Peptide functionalisation of nanocomposite polymer for bone tissue engineering using plasma surface polymerisation

RSC Advances ◽  
2015 ◽  
Vol 5 (97) ◽  
pp. 80039-80047 ◽  
Author(s):  
P. Gentile ◽  
C. Ghione ◽  
C. Tonda-Turo ◽  
D. M. Kalaskar
Keyword(s):  
Tissue Engineering ◽  
Surface Treatment ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Plasma Surface ◽  
Nanocomposite Polymer ◽  
Plasma Surface Treatment

Biofunctionalisation of POSS-PCU for bone tissue engineering by plasma surface treatment.

scholarly journals Biological Effect of Gas Plasma Treatment on CO2Gas Foaming/Salt Leaching Fabricated Porous Polycaprolactone Scaffolds in Bone Tissue Engineering

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Tae-Yeong Bak ◽  
Min-Suk Kook ◽  
Sang-Chul Jung ◽  
Byung-Hoon Kim
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Nitrogen Plasma ◽  
Salt Leaching ◽  
Foaming Process ◽  
Gas Plasma ◽  
Plasma Surface Treatment ◽  
Potential Applications ◽  
Gas Foaming

Porous polycaprolactone (PCL) scaffolds were fabricated by using the CO2gas foaming/salt leaching process and then PCL scaffolds surface was treated by oxygen or nitrogen gas plasma in order to enhance the cell adhesion, spreading, and proliferation. The PCL and NaCl were mixed in the ratios of 3 : 1. The supercritical CO2gas foaming process was carried out by solubilizing CO2within samples at 50°C and 8 MPa for 6 hr and depressurization rate was 0.4 MPa/s. The oxygen or nitrogen plasma treated porous PCL scaffolds were prepared at discharge power 100 W and 10 mTorr for 60 s. The mean pore size of porous PCL scaffolds showed 427.89 μm. The gas plasma treated porous PCL scaffolds surface showed hydrophilic property and the enhanced adhesion and proliferation of MC3T3-E1 cells comparing to untreated porous PCL scaffolds. The PCL scaffolds produced from the gas foaming/salt leaching and plasma surface treatment are suitable for potential applications in bone tissue engineering.

Biomimetic Apatite/Polycaprolactone (PCL) Nanofibres for Bone Tissue Engineering Scaffolds

2007 ◽  
Vol 330-332 ◽  
pp. 991-994 ◽  
Author(s):  
M. Ngiam ◽  
T.R. Hayes ◽  
S. Dhara ◽  
B. Su
Keyword(s):  
Tissue Engineering ◽  
Surface Treatment ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Functional Groups ◽  
Sodium Hydroxide Solution ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
Tissue Engineering Scaffolds ◽  
Biomimetic Apatite

Chemical treatment of polycaprolactone was carried out to bioactivite the biodegradable polymer for bone tissue engineering application. The results show that surface modifications are necessary to introduce functional groups such as carboxylic groups for the effective induction of apatite nucleation, prior to SBF treatment. The functional groups, acting as anchors between the polymer and the apatite nuclei, dictate the duration of the induction period need for apatite nucleation. After the surface treatment with sodium hydroxide solution, the apatite nuclei will form and grow spontaneously into a dense and uniform layer of apatite, by taking up Ca2+ and PO4 2- ions that are present in the SBF, as SBF is supersaturated with respect to apatite. Similar surface treatment was applied to electrospun PCL nanofibres. Biomimetic apatite/PCL nanofibres were formed which can potentially be used as bone tissue engineering scaffolds.

