scholarly journals Possible association between haemostasis dysfunction and early onset of microvascular complications in patients with type 1 diabetes

2020 ◽  
Vol 26 (2) ◽  
pp. 89-96
Author(s):  
Jarmila Vojtková ◽  
Katarína Motyková ◽  
Peter Bánovčin
Keyword(s):  
Type 1 Diabetes ◽  
Early Onset ◽  
Microvascular Complications

scholarly journals Risk of Microvascular Complications and Macrovascular Risk Factors in Early-Onset Type 1 Diabetes after at Least 10 Years Duration: An Analysis of Three Population-Based Cross-Sectional Surveys in Germany between 2009 and 2016

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Thaddäus Tönnies ◽  
Anna Stahl-Pehe ◽  
Christina Baechle ◽  
Katty Castillo ◽  
Oliver Kuss ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Early Onset ◽  
Microvascular Complications ◽  
Temporal Trends ◽  
Composite Endpoint ◽  
Population Based ◽  
Related Factors ◽  
Cross Sectional

Aims. To estimate the risk of microvascular complications and macrovascular risk factors among persons with early-onset (diagnosed at ages 0 to <5 years) and long-duration type 1 diabetes and determine temporal trends and associations with potential predictors. Methods. We conducted three population-based cross-sectional surveys in Germany (N=1789) to obtain information on exposures and five outcomes (retinopathy, nephropathy, dyslipidemia, hypertension, and a composite endpoint combining all four outcomes). For each outcome, log-binomial spline regression was applied to estimate the risk and dose-response relationship with diabetes duration and exposures. Results. The risk for microvascular complications increased after 14 years since diabetes diagnosis whereas dyslipidemia and hypertension were already prevalent at 10 years. The 15-year risk (95% confidence interval) of the composite endpoint for female and male patients was 22.9% (18.8%–27.9%) and 19.2% (15.5%–23.8%), respectively. Temporal trends suggested a decreasing risk between 2009 and 2016. Glycemic control, lifestyle-related factors, and SES, but not health care-related factors, were associated with the risk of the composite endpoint. Conclusions. In early-onset type 1 diabetes, there exists a considerable risk of complications and comorbidities already in young ages. Future research should focus on prevention of diabetic complications in young patients and clarification of pathways of the associations found.

Assessment of the prevalence of type 1 diabetes microvascular complications in young adults in the repablic of Belarus with regard to the duration of the disease

2017 ◽  
Author(s):  
Yuliya Dydyshka ◽  
Alla Shepelkevich ◽  
Vladislav Yurkovets ◽  
Elena Brutskaya-Stempkovskaya ◽  
Marina Mantachik
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Microvascular Complications

38-LB: Discovery Analysis of MicroRNAs (miRs) Associated with Microvascular Complications in Adults with Type 1 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 38-LB
Author(s):  
ANDRZEJ S. JANUSZEWSKI ◽  
EMMA S. SCOTT ◽  
MUGDHA JOGLEKAR ◽  
LUKE CARROLL ◽  
RYAN FARR ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Microvascular Complications

Early onset of subclinical atherosclerosis in young persons with type 1 diabetes

2004 ◽  
Vol 145 (4) ◽  
pp. 452-457 ◽  
Author(s):  
Jody S. Krantz ◽  
Wendy J. Mack ◽  
Howard N. Hodis ◽  
Chao-Ran Liu ◽  
Ci-Hua Liu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Early Onset ◽  
Subclinical Atherosclerosis

scholarly journals Age at menarche and the risk of diabetic microvascular complications in patients with type 1 diabetes

Diabetologia ◽  
2015 ◽  
Vol 59 (3) ◽  
pp. 472-480 ◽  
Author(s):  
Valma Harjutsalo ◽  
◽  
Christine Maric-Bilkan ◽  
Carol Forsblom ◽  
Per-Henrik Groop
Keyword(s):  
Type 1 Diabetes ◽  
Microvascular Complications ◽  
Age At Menarche ◽  
Diabetic Microvascular Complications

scholarly journals Retinal vascular fractals predict long-term microvascular complications in type 1 diabetes mellitus: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987)

