scholarly journals Biological Effect of Gas Plasma Treatment on CO2Gas Foaming/Salt Leaching Fabricated Porous Polycaprolactone Scaffolds in Bone Tissue Engineering

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Tae-Yeong Bak ◽  
Min-Suk Kook ◽  
Sang-Chul Jung ◽  
Byung-Hoon Kim
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Nitrogen Plasma ◽  
Salt Leaching ◽  
Foaming Process ◽  
Gas Plasma ◽  
Plasma Surface Treatment ◽  
Potential Applications ◽  
Gas Foaming

Porous polycaprolactone (PCL) scaffolds were fabricated by using the CO2gas foaming/salt leaching process and then PCL scaffolds surface was treated by oxygen or nitrogen gas plasma in order to enhance the cell adhesion, spreading, and proliferation. The PCL and NaCl were mixed in the ratios of 3 : 1. The supercritical CO2gas foaming process was carried out by solubilizing CO2within samples at 50°C and 8 MPa for 6 hr and depressurization rate was 0.4 MPa/s. The oxygen or nitrogen plasma treated porous PCL scaffolds were prepared at discharge power 100 W and 10 mTorr for 60 s. The mean pore size of porous PCL scaffolds showed 427.89 μm. The gas plasma treated porous PCL scaffolds surface showed hydrophilic property and the enhanced adhesion and proliferation of MC3T3-E1 cells comparing to untreated porous PCL scaffolds. The PCL scaffolds produced from the gas foaming/salt leaching and plasma surface treatment are suitable for potential applications in bone tissue engineering.

New calcium-free Na2 O-Al2 O3 -P2 O5 bioactive glasses with potential applications in bone tissue engineering

2017 ◽  
Vol 101 (2) ◽  
pp. 602-611 ◽  
Author(s):  
Oliwia Jeznach ◽  
Marcin Gajc ◽  
Karolina Korzeb ◽  
Andrzej Kłos ◽  
Krzysztof Orliński ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bioactive Glasses ◽  
Potential Applications

Poly(lactic-co-glycolic)/Nanostructured Merwinite Porous Composites for Bone Tissue Engineering. I. Preparation and Morphology

2011 ◽  
Vol 493-494 ◽  
pp. 718-722 ◽  
Author(s):  
Masoud Hafezi-Ardakani ◽  
Faranak Kavian ◽  
Fatollah Moztarzadeh ◽  
Mohamadreza Baghaban Eslaminejad ◽  
Ali Zamanian ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Weight Loss ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Solvent Casting ◽  
Salt Leaching ◽  
Uniform Microstructure ◽  
Porous Composites ◽  
Phosphate Buffered Saline ◽  
Interconnected Pores

A novel merwinite/ Poly(lactic-co-glycolic) nanocomposite was synthesized by a solvent casting/salt leaching technique with varying merwinite contents from 10 to 30% (w/w). Poly(lactic-co-glycolic) /merwinite foams with a co-continuous structure of interconnected pores were formed. The microstructure of the pores and the walls was controlled by varying the merwinite content. The pore structure becomes more and more irregular with increasing merwinite content. Pore sizes ranging from several microns to a few hundred microns were obtained. The degradation assessment of the scaffolds is performed in phosphate-buffered saline (PBS) solution at 37°C. Weight loss during storage at 37°C in PBS (pH 7.4) was determined for the scaffolds. Weight loss increased from pure to high content during incubation time. The prepared merwinite/ (Polylactic-co-glycolic) nanocomposite with uniform microstructure may be used in bone tissue engineering applications.

rBMSC and bacterial responses to isoelastic carbon fiber-reinforced poly(ether-ether-ketone) modified by zirconium implantation

2016 ◽  
Vol 4 (1) ◽  
pp. 96-104 ◽  
Author(s):  
Jian Li ◽  
Shi Qian ◽  
Congqin Ning ◽  
Xuanyong Liu
Keyword(s):  
Tissue Engineering ◽  
Carbon Fiber ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Fiber Reinforced ◽  
Hard Tissue ◽  
Ether Ether Ketone ◽  
Poly Ether Ether Ketone ◽  
Potential Applications ◽  
Ether Ketone

PEEK-based biomaterials have great potential applications as hard tissue substitutes in bone tissue engineering.

scholarly journals Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

2015 ◽  
Vol 12 (110) ◽  
pp. 20150509 ◽  
Author(s):  
J. P. Cattalini ◽  
A. Hoppe ◽  
F. Pishbin ◽  
J. Roether ◽  
A. R. Boccaccini ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Release ◽  
Umbilical Vein ◽  
Burst Release ◽  
Potential Applications ◽  
Cell Property ◽  
Umbilical Vein Endothelial Cells

This work aimed to develop novel composite biomaterials for bone tissue engineering (BTE) made of bioactive glass nanoparticles (Nbg) and alginate cross-linked with Cu 2+ or Ca 2+ (AlgNbgCu, AlgNbgCa, respectively). Two-dimensional scaffolds were prepared and the nanocomposite biomaterials were characterized in terms of morphology, mechanical strength, bioactivity, biodegradability, swelling capacity, release profile of the cross-linking cations and angiogenic properties. It was found that both Cu 2+ and Ca 2+ are released in a controlled and sustained manner with no burst release observed. Finally, in vitro results indicated that the bioactive ions released from both nanocomposite biomaterials were able to stimulate the differentiation of rat bone marrow-derived mesenchymal stem cells towards the osteogenic lineage. In addition, the typical endothelial cell property of forming tubes in Matrigel was observed for human umbilical vein endothelial cells when in contact with the novel biomaterials, particularly AlgNbgCu, which indicates their angiogenic properties. Hence, novel nanocomposite biomaterials made of Nbg and alginate cross-linked with Cu 2+ or Ca 2+ were developed with potential applications for preparation of multifunctional scaffolds for BTE.

