scholarly journals Aspirin Resistance and Promoting Blood Circulation and Removing Blood Stasis: Current Situation and Prospectives

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Jie Wang ◽  
Xingjiang Xiong ◽  
Bo Feng

Aspirin plays a crucial physiological and pathophysiological role in cardiovascular diseases and cerebrovascular diseases by irreversibly inhibiting thromboxane A2. However, some patients may be “resistant” to its effect. The resistance has close association with adverse cardiovascular outcomes and increased mortality, so that resolving the problem of aspirin resistance (AR) is widely concerned. By studying the correlation between AR and blood stasis syndrome (BSS), it is demonstrated that BSS may be one of the pathogenesis of AR in traditional Chinese medicine. Chinese herb and formulas definitely possess the advantage of whole body regulation by many ways and many targets. It is a new direction for treatment of AR to combine TCM and modern medicine to study the mechanism and prevention of AR.

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Yue Liu ◽  
Hui-Jun Yin ◽  
Da-zhuo Shi ◽  
Ke-ji Chen

Atherothrombosis, which directly threatens people's health and lives, is the main cause of morbidity and mortality all over the world. Platelets play a key role in the development of acute coronary syndromes (ACSs) and contribute to cardiovascular events. Oral antiplatelet drugs are a milestone in the therapy of cardiovascular atherothrombotic diseases. In recent years, many reports have shown the possibility that “resistance” to oral anti-platelet drugs and many adverse reactions, such as serious bleeding risk, which provides an impetus for developing new anti-platelet drugs possesses highly efficiency and fewer adverse effects. Study on the blood stasis syndrome and promoting blood circulation and removing blood stasis is the most active field of research of integration of traditional and western medicine in China. Blood-stasis syndrome and platelet activation have close relationship, many Chinese herb and formulas for promoting blood circulation and removing blood stasis possess definite anti-platelet effect. This paper covers the progress of anti-platelet mechanism of Chinese herb and formulas for promoting blood circulation and removing blood stasis and is to be deeply discussed in further research.


2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Shichao Zheng ◽  
Yanling Zhang ◽  
Yanjiang Qiao

Qishen Yiqi formula (QSYQ) has the effect of tonifying Qi and promoting blood circulation, which is widely used to treat the cardiovascular diseases with Qi deficiency and blood stasis syndrome. However, the mechanism of QSYQ to tonify Qi and promote blood circulation is rarely reported at molecular or systems level. This study aimed to elucidate the mechanism of QSYQ based on the protein interaction network (PIN) analysis. The targets’ information of the active components was obtained from ChEMBL and STITCH databases and was further used to search against protein-protein interactions by String database. Next, the PINs of QSYQ were constructed by Cytoscape and were analyzed by gene ontology enrichment analysis based on Markov Cluster algorithm. Finally, based on the topological parameters, the properties of scale-free, small world, and modularity of the QSYQ’s PINs were analyzed. And based on function modules, the mechanism of QSYQ was elucidated. The results indicated that Qi-tonifying efficacy of QSYQ may be partly attributed to the regulation of amino acid metabolism, carbohydrate metabolism, lipid metabolism, and cAMP metabolism, while QSYQ improves the blood stasis through the regulation of blood coagulation and cardiac muscle contraction. Meanwhile, the “synergy” of formula compatibility was also illuminated.


2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Mei Xue ◽  
Xuesong Yang ◽  
Lin Yang ◽  
Na Kou ◽  
Yu Miao ◽  
...  

The identification of single nucleotide polymorphisms (SNPs) related to aspirin resistance (AR) is of great significance for the explanation why some individuals demonstrate an incomplete response to aspirin and for optimizing the antiplatelet therapy strategy. The study was designed to investigate the possible associated genetic markers and clinical factors of AR for Chinese patients with chronic stable angina after PCI and to analyze the association between TXA2, PGI2, hs-CRP level, AR, and gene polymorphisms. Totally 207 chronic stable angina patients who received 100 mg maintenance dose daily of aspirin for more than 7 days were enrolled. The inhibition of platelets was assessed using light transmittance aggregometry. TXB2, 6-keto-PGF1α, and hs-CRP were measured by radioimmunoassay. Genotyping was performed using Taqman probe technique (rs5787 and rs5911) and gene sequencing technology (rs3842788). By using binary logistic regression analysis, the impact of clinical and genetic determinants on AR was evaluated. The prevalence of AR and aspirin semiresistance (ASR) was 3.86% and 20.76%, respectively, in Chinese chronic stable angina patients. rs5911 A/C and C/C versus A/A genotype (OR = 5.546, 95% CI = 1.812–11.404), rs3842788 A/G versus G/G genotype (OR = 8.358, 95% CI = 2.470–28.286), and blood stasis syndrome (BSS, OR = 10.220, 95% CI = 4.242–24.621) were associated with AR, but rs5787 variants were all homozygous of G/G genotype. Plasma TXB2 and hs-CRP increased significantly in AR and ASR group, while 6-keto-PGF1αshowed no difference, and TXB2 level was significantly higher in carriers of the rs3842788 A/G genotype. According to our results, rs5911 and rs3842788 are proved to be specific genetic markers of AR in Chinese chronic stable angina patients for the first time, and BSS was also proved to be a remarkable determinant for AR. The AR and ASR patients were with increased plasma TXB2 and hs-CRP levels, and the TXB2 level was influenced by the variation of rs3842788 genotype.


