scholarly journals Metastatic squamous cell carcinoma in situ in vulva associated with pigmentation.

1984 ◽  
Vol 23 (3) ◽  
pp. 443-447
Author(s):  
Toshihiko IGARASHI ◽  
Akira GOTO ◽  
Shoji KODAMA ◽  
Norio OBATA ◽  
Tamotsu HANDOU ◽  
...  
2018 ◽  
Vol 44 (5) ◽  
pp. 613-620 ◽  
Author(s):  
Andrew J. Matsumoto ◽  
Adam R. Schmitt ◽  
Logan M. Skelley ◽  
Christian L. Baum

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Rachel Roth ◽  
Susan Moffatt-Bruce ◽  
Marino E. Leon

Histopathologic techniques are insufficient for distinguishing primary squamous cell carcinoma (SCC) from metastatic SCC, which is clinically important. A patient with SCC of the anus was found to also have SCC of the lung, and the question of metastatic versus synchronous primary diseases was raised. Immunohistochemical and hematoxylin and eosin (H&E) staining on sections of tissue could not discriminate between the two entities. Immunostain for p16 and chromogenicin situhybridization for human papillomavirus (HPV) type 16 were positive in both tumors. Additionally, allelotyping for loss of heterozygosity displayed similar findings and confirmed the histopathological impression of anal SCC metastasis to the lung. The patient was treated with palliative chemotherapy instead of additional surgical treatment. When multiple tumors are present, determining metastatic versus synchronous primary tumors is necessary for appropriate treatment. Identification can be achieved using allelotyping for loss of heterozygosity.


2017 ◽  
Vol 58 (4) ◽  
pp. e275-e276
Author(s):  
Michelle T. Sun ◽  
Saul Rajak ◽  
Craig James ◽  
Shyamala C. Huilgol ◽  
Dinesh Selva

Ophthalmology ◽  
2008 ◽  
Vol 115 (10) ◽  
pp. 1673-1678 ◽  
Author(s):  
Carol L. Shields ◽  
Ajay Manchandia ◽  
Rajeeve Subbiah ◽  
Ralph C. Eagle ◽  
Jerry A. Shields

2008 ◽  
Vol 27 (1) ◽  
pp. 118-124 ◽  
Author(s):  
Jane E. Armes ◽  
Rohan Lourie ◽  
Greg Bowlay ◽  
Sepehr Tabrizi

2008 ◽  
Vol 61 (11) ◽  
pp. 880-883
Author(s):  
Hisae HACHIMURA ◽  
Kayo YAMAOKA ◽  
Tomoko KUYAMA ◽  
Kentaro TORIGOE ◽  
Kana SHIRAISHI ◽  
...  

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