scholarly journals A review of chitosan-, alginate-, and gelatin-based biocomposites for bone tissue engineering

2018 ◽  
Vol 5 (3-4) ◽  
pp. 97-109 ◽  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Repair ◽  
Bone Diseases ◽  
Natural Polymers ◽  
Antimicrobial Substances ◽  
Potential Applications

Bone diseases and injuries have a major impact on the quality of life. Classical treatments for bone repair/regeneration/replacement have various disadvantages. Bone tissue engineering (BTE) received a great attention in the last years. Natural polymers are intensively studied in this field due to their properties (biocompatibility, biodegradability, abundance in nature, high processability). Unfortunately, their mechanical properties are poor, which is why synthetic polymers or ceramics are added in order to provide the optimal compressive, elastic or fatigue strength. Moreover, growth factors, vitamins, or antimicrobial substances are also added to enhance the cell behavior (attachment, proliferation, and differentiation). In this review, new scientific results regarding potential applications of chitosan-, alginate-, and gelatin based biocomposites in BTE will be provided, along with their in vitro and/or in vivo tests.

scholarly journals Antibacterial graphene‐based hydroxyapatite/chitosan coating with gentamicin for potential applications in bone tissue engineering

2020 ◽  
Vol 108 (11) ◽  
pp. 2175-2189 ◽  
Author(s):  
Milena Stevanović ◽  
Marija Djošić ◽  
Ana Janković ◽  
Vesna Kojić ◽  
Maja Vukašinović‐Sekulić ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Chitosan Coating ◽  
Potential Applications

Surface modification of chitosan film via polydopamine coating to promote biomineralization in bone tissue engineering

2017 ◽  
Vol 33 (2) ◽  
pp. 134-145 ◽  
Author(s):  
Yang Liu ◽  
Zhongxun Zhang ◽  
Huilin Lv ◽  
Yong Qin ◽  
Linhong Deng
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Photoelectron Spectroscopy ◽  
Chitosan Film ◽  
Hydrophobic Surface ◽  
Modified Chitosan ◽  
Potential Applications

Chitosan-based material has been widely used as bone substitute due to its good biocompatibility and biodegradability. However, the hydrophobic surface of chitosan film constrains the osteogenesis mineralization in the process of bone regeneration. For this reason, we develop a novel polydopamine-modified chitosan film suitable for bone tissue engineering applications by a simple and feasible route in this study. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirm the process of surface modification. For comparison, surface wettability, the capacity of mineralization in vitro, and biocompatibility of the chitosan film and the polydopamine-modified chitosan film were assessed. Research results indicate that the polydopamine-modified chitosan film has good hydrophilicity. It is very evident that the polydopamine treatment significantly influences the biomineralization capacity of the chitosan-based substrates, which enhance the growth rate of apatite on the modified chitosan film. Besides, MC3T3-E1 osteoblast experiments demonstrate that the cells can adhere and grow well on the polydopamine-modified chitosan film. It is anticipated that this polydopamine-modified chitosan film, which can be prepared in large quantities simply, should have potential applications in bone tissue engineering.

Characterization of PCL/HA Composite Scaffolds for Bone Tissue Engineering

2007 ◽  
Vol 342-343 ◽  
pp. 109-112 ◽  
Author(s):  
Yong Taek Hyun ◽  
Seung Eon Kim ◽  
S.J. Heo ◽  
Jung Woog Shin
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Pore Size ◽  
Bone Tissue ◽  
Cell Attachment ◽  
Cell Number ◽  
Bone Cell ◽  
Composite Scaffolds ◽  
Initial Cell ◽  
Salt Leaching

Porous and bioactive composite scaffolds based on poly ε-caprolactone(PCL) and hydroxyapatite(HA) were successfully fabricated by solvent casting and salt leaching method. The scaffolds have interconnected pore structure with pore size ranging from 10μm to 500μm. The pore size of PCL scaffold and PCL/HA scaffold were similar to that of the salt particles. The pore walls became thick and the small pores on the surface of macropores were formed as the HA increased. MTT assay showed that HA content did not affect initial cell attachment in both PCL scaffolds and PCL/HA scaffolds. The osteoblasts proliferated in both scaffolds, but the cell number was higher in the PCL/HA composite scaffolds. It was found that the incorporation of hydroxyapatite enhances bone cell proliferation rather than initial cell attachment in PCL/HA composite scaffolds. The results suggest that the PCL/HA composite scaffolds have a potential for the bone tissue engineering applications.

Peptide functionalisation of nanocomposite polymer for bone tissue engineering using plasma surface polymerisation

RSC Advances ◽  
2015 ◽  
Vol 5 (97) ◽  
pp. 80039-80047 ◽  
Author(s):  
P. Gentile ◽  
C. Ghione ◽  
C. Tonda-Turo ◽  
D. M. Kalaskar
Keyword(s):  
Tissue Engineering ◽  
Surface Treatment ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Plasma Surface ◽  
Nanocomposite Polymer ◽  
Plasma Surface Treatment

Biofunctionalisation of POSS-PCU for bone tissue engineering by plasma surface treatment.

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