scholarly journals Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Jie Wang ◽  
Fei Lin ◽  
Li-li Guo ◽  
Xing-jiang Xiong ◽  
Xun Fan
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Artery Disease ◽  
Mitochondrial Dna ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cardiovascular System ◽  
Structure And Function ◽  
Mitochondrial Ros ◽  
Artery Disease ◽  
And Function

Recent studies demonstrated that mitochondria play an important role in the cardiovascular system and mutations of mitochondrial DNA affect coronary artery disease, resulting in hypertension, atherosclerosis, and cardiomyopathy. Traditional Chinese medicine (TCM) has been used for thousands of years to treat cardiovascular disease, but it is not yet clear how TCM affects mitochondrial function. By reviewing the interactions between the cardiovascular system, mitochondrial DNA, and TCM, we show that cardiovascular disease is negatively affected by mutations in mitochondrial DNA and that TCM can be used to treat cardiovascular disease by regulating the structure and function of mitochondria via increases in mitochondrial electron transport and oxidative phosphorylation, modulation of mitochondrial-mediated apoptosis, and decreases in mitochondrial ROS. However further research is still required to identify the mechanism by which TCM affects CVD and modifies mitochondrial DNA.

scholarly journals Retinal microvascular structure and function in patients with risk factors of atherosclerosis and coronary artery disease

2014 ◽  
Vol 233 (2) ◽  
pp. 478-484 ◽  
Author(s):  
Ali H. Al-Fiadh ◽  
Omar Farouque ◽  
Ryo Kawasaki ◽  
T.T. Nguyen ◽  
Nazim Uddin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Structure And Function ◽  
Artery Disease ◽  
And Function

scholarly journals Expert Survey on the Prevention and Treatment Situation of Traditional Chinese Medicine for Coronary Artery Disease

2015 ◽  
Vol 06 (02) ◽  
pp. 109-114 ◽  
Author(s):  
Ying-Fei Bi ◽  
Jing-Yuan Mao ◽  
Xian-Liang Wang ◽  
Zhi-Qiang Zhao ◽  
Bin Li ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Expert Survey ◽  
Treatment Situation ◽  
Prevention And Treatment ◽  
Artery Disease

scholarly journals Traditional Chinese Medicine for Coronary Artery Disease Treatment: Clinical Evidence From Randomized Controlled Trials

2021 ◽  
Vol 8 ◽  
Author(s):  
Bo Liang ◽  
Ning Gu
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Randomized Controlled Trials ◽  
Controlled Trials ◽  
Jadad Score ◽  
Randomized Controlled ◽  
Prevention And Treatment ◽  
Artery Disease

Traditional Chinese medicine has a history of more than 2,000 years and has been widely used in clinical practice. However, due to the lack of a reliable scientific basis, the role of traditional Chinese medicine in the prevention and treatment of coronary artery disease is not clear. At present, the existing randomized controlled trials about traditional Chinese medicine for coronary artery disease have defects, small sample sizes, and different results, so it is difficult to make a clear conclusion on the actual advantages and disadvantages of traditional Chinese medicine. In this review, the efficacy and safety of traditional Chinese medicine in the prevention and treatment of coronary artery disease were systematically evaluated through randomized controlled trials, most of which were double-blind trials. We reviewed 17 randomized controlled trials that included a total of 11,726 coronary artery disease patients. The methodological quality of the trials was generally high, with nine (52.94%) having a modified Jadad score of 7 and only three (17.65%) having a modified Jadad score of <3. There are 16 trials (94.12%) reporting safety; the safety of traditional Chinese medicine seems not to be inferior to that of mimetic, placebo, or western medications. Moreover, the results from 17 randomized controlled trials (100.00%) showed that traditional Chinese medicine can be applied as a complementary and alternative method to the primary and secondary prevention of coronary artery disease, and only six trials (35.29%) described adverse cardiovascular events specifically. However, it is necessary to assess the safety and efficacy of traditional Chinese medicine in treating coronary artery disease with long-term hard endpoints.

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