Loss of heterozygosity at 11q23.3 in vasculoinvasive and metastatic squamous cell carcinoma of the cervix

2001 ◽  
Vol 32 (5) ◽  
pp. 475-478 ◽  
Author(s):  
Maureen J. O'Sullivan ◽  
Janet S. Rader ◽  
Daniela S. Gerhard ◽  
Yan Li ◽  
Kathryn M. Trinkaus ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Loss Of Heterozygosity ◽  
Squamous Cell ◽  
Metastatic Squamous Cell Carcinoma

scholarly journals Metastatic Squamous Cell Carcinoma of the Anus to the Lung Confirmed with Allelotyping

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Rachel Roth ◽  
Susan Moffatt-Bruce ◽  
Marino E. Leon
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Loss Of Heterozygosity ◽  
Squamous Cell ◽  
Palliative Chemotherapy ◽  
Primary Tumors ◽  
Appropriate Treatment ◽  
Metastatic Squamous Cell Carcinoma ◽  
Hematoxylin And Eosin

Histopathologic techniques are insufficient for distinguishing primary squamous cell carcinoma (SCC) from metastatic SCC, which is clinically important. A patient with SCC of the anus was found to also have SCC of the lung, and the question of metastatic versus synchronous primary diseases was raised. Immunohistochemical and hematoxylin and eosin (H&E) staining on sections of tissue could not discriminate between the two entities. Immunostain for p16 and chromogenicin situhybridization for human papillomavirus (HPV) type 16 were positive in both tumors. Additionally, allelotyping for loss of heterozygosity displayed similar findings and confirmed the histopathological impression of anal SCC metastasis to the lung. The patient was treated with palliative chemotherapy instead of additional surgical treatment. When multiple tumors are present, determining metastatic versus synchronous primary tumors is necessary for appropriate treatment. Identification can be achieved using allelotyping for loss of heterozygosity.

scholarly journals MO3-2 Prognostic significance of metastatic sites in recurrent or metastatic squamous cell carcinoma of the head and neck

2021 ◽  
Vol 32 ◽  
pp. S296
Author(s):  
Ari Nishimura ◽  
Tomoya Yokota ◽  
Yoshiyuki Iida ◽  
Tomoyuki Kamijo ◽  
Takashi Mukaigawa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Metastatic Squamous Cell Carcinoma ◽  
Metastatic Sites

Prognostic factors in recurrent or metastatic squamous cell carcinoma of the head and neck

Head & Neck ◽  
2019 ◽  
Vol 41 (6) ◽  
pp. 1895-1902 ◽  
Author(s):  
Aurora Mirabile ◽  
Rosalba Miceli ◽  
Rosa Gioia Calderone ◽  
Laura Locati ◽  
Paolo Bossi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Metastatic Squamous Cell Carcinoma
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