Rheological and Microvascular Parameters in Diabetic Peripheral Neuropathy

1996 ◽  
Vol 90 (3) ◽  
pp. 183-187 ◽  
Author(s):  
M. J. Young ◽  
J. L. Bennett ◽  
S. A. Liderth ◽  
A. Veves ◽  
A. J. M. Boulton ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Diabetic Peripheral Neuropathy ◽  
Diabetic Control ◽  
Erythrocyte Aggregation ◽  
Diabetic Patients ◽  
Whole Blood Viscosity ◽  
Control Subjects ◽  
Flow Units

1. In order to determine whether rheological changes occur in neuropathic diabetic patients in the absence of smoking, proteinuria, retinopathy or other factors thought to influence haemorheology, three groups of subjects were studied; 24 non-diabetic control subjects (C), 24 non-neuropathic (D) and 24 neuropathic (N) diabetic patients. The groups were matched for age, sex, type and duration of diabetes. No patient or control was a current smoker. No patient had clinically detectable retinopathy or microalbuminuria. Neuropathy was defined as a peroneal conduction velocity < 40 ms−1. All subjects were tested resting semi-recumbent after a light breakfast. 2. There were no significant differences in rheological or microvascular parameters between uncomplicated diabetic patients and non-diabetic control subjects, although peroneal nerve motor conduction velocity was significantly reduced in otherwise uncomplicated diabetic patients [C 51.7 ± 6.0 ms−1 (mean ± SD) versus D 45.1 ± 5.2 ms−1 (P<0.05 C versus D)]. 3. Transcutaneous oxygen and laser Doppler flux measured at 44°C were higher in control subjects than in neuropathic diabetic patients [C 76 ± 16 mmHg versus D 71 ± 10 mmHg versus N 63 ± 9 mmHg, and C 72 ± 40 flow units versus D 64 ± 41 flow units versus N 50 ± 26 flow units respectively (both P not significant C versus D, P<0.05 N versus C). 4. Erythrocyte aggregation, plasma viscosity and plasma fibrinogen were all significantly higher in the neuropathic diabetic patients compared with non-diabetic control subjects (all P<0.05 N versus C). Erythrocyte filtration was not significantly different between groups but was lower in diabetic patients. Whole-blood viscosity (corrected to 45% haematocrit) was significantly higher at both high (100 s−1) and low (1 s−1) shear rates in neuropathic diabetic patients than in non-diabetic control subjects (both P not significant C versus D, P<0.05 N versus C). There were no significant differences in whole-blood viscosity at a shear rate of 0.01 s−1. 5. In summary, there were no significant differences in rheological or microvascular parameters between matched groups of uncomplicated diabetic patients and control subjects, but erythrocyte aggregation, fibrinogen and plasma and corrected whole-blood viscosity were all significantly different in neuropathic diabetic patients compared with control subjects, as were assessments of microvascular flow. These results suggest that haemorheological changes are associated with disturbances of microvascular flow and diabetic peripheral neuropathy in the absence of other diabetic complications.

scholarly journals The Efficacy of Adding Electromagnetic Therapy or Laser Therapy to Medications in Patients With Diabetic Peripheral Neuropathy

2020 ◽  
Vol 11 (1) ◽  
pp. 20-28 ◽  
Author(s):  
Alsayed A. Shanb ◽  
Enas F. Youssef ◽  
Waleed I. Al Baker ◽  
Fahd A. Al-Khamis ◽  
Ali Hassan ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Laser Therapy ◽  
Diabetic Peripheral Neuropathy ◽  
Diabetic Control ◽  
Common Disease ◽  
Diabetic Patients ◽  
Mean Values ◽  
Conduction Velocities ◽  
Significant Burden ◽  
Magnetic Therapy