HYDROXYAPATITE, ALGINATE, AND CHITOSAN FOR BONE SCAFFOLDS: SPECTROSCOPY STUDY

2016 ◽  
Vol 19 (2) ◽  
pp. 93-100
Author(s):  
Lalita El Milla
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Functional Groups ◽  
Bone Growth ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Tissue Engineering Scaffolds ◽  
Hydroxyapatite Powder ◽  
Materials Used

Scaffolds is three dimensional structure that serves as a framework for bone growth. Natural materials are often used in synthesis of bone tissue engineering scaffolds with respect to compliance with the content of the human body. Among the materials used to make scafffold was hydroxyapatite, alginate and chitosan. Hydroxyapatite powder obtained by mixing phosphoric acid and calcium hydroxide, alginate powders extracted from brown algae and chitosan powder acetylated from crab. The purpose of this study was to examine the functional groups of hydroxyapatite, alginate and chitosan. The method used in this study was laboratory experimental using Fourier Transform Infrared (FTIR) spectroscopy for hydroxyapatite, alginate and chitosan powders. The results indicated the presence of functional groups PO43-, O-H and CO32- in hydroxyapatite. In alginate there were O-H, C=O, COOH and C-O-C functional groups, whereas in chitosan there were O-H, N-H, C=O, C-N, and C-O-C. It was concluded that the third material containing functional groups as found in humans that correspond to the scaffolds material in bone tissue engineering.

Effect of Plasma Surface Treatment on Surface Energy and Adhesion Properties for Cr Coating on Substrates

2013 ◽  
Vol 51 (10) ◽  
pp. 735-741
Author(s):  
Dong-Yong Kim ◽  
Eun-Wook Jeong ◽  
Kwun Nam Hui ◽  
Youngson Choe ◽  
Jung-Ho Han ◽  
...  
Keyword(s):  
Surface Energy ◽  
Surface Treatment ◽  
Adhesion Properties ◽  
Plasma Surface ◽  
Plasma Surface Treatment ◽  
Cr Coating

Experimental Study on Plasma Surface Treatment of Capacitors Film

2008 ◽  
Vol 128 (5) ◽  
pp. 339-342
Author(s):  
Dai Ling ◽  
Yin Ting ◽  
Lin Fuchang ◽  
Yan Fei
Keyword(s):  
Experimental Study ◽  
Surface Treatment ◽  
Plasma Surface ◽  
Plasma Surface Treatment

PLGA+HA/βTCP scaffold incorporating simvastatin: a promising biomaterial for bone tissue engineering

2020 ◽  
Author(s):  
Mariane Beatriz Sordi ◽  
Ariadne Cristiane Cabral da Cruz ◽  
Águedo Aragones ◽  
Mabel Mariela Rodríguez Cordeiro ◽  
Ricardo de Souza Magini
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Thermal Analyses ◽  
Chemical Properties ◽  
Biological Properties ◽  
Scanning Calorimetry ◽  
Evaporation Technique ◽  
Porosity Analysis ◽  
Biphasic Ceramic

The aim of this study was to synthesize, characterize, and evaluate degradation and biocompatibility of poly(lactic-co-glycolic acid) + hydroxyapatite / β-tricalcium phosphate (PLGA+HA/βTCP) scaffolds incorporating simvastatin (SIM) to verify if this biomaterial might be promising for bone tissue engineering. Samples were obtained by the solvent evaporation technique. Biphasic ceramic particles (70% HA, 30% βTCP) were added to PLGA in a ratio of 1:1. Samples with SIM received 1% (m:m) of this medication. Scaffolds were synthesized in a cylindric-shape and sterilized by ethylene oxide. For degradation analysis, samples were immersed in PBS at 37 °C under constant stirring for 7, 14, 21, and 28 days. Non-degraded samples were taken as reference. Mass variation, scanning electron microscopy, porosity analysis, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetry were performed to evaluate physico-chemical properties. Wettability and cytotoxicity tests were conducted to evaluate the biocompatibility. Microscopic images revealed the presence of macro, meso, and micropores in the polymer structure with HA/βTCP particles homogeneously dispersed. Chemical and thermal analyses presented very similar results for both PLGA+HA/βTCP and PLGA+HA/βTCP+SIM. The incorporation of simvastatin improved the hydrophilicity of scaffolds. Additionally, PLGA+HA/βTCP and PLGA+HA/βTCP+SIM scaffolds were biocompatible for osteoblasts and mesenchymal stem cells. In summary, PLGA+HA/βTCP scaffolds incorporating simvastatin presented adequate structural, chemical, thermal, and biological properties for bone tissue engineering.

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