scholarly journals Rejuvenating of Kidney Tissues on Alloxan Induced Diabetic Mice under the Effect of Momordica charantia

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Bhaskar Sharma ◽  
Mohd. Sufiyan Siddiqui ◽  
Gurudayal Ram ◽  
Ranjeet Kumar Yadav ◽  
Arti Kumari ◽  
...  
Keyword(s):  
Body Weight ◽  
Kidney Tissue ◽  
Serum Glucose ◽  
Momordica Charantia ◽  
Histopathological Study ◽  
Diabetic Mice ◽  
Herbal Products ◽  
Mortality And Morbidity ◽  
Chronic Disorder ◽  
Treatment Of Diabetes

Diabetes mellitus is a chronic disorder in human and responsible for different complications and also causes mortality and morbidity. A wide number of herbal products are employed in the treatment of diabetes for their better efficacy and safety compared to synthetic medicine. The present studies have established the antidiabetic potential and rejuvenating capacity of kidney tissues under the effect of extract. Diabetes was induced in the Swiss albino mice by injecting alloxan at the dose of 150 mg/kg body weight and aqueous extract of Momordica charantia fruits at doses of 100 mg/kg body weight and 250 mg/kg body weight was administered orally for three weeks. After 21 days of treatment of the aqueous extracts of Momordica charantia significantly reduces serum glucose level, kidney function tests, lipid peroxidation as well as histopathological study also did show adverse alternation in the morphological architecture of the kidney tissue. Thus, from this study we concluded that Momordica charantia exhibited significant antihyperglycemic and rejuvenating capacity of kidney tissues activities in alloxan induced diabetic mice.

TOTAL POLYPHENOL CONTENT, FREE RADICAL SCAVENGING, ALPHA-GLUCOSIDASE INHIBITION CAPACITY, THE EFFICACY IN CONTROLLING BLOOD GLUCOSE OF DIABETIC RATS OF THE MIXTURE VOS EXTRACTED FROM THE LEAVES OF CLEISTOCALYX OPERCULATUS, PSIDIUM GUAJAVA AND NELUMBO NUCIFERA

2013 ◽  
pp. 50-55
Author(s):  
Tuyet Mai Truong ◽  
Thi Lam Nguyen ◽  
Lan Anh Pham ◽  
Hoang Kien Truong
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Radical Scavenging ◽  
Psidium Guajava ◽  
Free Radical Scavenging ◽  
Diabetic Mice ◽  
Cleistocalyx Operculatus ◽  
Prevention And Treatment ◽  
Treatment Of Diabetes ◽  
Alpha Glucosidase

Objective: Plant polyphenols have antioxidant capacity and alpha-glucosidase inhibition to supporting for prevention and treatment of diabetes. Materials and Method: Present study was conducted to determine the content of total polyphenols, free radical scavenging and alpha-glucosidase inhibition of the VOS mixture that extracted from leaves (Voi leaves - Cleistocalyx operculatus (V), Oi leaves - Psidium guajava (O), Sen leaves - Nelumbo nucifera (S)). Results: The efficacy of blood glucose controlling in diabetic mice was investigated. After 8 weeks of administration with 200 mg VOS/kg body weight and 400 mg VOS/kg body weight, VOS diabetic mice had significantly reduced blood glucose level as compared to control diabetic mice. VOS diabetic mice with 400 mg dosage are lower in blood glucose levels than that of the diabetic mice with 200 mg. Also, the significant reducing in HbA1c was observed in VOS diabetic mice as compared with control diabetic mice. Conclusion: VOS-product extracted from Cleistocalyx operculatus leaves, guava leaves, lotus leaves might be considered as a safe product and to be a potential product in the supporting of prevention and treatment of diabetes.

scholarly journals Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3262
Author(s):  
Nada Oršolić ◽  
Damir Sirovina ◽  
Dyana Odeh ◽  
Goran Gajski ◽  
Vedran Balta ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Caffeic Acid ◽  
Fasting Blood Glucose ◽  
Kidney Tissue ◽  
Serum Glucose ◽  
The Body ◽  
Diabetic Mice ◽  
Atherogenic Indices ◽  
Liver And Kidney ◽  
Hematological And Biochemical Parameters

