scholarly journals Effects ofMomordica charantiaL. on the Blood Rheological Properties in Diabetic Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Eduardo Luzía França ◽  
Elton Brito Ribeiro ◽  
Edson Fredulin Scherer ◽  
Déborah Giovanna Cantarini ◽  
Rafael Souza Pessôa ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Rheological Properties ◽  
Blood Viscosity ◽  
Room Temperature ◽  
Rheological Parameters ◽  
Diabetic Patients ◽  
Blood Disorders ◽  
Glycemic Status ◽  
Blood Samples ◽  
Whole Blood Viscosity

An evaluation of the rheological properties and the effects ofMomordica. charantiaL. (M. charantia) nanoparticles and polyethylene glycol (PEG) microspheres adsorbed withM. charantiananoparticles on the blood of hyperglycemic patients is presented. Blood samples were collected according to glycemic status: normoglycemic(N=56)and hyperglycemic(N=26). General and hematological characteristics were determined. Blood rheological parameters were determined at room temperature and under a temperature scan. We determined the effects on whole blood viscosity of treatment with an extract ofM. charantia, PEG, or PEG microspheres adsorbed with plant extract. The viscosity of the blood of hyperglycemic patients is greater than that of normoglycemic patients. Nanoparticles ofM. charantiaextracts lowered blood viscosity at equivalent rates in normo- and hyperglycemic individuals. PEG microspheres did not reduce blood viscosity in hyperglycemic individuals. However, PEG microspheres adsorbed with nanofraction extracts ofM. charantiareduced blood viscosity. These data suggest that the effects of diabetes on the viscosity of the blood should be considered. The use of a nanoparticles extract ofM. charantiaand its adsorption on PEG microspheres may represent an alternative for the control and treatment of blood disorders in diabetic patients.

scholarly journals Analysis of the Magnetic Field Influence on the Rheological Properties of Healthy Persons Blood

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Anna Marcinkowska-Gapinska ◽  
Honorata Nawrocka-Bogusz
Keyword(s):  
Magnetic Field ◽  
Rheological Properties ◽  
Blood Viscosity ◽  
Flow Curve ◽  
Rheological Parameters ◽  
Blood Samples ◽  
The Magnetic Field ◽  
Field Influence ◽  
Healthy Persons

The influence of magnetic field on whole blood rheological properties remains a weakly known phenomenon. Anin vitroanalysis of the magnetic field influence on the rheological properties of healthy persons blood is presented in this work. The study was performed on blood samples taken from 25 healthy nonsmoking persons and included comparative analysis of the results of both the standard rotary method (flow curve measurement) and the oscillatory method known also as the mechanical dynamic analysis, performed before and after exposition of blood samples to magnetic field. The principle of the oscillatory technique lies in determining the amplitude and phase of the oscillations of the studied sample subjected to action of a harmonic force of controlled amplitude and frequency. The flow curve measurement involved determining the shear rate dependence of blood viscosity. The viscoelastic properties of the blood samples were analyzed in terms of complex blood viscosity. All the measurements have been performed by means of the Contraves LS40 rheometer. The data obtained from the flow curve measurements complemented by hematocrit and plasma viscosity measurements have been analyzed using the rheological model of Quemada. No significant changes of the studied rheological parameters have been found.

Rheological and Microvascular Parameters in Diabetic Peripheral Neuropathy

1996 ◽  
Vol 90 (3) ◽  
pp. 183-187 ◽  
Author(s):  
M. J. Young ◽  
J. L. Bennett ◽  
S. A. Liderth ◽  
A. Veves ◽  
A. J. M. Boulton ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Diabetic Peripheral Neuropathy ◽  
Diabetic Control ◽  
Erythrocyte Aggregation ◽  
Diabetic Patients ◽  
Whole Blood Viscosity ◽  
Control Subjects ◽  
Flow Units

