scholarly journals Lectin fromCrataeva tapiaBark Improves Tissue Damages and Plasma Hyperglycemia in Alloxan-Induced Diabetic Mice

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Amanda Alves da Rocha ◽  
Tiago Ferreira da Silva Araújo ◽  
Caíque Silveira Martins da Fonseca ◽  
Diógenes Luís da Mota ◽  
Paloma Lys de Medeiros ◽  
...  
Keyword(s):  
Folk Medicine ◽  
Intraperitoneal Administration ◽  
Serum Glucose ◽  
Exchange Chromatography ◽  
Diabetic Mice ◽  
Progressive Decline ◽  
Glucose Levels ◽  
Patients With Diabetes ◽  
Tissue Damages ◽  
Treatment Of Diabetes

Crataeva tapiais a plant popularly used for diabetes treatment, in Brazil. Progressive decline in renal and hepatic functions has been described in patients with diabetes mellitus, and mortality rate is increased in patients with chronic liver and renal disease. This study aimed to evaluate whetherCrataeva tapiabark lectin (CrataBL) improves hyperglycemia and renal and hepatic damage in diabetic mice. CrataBL was purified by ion exchange chromatography on CM-cellulose, and intraperitoneal administration of CrataBL to alloxan-induced diabetic mice at dose of 10 mg/Kg/day and 20 mg/Kg/day for 10 days significantly reduced serum glucose levels by 14.9% and 55.9%, respectively. Serum urea, creatinine, aspartate aminotransferase, and alanine aminotransferase were also significantly reduced after treatment with both doses of CrataBL. Furthermore, histological analysis of liver, kidney, and pancreas revealed an improvement in the tissue morphology upon treatment with CrataBL. The results suggest that CrataBL has a beneficial hypoglycemic activity and improves the renal and hepatic complications of diabetes. Therefore, this lectin may be a promising agent for the treatment of diabetes, and this might be the basis for its use in the folk medicine as an alternative treatment to manage diabetes-related complications such as hyperglycemia and tissue damage.

Hypoglycaemia in the treatment of diabetes mellitus

2011 ◽  
pp. 1849-1861
Author(s):  
Pratik Choudhary ◽  
Stephanie A. Amiel
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Concentration ◽  
Cerebral Metabolism ◽  
Chronic Complications ◽  
Glucose Levels ◽  
Patients With Diabetes ◽  
Treatment Of Diabetes ◽  
Clinically Significant ◽  
The Brain

Hypoglycaemia (low blood glucose concentration) is the most important acute complication of the pharmacological treatment of diabetes mellitus. Low blood glucose impairs brain (and, potentially, cardiac) function. The brain has minimal endogenous stores of energy, with small amounts of glycogen in astroglial cells. The brain is therefore largely dependent on circulating glucose as the substrate to fuel cerebral metabolism and support cognitive performance. If blood glucose levels fall sufficiently, cognitive dysfunction is inevitable. In health, efficient glucose sensing and counterregulatory mechanisms exist to prevent clinically significant hypoglycaemia. These are impaired by diabetes and by its therapies. Patients with diabetes rank fear of hypoglycaemia as highly as fear of chronic complications such as nephropathy or retinopathy (1). Fear of hypoglycaemia, hypoglycaemia itself and attempts to avoid hypoglycaemia limit the degree to which glycaemic control can be intensified to reduce the risk of chronic complications of diabetes both for type 1 and type 2 diabetes.

scholarly journals Hypoglycemic potential of Trixis angustifolia aqueous extract in alloxan-induced diabetic mice

2019 ◽  
Vol 14 (2) ◽  
pp. 74-79 ◽  
Author(s):  
Anuar Salazar-Gómez ◽  
María Elena Vargas-Díaz ◽  
Leticia Garduño-Siciliano
Keyword(s):  
Aqueous Extract ◽  
Reducing Sugars ◽  
Low Density Lipoprotein ◽  
Folk Medicine ◽  
Density Lipoprotein ◽  
Diabetic Mice ◽  
Glucose Levels ◽  
Hypoglycemic Agent ◽  
Aerial Parts ◽  
Blood Glucose Levels

The aim of the present study was to evaluate the hypoglycemic potential of Trixis angustifolia in alloxan-induced diabetic mice. An intragastric adminis-tration of the aqueous extract (50, 100 and 200 mg/kg) prepared from the aerial parts of T. angustifolia was evaluated. The treatment with the extract at 100 mg/kg produced a significant lowered (30.5%) of the blood glucose levels in diabetic mice after 15 days of daily oral administration. In addition, the extract induced a significant decrease in serum total cholesterol, low density lipoprotein whereas increased the high-density lipoprotein level. Additionally, the presence of alkaloids, cumarins, saponins, flavonoids and reducing sugars were identified in the extract. These findings provide a basis explain-ing the traditional folk medicine use of this plant as a hypoglycemic agent by the Mexican people.

scholarly journals Hypoglycemic Activity of Aqueous Extracts fromCatharanthus roseus