2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mei Xue ◽  
Lin Yang ◽  
Na Kou ◽  
Yu Miao ◽  
Mingming Wang ◽  
...  

Aspirin should be continued indefinitely in patients after interventional therapy, but 10% to 40% of patients experience recurrent vascular events despite adequate aspirin therapy, a condition known as aspirin resistance (AR). Xuefuzhuyu oral liquid, derived from the classic recipe Xuefuzhuyu decoction, has been well documented to inhibit platelet aggregation and to improve hemorheology. The aims of this study were to investigate the effects of Xuefuzhuyu oral liquid on AR in patients with chronic stable angina after percutaneous coronary intervention (PCI) and the possible genetic markers related to the drug response. 43 patients diagnosed as having aspirin resistance or semi-resistance were randomly divided into control and treatment groups after screening 207 stable CHD patients. Platelet aggregation rate was determined using turbidimetry. Three single nucleotide polymorphisms in COX-1 (rs5787, rs3842788) and GP IIb (rs5911) were genotyped in whole blood samples using ABI PRISM 7900 HT Fast Real-Time instrument and ABI PRISM 3730 DNA Sequencer. The results showed that Xuefuzhuyu oral liquid could effectively improve blood stasis syndrome and AR by inhibiting ADP-induced platelet aggregation and that patients with the rs5911 genetic variant exhibited better drug response upon treatment with Xuefuzhuyu oral liquid, which suggests Xuefuzhuyu oral liquid as a new possible drug for the prevention of AR.


Author(s):  
Weibo LU

LANGUAGE NOTE | Document text in Chinese; abstract also in English.中西醫結合包含中醫和西醫之間的團結合作,但更重要的是中醫學和西醫學之間的互相結合。在世界上對傳統醫學曾有過三種方針,即“否定”,“容忍”和“平行”的方針,均不能充分發揮傳統醫學的作用和潛力。中國採取“結合”的方針,較好地解決了這一問題,不僅滿足當前醫療工作的需要,更重要的是在科學研究中,強調創新,兩種醫學的觀點、方法、優勢互補,獲得大量新的研究成果,如針刺原理和針麻研究,青萬素的發現,瘀血證研究等。雖然現代醫學是主流醫學,但尚不足以解決所有問題,如慢性病,老年病等。用結合的思想可以更好地解決各種難題,使醫學科學更快地向前發展,造福於人民。What attitude should we take toward traditional medicine? There have been three types of policies in this regard all over the world. First, the excluding policy prohibits practicing any traditional medicine. Traditional physicians are not qualified to possess the title of physician, and their practice is illegal. Second, the tolerating policy does not make illegal traditional medical practice, but it does not formally affirm the practice. Third, the paralleling policy allows both traditional and modem medical practices, but their use may not overlap. For example, traditional physicians may not use modem medical facilities.Since the establishment of the People’s Republic of China in 1949, a unique policy of integration has been adopted in China. This policy assumes that both traditional Chinese medicine and modern Western medicine have strengths and weaknesses. It requires that both types of medicine be integrated so as to develop more effective methods in treating diseases and preserving health.There are two senses of the integration of traditional Chinese and modern Western medicine. The first sense refers to the integration of the two types of the physicians, i.e., the cooperation between traditional Chinese practitioners and modern Western medical professionals. The second sense refers to the integration of the two disciplines; i.e., to use both traditional Chinese and modern Western medical theories and practices to create new forms of diagnostic and therapeutic approaches and means. The hope was to have the perspectives, methods, and solutions of both types of medicine complement each other.Under the integrating policy, traditional Chinese medicine has been developed tremendously in mainland China. 30 traditional Chinese medical colleges, 2457 traditional Chinese medical hospitals, and 170 traditional Chinese medical research institutions have been established. A number of well-known medical achievements, such as acupunctural analgesia and anesthesia, the discovery of a new type of anti-malaria drug - Qinghaosu (artemisinin), and the study of blood stasis syndrome, have been made by following the integrating strategy.With the rapid growth and development of the diagnostic and therapeutic technologies in modern Western medicine, some individuals are doubtful of the prospect of traditional Chinese medicine and of the necessity of China’s integrating strategy. However, no matter how advanced modern Western medicine as a form of medicine has become, it will not be able to handle all diseases or medical problems effectively and appropriately. The human body and medical reality are too complicated to be fixed by modern medicine once and for all. For instance, in the present time, chronic and geriatric diseases pose perplexing challenges to modern medicine. Possibilities are always open for traditional Chinese medicine as well as the integrated traditional Chinese and modern medicine to make their valuable contributions.DOWNLOAD HISTORY | This article has been downloaded 69 times in Digital Commons before migrating into this platform.


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