scholarly journals Analysis of the Magnetic Field Influence on the Rheological Properties of Healthy Persons Blood

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Anna Marcinkowska-Gapinska ◽  
Honorata Nawrocka-Bogusz
Keyword(s):  
Magnetic Field ◽  
Rheological Properties ◽  
Blood Viscosity ◽  
Flow Curve ◽  
Rheological Parameters ◽  
Blood Samples ◽  
The Magnetic Field ◽  
Field Influence ◽  
Healthy Persons

The influence of magnetic field on whole blood rheological properties remains a weakly known phenomenon. Anin vitroanalysis of the magnetic field influence on the rheological properties of healthy persons blood is presented in this work. The study was performed on blood samples taken from 25 healthy nonsmoking persons and included comparative analysis of the results of both the standard rotary method (flow curve measurement) and the oscillatory method known also as the mechanical dynamic analysis, performed before and after exposition of blood samples to magnetic field. The principle of the oscillatory technique lies in determining the amplitude and phase of the oscillations of the studied sample subjected to action of a harmonic force of controlled amplitude and frequency. The flow curve measurement involved determining the shear rate dependence of blood viscosity. The viscoelastic properties of the blood samples were analyzed in terms of complex blood viscosity. All the measurements have been performed by means of the Contraves LS40 rheometer. The data obtained from the flow curve measurements complemented by hematocrit and plasma viscosity measurements have been analyzed using the rheological model of Quemada. No significant changes of the studied rheological parameters have been found.

scholarly journals Effects ofMomordica charantiaL. on the Blood Rheological Properties in Diabetic Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Eduardo Luzía França ◽  
Elton Brito Ribeiro ◽  
Edson Fredulin Scherer ◽  
Déborah Giovanna Cantarini ◽  
Rafael Souza Pessôa ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Rheological Properties ◽  
Blood Viscosity ◽  
Room Temperature ◽  
Rheological Parameters ◽  
Diabetic Patients ◽  
Blood Disorders ◽  
Glycemic Status ◽  
Blood Samples ◽  
Whole Blood Viscosity

An evaluation of the rheological properties and the effects ofMomordica. charantiaL. (M. charantia) nanoparticles and polyethylene glycol (PEG) microspheres adsorbed withM. charantiananoparticles on the blood of hyperglycemic patients is presented. Blood samples were collected according to glycemic status: normoglycemic(N=56)and hyperglycemic(N=26). General and hematological characteristics were determined. Blood rheological parameters were determined at room temperature and under a temperature scan. We determined the effects on whole blood viscosity of treatment with an extract ofM. charantia, PEG, or PEG microspheres adsorbed with plant extract. The viscosity of the blood of hyperglycemic patients is greater than that of normoglycemic patients. Nanoparticles ofM. charantiaextracts lowered blood viscosity at equivalent rates in normo- and hyperglycemic individuals. PEG microspheres did not reduce blood viscosity in hyperglycemic individuals. However, PEG microspheres adsorbed with nanofraction extracts ofM. charantiareduced blood viscosity. These data suggest that the effects of diabetes on the viscosity of the blood should be considered. The use of a nanoparticles extract ofM. charantiaand its adsorption on PEG microspheres may represent an alternative for the control and treatment of blood disorders in diabetic patients.

In Vitro Evaluation of Capturing and Dissolving the Clot by Magnetic Nanoparticles Carrying a Thrombolytic Agents Instead of Temporary Inferior Vena Cava (IVC) Filter

2020 ◽  
Vol 16 (11) ◽  
pp. 1623-1632
Author(s):  
Abbas Moghanizadeh ◽  
Fakhreddin Ashrafizadeh ◽  
Jaleh Varshousaz ◽  
Mahshid Kharaziha
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Vena Cava ◽  
Simple Method ◽  
Thrombolytic Agents ◽  
Blood Clots ◽  
Life Threatening ◽  
The Magnetic Field ◽  
Different Levels

This study aims to evaluate the efficiency of a novel in vitro technique in clot capturing and dissolving them by applying magnetic force on magnetic nanoparticles (MNP) carrying thrombolytic agents. It is a quick and simple method to protect patients from a life-threatening pulmonary embolism in an emergency to provide time for the medical team. To analyze the in vitro efficiency of nano-magnetic capturing and dissolving of clots (NCDC), different levels of process parameter including strength magnetic field (0.1, 0.2 and 0.3 T) and fluid flow rate (2.5, 5 and 7 l/min) are exposed to different blood clots sizes from 5 × 10 to 20 × 10 mm2 (length × diameter), in an in vitro flow model. The results show that by increasing the parameters to their maximum values, it is possible to immobilize 100% of the clots and dissolve around 61.4% of clots weight. In addition, the clot-dissolving is directly proportional to the magnetic field strength. NCDC is an efficient technique in immobilizing and dissolving the clots and its efficiency depends on process parameters especially the magnetic field.