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Elisa Vega-Ávila ◽  
José Luis Cano-Velasco ◽  
Francisco J. Alarcón-Aguilar ◽  
María del Carmen Fajardo Ortíz ◽  
Julio César Almanza-Pérez ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Intraperitoneal Administration ◽  
Free Fraction ◽  
Hypoglycemic Activity ◽  
Aqueous Extracts ◽  
Diabetic Mice ◽  
Aqueous Fraction ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Stem Extract

Introduction.Catharanthus roseus(L.) is used in some countries to treat diabetes. The aim of this study was to evaluate the hypoglycemic activity of extracts from the flower, leaf, stem, and root in normal and alloxan-induced diabetic mice.Methods. Roots, leaves, flowers, and stems were separated to obtain organic and aqueous extracts. The blood glucose lowering activity of these extracts was determinate in healthy and alloxan-induced (75 mg/Kg) diabetic mice, after intraperitoneal administration (250 mg/Kg body weight). Blood samples were obtained and blood glucose levels were analyzed employing a glucometer. The data were statistically compared by ANOVA. The most active extract was fractioned. Phytochemical screen and chromatographic studies were also done.Results. The aqueous extracts fromC. roseusreduced the blood glucose of both healthy and diabetic mice. The aqueous stem extract (250 mg/Kg) and its alkaloid-free fraction (300 mg/Kg) significantly () reduced blood glucose in diabetic mice by 52.90 and 51.21%. Their hypoglycemic activity was comparable to tolbutamide (58.1%, ).Conclusions. The best hypoglycemic activity was presented for the aqueous extracts and by alkaloid-free stem aqueous fraction. This fraction is formed by three polyphenols compounds.

EFFECT OF ZINGIBER OFFICINALE (LINN) A ETHANOLIC EXTRACT ON METFORMIN INDUCED HYPOGLYCEMIA IN ALLOXAN INDUCED DIABETIC MICE

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (04) ◽  
pp. 30-38
Author(s):  
R. U Kshirsagar ◽  
◽  
U. M Joshi ◽  
K. R. Biyani
Keyword(s):  
Glucose Level ◽  
Standard Dose ◽  
Ethanolic Extract ◽  
Concomitant Administration ◽  
Zingiber Officinale ◽  
Serum Glucose ◽  
Diabetic Mice ◽  
Oral Hypoglycaemic Agents ◽  
Treatment Of Diabetes ◽  
Novel Drug

Zingiber officinale (Linn.) has been used in traditional medicine for the treatment of diabetes. The aim of the study was to evaluate the antidiabetic effect of ethanolic extract of Zingiber officinale (EthZO) by concomitantly administering with synthetic oral hypoglycaemic agents (OHA) in diabetic mice. (EthZO)150 mg-metformin (250 mg/kg) were administered orally alone as well as concomitantly in alloxan-induced diabetic mice. After acute and chronic treatment the serum glucose level was determined. Administration of EthZO (150 mg) + metformin (200 mg) with optimized dose was studied concomitantly at the interval of 15 min. Decreased blood glucose level (BGL) was compared with standard dose of metformin and was found to be lower than normoglycemia. Hence, it can be concluded that concomitant administration of EthZO and metformin causes synergistic significant effect than metformin alone. It can be investigated as the novel drug therapy in the treatment of diabetes mellitus.

scholarly journals Rejuvenating of Kidney Tissues on Alloxan Induced Diabetic Mice under the Effect of Momordica charantia

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Bhaskar Sharma ◽  
Mohd. Sufiyan Siddiqui ◽  
Gurudayal Ram ◽  
Ranjeet Kumar Yadav ◽  
Arti Kumari ◽  
...  
Keyword(s):  
Body Weight ◽  
Kidney Tissue ◽  
Serum Glucose ◽  
Momordica Charantia ◽  
Histopathological Study ◽  
Diabetic Mice ◽  
Herbal Products ◽  
Mortality And Morbidity ◽  
Chronic Disorder ◽  
Treatment Of Diabetes

Diabetes mellitus is a chronic disorder in human and responsible for different complications and also causes mortality and morbidity. A wide number of herbal products are employed in the treatment of diabetes for their better efficacy and safety compared to synthetic medicine. The present studies have established the antidiabetic potential and rejuvenating capacity of kidney tissues under the effect of extract. Diabetes was induced in the Swiss albino mice by injecting alloxan at the dose of 150 mg/kg body weight and aqueous extract of Momordica charantia fruits at doses of 100 mg/kg body weight and 250 mg/kg body weight was administered orally for three weeks. After 21 days of treatment of the aqueous extracts of Momordica charantia significantly reduces serum glucose level, kidney function tests, lipid peroxidation as well as histopathological study also did show adverse alternation in the morphological architecture of the kidney tissue. Thus, from this study we concluded that Momordica charantia exhibited significant antihyperglycemic and rejuvenating capacity of kidney tissues activities in alloxan induced diabetic mice.