Diabetologia ◽  
2014 ◽  
Vol 57 (10) ◽  
pp. 2215-2221 ◽  
Author(s):  
Rebecca Broe ◽  
Malin L. Rasmussen ◽  
Ulrik Frydkjaer-Olsen ◽  
Birthe S. Olsen ◽  
Henrik B. Mortensen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Pediatric Diabetes ◽  
Danish Cohort

scholarly journals Co-Morbidity between Early-Onset Leukemia and Type 1 Diabetes – Suggestive of a Shared Viral Etiology?

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e39523 ◽  
Author(s):  
Kari Hemminki ◽  
Richard Houlston ◽  
Jan Sundquist ◽  
Kristina Sundquist ◽  
Xiaochen Shu
Keyword(s):  
Type 1 Diabetes ◽  
Early Onset ◽  
Viral Etiology ◽  
Co Morbidity

scholarly journals INSULIN DEPENDENT DIABETES MELLITUS

2009 ◽  
Vol 16 (02) ◽  
pp. 178-186
Author(s):  
MUHAMMAD USMAN KHURSHID ◽  
MANSOOR-UL-HASSAN ALV I
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Sialic Acid ◽  
Urinary Albumin Excretion ◽  
Microvascular Complications ◽  
Urinary Albumin ◽  
Elevated Plasma ◽  
Albumin Excretion

A i m s & O b j e c t i v e s : To test the hypothesis that an increased plasma concentration of sialic acid, a marker of the acutephaseresponse, is related to the presence of diabetic retinopathy in type 1 diabetes mellitus or Insulin Dependant Diabetes Mellitus (IDDM).R e s e a r c h D e s i g n a n d M e t h o d s : We investigated the relationship between plasma sialic acid concentration and diabetic retinopathy in across-sectional survey of 1,369 people with type 1 diabetes. Subjects were participants in the IDDM Complications Study, which involveddiabetic centers of four different hospitals in Lahore. Results: There was a significantly increasing trend of plasma sialic acid with severityof retinopathy (P < 0.001 in men) and with degree of urinary albumin excretion (P < 0.001 men, P < 0.01 women). Elevated plasma sialicacid concentrations were also associated with several risk factors for diabetic vascular disease: diabetes duration, HbAlc, plasma triglycerideand cholesterol concentrations, waist-to-hip ratio, hypertension and smoking (in men), and low physical exercise (in women). In multiplelogistic regression analysis, plasma sialic acid was independently related to proliferative retinopathy and urinary albumin excretion rate inmen. Conclusions: We concluded that an elevated plasma sialic concentration is strongly related to the presence of microvascularcomplications in type 1 diabetes with retinopathy and nephropathy. Further study of acute-phase response markers and mediators asindicators or predictors of diabetic microvascular complications is therefore justified.

scholarly journals Perinatal risk factors for early onset of Type 1 diabetes in a 2000-2005 birth cohort

2009 ◽  
Vol 26 (12) ◽  
pp. 1193-1197 ◽  
Author(s):  
C. S. Algert ◽  
A. McElduff ◽  
J. M. Morris ◽  
C. L. Roberts
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Birth Cohort ◽  
Early Onset ◽  
Perinatal Risk Factors ◽  
Perinatal Risk

Influence of remission and its duration on development of early microvascular complications in young adults with type 1 diabetes

2015 ◽  
Vol 29 (8) ◽  
pp. 1105-1111 ◽  
Author(s):  
Pawel Niedzwiecki ◽  
Stanislaw Pilacinski ◽  
Aleksandra Uruska ◽  
Anna Adamska ◽  
Dariusz Naskret ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Microvascular Complications
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