New calcium-free Na2 O-Al2 O3 -P2 O5 bioactive glasses with potential applications in bone tissue engineering

2017 ◽  
Vol 101 (2) ◽  
pp. 602-611 ◽  
Author(s):  
Oliwia Jeznach ◽  
Marcin Gajc ◽  
Karolina Korzeb ◽  
Andrzej Kłos ◽  
Krzysztof Orliński ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bioactive Glasses ◽  
Potential Applications

scholarly journals Biological Effect of Gas Plasma Treatment on CO2Gas Foaming/Salt Leaching Fabricated Porous Polycaprolactone Scaffolds in Bone Tissue Engineering

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Tae-Yeong Bak ◽  
Min-Suk Kook ◽  
Sang-Chul Jung ◽  
Byung-Hoon Kim
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Nitrogen Plasma ◽  
Salt Leaching ◽  
Foaming Process ◽  
Gas Plasma ◽  
Plasma Surface Treatment ◽  
Potential Applications ◽  
Gas Foaming

Porous polycaprolactone (PCL) scaffolds were fabricated by using the CO2gas foaming/salt leaching process and then PCL scaffolds surface was treated by oxygen or nitrogen gas plasma in order to enhance the cell adhesion, spreading, and proliferation. The PCL and NaCl were mixed in the ratios of 3 : 1. The supercritical CO2gas foaming process was carried out by solubilizing CO2within samples at 50°C and 8 MPa for 6 hr and depressurization rate was 0.4 MPa/s. The oxygen or nitrogen plasma treated porous PCL scaffolds were prepared at discharge power 100 W and 10 mTorr for 60 s. The mean pore size of porous PCL scaffolds showed 427.89 μm. The gas plasma treated porous PCL scaffolds surface showed hydrophilic property and the enhanced adhesion and proliferation of MC3T3-E1 cells comparing to untreated porous PCL scaffolds. The PCL scaffolds produced from the gas foaming/salt leaching and plasma surface treatment are suitable for potential applications in bone tissue engineering.

Synthesis of magnetic, macro/mesoporous bioactive glasses based on coral skeleton for bone tissue engineering

2014 ◽  
Vol 8 (4) ◽  
pp. 275-281 ◽  
Author(s):  
Chunhui Bian ◽  
Huiming Lin ◽  
Feng Zhang ◽  
Jie Ma ◽  
Fengxiao Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Coral Skeleton ◽  
Bioactive Glasses

scholarly journals Cuttlefish Bone-Derived Biphasic Calcium Phosphate Scaffolds Coated with Sol-Gel Derived Bioactive Glass

Materials ◽  
2019 ◽  
Vol 12 (17) ◽  
pp. 2711
Author(s):  
Ana S. Neto ◽  
Daniela Brazete ◽  
José M.F. Ferreira
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Phosphates ◽  
Sol Gel ◽  
Biological Properties ◽  
X Ray Diffraction ◽  
Bioactive Glasses ◽  
Hydrothermal Transformation

The combination of calcium phosphates with bioactive glasses (BG) has received an increased interest in the field of bone tissue engineering. In the present work, biphasic calcium phosphates (BCP) obtained by hydrothermal transformation of cuttlefish bone (CB) were coated with a Sr-, Mg- and Zn-doped sol-gel derived BG. The scaffolds were characterized by X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy. The initial CB structure was maintained after hydrothermal transformation (HT) and the scaffold functionalization did not jeopardize the internal structure. The results of the in-vitro bioactivity after immersing the BG coated scaffolds in simulated body fluid (SBF) for 15 days showed the formation of apatite on the surface of the scaffolds. Overall, the functionalized CB derived BCP scaffolds revealed promising properties, but further assessment of the in-vitro biological properties is needed before being considered for their use in bone tissue engineering applications.

rBMSC and bacterial responses to isoelastic carbon fiber-reinforced poly(ether-ether-ketone) modified by zirconium implantation

2016 ◽  
Vol 4 (1) ◽  
pp. 96-104 ◽  
Author(s):  
Jian Li ◽  
Shi Qian ◽  
Congqin Ning ◽  
Xuanyong Liu
Keyword(s):  
Tissue Engineering ◽  
Carbon Fiber ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Fiber Reinforced ◽  
Hard Tissue ◽  
Ether Ether Ketone ◽  
Poly Ether Ether Ketone ◽  
Potential Applications ◽  
Ether Ketone

PEEK-based biomaterials have great potential applications as hard tissue substitutes in bone tissue engineering.

scholarly journals Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

2015 ◽  
Vol 12 (110) ◽  
pp. 20150509 ◽  
Author(s):  
J. P. Cattalini ◽  
A. Hoppe ◽  
F. Pishbin ◽  
J. Roether ◽  
A. R. Boccaccini ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Release ◽  
Umbilical Vein ◽  
Burst Release ◽  
Potential Applications ◽  
Cell Property ◽  
Umbilical Vein Endothelial Cells

This work aimed to develop novel composite biomaterials for bone tissue engineering (BTE) made of bioactive glass nanoparticles (Nbg) and alginate cross-linked with Cu 2+ or Ca 2+ (AlgNbgCu, AlgNbgCa, respectively). Two-dimensional scaffolds were prepared and the nanocomposite biomaterials were characterized in terms of morphology, mechanical strength, bioactivity, biodegradability, swelling capacity, release profile of the cross-linking cations and angiogenic properties. It was found that both Cu 2+ and Ca 2+ are released in a controlled and sustained manner with no burst release observed. Finally, in vitro results indicated that the bioactive ions released from both nanocomposite biomaterials were able to stimulate the differentiation of rat bone marrow-derived mesenchymal stem cells towards the osteogenic lineage. In addition, the typical endothelial cell property of forming tubes in Matrigel was observed for human umbilical vein endothelial cells when in contact with the novel biomaterials, particularly AlgNbgCu, which indicates their angiogenic properties. Hence, novel nanocomposite biomaterials made of Nbg and alginate cross-linked with Cu 2+ or Ca 2+ were developed with potential applications for preparation of multifunctional scaffolds for BTE.

scholarly journals Injectable self-gelling composites for bone tissue engineering based on gellan gum hydrogel enriched with different bioactive glasses

2016 ◽  
Vol 4 ◽  
Author(s):  
Douglas Timothy ◽  
Piwowarczyk Wojciech ◽  
Liskova Jana ◽  
Schaubroeck David ◽  
Leeuwenburgh Sander ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Gellan Gum ◽  
Bioactive Glasses

scholarly journals A review of chitosan-, alginate-, and gelatin-based biocomposites for bone tissue engineering

2018 ◽  
Vol 5 (3-4) ◽  
pp. 97-109 ◽  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Repair ◽  
Bone Diseases ◽  
Natural Polymers ◽  
Antimicrobial Substances ◽  
Potential Applications

Bone diseases and injuries have a major impact on the quality of life. Classical treatments for bone repair/regeneration/replacement have various disadvantages. Bone tissue engineering (BTE) received a great attention in the last years. Natural polymers are intensively studied in this field due to their properties (biocompatibility, biodegradability, abundance in nature, high processability). Unfortunately, their mechanical properties are poor, which is why synthetic polymers or ceramics are added in order to provide the optimal compressive, elastic or fatigue strength. Moreover, growth factors, vitamins, or antimicrobial substances are also added to enhance the cell behavior (attachment, proliferation, and differentiation). In this review, new scientific results regarding potential applications of chitosan-, alginate-, and gelatin based biocomposites in BTE will be provided, along with their in vitro and/or in vivo tests.

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