scholarly journals Association Between Left Ventricular Mechanics and Heart Rate Variability in Untreated Hypertensive Patients

2014 ◽  
Vol 17 (2) ◽  
pp. 118-125 ◽  
Author(s):  
Marijana Tadic ◽  
Cesare Cuspidi ◽  
Biljana Pencic ◽  
Sinisa U. Pavlovic ◽  
Branislava Ivanovic ◽  
...  
2011 ◽  
Vol 24 (4) ◽  
pp. 385-391 ◽  
Author(s):  
Vaida Mizariene ◽  
Silvija Bucyte ◽  
Diana Zaliaduonyte-Peksiene ◽  
Regina Jonkaitiene ◽  
Jolanta Vaskelyte ◽  
...  

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e232
Author(s):  
M. Tadic ◽  
C. Cuspidi ◽  
V. Celic ◽  
B. Ivanovic ◽  
B. Pencic ◽  
...  

Author(s):  
E. Yu. Gubareva ◽  
N. N. Kryukov ◽  
I. V. Gubareva

Aim. To study the catestatin plasma level in patients with primary hypertension of different cardiovascular risk and to assess its relationship with heart rate variability (HRV) parameters.Material and methods. One hundred eighty men aged 30-50 years were divided into groups: group 1 (n=28) — hypertensive patients with medium risk of developing cardiovascular complications (CVC), group 2 (n=76) — hypertensive patients with high risk of CVC, group 3 (n=31) — hypertensive patients with very high risk of CVC. The control group consisted of healthy men with normal blood pressure (BP) (n=45). We determined plasma catestatin (ng/ml) and conducted Holter monitoring.Results. A pattern was found to reduce the concentration of catestatin with increasing risk of CVC in hypertensive patients, but there were no significant differences between the studied groups (p>0,05).We determined corrections between catestatin levels and echocardiography thickness of left ventricular posterior wall (r=-0,523; p=0,045) and interventricular septum (r=-0,523, p=0,045) in diastole in group 2; thickness of left ventricular posterior wall (r=0,258; p=0,035) and interventricular septum (r=0,254; p=0,038) in systole in group 3. In patients of group 2, direct correlations of catestatin levels and sympathicotonia LF/HF were revealed during the whole observation period (r=0,301; p=0,019) and during wakefulness (r=0,308; p=0,019); inverse correlations — with parameters of parasympathetic tone: nHF during the whole observation time (r=-0,318; p=0,013) and during wakefulness (r=-0,342; p=0,007), pNN50 in the afternoon (r=-0,270; p=0,037).Conclusion. A decrease in catestatin concentrations in hypertensive patients is associated with the progression of disease and an increase in cardiovascular risk. It is assumed that catestatin is involved in the formation of HRV in patients with primary hypertension.


2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Luis Antonio Moreno-Ruíz ◽  
David Ibarra-Quevedo ◽  
Erika Rodríguez-Martínez ◽  
Perla D. Maldonado ◽  
Benito Sarabia-Ortega ◽  
...  

The oxidative stress state is characterized by an increase in oxygen reactive species that overwhelms the antioxidant defense; we do not know if these pathological changes are correlated with alterations in left ventricular mechanics. The aim was correlating the oxidative stress state with the left ventricular global longitudinal strain (GLS) and the left ventricular end diastolic pressure (LVEDP). Twenty-five patients with essential hypertension and 25 controls paired by age and gender were studied. All of the participants were subjected to echocardiography and biochemical determination of oxidative stress markers. The hypertensive patients, compared with control subjects, had significantly (p<0.05) higher levels of oxidized proteins (5.03±1.05versus4.06±0.63 nmol/mg), lower levels of extracellular superoxide dismutase (EC-SOD) activity (0.045±0.02versus0.082±0.02 U/mg), higher LVEDP (16.2±4.5versus11.3±1.6 mm Hg), and lower GLS (−12% versus −16%). Both groups had preserved ejection fraction and the results showed a positive correlation of oxidized proteins with GLS (r=0.386,p=0.006) and LVEDP (r=0.389,p=0.005); we also found a negative correlation of EC-SOD activity with GLS (r=-0.404,p=0.004) and LVEDP (r=-0.347,p=0.014).


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