Introduction: Diabetes mellitus (DM) is a common disease with a highly significant burden among the Saudi population. This study aimed to investigate the effects of adding either magnetic or laser therapy to medications in patients with diabetic peripheral neuropathy (DPN). Methods: Seventy-one medically controlled diabetic patients were randomly assigned to 1) Magnetic group: 26 patients were exposed to magnetic therapy for 20 minutes/session, 2 sessions/week, for 3 months 2) Laser group: 25 patients were exposed to laser therapy with intensity 5.7 J/cm2 for 30 minutes/session, 2 times/week, for 3 months. 3) Drug group: 20 patients received only the regular medications for diabetic control and pain analgesia. Pain and neuropathy were assessed by the visual analog scale (VAS) and the Toronto Clinical Neuropath Scoring System (TRCNSS). Conduction velocities and amplitudes of peroneal and sural nerves were measured by electromyography. Results: The results showed significant increases in conduction velocities and amplitudes in both magnetic and laser groups in parallel with significant reductions in TRCNSS. Non-significant changes were obtained only after using only medications (P>0.05). The mean values of VAS reduced significantly in the three groups. The least significant differences showed significant changes among the three groups, whereas non-significant differences were obtained between both magnetic and laser groups. Conclusion: There were non-significant differences between both magnetic and laser therapy groups. Addition of either magnetic or laser therapy to medications could bring extra positive benefits to patients with DPN. Both magnetic and laser therapy can be applied with medications for the treatment of patients with DPN.

Influence of Postoperative Patient-Controlled Analgesia on Hemorheology in Patients Undergoing Hip Arthroplasty

2019 ◽  
Vol 158 (01) ◽  
pp. 41-45
Author(s):  
Yiping Bai ◽  
Liqun Mo ◽  
Liming Luan ◽  
Daiying Zhang
Keyword(s):  
Shear Rate ◽  
Hip Arthroplasty ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Plasma Viscosity ◽  
Erythrocyte Aggregation ◽  
Control Group ◽  
Patient Controlled Analgesia ◽  
Noninvasive Blood Pressure ◽  
Whole Blood Viscosity

Abstract Objective To test the hypothesis that patient-controlled analgesia (PCA) contributes to improvement of hemorheology in patients undergoing hip arthroplasty. Methods 120 patients, aged 60 – 75 years old, undergoing hip arthroplasty under spinal anesthesia, were randomly divided into group PCA (n = 60) and control group (n = 60). Patients in PCA group received PCA in postoperative 3 days. Blood samples from the median cubital vein were collected at five time points: before anesthesia (T1), after surgery (T2), 6 h after surgery (T3), 24 h after surgery (T4), 48 h after surgery (T5). Hemorheological parameters were measured, including whole blood viscosity at a high shear rate (Hηb), whole blood viscosity at a low shear rate (Lηb), reduced viscosity (ηr), plasma viscosity (ηp), hematocrit (Hct), erythrocyte aggregation index(EAI) and erythrocyte deformation index (EDI). Noninvasive blood pressure and heart rate at T1-5 and pain scoring of visual analogue scale (VAS) score at T2-5 were recorded. Results (1) Compared with T1, Hηb, Lηb, ηp, ηr decreased significantly at T3–5 with EAI decreased significantly at T5 in group PCA (p < 0.05), EDI increased significantly at T5 in group C (p < 0.05). (2) Compared with group C, Hηb, Lηb, ηp, ηr, EAI decreased significantly at T5 with Lηb concurrently decreased at T4 in group PCA (p < 0.05). Conclusion Postoperative pain may increase blood viscosity in patients undergoing hip arthroplasty, mainly via plasma viscosity, erythrocyte aggregation and rigidity, and which could be improved by postoperative PCA.

