scholarly journals Linkage Analysis of Genomic Regions Contributing to the Expression of Type 1 Diabetes Microvascular Complications and Interaction with HLA

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Ettie M. Lipner ◽  
Yaron Tomer ◽  
Janelle A. Noble ◽  
Maria C. Monti ◽  
John T. Lonsdale ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Linkage Analysis ◽  
Microvascular Complications ◽  
Strong Association ◽  
Linkage Peak ◽  
Snp Markers ◽  
Chromosome 6 ◽  
The Novel ◽  
Genomic Regions

We conducted linkage analysis to follow up earlier work on microvascular complications of type 1 diabetes (T1D). We analyzed 415 families (2,008 individuals) previously genotyped for 402 SNP markers spanning chromosome 6. We did linkage analysis for the phenotypes of retinopathy and nephropathy. For retinopathy, two linkage peaks were mapped: one located at the HLA region and another novel locus telomeric to HLA. For nephropathy, a linkage peak centromeric to HLA was mapped, but the linkage peak telomeric to HLA seen in retinopathy was absent. Because of the strong association of T1D with DRB1*03:01 and DRB1*04:01, we stratified our analyses based on families whose probands were positive for DRB1*03:01 or DRB1*04:01. When analyzing the DRB1*03:01-positive retinopathy families, in addition to the novel telomeric locus, one centromeric to HLA was identified at the same location as the nephropathy peak. When we stratified on DRB1*04:01-positive families, the HLA telomeric peak strengthened but the centromeric peak disappeared. Our findings showed that HLA and non-HLA loci on chromosome 6 are involved in T1D complications’ expression. While the HLA region is a major contributor to the expression of T1D, our results suggest an interaction between specific HLA alleles and other loci that influence complications’ expression.

Assessment of the prevalence of type 1 diabetes microvascular complications in young adults in the repablic of Belarus with regard to the duration of the disease

2017 ◽  
Author(s):  
Yuliya Dydyshka ◽  
Alla Shepelkevich ◽  
Vladislav Yurkovets ◽  
Elena Brutskaya-Stempkovskaya ◽  
Marina Mantachik
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Microvascular Complications

38-LB: Discovery Analysis of MicroRNAs (miRs) Associated with Microvascular Complications in Adults with Type 1 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 38-LB
Author(s):  
ANDRZEJ S. JANUSZEWSKI ◽  
EMMA S. SCOTT ◽  
MUGDHA JOGLEKAR ◽  
LUKE CARROLL ◽  
RYAN FARR ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Microvascular Complications

scholarly journals Age at menarche and the risk of diabetic microvascular complications in patients with type 1 diabetes

Diabetologia ◽  
2015 ◽  
Vol 59 (3) ◽  
pp. 472-480 ◽  
Author(s):  
Valma Harjutsalo ◽  
◽  
Christine Maric-Bilkan ◽  
Carol Forsblom ◽  
Per-Henrik Groop
Keyword(s):  
Type 1 Diabetes ◽  
Microvascular Complications ◽  
Age At Menarche ◽  
Diabetic Microvascular Complications

scholarly journals Retinal vascular fractals predict long-term microvascular complications in type 1 diabetes mellitus: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987)

Diabetologia ◽  
2014 ◽  
Vol 57 (10) ◽  
pp. 2215-2221 ◽  
Author(s):  
Rebecca Broe ◽  
Malin L. Rasmussen ◽  
Ulrik Frydkjaer-Olsen ◽  
Birthe S. Olsen ◽  
Henrik B. Mortensen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Pediatric Diabetes ◽  
Danish Cohort

scholarly journals INSULIN DEPENDENT DIABETES MELLITUS

2009 ◽  
Vol 16 (02) ◽  
pp. 178-186
Author(s):  
MUHAMMAD USMAN KHURSHID ◽  
MANSOOR-UL-HASSAN ALV I
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Sialic Acid ◽  
Urinary Albumin Excretion ◽  
Microvascular Complications ◽  
Urinary Albumin ◽  
Elevated Plasma ◽  
Albumin Excretion

A i m s & O b j e c t i v e s : To test the hypothesis that an increased plasma concentration of sialic acid, a marker of the acutephaseresponse, is related to the presence of diabetic retinopathy in type 1 diabetes mellitus or Insulin Dependant Diabetes Mellitus (IDDM).R e s e a r c h D e s i g n a n d M e t h o d s : We investigated the relationship between plasma sialic acid concentration and diabetic retinopathy in across-sectional survey of 1,369 people with type 1 diabetes. Subjects were participants in the IDDM Complications Study, which involveddiabetic centers of four different hospitals in Lahore. Results: There was a significantly increasing trend of plasma sialic acid with severityof retinopathy (P < 0.001 in men) and with degree of urinary albumin excretion (P < 0.001 men, P < 0.01 women). Elevated plasma sialicacid concentrations were also associated with several risk factors for diabetic vascular disease: diabetes duration, HbAlc, plasma triglycerideand cholesterol concentrations, waist-to-hip ratio, hypertension and smoking (in men), and low physical exercise (in women). In multiplelogistic regression analysis, plasma sialic acid was independently related to proliferative retinopathy and urinary albumin excretion rate inmen. Conclusions: We concluded that an elevated plasma sialic concentration is strongly related to the presence of microvascularcomplications in type 1 diabetes with retinopathy and nephropathy. Further study of acute-phase response markers and mediators asindicators or predictors of diabetic microvascular complications is therefore justified.

Influence of remission and its duration on development of early microvascular complications in young adults with type 1 diabetes

2015 ◽  
Vol 29 (8) ◽  
pp. 1105-1111 ◽  
Author(s):  
Pawel Niedzwiecki ◽  
Stanislaw Pilacinski ◽  
Aleksandra Uruska ◽  
Anna Adamska ◽  
Dariusz Naskret ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Microvascular Complications

scholarly journals The increased risk of microvascular complications in South Asians with type 1 diabetes is influenced by migration

2019 ◽  
Vol 37 (12) ◽  
pp. 2136-2142
Author(s):  
M.R. Chetan ◽  
J.K. Miksza ◽  
I. Lawrence ◽  
R.M. Anjana ◽  
R. Unnikrishnan ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
South Asians ◽  
Microvascular Complications ◽  
Increased Risk
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