Diabetic dyslipidemia and hyperglycemia contribute to excessive reactive oxygen species (ROS) production, leading to deleterious complications, such as nephropathy, atherosclerosis and cardiac dysfunction, and target major organs in the body. The aim of this study was to investigate the effect of caffeic acid (CA) on mouse weight and survival, serum level of fasting blood glucose (FBG), serum lipid parameters and atherogenic indices, oxidative damage in blood, liver and kidney tissue, pathophysiological changes and their function markers in healthy and alloxan-induced type 1 diabetic mice. Diabetes was induced in mice with a single intravenous injection of alloxan (75 mg kg−1). Two days later, CA (50 mg kg−1) was given intraperitoneally for seven days in diabetic mice. Diabetes affected glucose level, lipid profile, hematological and biochemical parameters, induced DNA damage and apoptotic/necrotic death in whole blood cells, liver and kidney, leading to weight loss and a decreased lifespan. CA treatment of diabetic mice revealed a protective effect on the liver and kidney, hypoglycemic and hypolipidemic properties and high protection against atherogenic outcomes. The obtained results suggest that CA is a safe and potent agent against diabetes that acts as an effective antioxidant in reducing serum glucose, lipid profile and atherogenic indices, leading to increased lifespan in mice.

scholarly journals Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study / Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom

2016 ◽  
Vol 67 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Damir Sirovina ◽  
Nada Oršolić ◽  
Gordana Gregorović ◽  
Marijana Zovko Končić
Keyword(s):  
Lipid Peroxidation ◽  
Kidney Tissue ◽  
Thiobarbituric Acid ◽  
Diabetic Mice ◽  
Histopathological Changes ◽  
Thiobarbituric Acid Test ◽  
Liver And Kidney ◽  
Treatment Of Diabetes ◽  
Preliminary Study ◽  
Acid Test

Abstract The effect of naringenin, a flavonoid found in grapefruit, orange, and tomato, on lipid peroxidation and histopathological changes in the liver and kidneys of alloxan-induced diabetic mice were investigated. Two days after alloxan injection (75 mg kg−1, i.v.), naringenin ethanolic solution (0.5 % v/v) was given to mice intraperitoneally (50 mg kg−1 per day) for seven days. Naringenin’s impact on lipid peroxidation was measured by the 2-thiobarbituric acid test and histopathological changes were examined under a light microscope. Naringenin administration resulted in a significant decrease of lipid peroxidation level in liver and kidney tissue, as well as in a decreased number of vacuolated liver cells and degree of vacuolisation. Indications of tissue repair in kidney suggested that amelioration of diabetes-induced renal damage could be achieved over a longer period of time. Findings suggest that naringenin could be considered a dietary supplement in the prevention or treatment of diabetic complications and other diseases connected with oxidative stress, and gives a hope that it could show similar effects in the treatment of diabetes in humans.

EFFECT OF ZINGIBER OFFICINALE (LINN) A ETHANOLIC EXTRACT ON METFORMIN INDUCED HYPOGLYCEMIA IN ALLOXAN INDUCED DIABETIC MICE

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (04) ◽  
pp. 30-38
Author(s):  
R. U Kshirsagar ◽  
◽  
U. M Joshi ◽  
K. R. Biyani
Keyword(s):  
Glucose Level ◽  
Standard Dose ◽  
Ethanolic Extract ◽  
Concomitant Administration ◽  
Zingiber Officinale ◽  
Serum Glucose ◽  
Diabetic Mice ◽  
Oral Hypoglycaemic Agents ◽  
Treatment Of Diabetes ◽  
Novel Drug