Comparison between whole blood viscosity measured and calculated in subjects with monoclonal gammopathy of undetermined significance and in patients with multiple myeloma: Re-evaluation of our survey

2021 ◽  
pp. 1-9
Author(s):  
Melania Carlisi ◽  
Salvatrice Mancuso ◽  
Rosalia Lo Presti ◽  
Sergio Siragusa ◽  
Gregorio Caimi
Keyword(s):  
Plasma Protein ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Fibrinogen Level ◽  
Surrogate Marker ◽  
Plasma Viscosity ◽  
Erythrocyte Aggregation ◽  
Total Plasma ◽  
Whole Blood Viscosity ◽  
Total Plasma Protein

BACKGROUND: in this study, with a re-evaluation of the hemorheological determinants previously described in MGUS subjects and in MM patients, we have detected the calculated whole blood viscosity, according whether to the hematocrit and total plasma protein concentration (de Simone formula) or to the haematocrit and plasma fibrinogen level (Merrill formula), and a marker of the erythrocyte aggregation (albumin/fibrinogen level). METHODS: data were expressed as means±standard deviation. Student’s t test for unpaired data was used to compare MGUS subjects and MM patients. The correlation coefficient between mean erythrocyte aggregation (MEA) and hematocrit (Ht) was evaluated in MGUS, MM and MGUS + MM groups using the Spearman test. RESULTS: the comparison between MGUS and MM shows that the measured blood viscosity and calculated blood viscosity based on hematocrit and total plasma protein, but not which estimated in relation to the hematocrit and plasma fibrinogen, differentiate the two groups. A difference between the two groups also regards the measured erythrocyte aggregation and its surrogate marker. In addition, the measured plasma viscosity at low shear rate (0.51 s–1) and, in particular, the ratio between plasma viscosity at low (0.51 s–1) and high (450 s–1) shear rates distinguish MGUS and MM. CONCLUSIONS: calculated blood viscosity (de Simone formula and other formulas) and the surrogate marker of erythrocyte aggregation disclose an alike trend with the corresponding hemorheological determinants obtained by using their direct measurement.

scholarly journals Protective Effects of Fufang Xueshuantong on Diabetic Retinopathy in Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Huihui Duan ◽  
Jianmei Huang ◽  
Wei Li ◽  
Minke Tang
Keyword(s):  
Diabetic Retinopathy ◽  
Aldose Reductase ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Plasma Viscosity ◽  
Erythrocyte Aggregation ◽  
Protective Effects ◽  
Whole Blood Viscosity ◽  
Vessel Morphology ◽  
Acellular Capillaries

The aim of this study was to evaluate the protective effects of Fufang Xueshuantong (FXT) on diabetic retinopathy in rats induced by streptozotocin (STZ). Diabetes was induced in Sprague-Dawley rats by a single injection of 60 mg/kg STZ. One week after STZ, FXT 0.525 g/kg or 1.05 g/kg was administrated to the rats by intragastric gavage (ig) once daily consecutively for 24 weeks. The control rats and untreated STZ rats received vehicle the same way. At the end of the experiment, the erythrocyte aggregation and blood viscosity were assayed. The retina vessel morphology was observed in retinal digestive preparations. Expression of occludin and intercellular adhesion molecule-1 (ICAM-1) in retina was measured by western blotting. Expression of vascular endothelial growth factor (VEGF) and pigment epithelium derived factor (PEDF) in retina was detected by immunohistochemistry. The activity of aldose reductase in retina was investigated with a NADPH oxidation method. The results showed that, in STZ rats, there were distinct lesions in retinal vessel, including decrease of pericytes and increase of acellular capillaries, together with dilatation of retinal veins. The expression of VEGF and ICAM-1 increased, while the expression of PEDF and occludin decreased. The activity of aldose reductase elevated, and the whole blood viscosity, plasma viscosity, and erythrocyte aggregation also increased after STZ stimulation. FXT 0.525 g/kg and 1.05 g/kg demonstrated significant protective effects against STZ induced microvessel lesion in the retina with increased pericytes and reduced acellular capillaries. FXT also reduced the expression of VEGF and ICAM-1 and enhanced the expression of PEDF and occludin in STZ insulted rats. The activity of aldose reductase, the whole blood viscosity, plasma viscosity, and erythrocyte aggregation also decreased after FXT treatment. The results demonstrated that FXT has protective effect on STZ induced diabetic retinopathy in rats.