scholarly journals Urate-lowering effects of dipeptidyl peptidase-4 inhibitors

2020 ◽  
Vol 23 (4) ◽  
pp. 349-356
Author(s):  
Taras S. Panevin ◽  
Olga V. Zhelyabina ◽  
Maxim S. Eliseev ◽  
Marina V. Shestakova
Keyword(s):  
Extracellular Fluid ◽  
Dipeptidyl Peptidase ◽  
Serum Glucose ◽  
Dipeptidyl Peptidase 4 ◽  
Glucose Levels ◽  
Dipeptidyl Peptidase 4 Inhibitors ◽  
Treatment Of Diabetes ◽  
Positive Effect ◽  
Metabolic Syndrome Components

Hyperuricemia is an increase of uric acid (UA) concentration in blood serum >420 pmol/L in men or >360 pmol/L in women and is considered to be a common biochemical abnormality. This condition shows that the extracellular fluid is oversaturated with urates, which concentration exceeds the limit of their solubility. This fact predisposes to the formation of crystals of sodium salt of UA and results in gout, urolithiasis, and other diseases. The frequent combination and relationship between purine and carbohydrate metabolism were noted in previous studies. In this regard, the choice of drugs for correcting these disorders should consider the possibility of a combined positive effect on the UA and serum glucose levels. The hypoglycemic drugs with pleiotropic effects on several metabolic syndrome components are considered to be of particular interest. Currently, one of the most frequently prescribed groups of drugs in the treatment of diabetes mellitus type 2 are dipeptidyl peptidase-4 inhibitors, which affect the level of incretins (gliptins). These drugs can be potentially attractive in patients with purine metabolism disorders since the available data indicate that these drugs affect UA level.

scholarly journals Glucocorticoid pulse therapy аnd carbohydrate metabolism in rheumatic diseases

2013 ◽  
Vol 94 (6) ◽  
pp. 920-923
Author(s):  
G I Nurullina
Keyword(s):  
Lupus Erythematosus ◽  
Inflammatory Diseases ◽  
Pulse Therapy ◽  
Serum Glucose ◽  
Peripheral Tissues ◽  
Family History Of Diabetes ◽  
Glucose Levels ◽  
Increased Risk ◽  
Patients With Diabetes ◽  
High Doses

Glucocorticoids are used in clinical practice for more than 50 years and are a great advance in the treatment of systemic inflammatory diseases. High doses of intravenous glucocorticoids (pulse therapy) are effective in conditions requiring rapid immunosuppression and antiinflammatory effect, such as systemic lupus erythematosus, rheumatoid arthritis, glomerulonephritis and systemic vasculitides. The advantage of this method are increased efficacy and lower rate of complications associated with prolonged administration of glucocorticoids. At the same time, glucocorticoid pulse therapy is associated with increased risk of hyperglycemia or even can be a cause of steroid-induced diabetes in patients without known hyperglycemia, as well as worsen glycemia control in patients with diabetes. Increased hepatic gluconeogenesis, inhibition of glucose uptake and metabolism in peripheral tissues and altered both receptor and post-receptor insulin action can lead to an increased serum glucose levels. In patients with inadequate compensatory reserves of pancreas, a clinical picture of diabetus mellitus can develop while treated with glucocorticoids. Blood glucose levels begin to rise 6-12 hours after the infusion of high doses of glucocorticoids. Risk factors for developing glucose intolerance and diabetes include advanced age, obesity, family history of diabetes and high cumulative doses of glucocorticoids. Glucocorticoid-induced diabetes is a common complication of pulse therapy, but exact causes are still not elucidated yet, current literature data on glucocorticoid-induced hyperglycemia are scarce.

scholarly journals Effect of Ethanolic Olive leaf and its Callus Ethanol Extracts in Alloxan- induced Diabetic mice (Blood glucose and lipid profiles)

2013 ◽  
Vol 7 (2) ◽  
pp. 63-69
Author(s):  
Sally Badawi ◽  
Saleh Ahmed ◽  
Nabeel Al -Ani
Keyword(s):  
Blood Glucose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Glucose ◽  
Hypoglycemic Effect ◽  
Lipid Lowering ◽  
Low Density ◽  
Diabetic Mice ◽  
Olive Leaf ◽  
Glucose Levels

This study was designed to test the lipid-lowering and antidiabetic activities of olive leaf and its callus extract. Diabetes in mice was induced by intraperitoneal injections of alloxan. The serum glucose and serum lipid were examined. Diabetic mice showed hypeglycemia, hypelipidemia. The administration, for 2 weeks of olive leaf and its callus extracts significantly decreased the Total cholesterol (TC). Triglycerides (TG). Low density lipoprotein (LDL), very low density lipoprotein (VLDL). Both types of olive extracts had significant hypoglycemic effects on blood glucose levels in diabetic mice. This hypoglycemic effect was as potent as the hypoglycemic effect of insulin. However, the callus extract was more potent than the leaves extracts and most potent than insulin in causing a significant decrease in LDL, VLDL, TC, TG and in antidiabetic effects.

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