Zingiber officinale (Linn.) has been used in traditional medicine for the treatment of diabetes. The aim of the study was to evaluate the antidiabetic effect of ethanolic extract of Zingiber officinale (EthZO) by concomitantly administering with synthetic oral hypoglycaemic agents (OHA) in diabetic mice. (EthZO)150 mg-metformin (250 mg/kg) were administered orally alone as well as concomitantly in alloxan-induced diabetic mice. After acute and chronic treatment the serum glucose level was determined. Administration of EthZO (150 mg) + metformin (200 mg) with optimized dose was studied concomitantly at the interval of 15 min. Decreased blood glucose level (BGL) was compared with standard dose of metformin and was found to be lower than normoglycemia. Hence, it can be concluded that concomitant administration of EthZO and metformin causes synergistic significant effect than metformin alone. It can be investigated as the novel drug therapy in the treatment of diabetes mellitus.

scholarly journals Antidiabetic potential of Triphala Guggul - an ayurvedic formulation in alloxan-induced diabetes animal model

2020 ◽  
Vol 11 (1) ◽  
pp. 315-322
Author(s):  
Krishna Murthy ◽  
Snehal D. Jagadale ◽  
Solunke R. S. ◽  
Shete R. V. ◽  
Priyanka Nangare
Keyword(s):  
Diabetes Mellitus ◽  
Animal Model ◽  
Body Weight ◽  
Normal Control ◽  
Serum Glucose ◽  
Oral Glucose ◽  
Standard Group ◽  
Oral Glucose Tolerance ◽  
Antidiabetic Drug ◽  
Treatment Of Diabetes

The purpose of this study was to evaluate the potential antidiabetic drug Triphala guggul (TG), an indigenous polyherbal Ayurvedic formulation in an alloxan-induced diabetes rat model. Diabetes mellitus was induced in rats. The rats were divided into nine groups, including the groups of normal control which received the vehicle, the standard group (Glibenclamide) and rats with induced diabetes were treated with the tablet of Triphala guggul and Triphala guggul churna in doses of 100, 200, 400 mg/kg body weight, respectively. They were administered orally for 28 days on a single dose. Blood was collected from the vein in the tail on days 7, 14, 21 and 28. Biochemical estimates were made using blood serum. Acute toxicity studies did not reveal toxicity in rats. For 28 days, Administration of Triphala guggul tablet and Triphala guggul churna formulations improved oral glucose tolerance in diabetes-induced rats and after 28 days, resulted in a significant reduction in serum glucose level compared to normal control rats. These formulations do not affect the kidney, adipose tissue, and liver. The Triphala guggul formulation has a promising antidiabetic property and is effective in the treatment of diabetes.

DEVELOPMENT OF THE INSULIN SECRETORY DEFECT IN GENETICALLY DIABETIC (db/db) MOUSE

1978 ◽  
Vol 87 (3) ◽  
pp. 543-551 ◽  
Author(s):  
Ove Berglund ◽  
Barbara J. Frankel ◽  
Bo Hellman
Keyword(s):  
Body Weight ◽  
Serum Insulin ◽  
Insulin Response ◽  
Serum Glucose ◽  
Pancreatic Β Cell ◽  
Diabetic Mice ◽  
Perfused Pancreas ◽  
Β Cell ◽  
Cell Hyperplasia ◽  
Genetically Diabetic Mice

ABSTRACT Genetically diabetic mice (C57BL/KsJ-db/db) were used as a model to study the development of defects of insulin secretion in relation to common metabolic indicators (body weight, serum glucose and insulin, and islet insulin contant). Consistent with the idea of a protective effect of oestrogen on the pancreatic β-cell, the female diabetic mice survived longer than the males. In males, while serum insulin decreased in the later stages of the disease, serum glucose increased progressively with age. Perfusion of the diabetic pancreases revealed a rise and subsequent fall with age of the basal insulin released at 3 mm glucose. Despite previous reports of β-cell hyperplasia, progressive impairment of the insulin response to 20 mm glucose, or to 20 mm glucose and 1 mm 3-isobutyl-1-methylxanthine, was seen with increasing age in experiments with perfused pancreas or microdissected islets. Islet content of insulin also decreased progressively with age in the diabetic animals.

scholarly journals Neuroprotective Effect of Cinamomum zeylanicum in streptozotocin induced diabetes in Mice