scholarly journals Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death

2018 ◽  
Author(s):  
Mahendran Subramanian ◽  
Arkadiusz Miaskowski ◽  
Stuart Iain Jenkins ◽  
Jenson Lim ◽  
Jon Dobson
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Field Gradient ◽  
Biomedical Applications ◽  
Magnetic Field Gradient ◽  
Field Source ◽  
Remote Manipulation ◽  
Cancer Cell Death ◽  
The Magnetic Field

AbstractThe manipulation of magnetic nanoparticles (MNPs) using an external magnetic field, has been demonstrated to be useful in various biomedical applications. Some techniques have evolved utilizing this non-invasive external stimulus but the scientific community widely adopts few, and there is an excellent potential for more novel methods. The primary focus of this study is on understanding the manipulation of MNPs by a time-varying static magnetic field and how this can be used, at different frequencies and displacement, to manipulate cellular function. Here we explore, using numerical modeling, the physical mechanism which underlies this kind of manipulation, and we discuss potential improvements which would enhance such manipulation with its use in biomedical applications, i.e., increasing the MNP response by improving the field parameters. From our observations and other related studies, we infer that such manipulation depends mostly on the magnetic field gradient, the magnetic susceptibility and size of the MNPs, the magnet array oscillating frequency, the viscosity of the medium surrounding MNPs, and the distance between the magnetic field source and the MNPs. Additionally, we demonstrate cytotoxicity in neuroblastoma (SH-SY5Y) and hepatocellular carcinoma (HepG2) cells in vitro. This was induced by incubation with MNPs, followed by exposure to a magnetic field gradient, physically oscillating at various frequencies and displacement amplitudes. Even though this technique reliably produces MNP endocytosis and/or cytotoxicity, a better biophysical understanding is required to develop the mechanism used for this precision manipulation of MNPs, in vitro.

scholarly journals Velocity and temperature maldistribution due to the magnetic field influence

2014 ◽  
Vol 31 (86(3/2014)) ◽  
pp. 425-432 ◽  
Author(s):  
Łukasz Pleskacz ◽  
Elżbieta Fornalik-Wajs ◽  
Aleksandra Roszko
Keyword(s):  
Magnetic Field ◽  
The Magnetic Field ◽  
Field Influence

The effect of propranolol on blood viscosity changes induced by experimental coronary occlusion

1984 ◽  
Vol 62 (10) ◽  
pp. 1333-1337 ◽  
Author(s):  
G. P. Biro ◽  
Diana Beresford-Kroeger
Keyword(s):  
Coronary Artery ◽  
Blood Viscosity ◽  
Coronary Occlusion ◽  
Blood Samples ◽  
Coronary Ligation ◽  
Anesthetized Dogs ◽  
Propranolol Treatment ◽  
Viscosity Changes ◽  
Low Shear

The effect of propranolol treatment was investigated in the myocardial ischemia-induced hyperviscosity state in anesthetized dogs. In untreated control dogs, low shear blood viscosity rose progressively, following an acute occlusion of the left anterior descending coronary artery; this effect was partially but significantly reduced by intravenously administered propranolol (0.2 mg/kg). The effect of the in vitro addition of propranolol was also determined upon viscosity of blood samples obtained at hourly intervals from dogs subjected to similar coronary ligation. The in vitro addition of propranolol did not produce a similar reversal of the hyperviscosity state observed in the blood obtained from dogs after coronary ligation.

The Magnetic Field Influence on a Superconducting Bisoliton Condensate

1990 ◽  
Vol 157 (1) ◽  
pp. 417-424 ◽  
Author(s):  
L. S. Brizhik ◽  
A. S. Davydov ◽  
V. N. Ermakov
Keyword(s):  
Magnetic Field ◽  
The Magnetic Field ◽  
Field Influence

Arg-Gly-Asp Peptide-Functionalized Superparamagnetic γ-Fe2O3 Nanoparticles Enhance Osteoblast Migration In Vitro

2020 ◽  
Vol 20 (10) ◽  
pp. 6173-6179
Author(s):  
Xue Liu ◽  
Xiao-Ling Yang ◽  
Qiao Hu ◽  
Mao-Shi Liu ◽  
Tao Peng ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Cell Therapy ◽  
Bone Repair ◽  
Cartilage Regeneration ◽  
Uniform Size ◽  
Low Cytotoxicity ◽  
The Magnetic Field ◽  
And Cartilage ◽  
Osteoblast Migration

Making osteoblast migration manageably target to injury sites has been the key challenging in cell therapy for bone and cartilage regeneration. Superparamagnetic materials, the magnetic guide for cell migration, have been applied to increase cell retention. However, additional targeting modifications are still needed to accelerate the low uptake efficiency and moving speed. Arg-Gly-Asp peptide (RGD)-functionalized magnetic nanoparticles showed cutting-edge competence in cell differentiation control and targeted drug delivery. However, more evidence was required to corroborate its role in osteoblast migration in bone repair. In the present study, RGD-modified γ-Fe2O3 nanoparticles (RGD-Fe2O3 NPs) were prefabricated with the grafting ratio of 33.3–37.4%. The RGD-Fe2O3 NPs unveiled excellent water dispersibility with uniform size distribution at 5–6 nm and negligibly low cytotoxicity. As a result, MC3T3-E1 osteoblasts treated with RGD-Fe2O3 NPs boosted its migration speed in a magnetic field compared with those incubated with unmodified Fe2O3 NPs. Furthermore, osteoblasts treated with RGD-Fe2O3 NPs exhibited more Fe uptake. The results exposed the fact that RGD-mediated specific cellular uptake presented higher efficiency than the non-RGD-mediated one, resulting from a stronger superparamagnetic force between the labeled cells and the magnetic field. These findings indicate that the RGD-functionalized Fe2O3 NPs can promote osteoblast migration in the magnetic field, providing a promising strategy in magnet-guided cell therapy for bone and cartilage regeneration.

