electrophysiological recordings

2021 ◽  
Author(s):  
Laura Ferlauto ◽  
Paola Vagni ◽  
Elodie Geneviève Zollinger ◽  
Adele Fanelli ◽  
Katia Monsorno ◽  
...  
Keyword(s):  
Foreign Body ◽  
Medical Devices ◽  
Foreign Body Reaction ◽  
Brain Activity ◽  
Degradation Process ◽  
Proof Of Concept ◽  
Neural Probes ◽  
Electrophysiological Recordings ◽  
Transient Metals

AbstractTransient bioelectronics has grown fast, opening possibilities never thought before. In medicine, transient implantable devices are interesting because they could eliminate the risks related to surgical retrieval and reduce the chronic foreign body reaction. However, despite recent progress in this area, the short functional lifetime of devices due to short-lived transient metals, which is typically a few days or weeks, still limits the potential of transient medical devices. We report that a switch from transient metals to an entirely polymer-based approach allows for a slower degradation process and a longer lifetime of the transient probe, thus opening new possibilities for transient medical devices. As a proof-of-concept, we fabricated all-polymeric transient neural probes that can monitor brain activity in mice for a few months rather than a few days or weeks. Also, we extensively evaluated the foreign body reaction around the implant during the probe’s degradation. This kind of devices might pave the way for several applications in neuroprosthetics.

Early Foreign Body Reaction in the Mouse Lung to Intravenously Injected Polymer Beads

1980 ◽  
Vol 38 ◽  
pp. 434-435
Author(s):  
S. E. Coleman ◽  
C. I. Hood ◽  
F. J. Schoen ◽  
M. Robinson
Keyword(s):  
Foreign Body ◽  
Foreign Body Reaction ◽  
Light And Electron Microscopy ◽  
Average Diameter ◽  
Mouse Lung ◽  
Surgical Trauma ◽  
Qualitative And Quantitative ◽  
Surgical Model ◽  
Implanted Medical Devices ◽  
Surgical Implantation

The local interaction between biomaterials and host tissue is important in a number of problems involving surgically implanted medical devices. The foreign body reaction (FBR) is typically studied by surgical implantation, but it is difficult to distinguish the differences between surgical trauma and FBR, especially after short implantation times. In particular, surgical implantation models preclude mechanistic inferences as well as qualitative and quantitative assessment of fine differences in biocompatibility among materials. To develop a non-surgical model for FBR, divinyl benzene copolymer beads (Biobeads SX-8, BioRad) were injected into the tail vein of mice, embolizing to the lung. We observed granuloma development over periods of 5 minutes to 1 year. Each animal was injected with 10,000 Biobeads (average diameter, 0.005 cm). After intervals of 5 minutes; 3, 6, 12, 24 and 48 hours; 4 and 8 days; 6 and 16 weeks; and 1 year, the animals were sacrificed, the lungs perfused per trachea with glutaraldehyde-paraformaldehyde fixative and prepared for light and electron microscopy.

In Vitro Models of Biological Responses to Implant Microbiological Models

1999 ◽  
Vol 13 (1) ◽  
pp. 67-72 ◽  
Author(s):  
Andrea Mombelli
Keyword(s):  
Medical Devices ◽  
Antimicrobial Agents ◽  
In Vitro Models ◽  
Implantable Medical Devices ◽  
Oral Implants ◽  
Common Features ◽  
Biological Responses ◽  
Implanted Medical Devices ◽  
Micro Organisms

To study the etiology and explore possibilities for the therapy of implant-associated infections, investigators have developed and utilized various in vitro models. Major contributions have come from the non-oral medical field, where device-related infections can create life-threatening situations. Microbiological models may include (i) models to study the reaction of micro-organisms to the presence of implants, (ii) models to study the reaction of implant-associated micro-organisms to antimicrobial agents, and (iii) models to study the reaction of the host tissues to the presence of implants contaminated with micro-organisms. In evaluating the potential usefulness of these models for research in oral implantology, one must consider common features as well as important differences between implanted medical devices and oral implants. Although infections associated with implantable medical devices and oral peri-implant infections share a remarkable number of common features, there are also important differences that need attention when findings from in vitro experiments are extrapolated to clinical relevance.

Wireless Power Transfer to Implantable Medical Devices With Multi-Layer Planar Spiral Coils

2019 ◽  
pp. 203-227
Author(s):  
N. Sertac Artan ◽  
Reza K. Amineh
Keyword(s):  
Medical Devices ◽  
Wireless Power Transfer ◽  
Health Condition ◽  
Implantable Cardioverter Defibrillators ◽  
Power Transfer ◽  
Wireless Power ◽  
Implantable Medical Devices ◽  
Implanted Medical Devices ◽  
Spiral Coils ◽  
Cardioverter Defibrillators

Implantable medical devices such as pacemakers, implantable cardioverter defibrillators, deep brain stimulators, retinal and cochlear implants are gaining significant attraction and growth due to their capability to monitor the health condition in real time, diagnose a particular disease, or provide treatment for a particular disease. In order to charge these devices, wireless power transfer technology is considered as a powerful means. This eliminates the need for extra surgery to replace the battery. In this chapter, some of the major implanted medical devices are reviewed. Then, various wireless power transfer configurations are reviewed briefly for charging such devices. The chapter continues with reviewing wireless power transfer configurations based on the multi-layer printed or non-printed planar spiral coils. At the end, some of the recent works related to using multi-layer planar spiral coils for safe and efficient powering of IMDs will be discussed.

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