2016 ◽  
Vol 4 (01) ◽  
pp. 63-73 ◽  
Author(s):  
Rozina Parul ◽  
Md. Jahir Alam ◽  
Md. Sohel Rana
Keyword(s):  
Body Weight ◽  
Cerebral Ischemia ◽  
Neuroprotective Effect ◽  
Serum Glucose ◽  
Global Cerebral Ischemia ◽  
Glutathione Level ◽  
Cinnamomum Zeylanicum ◽  
Diabetes In Mice ◽  
Streptozotocin Induced Diabetes ◽  
Treatment Of Diabetes

Background: Diabetes is recognized as one of the leading causes of morbidity and mortality and representing as an emerging global epidemic worldwide. Diabetes and stroke both are the conditions which share various common threats. A patient with Diabetes has higher risk of stroke as compared to non Diabetics. Diabetes and stroke both affects the blood vessels. There are several biochemical pathways which are responsible for the developments of vascular complications due to hyperglycemia. Thus prevention and treatment of diabetes and stroke can reduce the risk of various vascular diseases. Cinnamomum zeylanicum has been used for the treatment of diabetes since long time. Cinnamomum zeylanicum rich in phenolic contents (antioxidants) have been identified as a major active component exhibiting antioxidant, and neuroprotective effects. The present study evaluate the neuroprotective effect of Cinnamomum zeylanicum in streptozotocin induced diabetes in mice and experimentally induced global cerebral ischemia/reperfusion injury in mice. Materials and methods: Swiss albino mice (male) weighing 20-30 g were randomized into eight groups. Diabetes was induced by administering streptozotocin (65 mg/kg, i.p).Starting from seven days after streptozotocin injection, insulin and Cinnamomum zeylanicum were administered for 3 weeks. Serum glucose level and body weight were measured weekly. Neuroprotective activity was carried out by global cerebral ischemia on swiss albino mice by carotid artery occlusion for 10 min followed by 24 hr. reperfusion. Measurement of Triglycerides, Malondialdehyde , cerebral infarct size and glutathione level was carried out at the end of the study. Results: After 21 days of treatment with Cinnamomum zeylanicum (75 mg/kg, 150 mg/kg and 300 mg/kg, p.o) significant increase in body weight and glutathione level and a significant reduction in serum glucose level, triglycerides, MDA levels and cerebral infarct size was observed as compared to diabetic control and diabetic+ stroke group. Conclusion: The present study concludes that Polyphenolic fraction of Cinnamomum zeylanicum not only attenuates the diabetes but also reverse the cerebral infarction in mice through its neuroprotective actions and thus Cinnamomum zeylanicum may serves as a new therapeutic alternative for management of brain damage associated with type-1 diabetes.

scholarly journals Lectin fromCrataeva tapiaBark Improves Tissue Damages and Plasma Hyperglycemia in Alloxan-Induced Diabetic Mice

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Amanda Alves da Rocha ◽  
Tiago Ferreira da Silva Araújo ◽  
Caíque Silveira Martins da Fonseca ◽  
Diógenes Luís da Mota ◽  
Paloma Lys de Medeiros ◽  
...  
Keyword(s):  
Folk Medicine ◽  
Intraperitoneal Administration ◽  
Serum Glucose ◽  
Exchange Chromatography ◽  
Diabetic Mice ◽  
Progressive Decline ◽  
Glucose Levels ◽  
Patients With Diabetes ◽  
Tissue Damages ◽  
Treatment Of Diabetes

Crataeva tapiais a plant popularly used for diabetes treatment, in Brazil. Progressive decline in renal and hepatic functions has been described in patients with diabetes mellitus, and mortality rate is increased in patients with chronic liver and renal disease. This study aimed to evaluate whetherCrataeva tapiabark lectin (CrataBL) improves hyperglycemia and renal and hepatic damage in diabetic mice. CrataBL was purified by ion exchange chromatography on CM-cellulose, and intraperitoneal administration of CrataBL to alloxan-induced diabetic mice at dose of 10 mg/Kg/day and 20 mg/Kg/day for 10 days significantly reduced serum glucose levels by 14.9% and 55.9%, respectively. Serum urea, creatinine, aspartate aminotransferase, and alanine aminotransferase were also significantly reduced after treatment with both doses of CrataBL. Furthermore, histological analysis of liver, kidney, and pancreas revealed an improvement in the tissue morphology upon treatment with CrataBL. The results suggest that CrataBL has a beneficial hypoglycemic activity and improves the renal and hepatic complications of diabetes. Therefore, this lectin may be a promising agent for the treatment of diabetes, and this might be the basis for its use in the folk medicine as an alternative treatment to manage diabetes-related complications such as hyperglycemia and tissue damage.

Hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin-induced diabetic rats

2016 ◽  
Vol 5 (06) ◽  
pp. 4641 ◽  
Author(s):  
Adel Abdel Moneim* ◽  
Sanaa M. Abd El-Twab ◽  
Mohamed B. Ashour ◽  
Ahmed I. Yousef
Keyword(s):  
Body Weight ◽  
Gallic Acid ◽  
Protein Profile ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Hypoglycemic Agents ◽  
Protective Effects ◽  
Coumaric Acid ◽  
Experimental Type

The goal of diabetes treatment is primarily to save life and alleviate symptoms and secondary to prevent long-term diabetic complications resulting from hyperglycemia. Thus, our present investigation was designed to evaluate the hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin (NA/STZ)-induced diabetic rats. Experimental type 2 diabetes was induced by a single intraperitoneal (i.p.) injection of STZ (65 mg/kg b.wt.), after 15 min of i.p. injection of NA (120 mg/kg b.wt.). Gallic acid and p-coumaric acid were orally administered to diabetic rats at a dose of 20, 40 mg/kg b.wt./day, respectively, for 6 weeks. Body weight, serum glucose, protein profile, liver function enzymes and kidney function indicators was assayed. Treatment with either gallic acid or p-coumaric acid significantly ameliorated the elevated levels of glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and uric acid. Both compounds were also found to restore total protein, albumin, and globulin as well as body weight of diabetic rats to near normal values. It can conclude that both gallic acid and p-coumaric acid have potent hypoglycemic and hepato-renal protective effects in diabetic rats. Therefore, our results suggest promising hypoglycemic agents that can attenuate the progression of diabetic hepatopathy and nephropathy.

scholarly journals The Effects of Medicinal Plants and Bioactive Natural Compounds on Homocysteine

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3081
Author(s):  
Mohammad Amin Atazadegan ◽  
Mohammad Bagherniya ◽  
Gholamreza Askari ◽  
Aida Tasbandi ◽  
Amirhossein Sahebkar
Keyword(s):  
Clinical Trials ◽  
Medicinal Plants ◽  
Vascular Endothelium ◽  
Animal Studies ◽  
Natural Compounds ◽  
Herbal Products ◽  
Mortality And Morbidity ◽  
Beneficial Effects ◽  
Serum Homocysteine ◽  
Prevention And Treatment

Background: Among non-communicable diseases, cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity in global communities. By 2030, CVD-related deaths are projected to reach a global rise of 25 million. Obesity, smoking, alcohol, hyperlipidemia, hypertension, and hyperhomocysteinemia are several known risk factors for CVDs. Elevated homocysteine is tightly related to CVDs through multiple mechanisms, including inflammation of the vascular endothelium. The strategies for appropriate management of CVDs are constantly evolving; medicinal plants have received remarkable attention in recent researches, since these natural products have promising effects on the prevention and treatment of various chronic diseases. The effects of nutraceuticals and herbal products on CVD/dyslipidemia have been previously studied. However, to our knowledge, the association between herbal bioactive compounds and homocysteine has not been reviewed in details. Thus, the main objective of this study is to review the efficacy of bioactive natural compounds on homocysteine levels according to clinical trials and animal studies. Results: Based on animal studies, black and green tea, cinnamon, resveratrol, curcumin, garlic extract, ginger, and soy significantly reduced the homocysteine levels. According to the clinical trials, curcumin and resveratrol showed favorable effects on serum homocysteine. In conclusion, this review highlighted the beneficial effects of medicinal plants as natural, inexpensive, and accessible agents on homocysteine levels based on animal studies. Nevertheless, the results of the clinical trials were not uniform, suggesting that more well-designed trials are warranted.

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