Investigation of DC Vacuum Arc Interruption Ability with Combined Axial and Radial Magnetic Field

2012 ◽  
Vol 516-517 ◽  
pp. 1791-1797 ◽  
Author(s):  
Mohmmad Al Dweikat ◽  
Yu Long Huang ◽  
Xiao Lin Shen ◽  
Wei Dong Liu
Keyword(s):  
Magnetic Field ◽  
Axial Magnetic Field ◽  
Vacuum Arc ◽  
Axial Component ◽  
Circuit Breakers ◽  
Radial Magnetic Field ◽  
Vacuum Interrupter ◽  
Magnetic Field Simulation ◽  
The Magnetic Field ◽  
Field Influence

DC Vacuum Circuit Breakers based arc control has been a major topic in the last few decades. Understanding vacuum arc (VA) gives the ability to improve vacuum circuit breakers capacity. In this paper, the interaction of a DC vacuum arc with a combined Axial-Radial magnetic field was investigated. The proposed system contains an external coil to produce axial magnetic field (AMF) across the vacuum chamber. The vacuum interrupter (VI) contacts were assumed to be untreated radial magnetic field (RMF) contacts. For this purpose, Finite Element Method (FEM) based Multiphysics simulation of the immerging magnetic field influence on the VA is presented. The simulation shown the ability of the presented system to deflect high DC vacuum arc, also reveals that the vacuum arc interruption capability increases with the rise of the axial component of the magnetic field. Simulation results shown that this method can be applied to improve the interruption capability of the VI.

scholarly journals Rheological Properties of the Erythrocytes in Weakened Static Magnetic Field of the Earth In vitro Study

2019 ◽  
pp. 1-12
Author(s):  
L. N. Katiukhin
Keyword(s):  
Magnetic Field ◽  
Rheological Properties ◽  
In Vitro Study ◽  
Body Volume ◽  
Osmotic Gradient ◽  
Long Term Storage ◽  
The Earth ◽  
Average Body

Background: The magnetobiological effect of the weakened magnetic field of the Earth is of interest due to the consequences of the long stay of astronauts in space. Objective: The rheological properties of erythrocytes in a weakened magnetic field of the Earth are investigated. Methods: Osmotic gradient ektacytometry, aggregometry. Results: A study of the rheological properties of erythrocytes of blood rats in vitro, exposed at a temperature of 0°C in a natural and weakened magnetic field of the Earth, was carried out. It is established that a weakened magnetic field leads to a decrease in the rate of hemolysis, the average body volume, transformation, and decrease in the specific surface of the erythrocyte, potentiates the weakening of the deformation and aggregation properties. Conclusions: The results of the work should be taken into account not only to predict the rheological behavior of the blood system when the natural magnetic field is weakened but also to optimize the conditions for the long-term storage of donor blood.

scholarly journals Moderate Range Static Magnetic Field Promoted Variation of Blood Parameters: An In vitro Study

2020 ◽  
Vol 8 (1) ◽  
pp. 55-64
Author(s):  
Bestoon T. Mustafa ◽  
Sardar P. Yaba ◽  
Asaad H. Ismail
Keyword(s):  
Magnetic Field ◽  
Blood Cell ◽  
Static Magnetic Field ◽  
Blood Cells ◽  
White Blood Cells ◽  
Albino Rats ◽  
Field Exposure ◽  
Blood Samples ◽  
Cell Counts

This study was undertaken to investigate the influence of a homogenous and uniform static magnetic field (SMF) on the main blood cell counts in vitro experiment. Fresh blood samples were collected from albino rats and exposed to SMF (2.4, 6, 25, 50, 75, and 100 mT) versus 15–60 min. Results showed a significant change of blood counts under the low field effects. A 2.4 mT was a trend of white blood cells (WBCs) count increase non-linearly. However, a 6 mT exposure reduced WBCs with about 39%. Other variations fluctuated within 30%. The 25 mT decreased red blood cells (RBCs), hemoglobin, and hematocrit levels with 13% similarly. The lower exposure field, (2.4 and 6) mT, and effects on RBCs were 6% fluctuation. The 6 mT reduced platelet counts with half in comparison to control blood samples. About 20% increase obtained due to 50 mT exposure during all period. None of 75 and 100 mT exposures dominated blood counts alterations. The quiet magnetic field exposure for a certain time can be interesting to control blood cell count-related diseases.

Sign in / Sign up

Export Citation Format

Share Document