scholarly journals Metastatic Squamous Cell Carcinoma of the Anus to the Lung Confirmed with Allelotyping

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Rachel Roth ◽  
Susan Moffatt-Bruce ◽  
Marino E. Leon
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Loss Of Heterozygosity ◽  
Squamous Cell ◽  
Palliative Chemotherapy ◽  
Primary Tumors ◽  
Appropriate Treatment ◽  
Metastatic Squamous Cell Carcinoma ◽  
Hematoxylin And Eosin

Histopathologic techniques are insufficient for distinguishing primary squamous cell carcinoma (SCC) from metastatic SCC, which is clinically important. A patient with SCC of the anus was found to also have SCC of the lung, and the question of metastatic versus synchronous primary diseases was raised. Immunohistochemical and hematoxylin and eosin (H&E) staining on sections of tissue could not discriminate between the two entities. Immunostain for p16 and chromogenicin situhybridization for human papillomavirus (HPV) type 16 were positive in both tumors. Additionally, allelotyping for loss of heterozygosity displayed similar findings and confirmed the histopathological impression of anal SCC metastasis to the lung. The patient was treated with palliative chemotherapy instead of additional surgical treatment. When multiple tumors are present, determining metastatic versus synchronous primary tumors is necessary for appropriate treatment. Identification can be achieved using allelotyping for loss of heterozygosity.

scholarly journals Metastatic squamous cell carcinoma in situ in vulva associated with pigmentation.

1984 ◽  
Vol 23 (3) ◽  
pp. 443-447
Author(s):  
Toshihiko IGARASHI ◽  
Akira GOTO ◽  
Shoji KODAMA ◽  
Norio OBATA ◽  
Tamotsu HANDOU ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma In Situ ◽  
Metastatic Squamous Cell Carcinoma

scholarly journals Metastatic Squamous Cell Carcinoma of the Tonsil Mimicking Choroidal Melanoma

2020 ◽  
Vol 6 (6) ◽  
pp. 405-409
Author(s):  
Elaine M. Binkley ◽  
Aron D. Sampson ◽  
Nasreen A. Syed ◽  
H. Culver Boldt
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Choroidal Melanoma ◽  
Vascular Tumor ◽  
Needle Aspiration ◽  
Primary Tumors ◽  
Metastatic Squamous Cell Carcinoma ◽  
History Of ◽  
Positive Angle

We describe a case of a 53-year-old man with a history of metastatic squamous cell carcinoma of the tonsil who presented with a large, dome-shaped, choroidal mass in the left eye with concern for extra-ocular extension. Standardized echography showed a choroidal mass with low-to-medium internal reflectivity, pockets of very low reflectivity, positive angle kappa, and 1+ vascularity that were concerning for primary choroidal melanoma. Biopsy of the lesion was consistent with metastatic squamous cell carcinoma of the tonsil rather than melanoma. This is only the second reported case of metastatic squamous cell carcinoma to the choroid presenting with a large vascular tumor with echographic characteristics consistent with choroidal melanoma. The unique vascularity present in some cases of squamous cell carcinoma of the tonsil may explain the vascularity and large height of this patient’s lesion. Tumor fine-needle aspiration biopsy can play an important role in patients with choroidal lesions in the setting of unusual primary tumors.

scholarly journals Immunohistochemical Study of IMP3 Expression in Laryngeal Squamous Cell Carcinoma

2021 ◽  
Vol 9 (A) ◽  
pp. 1168-1173
Author(s):  
Wala’a Ahmad Al-Sayed Ashmawy ◽  
Ahmed Mahmoud Abd-Elaziz ◽  
Amira Mohamed Bassam ◽  
Heba Abdelmonem Ibrahim
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Tissue ◽  
Rna Binding ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Malignant Tumors ◽  
Hematoxylin And Eosin ◽  
Department Faculty

BACKGROUND: IMP3 is an RNA binding protein, which is strongly expressed in malignant tumors, promoting tumor cell proliferation. AIM: The aim of the study was to evaluate the expression of IMP3 in laryngeal squamous cell carcinoma (SCC) and to correlate the expression of IMP3 with available clinicopathological data. METHODS: Sixty one total laryngectomy and laryngoscopic biopsies; collected from the Pathology Department, Faculty of Medicine, Cairo University. Two slides were prepared from each paraffin embedded tumor block, one slide for Hematoxylin and Eosin staining, and the other for immunohistochemical staining by IMP3 polyclonal antibody. RESULTS: Thirty-seven cases (60.7%) showed positive IMP3 expression, and a statistically significant correlation was found between IMP3 expressions in normal, dysplastic epithelium/in situ component, and the invasive malignant tumor tissue. Correlations between IMP3 expression and other available clinicopathological data were all non-significant. CONCLUSION: This study suggests that IMP3 might play a role in laryngeal SCC carcinogenesis and progression process from normal to dysplastic to malignant epithelium, and thus IMP3 might be targeted by gene therapy.

Loss of heterozygosity at 11q23.3 in vasculoinvasive and metastatic squamous cell carcinoma of the cervix

2001 ◽  
Vol 32 (5) ◽  
pp. 475-478 ◽  
Author(s):  
Maureen J. O'Sullivan ◽  
Janet S. Rader ◽  
Daniela S. Gerhard ◽  
Yan Li ◽  
Kathryn M. Trinkaus ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Loss Of Heterozygosity ◽  
Squamous Cell ◽  
Metastatic Squamous Cell Carcinoma
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