scholarly journals Chinese Herb and Formulas for Promoting Blood Circulation and Removing Blood Stasis and Antiplatelet Therapies

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Yue Liu ◽  
Hui-Jun Yin ◽  
Da-zhuo Shi ◽  
Ke-ji Chen
Keyword(s):  
Acute Coronary Syndromes ◽  
Blood Circulation ◽  
Adverse Reactions ◽  
Chinese Herb ◽  
Blood Stasis ◽  
Bleeding Risk ◽  
Blood Stasis Syndrome ◽  
The World ◽  
Close Relationship ◽  
Coronary Syndromes

Atherothrombosis, which directly threatens people's health and lives, is the main cause of morbidity and mortality all over the world. Platelets play a key role in the development of acute coronary syndromes (ACSs) and contribute to cardiovascular events. Oral antiplatelet drugs are a milestone in the therapy of cardiovascular atherothrombotic diseases. In recent years, many reports have shown the possibility that “resistance” to oral anti-platelet drugs and many adverse reactions, such as serious bleeding risk, which provides an impetus for developing new anti-platelet drugs possesses highly efficiency and fewer adverse effects. Study on the blood stasis syndrome and promoting blood circulation and removing blood stasis is the most active field of research of integration of traditional and western medicine in China. Blood-stasis syndrome and platelet activation have close relationship, many Chinese herb and formulas for promoting blood circulation and removing blood stasis possess definite anti-platelet effect. This paper covers the progress of anti-platelet mechanism of Chinese herb and formulas for promoting blood circulation and removing blood stasis and is to be deeply discussed in further research.

scholarly journals Aspirin Resistance and Promoting Blood Circulation and Removing Blood Stasis: Current Situation and Prospectives

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Jie Wang ◽  
Xingjiang Xiong ◽  
Bo Feng
Keyword(s):  
Blood Circulation ◽  
Close Association ◽  
Chinese Herb ◽  
Blood Stasis ◽  
Aspirin Resistance ◽  
Modern Medicine ◽  
Cerebrovascular Diseases ◽  
Blood Stasis Syndrome ◽  
Whole Body ◽  
Pathophysiological Role

Aspirin plays a crucial physiological and pathophysiological role in cardiovascular diseases and cerebrovascular diseases by irreversibly inhibiting thromboxane A2. However, some patients may be “resistant” to its effect. The resistance has close association with adverse cardiovascular outcomes and increased mortality, so that resolving the problem of aspirin resistance (AR) is widely concerned. By studying the correlation between AR and blood stasis syndrome (BSS), it is demonstrated that BSS may be one of the pathogenesis of AR in traditional Chinese medicine. Chinese herb and formulas definitely possess the advantage of whole body regulation by many ways and many targets. It is a new direction for treatment of AR to combine TCM and modern medicine to study the mechanism and prevention of AR.

Is there Sex-related Outcome Difference According to oral P2Y12 Inhibitors in Patients with Acute Coronary Syndromes? A Systematic Review and Meta-Analysis of 107,126 Patients

2019 ◽  
Vol 17 (2) ◽  
pp. 191-203
Author(s):  
Oliver Brown ◽  
Jennifer Rossington ◽  
Gill Louise Buchanan ◽  
Giuseppe Patti ◽  
Angela Hoye
Keyword(s):  
Systematic Review ◽  
Acute Coronary Syndromes ◽  
Meta Analysis ◽  
Indirect Comparison ◽  
Bleeding Risk ◽  
Cardiovascular Death ◽  
P2y12 Inhibitors ◽  
Significant Difference ◽  
Coronary Syndromes ◽  
Randomised Controlled

Background and Objectives: The majority of patients included in trials of anti-platelet therapy are male. This systematic review and meta-analysis aimed to determine whether, in addition to aspirin, P2Y12 blockade is beneficial in both women and men with acute coronary syndromes. </P><P> Methods: Electronic databases were searched and nine eligible randomised controlled studies were identified that had sex-specific clinical outcomes (n=107,126 patients). Risk Ratios (RR) and 95% Confidence Intervals (CI) were calculated for a composite of cardiovascular death, myocardial infarction or stroke (MACE), and a safety endpoint of major bleeding for each sex. Indirect comparison analysis was performed to statistically compare ticagrelor against prasugrel. </P><P> Results: Compared to aspirin alone, clopidogrel reduced MACE in men (RR, 0.79; 95% CI, 0.68 to 0.92; p=0.003), but was not statistically significant in women (RR, 0.88; 95% CI, 0.75 to 1.02, p=0.08). Clopidogrel therapy significantly increased bleeding in women but not men. Compared to clopidogrel, prasugrel was beneficial in men (RR, 0.84; 95% CI, 0.73 to 0.97; p=0.02) but not statistically significant in women (RR, 0.94; 95% CI, 0.83 to 1.06; p=0.30); ticagrelor reduced MACE in both men (RR, 0.85; 95% CI, 0.77 to 0.94; p=0.001) and women (RR, 0.84; 95% CI, 0.73 to 0.97; p=0.02). Indirect comparison demonstrated no significant difference between ticagrelor and prasugrel in either sex. Compared to clopidogrel, ticagrelor and prasugrel increased bleeding risk in both women and men. </P><P> Conclusion: In summary, in comparison to monotherapy with aspirin, P2Y12 inhibitors reduce MACE in women and men. Ticagrelor was shown to be superior to clopidogrel in both sexes. Prasugrel showed a statistically significant benefit only in men; however indirect comparison did not demonstrate superiority of ticagrelor over prasugrel in women.

scholarly journals Bleeding risk assessment and comorbidities in elderly patients with acute coronary syndromes

2016 ◽  
Vol 35 (4) ◽  
pp. 247-248
Author(s):  
Albert Ariza-Solé ◽  
Francesc Formiga ◽  
Eva Bernal ◽  
Alberto Garay
Keyword(s):  
Risk Assessment ◽  
Elderly Patients ◽  
Acute Coronary Syndromes ◽  
Bleeding Risk ◽  
Coronary Syndromes

Is it possible to separate ischemic and bleeding risk in patients with non-ST segment elevation acute coronary syndromes?

2014 ◽  
Vol 171 (3) ◽  
pp. 448-450 ◽  
Author(s):  
Albert Ariza-Solé ◽  
José C. Sánchez-Salado ◽  
Victoria Lorente ◽  
Guillermo Sánchez-Elvira ◽  
Guillem Muntané ◽  
...  
Keyword(s):  
Acute Coronary Syndromes ◽  
Bleeding Risk ◽  
St Segment Elevation ◽  
St Segment ◽  
Coronary Syndromes

scholarly journals Does anemia affect the predictive ability of bleeding risk scores in patients with acute coronary syndromes?

2016 ◽  
Vol 35 (12) ◽  
pp. 637-644
Author(s):  
Alberto Garay ◽  
Albert Ariza-Solé ◽  
Francesc Formiga ◽  
Victoria Lorente ◽  
José C. Sánchez-Salado ◽  
...  
Keyword(s):  
Acute Coronary Syndromes ◽  
Predictive Ability ◽  
Bleeding Risk ◽  
Risk Scores ◽  
Coronary Syndromes
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