scholarly journals Oxidative Stress State Is Associated with Left Ventricular Mechanics Changes, Measured by Speckle Tracking in Essential Hypertensive Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Luis Antonio Moreno-Ruíz ◽  
David Ibarra-Quevedo ◽  
Erika Rodríguez-Martínez ◽  
Perla D. Maldonado ◽  
Benito Sarabia-Ortega ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress State ◽  
Diastolic Pressure ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Sod Activity ◽  
Hypertensive Patients ◽  
Oxidized Proteins ◽  
Ventricular Mechanics ◽  
Left Ventricular Mechanics

The oxidative stress state is characterized by an increase in oxygen reactive species that overwhelms the antioxidant defense; we do not know if these pathological changes are correlated with alterations in left ventricular mechanics. The aim was correlating the oxidative stress state with the left ventricular global longitudinal strain (GLS) and the left ventricular end diastolic pressure (LVEDP). Twenty-five patients with essential hypertension and 25 controls paired by age and gender were studied. All of the participants were subjected to echocardiography and biochemical determination of oxidative stress markers. The hypertensive patients, compared with control subjects, had significantly (p<0.05) higher levels of oxidized proteins (5.03±1.05versus4.06±0.63 nmol/mg), lower levels of extracellular superoxide dismutase (EC-SOD) activity (0.045±0.02versus0.082±0.02 U/mg), higher LVEDP (16.2±4.5versus11.3±1.6 mm Hg), and lower GLS (−12% versus −16%). Both groups had preserved ejection fraction and the results showed a positive correlation of oxidized proteins with GLS (r=0.386,p=0.006) and LVEDP (r=0.389,p=0.005); we also found a negative correlation of EC-SOD activity with GLS (r=-0.404,p=0.004) and LVEDP (r=-0.347,p=0.014).

Left Ventricular Mechanics in Asymptomatic Normotensive and Hypertensive Patients with Aortic Regurgitation

2011 ◽  
Vol 24 (4) ◽  
pp. 385-391 ◽  
Author(s):  
Vaida Mizariene ◽  
Silvija Bucyte ◽  
Diana Zaliaduonyte-Peksiene ◽  
Regina Jonkaitiene ◽  
Jolanta Vaskelyte ◽  
...  
Keyword(s):  
Aortic Regurgitation ◽  
Left Ventricular ◽  
Hypertensive Patients ◽  
Ventricular Mechanics ◽  
Left Ventricular Mechanics

THE INFLUENCE OF GENDER ON LEFT VENTRICULAR MECHANICS IN HYPERTENSIVE PATIENTS

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e232
Author(s):  
M. Tadic ◽  
C. Cuspidi ◽  
V. Celic ◽  
B. Ivanovic ◽  
B. Pencic ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Hypertensive Patients ◽  
Ventricular Mechanics ◽  
Left Ventricular Mechanics

OP-215 RELATION OF LEFT VENTRICULAR END-DIASTOLIC PRESSURE WITH LEFT VENTRICULAR MECHANICS

2012 ◽  
Vol 155 ◽  
pp. S54
Author(s):  
M. Kurt ◽  
I.H. Tanboga ◽  
T. Isik ◽  
A. Kaya ◽  
M. Ekinci ◽  
...  
Keyword(s):  
Diastolic Pressure ◽  
Left Ventricular ◽  
Ventricular Mechanics ◽  
Left Ventricular Mechanics

Effects of acute lung injury and anesthesia on left ventricular mechanics

1986 ◽  
Vol 251 (6) ◽  
pp. H1195-H1204 ◽  
Author(s):  
D. E. Hansen ◽  
K. M. Borow ◽  
A. Neumann ◽  
R. M. Lang ◽  
A. M. Fujii ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Diastolic Pressure ◽  
Left Ventricular ◽  
Lv Function ◽  
Ventricular Mechanics ◽  
Wide Range ◽  
Left Ventricular Mechanics ◽  
Anesthetized Dogs ◽  
Time Dependent Effect

Traditional left ventricular (LV) function curves are frequently depressed in patients with acute lung injury. Similar findings in pentobarbital sodium-anesthetized dogs with oleic acid lung injury (OALI) have been observed. To test the hypothesis that acute OALI produces a significant injury to the heart, the LV mechanics of pentobarbital-anesthetized dogs with (n = 6) and without (n = 6) OALI were evaluated. End-systolic force-length and force-velocity relations determined echocardiographically during afterload manipulation with sodium nitroprusside demonstrated a marked deterioration in LV shortening characteristics over 90 min in both groups of pentobarbital-anesthetized dogs. In contrast, LV mechanics studied using the same protocol in fentanyl-anesthetized dogs were unchanged in both the injured (n = 6) and noninjured (n = 6) lung groups. Comparisons with data acquired over a wide range of LV afterload from six conscious, instrumented dogs showed that LV contractile state was normal to slightly increased with fentanyl and markedly depressed with pentobarbital. Diastolic properties, as assessed by end-diastolic pressure-dimension relations, were essentially unchanged in all anesthetized animals. We conclude that OALI has no effect on LV systolic or diastolic mechanics; the LV dysfunction attributed to OALI in previous studies is due to an acute, severe cardiomyopathy induced by pentobarbital; and unlike pentobarbital, anesthesia with fentanyl has no discernible time-dependent effect on LV mechanics. These findings have important implications for future studies of canine cardiovascular physiology employing anesthetized animal preparations.

scholarly journals Association Between Left Ventricular Mechanics and Heart Rate Variability in Untreated Hypertensive Patients

2014 ◽  
Vol 17 (2) ◽  
pp. 118-125 ◽  
Author(s):  
Marijana Tadic ◽  
Cesare Cuspidi ◽  
Biljana Pencic ◽  
Sinisa U. Pavlovic ◽  
Branislava Ivanovic ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Left Ventricular ◽  
Hypertensive Patients ◽  
Ventricular Mechanics ◽  
Left Ventricular Mechanics

scholarly journals Pregnancy-related changes in Doppler gradients and left ventricular mechanics in women with subvalvular or valvular aortic stenosis.