1. In order to determine whether rheological changes occur in neuropathic diabetic patients in the absence of smoking, proteinuria, retinopathy or other factors thought to influence haemorheology, three groups of subjects were studied; 24 non-diabetic control subjects (C), 24 non-neuropathic (D) and 24 neuropathic (N) diabetic patients. The groups were matched for age, sex, type and duration of diabetes. No patient or control was a current smoker. No patient had clinically detectable retinopathy or microalbuminuria. Neuropathy was defined as a peroneal conduction velocity < 40 ms−1. All subjects were tested resting semi-recumbent after a light breakfast. 2. There were no significant differences in rheological or microvascular parameters between uncomplicated diabetic patients and non-diabetic control subjects, although peroneal nerve motor conduction velocity was significantly reduced in otherwise uncomplicated diabetic patients [C 51.7 ± 6.0 ms−1 (mean ± SD) versus D 45.1 ± 5.2 ms−1 (P<0.05 C versus D)]. 3. Transcutaneous oxygen and laser Doppler flux measured at 44°C were higher in control subjects than in neuropathic diabetic patients [C 76 ± 16 mmHg versus D 71 ± 10 mmHg versus N 63 ± 9 mmHg, and C 72 ± 40 flow units versus D 64 ± 41 flow units versus N 50 ± 26 flow units respectively (both P not significant C versus D, P<0.05 N versus C). 4. Erythrocyte aggregation, plasma viscosity and plasma fibrinogen were all significantly higher in the neuropathic diabetic patients compared with non-diabetic control subjects (all P<0.05 N versus C). Erythrocyte filtration was not significantly different between groups but was lower in diabetic patients. Whole-blood viscosity (corrected to 45% haematocrit) was significantly higher at both high (100 s−1) and low (1 s−1) shear rates in neuropathic diabetic patients than in non-diabetic control subjects (both P not significant C versus D, P<0.05 N versus C). There were no significant differences in whole-blood viscosity at a shear rate of 0.01 s−1. 5. In summary, there were no significant differences in rheological or microvascular parameters between matched groups of uncomplicated diabetic patients and control subjects, but erythrocyte aggregation, fibrinogen and plasma and corrected whole-blood viscosity were all significantly different in neuropathic diabetic patients compared with control subjects, as were assessments of microvascular flow. These results suggest that haemorheological changes are associated with disturbances of microvascular flow and diabetic peripheral neuropathy in the absence of other diabetic complications.

Change in Hemorrheological and Biochemical Parameters following Membrane Differential Filtration

1995 ◽  
Vol 18 (12) ◽  
pp. 794-798 ◽  
Author(s):  
R. Brunner ◽  
R.A. Widder ◽  
P. Walter ◽  
H. Borberg ◽  
K. Oette
Keyword(s):  
Visual Acuity ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Biochemical Parameters ◽  
Hdl Cholesterol ◽  
Plasma Viscosity ◽  
Erythrocyte Aggregation ◽  
Rheological Parameters ◽  
Whole Blood Viscosity ◽  
Differential Filtration

Introduction: The elimination of high molecular weight proteins may have a positive influence on disorders of the microcirculation due to an improvement in rheological parameters. We therefore attempted to evaluate the rheological efficacy of membrane differential filtration (MDF). Patients and methods: Ten patients suffering from macular disease underwent MDF. Rheological and biochemical parameters as well as visual acuity were determined one day before and after therapy: The study aimed at a reduction in plasma viscosity, standardized whole blood viscosity at hematocrit 0.45 and erythrocyte aggregation at hematocrit 0.3. Results: Severe side-effects were not observed. The rheological parameters were significantly reduced. In detail the posttreatment values were reduced as compared to the pretreatment values as follows: plasma viscosity 85%, standardised whole blood viscosity 86% (hematocrit 0.45), erythrocyte aggregation 59% (hematocrit 0.3), total protein 81%, IgG 66%, IgA 59%, IgM 33%, alpha-2-macroglobulin 30%, triglycerides 102%, total cholesterol 47%, VLDL cholesterol 94%, LDL cholesterol 33%, HDL cholesterol 62%. Visual acuity was improved in 7/10 patients. Conclusions: MDF is a safe and highly effective method for lowering biochemical and improving rheological parameters which led to improvement in visual acuity. We have already replaced plasma exchange with MDF in our clinical practice of hemorrheological therapy.

scholarly journals Vinpocetine and Pyritinol: A New Model for Blood Rheological Modulation in Cerebrovascular Disorders—A Randomized Controlled Clinical Study

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Hayder M. Alkuraishy ◽  
Ali I. Al-Gareeb ◽  
Ali K. Albuhadilly
Keyword(s):  
Blood Viscosity ◽  
Whole Blood ◽  
Cerebrovascular Disorders ◽  
Plasma Viscosity ◽  
Rheological Parameters ◽  
Total Serum Protein ◽  
Total Serum ◽  
Cell Deformability ◽  
Factors Affecting ◽  
Whole Blood Viscosity