Change in Hemorrheological and Biochemical Parameters following Membrane Differential Filtration

1995 ◽  
Vol 18 (12) ◽  
pp. 794-798 ◽  
Author(s):  
R. Brunner ◽  
R.A. Widder ◽  
P. Walter ◽  
H. Borberg ◽  
K. Oette
Keyword(s):  
Visual Acuity ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Biochemical Parameters ◽  
Hdl Cholesterol ◽  
Plasma Viscosity ◽  
Erythrocyte Aggregation ◽  
Rheological Parameters ◽  
Whole Blood Viscosity ◽  
Differential Filtration

Introduction: The elimination of high molecular weight proteins may have a positive influence on disorders of the microcirculation due to an improvement in rheological parameters. We therefore attempted to evaluate the rheological efficacy of membrane differential filtration (MDF). Patients and methods: Ten patients suffering from macular disease underwent MDF. Rheological and biochemical parameters as well as visual acuity were determined one day before and after therapy: The study aimed at a reduction in plasma viscosity, standardized whole blood viscosity at hematocrit 0.45 and erythrocyte aggregation at hematocrit 0.3. Results: Severe side-effects were not observed. The rheological parameters were significantly reduced. In detail the posttreatment values were reduced as compared to the pretreatment values as follows: plasma viscosity 85%, standardised whole blood viscosity 86% (hematocrit 0.45), erythrocyte aggregation 59% (hematocrit 0.3), total protein 81%, IgG 66%, IgA 59%, IgM 33%, alpha-2-macroglobulin 30%, triglycerides 102%, total cholesterol 47%, VLDL cholesterol 94%, LDL cholesterol 33%, HDL cholesterol 62%. Visual acuity was improved in 7/10 patients. Conclusions: MDF is a safe and highly effective method for lowering biochemical and improving rheological parameters which led to improvement in visual acuity. We have already replaced plasma exchange with MDF in our clinical practice of hemorrheological therapy.

scholarly journals The effect of improvement in diabetic control on plasma and whole blood viscosity

Diabetologia ◽  
1980 ◽  
Vol 19 (4) ◽  
pp. 345-349 ◽  
Author(s):  
R. B. Paisey ◽  
J. Harkness ◽  
M. Hartog ◽  
T. Chadwick
Keyword(s):  
Blood Viscosity ◽  
Whole Blood ◽  
Diabetic Control ◽  
Whole Blood Viscosity

Viscosity and Red Cell Deformity in Arterial Disease

1979 ◽  
Author(s):  
G Cella ◽  
H de Haas ◽  
M Rampling ◽  
V Kakkar
Keyword(s):  
Vascular Disease ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Arterial Disease ◽  
Plasma Viscosity ◽  
Control Group ◽  
Fibrinogen Concentration ◽  
Red Cell ◽  
Whole Blood Viscosity ◽  
Significant Difference

Haemorrheological factors have been shown to be affected in many kings of vascular disease. The present study was undertaken to correlate these factors in normal subjects and patients suffering from peripheral arterial disease. Twenty-two patients were investigated; they had moderate or severe intermittent claudication, extent of disease being confirmed by aorto-arteriography and ankle-systolic pressure studies. Twenty-five controls with no symptoms or signs of arterial disease were selected with comparable age and sex distribution. Whole blood viscosity was measured at shear rates of 230 secs-1 and 23 secs-lat 37°c using a Wells Brookfield cone plate microvisco meter. Plasma viscosity was also measured in an identical manner. Erythrocyte flexibility was measured by centrifuge technique and fibrinogen concentration as well as haematocrit by standard techniques. The fibrinogen concentration appeared to be the only significant parameter; the mean concentration in patients with peripheral vascular disease of 463 ± 73mg/l00ml in the control group ( < 0.05). Although whole blood viscosity was high in patients, when corrected to a common haematocrit, there was no significant difference between patients and controls. The same megative correlation was found for plasma viscosity. The red cell flexibility was found to be increased in patients as compared to the control group, but this effect appeared to be simply proportional to the fibrinogen concentration.

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