38-LB: Discovery Analysis of MicroRNAs (miRs) Associated with Microvascular Complications in Adults with Type 1 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 38-LB
Author(s):  
ANDRZEJ S. JANUSZEWSKI ◽  
EMMA S. SCOTT ◽  
MUGDHA JOGLEKAR ◽  
LUKE CARROLL ◽  
RYAN FARR ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Microvascular Complications

Assessment of the prevalence of type 1 diabetes microvascular complications in young adults in the repablic of Belarus with regard to the duration of the disease

2017 ◽  
Author(s):  
Yuliya Dydyshka ◽  
Alla Shepelkevich ◽  
Vladislav Yurkovets ◽  
Elena Brutskaya-Stempkovskaya ◽  
Marina Mantachik
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Microvascular Complications

scholarly journals Age at menarche and the risk of diabetic microvascular complications in patients with type 1 diabetes

Diabetologia ◽  
2015 ◽  
Vol 59 (3) ◽  
pp. 472-480 ◽  
Author(s):  
Valma Harjutsalo ◽  
◽  
Christine Maric-Bilkan ◽  
Carol Forsblom ◽  
Per-Henrik Groop
Keyword(s):  
Type 1 Diabetes ◽  
Microvascular Complications ◽  
Age At Menarche ◽  
Diabetic Microvascular Complications

scholarly journals Retinal vascular fractals predict long-term microvascular complications in type 1 diabetes mellitus: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987)

Diabetologia ◽  
2014 ◽  
Vol 57 (10) ◽  
pp. 2215-2221 ◽  
Author(s):  
Rebecca Broe ◽  
Malin L. Rasmussen ◽  
Ulrik Frydkjaer-Olsen ◽  
Birthe S. Olsen ◽  
Henrik B. Mortensen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Pediatric Diabetes ◽  
Danish Cohort

scholarly journals INSULIN DEPENDENT DIABETES MELLITUS

2009 ◽  
Vol 16 (02) ◽  
pp. 178-186
Author(s):  
MUHAMMAD USMAN KHURSHID ◽  
MANSOOR-UL-HASSAN ALV I
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Sialic Acid ◽  
Urinary Albumin Excretion ◽  
Microvascular Complications ◽  
Urinary Albumin ◽  
Elevated Plasma ◽  
Albumin Excretion

A i m s & O b j e c t i v e s : To test the hypothesis that an increased plasma concentration of sialic acid, a marker of the acutephaseresponse, is related to the presence of diabetic retinopathy in type 1 diabetes mellitus or Insulin Dependant Diabetes Mellitus (IDDM).R e s e a r c h D e s i g n a n d M e t h o d s : We investigated the relationship between plasma sialic acid concentration and diabetic retinopathy in across-sectional survey of 1,369 people with type 1 diabetes. Subjects were participants in the IDDM Complications Study, which involveddiabetic centers of four different hospitals in Lahore. Results: There was a significantly increasing trend of plasma sialic acid with severityof retinopathy (P < 0.001 in men) and with degree of urinary albumin excretion (P < 0.001 men, P < 0.01 women). Elevated plasma sialicacid concentrations were also associated with several risk factors for diabetic vascular disease: diabetes duration, HbAlc, plasma triglycerideand cholesterol concentrations, waist-to-hip ratio, hypertension and smoking (in men), and low physical exercise (in women). In multiplelogistic regression analysis, plasma sialic acid was independently related to proliferative retinopathy and urinary albumin excretion rate inmen. Conclusions: We concluded that an elevated plasma sialic concentration is strongly related to the presence of microvascularcomplications in type 1 diabetes with retinopathy and nephropathy. Further study of acute-phase response markers and mediators asindicators or predictors of diabetic microvascular complications is therefore justified.

Influence of remission and its duration on development of early microvascular complications in young adults with type 1 diabetes

2015 ◽  
Vol 29 (8) ◽  
pp. 1105-1111 ◽  
Author(s):  
Pawel Niedzwiecki ◽  
Stanislaw Pilacinski ◽  
Aleksandra Uruska ◽  
Anna Adamska ◽  
Dariusz Naskret ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Microvascular Complications

scholarly journals The increased risk of microvascular complications in South Asians with type 1 diabetes is influenced by migration

2019 ◽  
Vol 37 (12) ◽  
pp. 2136-2142
Author(s):  
M.R. Chetan ◽  
J.K. Miksza ◽  
I. Lawrence ◽  
R.M. Anjana ◽  
R. Unnikrishnan ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
South Asians ◽  
Microvascular Complications ◽  
Increased Risk

Clustering of microvascular complications in Type 1 diabetes mellitus

2018 ◽  
Vol 32 (4) ◽  
pp. 393-399 ◽  
Author(s):  
Lasse Bjerg ◽  
Adam Hulman ◽  
Morten Charles ◽  
Marit Eika Jørgensen ◽  
Daniel Rinse Witte
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Microvascular Complications

scholarly journals Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes

2019 ◽  
Vol 16 (3) ◽  
pp. 297-299 ◽  
Author(s):  
Sharon Nina Admoni ◽  
Daniele Pereira Santos-Bezerra ◽  
Ricardo Vesoni Perez ◽  
Thiago Andrade Patente ◽  
Maria Beatriz Monteiro ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glutathione Peroxidase ◽  
Autonomic Neuropathy ◽  
Microvascular Complications ◽  
Diabetic Complication ◽  
Cardiac Autonomic Neuropathy ◽  
Inverse Association ◽  
Gene Encoding ◽  
Functional Variant

Cardiac autonomic neuropathy is a neglected diabetic chronic complication for which genetic predictors are rarely reported. Oxidative stress is implicated in the pathogenesis of microvascular complications, and glutathione peroxidase 4 is involved in the detoxification of peroxides and of reactive oxygen species. Thus, the association of a functional variant in the gene encoding glutathione peroxidase 4 (rs713041) with this diabetic complication was investigated in 341 individuals with type 1 diabetes evaluated for cardiac autonomic neuropathy status (61.7% women, 34 [27–42] years old; diabetes duration: 21 [15–27] years; HbA1c: 8.3% [7.4–9.4]; as median [interquartile interval]). Cardiac autonomic neuropathy was present in 29% of the participants. There was an inverse association of the minor T allele of rs713041 with cardiac autonomic neuropathy (odds ratio = 0.39; 95% confidence interval = 0.17–0.90; p  = 0.0271) after adjustment for potential confounders. The functional glutathione peroxidase 4 variant rs713041 modulated the risk for cardiac autonomic neuropathy in the studied population with type 1 diabetes.

Sign in / Sign up

Export Citation Format

Share Document