Blood and plasma viscosity are the major factors affecting blood flow and normal circulation. Whole blood viscosity is mainly affected by plasma viscosity, red blood cell deformability/aggregation and hematocrit, and other physiological factors. Thirty patients (twenty males + ten females) with age range 50–65 years, normotensive with history of cerebrovascular disorders, were selected according to the American Heart Stroke Association. Blood viscosity and other rheological parameters were measured after two-day abstinence from any medications. Dual effects of vinpocetine and pyritinol exhibit significant effects on all hemorheological parameters (P<0.05), especially on low shear whole blood viscosity (P<0.01), but they produced insignificant effects on total serum protein and high shear whole blood viscosity (P>0.05). Therefore, joint effects of vinpocetine and pyritinol improve blood and plasma viscosity in patients with cerebrovascular disorders.

scholarly journals The Differences Result Of Platelets Count In K3edta Blood At Room Temperature (24-29°C) And Refrigerator (2-8°C) For 2 Hours

2018 ◽  
Vol 14 (1) ◽  
pp. 1-4
Author(s):  
Ratih Hardisari
Keyword(s):  
Room Temperature ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Blood Disorders ◽  
Cross Sectional ◽  
Blood Samples ◽  
Blood Tests ◽  
History Of ◽  
Laboratory Workers

Examination of platelets count is one of hematological examinations. This examination used K3EDTA blood samples which is better to be examined directly. The large number of blood samples in hospital causes nurses who take the sample do not directly bring them to laboratory and process of changing shifts on laboratory workers allows for a delay, causing platelets count decrease, so the K3EDTA blood sample should be stored at the refigerator (2-8°C) when examination delays. This study was aimed to find out the differences result of platelets count in the K3EDTA blood stored at room temperature (24-29ºC) and refigerator (2-8oC) for 2 hours. This study is a quantitative approach to the design of observational analytic with cross-sectional study, where K3EDTA blood tests stored at room temperature (24-29ºC) and refigerator (2-8º C) at the same time. The subjects of this research were 30 blood samples were taken using vein puncture from Health Analyst students aged around 18-21 years old and had no history of blood disorders, especially abnormalities of platelet count. The result of platelets count examination of K3EDTA blood stored in refigerator (2-8°C) for 2 hours tend to be higher than in K3EDTA blood samples stored at room temperature (24-29°C), with p value 0.046 (p <0,05). The average number of platelets in the K3EDTA blood stored at room temperature (24-29°C) was 276,000 cells/mm3 and stored in refrigerator (2-8°C) was 304 000 cells/mm3. The conclusion is there are significant differences in the result of platelets count in the K3EDTA blood stored at room temperature (24-29ºC) and refigerator (2-8°C) for 2 hours.

Viscosity and Red Cell Deformity in Arterial Disease

1979 ◽  
Author(s):  
G Cella ◽  
H de Haas ◽  
M Rampling ◽  
V Kakkar
Keyword(s):  
Vascular Disease ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Arterial Disease ◽  
Plasma Viscosity ◽  
Control Group ◽  
Fibrinogen Concentration ◽  
Red Cell ◽  
Whole Blood Viscosity ◽  
Significant Difference

Haemorrheological factors have been shown to be affected in many kings of vascular disease. The present study was undertaken to correlate these factors in normal subjects and patients suffering from peripheral arterial disease. Twenty-two patients were investigated; they had moderate or severe intermittent claudication, extent of disease being confirmed by aorto-arteriography and ankle-systolic pressure studies. Twenty-five controls with no symptoms or signs of arterial disease were selected with comparable age and sex distribution. Whole blood viscosity was measured at shear rates of 230 secs-1 and 23 secs-lat 37°c using a Wells Brookfield cone plate microvisco meter. Plasma viscosity was also measured in an identical manner. Erythrocyte flexibility was measured by centrifuge technique and fibrinogen concentration as well as haematocrit by standard techniques. The fibrinogen concentration appeared to be the only significant parameter; the mean concentration in patients with peripheral vascular disease of 463 ± 73mg/l00ml in the control group ( < 0.05). Although whole blood viscosity was high in patients, when corrected to a common haematocrit, there was no significant difference between patients and controls. The same megative correlation was found for plasma viscosity. The red cell flexibility was found to be increased in patients as compared to the control group, but this effect appeared to be simply proportional to the fibrinogen concentration.