2021 ◽  
Author(s):  
Soohyun Chang ◽  
Parm Khakh ◽  
Mikyla Janzen ◽  
Marla Kiess ◽  
Valerie Rychel ◽  
...  
Keyword(s):  
Global Longitudinal Strain ◽  
Structural Heart Disease ◽  
Left Ventricular ◽  
Control Group ◽  
Ventricular Mechanics ◽  
Healthy Pregnancy ◽  
Echocardiographic Evaluation ◽  
Left Ventricular Mechanics ◽  
Valvular Aortic Stenosis ◽  
The Relationship

Background: The aim of our study was to characterize echocardiographic changes during pregnancy in women with known LVOT obstruction or AS compared to the healthy pregnancy controls, and to assess the relationship with pregnancy outcomes. Methods: We retrospectively studied 34 pregnant patients with congenital LVOT obstruction or AS with healthy age-matched pregnant controls. Patients with other significant valvular lesions, structural heart disease (LVEF <40%), or prior valve surgery were excluded. All LVOTO/AS patients underwent a minimum of 2 consecutive echocardiograms between 1 year pre-conception up to 1 year postpartum, with at least 2 studies during the pregnancy. Comprehensive echocardiographic evaluation was performed including speckle-tracking LV global longitudinal strain. Results: A total of 83 echocardiograms from the study group and 34 echocardiograms from the control group were evaluated. Over the range of LVOTO/AS, a significantly greater increase in the AV gradients and LV and LA volumes were observed as compared with the controls. In the sub-group of LVOTO/AS pregnant women with > moderate (n=8) vs.

scholarly journals Impact of BMI z-score On Left Ventricular Mechanics in a Pediatric Population

2021 ◽  
Author(s):  
Justine Paysal ◽  
Etienne Merlin ◽  
Emmanuelle Rochette ◽  
Daniel Terral ◽  
Stephane Nottin
Keyword(s):  
Pediatric Population ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Female Adolescents ◽  
Lv Function ◽  
Z Score ◽  
Ventricular Mechanics ◽  
Lv Mass ◽  
Left Ventricular Mechanics ◽  
Longitudinal Strains

Abstract Background: Adolescent weight disorders ranging from anorexia nervosa (AN) to obesity (OB) can impact the heart by causing opposite alterations in its morphology, suggesting a direct impact of BMI on the heart. Cardiac function is relatively preserved as assessed by standard ultrasound methods. However, few studies have used speckle-tracking echocardiography (STE), which can detect subtle alterations of left ventricular (LV) function by evaluating deformations. The aim of this study was to assess the link between BMI z-score of female adolescents and myocardial function. Methods: Ninety-one female adolescents comprising 26 AN patient (age 14.6 ± 1.9 y), 28 OB patients (age 13.2 ± 1.4 y), and 37 controls (age 14.0 ± 2.0 y) underwent STE to assess LV morphology and myocardial regional deformations. Findings: The BMI z-score of our population ranged from −4.6 to 5.2. LV morphological remodeling was significantly and positively correlated with BMI z-score (R² = 0.456, p < 0.0001 for LV mass). Global longitudinal strain (LS) and regional LS recorded at the mid and apical levels were significantly correlated with BMI z-score (R² = 0.196, p = 0.0001 and R² = 0.274, p < 0.0001 respectively for apical and medial LS). Circumferential strains and twisting mechanics were not correlated with BMI z-score. Fibrinogen and SBP were the main variables explaining the alteration of longitudinal strains. Conclusion: A impact of BMI z-score on LV mechanics was observed especially on medial and apical LS. Neither circumferential nor twisting mechanics were altered by BMI z-score in female adolescents.

scholarly journals Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic review

2020 ◽  
Vol 7 (3) ◽  
pp. 39-48
Author(s):  
Diana deCampos ◽  
Rogério Teixeira ◽  
Carolina Saleiro ◽  
Ana Botelho ◽  
Lino Gonçalves
Keyword(s):  
Systematic Review ◽  
Disease Progression ◽  
Aortic Regurgitation ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Ventricular Mechanics ◽  
Left Ventricular Mechanics ◽  
Long Time ◽  
Chronic Aortic Regurgitation

Chronic aortic regurgitation (AR) patients typically remain asymptomatic for a long time. Left ventricular mechanics, namely global longitudinal strain (GLS), has been associated with outcomes in AR patients. The authors conducted a systematic review to summarize and appraise GLS impact on mortality, the need for aortic valve replacement (AVR) and disease progression in AR patients. A literature search was performed using these key terms ‘aortic regurgitation’ and ‘longitudinal strain’ looking at all randomized and nonrandomized studies conducted on chronic aortic regurgitation. The search yielded six observational studies published from 2011 and 2018 with a total of 1571 patients with moderate to severe chronic AR. Only two studies included all-cause mortality as their endpoint. The other studies looked at the association between GLS with AVR and disease progression. The mean follow-up period was 4.2 years. We noted a great variability of clinical, methodological and/or statistical origin. Thus, meta-analytic portion of our study was limited. Despite a relevant heterogeneity, an impaired GLS was associated with adverse cardiac outcomes. Left ventricular GLS may offer incremental value in risk stratification and decision-making.

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