Metagenomics approach the intestinal microbiome structure and function in the anti-H1N1 of a traditional chinese medicine acid polysaccharide

2020 ◽  
Vol 147 ◽  
pp. 104351
Author(s):  
Lin Xiaoting ◽  
Liang Shanshan ◽  
Wang Qiuhong ◽  
Duanmu Weichen ◽  
Kuang Haixue
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Structure And Function ◽  
Intestinal Microbiome ◽  
Acid Polysaccharide ◽  
And Function

scholarly journals Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Jie Wang ◽  
Fei Lin ◽  
Li-li Guo ◽  
Xing-jiang Xiong ◽  
Xun Fan
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Artery Disease ◽  
Mitochondrial Dna ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cardiovascular System ◽  
Structure And Function ◽  
Mitochondrial Ros ◽  
Artery Disease ◽  
And Function

Recent studies demonstrated that mitochondria play an important role in the cardiovascular system and mutations of mitochondrial DNA affect coronary artery disease, resulting in hypertension, atherosclerosis, and cardiomyopathy. Traditional Chinese medicine (TCM) has been used for thousands of years to treat cardiovascular disease, but it is not yet clear how TCM affects mitochondrial function. By reviewing the interactions between the cardiovascular system, mitochondrial DNA, and TCM, we show that cardiovascular disease is negatively affected by mutations in mitochondrial DNA and that TCM can be used to treat cardiovascular disease by regulating the structure and function of mitochondria via increases in mitochondrial electron transport and oxidative phosphorylation, modulation of mitochondrial-mediated apoptosis, and decreases in mitochondrial ROS. However further research is still required to identify the mechanism by which TCM affects CVD and modifies mitochondrial DNA.

scholarly journals Imaging Diagnosis of Transient Ischemic Attack in Clinic and Traditional Chinese Medicine

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Qigu Yao ◽  
Lincheng Zhang ◽  
Jing Zhou ◽  
Min Li ◽  
Weifeng Jing ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Transient Ischemic Attack ◽  
Doppler Sonography ◽  
Clinical Symptoms ◽  
Transcranial Doppler Sonography ◽  
Imaging Modalities ◽  
Ischemic Attack ◽  
And Function ◽  
Ct And Mri

Neuroimaging plays a pivotal role in Transient Ischemic Attack (TIA). Generally, clinicians focus on the specific changes in morphology and function, but the diagnosis of TIA often depends on imaging evidence. Whereas Traditional Chinese Medicine (TCM) is concerned with the performance of clinical symptoms, they began to use imaging methods to diagnose TIA. CT and MRI are the recommended modality to diagnose TIA and image ischemic lesions. In addition, Transcranial Doppler sonography (TCD) and Digital Subtraction Angiography (DSA) are two acceptable alternatives for diagnosing TIA patients. This article elaborates the update of imaging modalities in clinic and the development of imaging modalities in TCM. Besides, multiple joint imaging technologies also will be evaluated whether enhanced diagnostic yields availably.

A metagenomics approach to the intestinal microbiome structure and function in high fat diet-induced obesity mice fed with oolong tea polyphenols

2018 ◽  
Vol 9 (2) ◽  
pp. 1079-1087 ◽  
Author(s):  
Mei Cheng ◽  
Xin Zhang ◽  
Jieyu Zhu ◽  
Lu Cheng ◽  
Jinxuan Cao ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Structure And Function ◽  
Tea Polyphenols ◽  
Intestinal Microbiome ◽  
Obese Mice ◽  
High Fat ◽  
Oolong Tea ◽  
Diet Induced Obesity ◽  
And Function ◽  
Human Flora

We investigate the modulatory effect of oolong tea polyphenols on the intestinal microbiota in human flora-associated high fat diet induced obese mice.

scholarly journals Intestinal Microbiota and Liver Diseases: Insights into Therapeutic Use of Traditional Chinese Medicine

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Tingshuai Wang ◽  
Shaodong Huang ◽  
Cong Wu ◽  
Na Wang ◽  
Rongzhen Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Intestinal Microbiota ◽  
High Throughput Sequencing ◽  
Rapid Development ◽  
Alternative Therapy ◽  
Intestinal Microbiome ◽  
Bile Acid Metabolism

Liver disease is a leading cause of global morbidity and mortality, for which inflammation, alcohol use, lipid metabolic disorders, disturbance to bile acid metabolism, and endotoxins are common risk factors. Traditional Chinese Medicine (TCM) with its “holistic approach” is widely used throughout the world as a complementary, alternative therapy, due to its clinical efficacy and reduced side effects compared with conventional medicines. However, due to a lack of reliable scientific evidence, the role of TCM in the prevention and treatment of liver disease remains unclear. Over recent years, with the rapid development of high-throughput sequencing, 16S rRNA detection, and bioinformatics methodology, it has been gradually recognized that the regulation of intestinal microbiota by TCM can play a substantial role in the treatment of liver disease. To better understand how TCM regulates the intestinal microbiota and suppresses liver disease, we have reviewed and analyzed the results of existing studies and summarized the relationship and risk factors between intestinal microbiota and liver disease. The present review summarizes the related mechanisms by which TCM affects the composition and metabolites of the intestinal microbiome.

scholarly journals QiShenYiQi Pills, a Compound Chinese Medicine, Ameliorates Doxorubicin-Induced Myocardial Structure Damage and Cardiac Dysfunction in Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Dong-Xin Tang ◽  
Hai-Ping Zhao ◽  
Chun-Shui Pan ◽  
Yu-Ying Liu ◽  
Xiao-Hong Wei ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Left Ventricle ◽  
Left Ventricular ◽  
Structure And Function ◽  
Heart Weight ◽  
Internal Diameter ◽  
Cardiac Structure ◽  
Sprague Dawley ◽  
Cardiac Structure And Function ◽  
And Function

QiShenYiQi Pills (QSYQ) is a compound Chinese medicine used for treatment of cardiovascular diseases. The present study investigated the effects of QSYQ on the Doxorubicin- (DOX-) induced disorders in rat cardiac structure and function and the possible mechanism underlying. A total of 24 male Sprague-Dawley rats were administrated by intraperitoneal injections with DOX at a dose of 2.5 mg/kg, once every day for a total of 6 times. After the 6th injection, the rats were evaluated by echocardiographic analysis, and the animals with injured heart(n=14)were divided into 2 groups and further treated with(n=7)or without(n=7)QSYQ by gavage at a dose of 0.2 g/day, once a day, over the next 2 weeks. Two weeks after QSYQ treatment, the following variables were assessed: myocardial blood flow (MBF) by Laser-Doppler Perfusion Imager, the ratio of heart weight to body weight (HW/BW), myocardial histology, myocardial content of ATP, AMP, free fatty acids (FFAs) and AMP/ATP by ELISA, and expression of PPARα, PGC-1α, and ATP 5D by Western blot. Statistical analysis was performed using one-way ANOVA followed by Turkey test for multiple comparisons. DOX challenge significantly increased left ventricular internal diameter and HW/BW and decreased the thickness of the left ventricular posterior wall, the left ventricle ejection fraction, and the left ventricle fractional shortening. DOX also increased AMP, FFA, and AMP/ATP, decreased ATP, and downregulated the protein content of ATP 5D, PPARα, and PGC-1α. All these DOX-induced cardiac insults were attenuated significantly by QSYQ treatment. These results show the potential of QSYQ to ameliorate DOX-induced disorders in cardiac structure and function; this effect may be related to the increase in myocardial ATP content via the upregulation of ATP 5D, PPARα, and PGC-1αand the oxidation of FFA.

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