Seed-mediated synthesis and PEG coating of gold nanoparticles for controlling morphology and sizes

MRS Advances ◽  
2020 ◽  
Vol 5 (63) ◽  
pp. 3353-3360
Author(s):  
Susana Helena Arellano Ramírez ◽  
Perla García Casillas ◽  
Christian Chapa González
Keyword(s):  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Room Temperature ◽  
Colloidal Stability ◽  
Infrared Spectrometry ◽  
Ammonium Bromide ◽  
Chloroauric Acid ◽  
Vis Spectroscopy ◽  
Seed Mediated ◽  
Peg Coating

AbstractA significant area of research is biomedical applications of nanoparticles which involves efforts to control the physicochemical properties through simple and scalable processes. Gold nanoparticles have received considerable attention due to their unique properties that they exhibit based on their morphology. Gold nanospheres (AuNSs) and nanorods (AuNRs) were prepared with a seed-mediated method followed of polyethylene glycol (PEG)-coating. The seeds were prepared with 0.1 M cetyltrimethyl-ammonium bromide (CTAB), 0.005 M chloroauric acid (HAuCl4), and 0.01 M sodium borohydride (NaBH4) solution. Gold nanoparticles with spherical morphology was achieved by growth by aggregation at room temperature, while to achieve the rod morphology 0.1 M silver nitrate (AgNO3) and 0.1 M ascorbic acid solution were added. The gold nanoparticles obtained by the seed-mediated synthesis have spherical or rod shapes, depending on the experimental conditions, and a uniform particle size. Surface functionalization was developed using polyethylene glycol. Morphology, and size distribution of AuNPs were evaluated by Field Emission Scanning Electron Microscopy. The average size of AuNSs, and AuNRs was 7.85nm and 7.96 x 31.47nm respectively. Fourier transform infrared spectrometry was performed to corroborate the presence of PEG in the AuNPs surface. Additionally, suspensions of AuNSs and AuNRs were evaluated by UV-Vis spectroscopy. Gold nanoparticles were stored for several days at room temperature and it was observed that the colloidal stability increased once gold nanoparticles were coated with PEG due to the shield formed in the surface of the NPs and the increase in size which were 9.65±1.90 nm of diameter for AuNSs and for AuNRs were 29.03±5.88 and 8.39±1.02 nm for length and transverse axis, respectively.

scholarly journals Influence of biopolymers on the rheological properties of seafloor sediments and the runout behavior of submarine debris flows

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jun Kameda ◽  
Hamada Yohei
Keyword(s):  
Rheological Properties ◽  
Debris Flows ◽  
Extracellular Polymeric Substances ◽  
Flow Behavior ◽  
Mass Movement ◽  
Rheological Parameters ◽  
Natural Environments ◽  
Natural Systems ◽  
Chemical Conditions ◽  
Seafloor Sediments

AbstractSubmarine debris flows are mass movement processes on the seafloor, and are geohazards for seafloor infrastructure such as pipelines, communication cables, and submarine structures. Understanding the generation and run-out behavior of submarine debris flows is thus critical for assessing the risk of such geohazards. The rheological properties of seafloor sediments are governed by factors including sediment composition, grain size, water content, and physico-chemical conditions. In addition, extracellular polymeric substances (EPS) generated by microorganisms can affect rheological properties in natural systems. Here we show that a small quantity of EPS (~ 0.1 wt%) can potentially increase slope stability and decrease the mobility of submarine debris flows by increasing the internal cohesion of seafloor sediment. Our experiments demonstrated that the flow behavior of sediment suspensions mixed with an analogue material of EPS (xanthan gum) can be described by a Herschel–Bulkley model, with the rheological parameters being modified progressively, but not monotonously, with increasing EPS content. Numerical modeling of debris flows demonstrated that the run-out distance markedly decreases if even 0.1 wt% of EPS is added. The addition of EPS can also enhance the resistivity of sediment to fluidization triggered by cyclic loading, by means of formation of an EPS network that binds sediment particles. These findings suggest that the presence of EPS in natural environments reduces the likelihood of submarine geohazards.

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